Name: SUA, TRIXIELA

Section: BSN – 1C

Review of recent developments in wound healing:

Biomaterial uses and medical technology

Abstract

The complex process of wound healing is essential for reestablishing the skin's barrier
function. Numerous illnesses have the potential to halt this process, leaving behind chronic
wounds that are extremely expensive to treat. Such wounds frequently get aggravated by a
pro-inflammatory environment brought on by elevated proteinases, hypoxia, and bacterial
buildup, and they fail to heal according to the stages of healing. Due to the complicated
symptoms brought on by the metabolic dysfunction of the wound microenvironment, the
comprehensive treatment of chronic wounds is still recognized as a substantial unmet medical
need. To address the chronic wound environment and achieve skin tissue regeneration, a
number of cutting-edge medical products, including wound dressings, wearable wound
monitoring, negative pressure wound therapy devices, and surgical sutures, have been
created. The majority of medical devices are made from a variety of materials, including
bioactive molecules like chemical drugs, silver, growth factors, stem cells, and plant
compounds, as well as natural and synthetic polymers like chitosan, keratin, casein, collagen,
hyaluronic acid, alginate, and silk fibroin. In order to provide a vital theoretical reference for
future studies on chronic wound healing, this review discusses these medical devices with an
emphasis on biomaterials and applications.