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1
Fungal infectious occur due to :
1- Abuse of broad spectrum antibiotics
2- Decrease in the patient immunity
pengelompokan fungal infections
1. Superficial : Affect skin – mucous
membrane.e.g.
Tinea versicolor
Dermatophytes : Fungi that affect keratin
layer of skin, hair, nail.e.g.tinea pedis ,ring
worm infection
Candidiasis : Yeast-like, oral thrush,
vulvo-vaginitis , nail infections.
2- Deep infections
Affect internal organs as : lung ,heart ,
brain leading to pneumonia ,
endocarditis , meningitis.
FUNGAL INFECTIONS
SYSTEMIC LOCAL
HISTOPLASMOSIS DERMATOPHYTOn
ASPERGILLOSIS SPOROTRICHIOSIs
CRYPTOCOCCOSI ZYGOMYCOSIS
BLASTOMYCOSIS CHROMOMYCOSIs
MUCORMYCOSIS RHINOSPOIDIOSIS
CANDIDIASIS
PATKI 5
Classification of Antifungal Drugs
1- Antifungal Antibiotics :
Griseofulvin
Polyene macrolide : Amphotericin- B & Nystatin
2- Synthetic :
Azoles :
A) Imidazoles : Ketoconazole , Miconazole
B) Triazoles : Fluconazole , Itraconazole
Flucytosine
Squalene epoxidase inhibitors : e.g. Terbinafine & Naftifine.
Classification According to Route of
Administration
Systemic :
Griseofulvin , Amphotericin- B , Ketoconazole ,
Fluconazole , Terbinafine.
Topical
In candidiasis :
Imidazoles : Ketoconazole , Miconazole.
Triazoles : Terconazole.
Polyene macrolides : Nystatin , Amphotericin-B
Gentian violet : Has antifungal & antibacterial.
In Dermatophytes :
Squalene epoxidase inhibitors : Terbinafine &
Naftifine.
Tolnaftate.
White field ointment : 12% Benzoic acid &
6% Salicylic acid .
Castellani paint.
Cell Wall Active Antifungals
Cell membrane
• Polyene antibiotics
• Azole antifungals
DNA/RNA synthesis
• Pyrimidine analogues
- Flucytosine
Cell wall
• Echinocandins
-Caspofungin acetate (Cancidas)