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    Nanying Liang
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    Over 20% of 103 cancer patients studied had delayed clearance of the COVID-19 virus. Those with delayed clearance lost antibodies to viral proteins and instead developed compensatory T-cell responses with increased CD8+ effector T-cells but a poorly focused T-cell receptor repertoire. In contrast, patients with a dominant CD4+ T-cell response had a lower rate of prolonged disease and a more focused T-cell receptor repertoire against COVID, consistent with effective viral clearance and memory development. The results show the importance of coordinated B-cell and CD4+ T-cell immunity in durable viral clearance and long-term control of COVID-19.

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    Over 20% of 103 cancer patients studied had delayed clearance of the COVID-19 virus. Those with delayed clearance lost antibodies to viral proteins and instead developed compensatory T-cell responses with increased CD8+ effector T-cells but a poorly focused T-cell receptor repertoire. In contrast, patients with a dominant CD4+ T-cell response had a lower rate of prolonged disease and a more focused T-cell receptor repertoire against COVID, consistent with effective viral clearance and memory development. The results show the importance of coordinated B-cell and CD4+ T-cell immunity in durable viral clearance and long-term control of COVID-19.

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    6 views1 page

    English 3

    Uploaded by

    Nanying Liang
    Over 20% of 103 cancer patients studied had delayed clearance of the COVID-19 virus. Those with delayed clearance lost antibodies to viral proteins and instead developed compensatory T-cell responses with increased CD8+ effector T-cells but a poorly focused T-cell receptor repertoire. In contrast, patients with a dominant CD4+ T-cell response had a lower rate of prolonged disease and a more focused T-cell receptor repertoire against COVID, consistent with effective viral clearance and memory development. The results show the importance of coordinated B-cell and CD4+ T-cell immunity in durable viral clearance and long-term control of COVID-19.

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    © All Rights Reserved
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    of 1

    How immune dysregulation affects recovery from

    COVID-19 infection in patients with cancer remains


    unclear. We analyzed cellular and humoral immune
    responses in 103 patients with prior COVID-19
    infection, over 20% of whom had delayed viral
    clearance. Delayed clearance was associated with
    loss of antibodies to nucleocapsid and spike
    proteins with a compensatory increase in
    functional T-cell responses. High-dimensional
    analysis of peripheral blood samples demonstrated
    increased CD8+ effector T-cell differentiation and a
    broad but poorly converged COVID-specific TCR
    repertoire in patients with prolonged disease.
    Conversely, patients with a CD4+ dominant
    immunophenotype had a lower incidence of
    prolonged disease and exhibited a deep and highly
    selected COVID-associated TCR repertoire,
    consistent with effective viral clearance and
    development of T-cell memory. These results
    highlight the importance of B-cells and CD4+ T-
    cells in promoting durable SARS-CoV-2 clearance
    and the significance of coordinated cellular and
    humoral immunity for long-term disease control.

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