•

•
• Competencia por nutrientes y

• Producción de compuestos beneficiosos

• Función de barrera mejorada
•

Adjusted from www.customprobiotics.com

 Probióticos y un intestino sano
1. Competencia por nutrientes
2. Bioconversión
3. Producción de sustratos de crecimiento
4. Antagonismo directo
5. Exclusión competitiva
6. Función de barrera mejorada
7. Reducción de la inflamación
8. Estimulación de la respuesta inmune

Adjusted from www.customprobiotics.com Bermudez-Brito et al, 2012 Cual es el probiotico de eleccion?

8
 Probiótico Metabolito Efecto primario
Lactobacillus ácido láctico pH intestinal
Bacillus licheniformis liquenicidina C. perfringens
Bacillus subtilis Enzimas Digestión


 Streptococcus

Bacillus
Lactobacillus

Enterococcus

Pediococcus Bifidobacterium

Dong et al., 2017







o

13 Germinated state (A, B) and spore (C), Vogel et al. (2008)

ID de la muestra Células recuperadas

Lactobacillus <1 %

E. faecium 18 %

B. licheniformis ± 100 %

14
B-Act®

15
15
 
B-Act®

Scientific poster IHSIG 2019

16
16
•


Cama
humeda

C.
Disbiosis perfringens
EN
•

•
•
•

•
•
•

2020_W.Van der Veken_Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of C. perfringens-induced necrotic enteritis in broilers
Different letters indicate significant differences (P<0.05)

2020_W.Van der Veken_Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of C. perfringens-induced necrotic enteritis in broilers
Different letters indicate significant differences (P<0.05)

®
Rivera-Chavez et al., 2016
Rivera-Chavez et al., 2016
•

Rivera-Chavez et al., 2016

•

•
•
 Group 1

Regular dose
Group 2

Group 3

Seeder birds Salmonella negative birds

Salmonella Salmonella
negative positive birds
birds

Group 1

High dose
Group 2

Group 3
Seeder birds Salmonella negative birds negative
Salmonella Salmonella positive birds
birds
 Group 1

Regular dose
Group 2

Group 3

Seeder birds Salmonella negative birds

Salmonella Salmonella
negative positive birds
birds

Group 1

High dose
Group 2

Group 3
Seeder birds Salmonella negative birds negative
Salmonella Salmonella positive birds
birds


•
•
•
 Caecal microbiota
10.00 9.55 9.60

8.90 9.03
9.00 8.64
8.47a
8.10a 8.22a
7.82
8.00 7.55b
7.29b
7.00b
7.00

6.00
log CFU/g

5.00

4.00

3.00

2.00

1.00

0.00
Enterococci E. coli Enterococci E. coli Enterococci E. coli
Day 1 Day 10 Day 42
Control Miya-Gold®
Top Gut (1 kg/mton of feed)
 Butyrate levels in the caecum (d42) Technical performance (day 0-49)
140 3300.00 2.10
2.08b
132.12b 3231.67b
130 3200.00 2.05

120
3100.00 2.00

Average weight (g)

110
3000.00 1.95
103.41a
100
mmol

FCR
2900.00 1.90
90

2800.00 2780.91a 1.84a 1.85

80

2700.00 1.80
70

2600.00 1.75
60

50 2500.00 1.70
Control Top Gut (1 kg/mton of feed)
Miya-Gold® Control Miya-Gold®
Top Gut (1 kg/mton of feed)
Average weight (g) FCR
•
•
•
•
•
•

39
40


41
42


43
44
•




45
•
•
46
➢

47
®

48
 Potency at 40°C and 75% RH
120

100

80

Bio D® Synthetic
60
0 2 4 6
Month

49
50


51
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•
•
•