Régis Méjard, Hans J.

Griesser, Benjamin Thierry,

Optical biosensing for label-free cellular studies,
TrAC Trends in Analytical Chemistry,
Volume 53,
2014,
Pages 178-186,
ISSN 0165-9936,
https://doi.org/10.1016/j.trac.2013.08.012.
(https://www.sciencedirect.com/science/article/pii/S0165993613002422)
Abstract: Optical biosensors such as waveguides and surface-plasmon resonance (SPR)
sensors have found numerous applications in biomolecular sciences. We provide an
overview of these technologies in relation to the specific requirements of label-
free and high-throughput cellular studies. We dedicate specific emphasis to SPR-
based biosensors and recent developments particularly suitable for cellular
studies, such as long-range SPR. We discuss the advantages and the disadvantages of
the most successful optical-sensing technologies, and potential approaches in the
next generation of optical technologies.
Keywords: Biosensor; Cell-based assay; Cellular study; Detection; Label free; Long-
range SPR; Microorganism; Optical biosensing; Surface-plasmon resonance (SPR);
Waveguide