CN 103287200 A (19) PH A RSA BAAR ey =p (12) SBS A IR (21) RFS 201210035688. 8 (22) IRF 2012. 02.17 CY RIRA VERE OTA a Heh 100080 dk RT ER KM Br 49-3 UAE LL (72) BEABA RAE (61) Int. cl. GOIN 30/88( 2006.01) GOIN 30/06 (2006. 01) (10) LIRA CN 103257200 4 (43) FIBA A 2013.08. 21 WERE SITE NSO ERT (64) RMA Ab STL TE a BA AL SUSE Reh PE ITIL, (6) %E Ae BG BEL EAT A BB HOHE Ie Be i EE RN HT, LEE CAF AaB PR ACER, CEREAL A SAAT UME AT ATE, FS TE EI J EA ADIN AR SELEAT 785, ULI SH ABET PT PD eb i rR PE CH (QFELIE Cube 2c PE SEI RR AA i SD TA, ZR A AE RA BR BC PAS AY WAGE PAUL, TT ALT DAB EDIE. te Sis DEO Ga, SRE, RE BS ES EME A YF Be SABA — a EL SE AS Wl ex ih at aE AE.(ON 103257200 4 QR wHe R + Aw Le 732 Fe SB TBC oe PE BS BT TES, SORE Ts GET LAE FR OP ee ae 15 AEA RS A JS A EE A EF IM 2a BEST AEHGELAT ETAT AE TE oe PUD ik» PURE A HBA IME HAD OFA tei ACL AR i (KS oe fe PD SE RE, TA ARAM, Agi lentG,,, 4.5% 250mm, 5 wm HEY 0. Sm L/min see Pe Vit SAH LEA y FARR + AK = 75425 ERE RE LO WL HEM 40°C sR SPH HMR GREE 3 L4nm, 2. RA AUSBESRS 1 PATS FA CE (IM BE BT TES TE APE TCE AA- PROD CERR HE CR AE IMA HE AT ER AT ATE INAS 2m. ARPS RTE BE FH LL. UC RRA HEN, N~ SRO 6 Se HRA BCAUSESRS 1 PITS FRA CE 0 BE TV TES, TE AP GECE TAEDA ROP AR EEC AS PERE 0. SL /min, See EAL AR Ee Bal FP + IK= 754250 A, HAE AAUSEESR. 1 PITHY FRA EA eo PH ETL, SE APIECE YD ETAL RD 1, IPT AV EAE 34m,CN 103257200 4 wom Fs 3H ABD GH ROMO HS SC Be BRASWAK [0001] bk menace BLATT EAB ANS ae i AY EA HT TAS, A EAS 9 Pt PERE BU TTI BRA [ooo] ABER, HL A LAL Sa ALL ITPA EY 8 aD» 18) 30.45 BPS A ARE ES 3 AP 5 Bd EF 9 tS UH ERS teh We [000s] PHRF AE, AeA REIL RAL A RPA RIE IRAE ETAL ARN DE CR AS ot EE FR HAN AL A BG EFL» ADH ee eT Fil PEP SLIR AAR AS ITU FL HEL ZETA HE GB 2760 +f Wa Ms Be EE HE it F(R Se AHS Bak (ooo4] i HIST Pa Shed ested td Ree a UL as A CATA. SEU SUTRA NH UR EL AT i eh Ke Sib » ANSEF FU et EAE SS AT Eh AOR A SS, EWR TE EE IA RR PEST RE RR EL AN, N- ROR RRS OMA EERE REE GIA PEA TERE SIRTF TE Cube I EL UAE A IMA Zo POR ERATE AC NB IL BPE ASL AY A BAEC LL ELA] CAFS EC HEIL Cooos) x ANY BE fee eke 2 AR ad EF Aes BO Ee 8 FO) A BP OU E,W LESS PEE 3 A PAS oP BRA (ooos] A ALHALE ALAS AL A HE oh RR RET, ALE PAGS [0007] 1 es Coos] sR E THY Fi bie Pr Fl ak SEF PE ZIM Ai RS ERR HH N, N- SOR ORES Se ACHAT AE TE, SME BE (000s) 2 iAH) SHE [ooo] ER IAT BRIE MITT TATA CABS, SE Lak RA foort] 2.1 RE [0012] 2. 2 EEE [0013] 2.3 CARER

98% « [oo1s] 2. ORME REI (1. mg/mL) PAPI 0. 0163 PR CL Be AIM A HEMT FATE RIPE AE 10. OmLo (ooz0] 2. 10 Har HR FA) A Hh ER CLE HE A Ha HE HR AL, HK PRE Hy 24. 00,16, 0,32. 0, 80. 0,160. Omg/Le (oozt] 3 (uaa at (ooz2] 3.1 HAASE TER sAOAT SRI TAS (VWD) o [0023] 3.2 AL HLs [0024] 3.3 BK. (0025) 3. 4 7Ki4. [0026] 3.5 RK Cooa7] 4 PEA Se bavi etait itll (ooze) 4.1 PERU (o029] a) 48H [0030] IK 10.0 SEIN RE TD 50mL SAF INA GOmL ARIA HE 2 EE FPL 30 3h HBR EAE. (oos1]b) 14 (oos2] 1 HAN TRAST RE EBS EH 250mL SBIR, DMA 50mL IE ei WARS, EAT UAH, AAA Coosa] 2, ETRE HAE A «DNA ERC PPP ZR EAL SL, BY A ABR AE EVRGAROS TAL, TARE » DAK 2 AEE AURE, 5000r/min BYLy min, EAA APT. [0034] c) fini [0035] WHR 1OmL PEMA MER. DA, mL TAAL SL TE ChE. LiL, PCN RE HA ETE i Amin, HAA, PRL IE Cet, FEI AL Sil, eR ANA, HME min, WR IE Oe hes ak 0, 22 um HERR, PE HPLC 4} 8. (oose] 4. 2 drifiee atl 4 [0037] FR HER IE AE BI RHEE 4. 00,16. 0,32. 0,80. 0,160. Omg/L, 4% 10. Le EUR. (oose] 5 wiz (ooss] 5. 1 HMA ES 128-5 ARE [0040] (Gi#HE C18,5 nm, 4. 5% 250mm, (oo41] fiat FA + k= [0042] HERE :10uL. [0043] FEI -40°C. [0044] ROWE RSPAS, A = 314m. [0045] Hi 20. 8ml /min. (oose] 5. 2 2 Hee RG Coo4a7] HAR 5. 1 HBA Ea 4 PML PE th Bet 4 > LARC ERE ET 22» A a eS EE©N 103257200 A ie 3/3 C (mg/L) RHEE A A IRLVELSD A, SE MELA, DPS Loose] 6 HERTS [0049] RRP ARM TRE mglkg) = SY [oos0] Ax () foos1] ak (loose) C——#8 br ME NBR HE SEA PEEP Hl dat PORE me /L 5 [0053] Vs E(B AR, mL. 5 [0054] m——F PEL, ARTHAK Coos] Sit 1s [0056] a) PKI 10.0 SEERA F 50mL BUDE, IMA 6OmL ARR BE 2 FPR. AE PEDAT ZAPPED A Sm ELD TPS 30 4} BP, 9 81S SA TK 9 PEE AE HE WRAL, VA 5000r/min BL 3min, Lis. [0057] b) fir Coosa] RH LOmL PEMA MER. DUA, mL AEARRIEEIBL SL TE Chie. LiL, Pi STS BE HA EAE i lmin, FAA, ARATE Cet, FEAL SL, SUL NAR, HME min, HATE Ot fas ak 0, 22 um HEN, (HE HPLC 4} Bf. [loose] c) prvi dH 2k 9 iil ae [oo6o] Hi) ER HE 2a ERG BN be HEAR 4. 00. 16. 0.32. 0,80. 0, 160. Omg/L, He EAS Tid SE OREGSEAT OT» ARCH AE LN siz Fe PAM A a a VR a 8, Bd FA 1 AI 2 iz. foo] 1 [0062] FEE (wg) 16 32 80, 160. Ca 67, 16.620 | 33.470 | 91.303 [ 183.650. Coosa] 2. eit Imbel aie [o0c4] AUR PATER AUREAA 10g, Ibe EY 25me/ke, HR 4.1 RARE I BTR TEFEN We SPP FA 3 as. [ooes] Pei HR CAE a AER A ay RH 94.8%. Cooee] — STi 5h WL, Ax HUBLI YE AA AA, WOR ER teh PRS Bg TAREE IU TVA, PNAS SAE RY LT ETH TH Coos 7] bes ii (IEA AS Be HI ZF Mn IPA A AS DDB il» FF AR RT SELLE ASA CE ASIDES A a UES FAA IE» AT a Re I DE TA TA LEASH AR WLI PAS Be BN ELI, Ae FS SA RAP ASE RE, AK (DUG, BRB 23. Tme/ ke, ELBCRYCN 103257200 4 Ares 475 150 125 100 7s 2s eves 02> Spent a = be oo Area = 1.1335036"Amt-0.8820715 Rel, Res%(1): -7.809 50 MISE: 0.00007 eran 1A