Značajnije publikacije vezane za bolest COVID-19 (15. veljače 2022.

1. Imunitet stečen preboljenjem je dugotrajnošću, efektivnošću i polivalentnošću superioran

imunitetu stečenom bilo kojom kombinacijom cijepljenja.

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection (nih.gov)

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to
viral escape mutations (nih.gov)

Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus

breakthrough infections | medRxiv

Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus Infection by Ellie
Ivanova, Joseph Devlin, Terkild Buus, Akiko Koide, Amber Cornelius, Marie Samanovic, Alberto
Herrera, Chenzhen Zhang, Ludovic Desvignes, Niels Odum, Robert Ulrich, Mark J. Mulligan, Shohei
Koide, Kelly V. Ruggles, Ramin Herati, Sergei B. Koralov :: SSRN

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans (nih.gov)

Anti-spike antibody response to natural SARS-CoV-2 infection in the general population | Nature
Communications

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants (science.org)

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection (nih.gov)

Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection

(nih.gov)

SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers

in England: a large, multicentre, prospective cohort study (SIREN) - The Lancet

High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and
atypical memory B cells than those primed by mRNA vaccines: Cell Reports

Severity of SARS-CoV-2 Reinfections as Compared with Primary Infections | NEJM

150 Research Studies Affirm Naturally Acquired Immunity to Covid-19: Documented, Linked, and
Quoted ⋆ Brownstone Institute

Antibodies perform best after covid infection, not vaccine: https://drive.google.com/file/d/17Hjiz-

d8JXsbTdVpmHQNpmKn_jvSWXIf/view

Immunity to SARS-CoV-2 up to 15 months after infection | bioRxiv

Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses

up to 16 months after infection | Nature Microbiology

Protective immunity after recovery from SARS-CoV-2 infection - The Lancet Infectious Diseases

Health-care workers recovered from natural SARS-CoV-2 infection should be exempt from mandatory
vaccination edicts - The Lancet Rheumatology

Necessity of COVID-19 Vaccination in Persons Who Have Already Had COVID-19 | Clinical Infectious
Diseases | Oxford Academic (oup.com)

Prevalence and Durability of SARS-CoV-2 Antibodies Among Unvaccinated US Adults by History of

COVID-19 | Coronavirus (COVID-19) | JAMA | JAMA Network
 2. SARS-CoV-2 cijepiva nisu neutralizirajuća cijepiva, ne stvaraju mukoznu imunost i cijepljene
osobe se mogu zaraziti i prenositi virus na druge osobe i to sličnom infektivnošću kao
necijepljene osobe koje prethodno nisu preboljele COVID-19. Zaštitni potencijal cijepiva protiv
teških oblika bolesti i smrti je zabilježen međutim pojavom novih sojeva vrlo brzo opada već
nekoliko mjeseci nakon poslijednje doze

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in
vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study (nih.gov)

Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce | NEJM

Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in
the United States | SpringerLink

Effectiveness of Covid-19 Vaccination Against Risk of Symptomatic Infection, Hospitalization, and

Death Up to 9 Months: A Swedish Total-Population Cohort Study by Peter Nordström, Marcel Ballin,
Anna Nordström :: SSRN

No Significant Difference in Viral Load Between Vaccinated and Unvaccinated, Asymptomatic and
Symptomatic Groups When Infected with SARS-CoV-2 Delta Variant | medRxiv

Vaccinated and unvaccinated individuals have similar viral loads in communities with a high
prevalence of the SARS-CoV-2 delta variant | medRxiv

Transmissibility of SARS-CoV-2 among fully vaccinated individuals – Authors' reply (nih.gov)

Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months | NEJM

Waning Immunity after the BNT162b2 Vaccine in Israel | NEJM

3. COVID-19 se u značajnoj mjeri može razviti u ozbiljnu bolest sa smrtnim ishodom kod ljudi koji
imaju određena bolesna stanja i deficijencije homeostaze organizma kao što su hipertenzija,
poremećaji u metabolizmu lipida, pretilost, neregulirani dijabetes, anksioznost te deficit D
vitamina. Istraživanje na uzorku od 4,9 milijuna hospitaliziranih odraslih je pokazalo da je
94,9% pacijenata hospitaliziranih s COVID-19 imalo prethodno dijagnosticirano najmanje 1
bolesno stanje.

Peer Reviewed: Underlying Medical Conditions and Severe Illness Among 540,667 Adults
Hospitalized With COVID-19, March 2020–March 2021 (nih.gov)

Genetic and phenotypic analysis of the causal relationship between aging and COVID-19 |
Communications Medicine (nature.com)

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness (plos.org)

4. Rizik komplikacija i smrti od bolesti COVID-19 za pedijatrijsku populaciju bez komorbiditeta je

iznimno nizak i usporediv s drugim respiratornim virusima koji kruže u općoj populaciji.
Imunokompromitirana i asmatičarska pedijatrijska populacija nema povećani rizik teških
ishoda bolesti COVID-19. Velika studija s odgovarajućom kontrolom skupinom je opovrgnula
hipoteze o dječijem 'long COVID' fenomenu.

Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-
2 infection | Nature Immunology

Local and systemic responses to SARS-CoV-2 infection in children and adults | Nature

Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with
SARS-CoV-2 infection in Germany | medRxiv
Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic
year | Nature Medicine

Immunocompromised children and young people are at no increased risk of severe COVID-19 -
ScienceDirect

Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study |
SpringerLink

Asthma and COVID-19: a systematic review (nih.gov)

5. Rizici cijepljenja djece;miokarditis, poremećaji u menstrualnom ciklusu i opasnosti

zaobilaženja genotoksičnih i kancerogenih kliničkih ispitivanja mRNA cijepiva.

Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December
2020 to August 2021 | Cardiology | JAMA | JAMA Network

Risk of Myocarditis from COVID-19 Infection in People Under Age 20: A Population-Based Analysis
(nih.gov)

Association Between Menstrual Cycle Length and Coronavirus D... : Obstetrics & Gynecology
(lww.com)

mRNA vaccines: Why is the biology of retroposition ignored?: paper_final_01 (nzdsos.com)

6. PANDEMIJSKE MJERE

Pandemijske mjere i njihov utjecaj na stil života rezultirale su porastom pretilosti kako kod odrasle tako
i kod pedijatrijske populacije.

Body Weight Changes During Pandemic-Related Shelter-in-Place in a Longitudinal Cohort Study |

Lifestyle Behaviors | JAMA Network Open | JAMA Network

Changes in Body Mass Index Among Children and Adolescents During the COVID-19 Pandemic |
Adolescent Medicine | JAMA | JAMA Network

Pandemijska mjera samoizolacije i prisilnog dugotrajnog kontakta članova istog kućanstva u

zatvorenom prostoru rezultirala je isporukom visokog titra virusa među članovima obitelji i dovela do
značajno lošijih ishoda zaraze. Kao kod svih respiratornih virusa ozbiljnost simptoma pa tako i konačni
ishod zaraze, osobito za osobe s komorbiditetima, itekako ovisi o dozi primljenog virusa. Što se tiče
smrtnih ishoda, problem izloženosti nije u brojnosti kontakata, nego u bliskosti i dugotrajnosti
pojedinog kontakta na što je velik utjecaj imao lockdown i mjera samoizolacije za kontakte koji su
najčešće članovi istog kućanstva. Izostanak uobičajenih socijalnih kontakata zbog izolacija i upotrebe
maski imao je negativan učinak na imunološku homeostazu zbog izostanka pripreme prirodnog
imuniteta vrlo niskim dozama virusnih čestica kojima se tijelo upoznaje s virusom u procesom tzv.
‘abortivne zaraze’. Negiranje sezonalnosti virusa je u mnogim zemljama spriječilo opuštanje mjere
socijalnog distanciranja i dodatno onemogućilo imuniziranje populacije u uvijetima boljeg imuniteta i
slabije zaraznosti virusa.

Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-
19 (plos.org)

Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection |
Nature Communications

Climatic signatures in the different COVID-19 pandemic waves across both hemispheres | Nature
Computational Science

Negativan utjecaj pandemijskih mjera na psihičko zdravlje odraslih i djece.

Mental health concerns during the COVID-19 pandemic as revealed by helpline calls | Nature

7. SARS-CoV-2 i dominacija Omikron varijante - evolucija pandemijskog virusa u virus prehlade.

The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine
escape and a switch in cell entry mechanism | medRxiv

The SARS-CoV-2 variant, Omicron, shows rapid replication in human primary nasal epithelial cultures
and efficiently uses the endosomal route of entry | bioRxiv

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta
variants strains in a mouse model of severe COVID-19 | bioRxiv

The SARS-CoV-2 B.1.1.529 Omicron virus causes attenuated infection and disease in mice and
hamsters (nih.gov)

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant | Nature

T cell responses to SARS-CoV-2 spike cross-recognize Omicron (nature.com)

Comparative Analysis of the Risks of Hospitalisation and Death Associated with SARS-CoV-2
Omicron (B.1.1.529) and Delta (B.1.617.2) Variants in England by Tommy Nyberg, Neil M. Ferguson,
Sophie G. Nash, Harriet H. Webster, Seth Flaxman, Nick Andrews, Wes Hinsley, Jamie Lopez Bernal,
Meaghan Kall, Samir Bhatt, Paula Bianca Blomquist, Asad Zaidi, Erik Volz, Nurin Abdul Aziz, Katie
Harman, Russell Hope, Andre Charlett, Meera A. Chand, Azra Ghani, Shaun Seaman, Gavin Dabrera,
Daniela DeAngelis, Anne M. Presanis, Simon Thelwall :: SSRN

Protection against the Omicron Variant from Previous SARS-CoV-2 Infection | NEJM

8. Životni ciklus virusa SARS-Cov-2 - kako virus ulazi u ljudsku stanicu i zaobilazi stanične
mehanizme obrane od invazije

How the coronavirus infects cells — and why Delta is so dangerous (nature.com)

Sastavila dr.sc.mol.biol. Josipa Nemet, izvorni oblik ovog dokumenta može se koristiti za informiranje i
edukaciju ali se ne smije mijenjati bez dozvole autora.

Josipa Nemet, dr.sc.mol.biol.