Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Farah J. Nassar, Zahraa S. Msheik, Circulating miRNA as Revista Diagnostics
Maha M. Itani, Remie El Helou, biomarkers for Año 2021
Ruba Hadla, Firas Kreidieh, colorectal cancer Vol. 11
Rachelle Bejjany, Deborah diagnosis and liver
Mukherji, Ali Shamseddine, Rihab metastasis. Num. 1-15
R. Nasr, Sally N. Temraz.
SECCIÓN DE INTERÉS
Discussion
Several studies have been exploring circulating miRNA as potential biomarkers for CRC diagnosis,
prognosis and therapy prediction. However, most of the diagnostic studies were concerned with finding
these biomarkers for early stage CRC detection. In this study, we investigated the expression of
extensively studied circulating miRNAs in Lebanese Stage IV CRC patients and evaluated their potential
to be used as diagnostic biomarkers for advanced CRC and its liver metastasis. Our results showed that
miR-21, miR-145, miR-203, miR-155, miR-210, miR-31, and miR-345 were significantly upregulated in
the plasma of surgery naïve CRC patients when compared to healthy individuals. However, miR-19a,
miR-29a, and miR-23a were non-significantly dysregulated in the plasma of the surgery naïve CRC
patients. Moreover, we identified three panels of miRNA that could be used for diagnosis of Stage IV
CRC (miR-21 and miR-210) and liver metastasis in CRC (miR-210 and miR-203) and (miR-21, 203, 210
and 31).

Karla María Escobedo Uribe

 Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Weigang Chen, Chang Gao, Yong Bioinformatics analysis of Revista Frontiers in Genetics
Liu, Ying Wen, Xiaoling Hong, & prognostic miRNA Año 2020
Zunnan Huang. signature and potential Vol. 11
critical genes in colon
Num. 1-15
cancer.
SECCIÓN DE INTERÉS
Discussion
Targeting relationships are available between 8 prognostic miRNAs and 14 critical genes. Specifically
DTL, HMMR, MKI67, and RACGAP1 were predicted as the target genes of hsa-mir-6854. FANCI, KIF15,
NEK2, UBE2C, and ZWILCH were the target genes of hsa-mir-3189, hsa-mir-3677, hsa-mir-216a, hsa-
mir-4437, and hsa-mir-4999, respectively. MCM6 and TOP2A were the target genes of hsa-mir-887, and
CEP55, NCAPG2, and RRM2 were the target genes of hsa-mir-34b. To date, there have been no
experiments to confirm any of the above targeting relationships. Therefore, we speculate the existence
of these targeting relationships for further study, which might clarify the mechanisms of colon cancer
and provide novel methods for future exploration of prevention and treatment.

Karla María Escobedo Uribe

 Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Amirhossein Bahreyni, Diagnostic, prognostic, and Journal of celular
Revista
Melika Rezaei, Afsane therapeutic potency of physiology
Bahrami, Majid Khazaei, microRNA 21 in the Año 2018
Hamid Fiuji, Mikhali pathogenesis of colon cancer, Vol. 234
Ryzhikov, Gordon A. current status and
Ferns, Amir Avan, & Seyed prospective. Num. 8075-8081
Mahdi Hassanian.
SECCIÓN DE INTERÉS
Conclusion
Several studies showed that miR-21 tissue expression is positively associated with CRC
progression, shorter recurrence-free survival, and lymph node metastases. Furthermore, miR-21
plays a pivotal role in regulation of several tumor properties such as tumor growth, invasion, and
metastasis, at least partially by regulating expression of tumor suppressors, proapoptotic, and
metastatic genes including Ras homolog gene family member B, PTEN, Sprouty2, programmed cell
death 4, Integrin-ß4, and E-cadherin. The miR-21 overexpression is associated with a poor survival
in patients with CRC and enhances tumor growth via different mechanisms including inhibition of
apoptosis, promoting cell proliferations, and increasing metastasis and invasion in patients with
CRC.

Karla María Escobedo Uribe

 Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Xiaoping Yang, Yi Yu, Zirui NOX4 has the potential to be Revista Frontiers in Oncology
Wang, Pingfan Wu, Xiaolu Su, a biomarker associated with Año 2022
Zhiping Wu, Jianxin Gan, & colon cancer ferroptosis and Vol. 12
Dekui Zhang. immune infiltration based on Num.
1-16
bioinformatics análisis.
SECCIÓN DE INTERÉS
Results and Conclusion
Results showed that there were 4 DElncRNA, 4 DEmiRNA and 126 DEmRNA in ceRNA network.
NADPH oxidase 4 protein (NOX4) was a DEmRNA associated with immunity and ferroptosis in
ceRNA network. NOX4 was highly expressed in CC and connected with unfavourable prognosis.
NOX4 was obviously enriched in pathways connected with carcinogenesis and significantly
correlated with six kinds of immune cells. Immune checkpoints and NOX4 spearman correlation
analysis showed that the expression of NOX4 was positively related to programmed cell death
protein 1 (PD-1)-PDCD1, programmed cell death-Ligand 1 (PD-L1)-CD274 and cytotoxic T-
lymphocyte-associated protein 4 (CTLA4). To conclude, our study suggests that NOX4 is
associated with both ferroptosis and tumor immunity, and might be a biomarker associated with
the carcinogenesis, prognosis of CC and a potential target of CC immunotherapy.

Karla María Escobedo Uribe

 Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Huiya Liu, Lin Ma, Ling MicroRNA-937 is Revista Diagnostic Pathology
Wang, & Yizuo Yang. overexpressed and predicts Año 2019
poor prognosis in patients Vol. 14
with colon cancer. Num. 1-8
SECCIÓN DE INTERÉS
Discussion
In the present study, our results showed that the expression level of miR-937 was significantly
upregulated in colon cancer tissue specimens. The upregulation of miR-937 was remarkably
associated with lymph node metastasis and TNM stage. And colon cancer patients with high
miR-937 expression had a shorter overall survival rate. In addition, the expression levels of
miR-937 were also higher in colon cancer cell lines. Upregulation or downregulation of miR-937
promoted or inhibited the proliferation, migration, and invasión capacities of colon cancer cells
in vitro.

Karla María Escobedo Uribe

 Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Antonio Martínez A microRNA panel that Biochemistry and
Revista
Gutiérrez, Berenice regulates proinflammatory Biophysics Reports
Carbajal López, Triet M. cytokines as diagnostic and Año 2022
Bui, Monica Mendoza prognosis biomarkers in Vol. 30
Rodriguez, Alma D. colon cancer.
Campos Parra, Germán
Calderillo Ruiz, David
Cantú de Leon, Eduardo
Num. 1-7
Osiris Madrigal Santillán,
Ronen Sumagin, Carlos
Pérez Plascencia, Eloy
Andrés Pérez Yépez.
SECCIÓN DE INTERÉS
Abstract
Colon cancer (CC) is the third most common neoplasm and the fourth cause of cancer-related
death worldwide in both sexes. It has been established that inflammation plays a critical role in
tumorigenesis and progression of CC. Immune, stromal and tumor cells supply the tumor
microenvironment with pro-inflammatory cytokines such as interleukin 1ß, TNFa, IL-6 and IL-
11, to hyperactivate signaling pathways linked to cancerous processes. Recent findings suggest
a putative role of microRNAs (miRNAs) in the progression and management of the inflammator
response in intestinal diseases. Moreover, miRNAs are able to regulate expression of molecular
mediators that are linking inflammation and cancer. In this work a miRNA panel differentially
expressed between healthy, inflammatory bowel disease (IBD) and CC tissue was established.
Identified miRNAs regulate signaling pathways related to inflammation and cancer progression.
An inflammation associated-miRNA panel composed of 11-miRNAs was found to be
overexpressed in CC but not in inflamed or normal tissues (miR-21-5p, miR-304-5p, miR-577,
miR-335-5p, miR-21-3p, miR-27b-5p, miR-335-3p, miR-215-5p, miR-30b-5p, miR-192-5p, miR-
3065-5p). The association of top hit miRNAs, miR-3065-5p and miR-30b-5p expression with
overall survival of CC patients was demonstrated using Kaplan-Meier tests. Finally, differential
miRNA expression was validated using an inflammation-associated CC model induced by
Azoxymethane/Dextran Sodium Sulfate (AOM/DSS) to compare miRNA expression in normal
and inflamed tissue versus CC tissues. Based on these findings we propose the identified
inflammatory miRNA panel as a potent diagnostic tool for CC determination.

Karla María Escobedo Uribe

 Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Li Min, Shengtao Zhu, Lei Chen, Evaluation of circulating small Journal of
Xiang Liu, Rui Wei, Libo Zhao, extracelular vesicles derived Revista extracellular
Yuqing Yang, Zheng Zhang, miRNAs as biomarkers of vesicles.
Guanyi Kong, Peng Li, & Shutian early colon cancer: a Año 2019
Zhang. comparison with plasma total Vol. 8
miRNAs. Num. 1-17
SECCIÓN DE INTERÉS
Discussion
In summary, our results supported the opinion that sEVs derived miRNAs had a different
biological origin from other free-floating circulating miRNAs in blood. It is known that sEVs
derived miRNAs are loaded into exosomes selectively by a specific process, thus, the sEVs
derived miRNA profile is pre-specified and is not random, which refers to the fact that
exosomes induce changes which are preprogrammed in the host cells. In brief, plasma sEVs
derived miRNA and plasma total miRNA are two completely different kinds of tumor
biomarkers. We also compared the identification ability of CC between plasma sEVs derived
miRNA and plasma total miRNA. Our results showed that the AUC of plasma sEVs derived
miRNA was about 0.1 higher than the total miRNA of plasma for let-7b-3p, miR-139-3p, miR-
150-3p and miR-145-3p.

Karla María Escobedo Uribe

Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULODATOS DE LA REVISTA

Yunxia Lv, Jinzhong Identifying a new Revista PLoS ONE
Duanmu, Xiaorui Fu, microRNA signatura as a Año 2020
Taiyuan Li, & Qunguang prognostic biomarker in Vol. 15
Jiang. colon cancer. Num. 1-13
SECCIÓN DE INTERÉS
Results and Conclusion
Between the matched normal tissues and colon cancer tissues, 267 differentially expressed
miRNAs were detected, and a single-factor CoxPH model showed that 13 miRNAs were
related to overall survival in the training cohort. Then, a five-miRNA signature was identified
using a CoxPH regression model with multiple factors. The five-miRNA signature had
significant prognostic value in the training cohort and was validated in the validation cohort
and combined cohort. A total of 193 target genes of the miRNA signature were identified.
According to the results of functional analysis of the target genes, the signaling pathways
MAPK, AMPK and PI3K-Akt, focal adhesion, and microRNAs in cancer were remarkably
enriched. A five-miRNA signature had increased prognostic value for CC, which may provide
important biological insights for the discovery and development of molecular predictors to
improve the prognosis of patients with CC.

Karla María Escobedo Uribe

Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Junfeng Zhu, Ying Xu, MicroRNAs associated with Frontiers in
Shanshan Liu, Li Qiao, colon cancer: new potential Revista Bioengineering and
Jianqiang Sun, & Qi prognostic markers and Biotechnology
Zhao. targets for therapy. Año 2020
Vol. 8
Num. 1-10
SECCIÓN DE INTERÉS
Abstract
MicroRNAs (miRNAs) are a kind of non-coding RNA (ncRNA) that regulate the expression
of target genes and play a role in the occurrence and development of cancers. Colon cancer
(COAD) is the second most common cause of cancer-related mortality. However, the
prognostic value of miRNAs in COAD is still confusing. In this study, we obtain miRNAs
and messenger RNAs (mRNAs) expression profiles of COAD from the Cancer Genome
Atlas (TCGA) database. After preliminary data screening and preprocessing, we acquire the
expression data of 894 miRNAs and 17,019 mRNAs. Then, compared with the normal
samples, 39 upregulated miRNAs and 54 downregulated miRNAs are identified by
differential expression analysis. Furthermore, we obtain 1,487 upregulated mRNAs and
2,847 downregulated mRNAs. We confirm nine key miRNAs related to the survival rate of
COAD patients. Moreover, by using bioinformatics methods, we get 461 common genes
from both the target genes of these nine key miRNAs and differentially expressed mRNAs.
Through analyzing the protein-protein interaction (PPI) network of these 461 common
genes and survival analysis, we confirm five hub genes as promising biomarkers for COAD
prognosis. It is worth mentioning that no previous reports have found that PGR and KCNB1
are related to COAD. We expect these key miRNAs and hub genes will provide a new way
for the study of COAD.

Karla María Escobedo Uribe

Revisión de Literatura para la Investigación 07-Julio-2023

AUTORES TÍTULO DEL ARTÍCULO DATOS DE LA REVISTA

Cigdem Gungormez, Novel miRNAs as Molecular Biology
Revista
Hatice Gumushan Aktas, potential biomarkers in Reports
Nihat Dilsiz, & Ersin stage II colon cancer: Año 2019
Borazan. microarray analysis. Vol. 46
Num. 4175-4183
SECCIÓN DE INTERÉS
Discussion
In the present study, the obtained results showed that these eight miRNAs from miR-378
family (hsa-miR-378i, hsa-miR-378c, hsa-miR-378f, hsa-miR-378d, hsa-miR-378e, hsa-miR-
378g, hsa-miR-378a-3p and hsa-miR-378a-5p) targeted 12 genes. As a result of
bioinformatics analysis, it was noted that the signaling pathways found to be related to
these 12 genes were mostly involved in cell proliferation, apoptosis, and cell
communication. Thus, these miRNAs may have an important role in the molecular
mechanisms that affect the initiation and progression of stage II colon cancer. Indeed, other
studies have shown that miR-378 down-regulated and affected many cellular processes
such as cell reproduction, differentiation, and apoptosis; and could be used as a non-
invasive biomarker for diagnosis and treatment in colorectal cancer tissue.

Karla María Escobedo Uribe