DDS Laboratory Postlab (Tablets) Tablet Coating

Types of Tablets: - Done to:

1. Compressed tablets ✓ Protect medicinal agent
2. Multiple compressed tablets ✓ Mask taste of drug
3. Sugar coated tablets ✓ Provide special characteristics of drug release
4. Film coated tablets ✓ Provide aesthetics or distinction
5. Gelatin coated tablets Sugar Coating
6. Enteric coated tablets 1. Waterproofing and sealing of coats
7. Buccal tablet 2. Subcoating
8. Sublingual tablet 3. Smoothing and final rounding
9. Chewable tablet 4. Finishing and coloring
10. Effervescent tablet 5. Imprinting
11. Molded tablet 6. Polishing
12. Tablet triturates Problems encountered in tablets:
13. Hypodermic tablets a. Lamination
14. Immediate release tablets b. Capping
15. Rapidly disintegrating tablets c. Picking
16. Extended-release tablet d. Peeling
17. Vaginal tablet e. Mottling
f. Orange peel effect
Method of Manufacture of Tablets: g. Bridging
1. Wet Granulation h. Tablet erosion
a. Weighing and blending of ingredients
b. Preparing a dampened powder/damp Packaging and Storage of Tablets:
mass - Packed in tight containers
c. Screening the damp mass - Stored in places of low humidity
d. Drying the granulation - Protect from extreme temperatures
e. Sizing the granulation - Moisture labile drugs are packed with a desiccant
f. Adding a lubricant then blending packet
g. Tableting by compression - Light labile drugs are packed in light-resistant
containers, such as amber bottles
2. Dry Granulation
a. Weighing and blending of ingredients
b. Slugging
c. Adding lubricant and blending
d. Tableting by compression

3. Direct Compression
- Some granular chemicals have free flowing
and cohesive properties allowing them to be
compressed directly
- Example: Potassium Chloride
- For chemicals lacking such qualities, special
pharmaceutical excipients may be used to
impart necessary qualities for direct
compression
- These excipients include:
✓ Fillers
✓ Disintegrating agents
✓ Lubricants
✓ Glidants