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179 - Metabolism Physiology) Pentose Phosphate Pathway
179 - Metabolism Physiology) Pentose Phosphate Pathway
Cleavage of Fructose-1,6-bisphosphate
Net ATP Yield
• Aldolase cleaves fructose 1,6-bisphosphate (F1,6-BP) to
dihydroxyacetone phosphate (DHAP) and glyceraldehyde – 2 ATP + 4 ATP = 2 ATP
3-phosphate (G3P) (Figure 2)
Formation of Ribulose-5-phosphate
Oxidation of 6-phosphogluconate forming ribulose-5-
phosphate (Figure 6)
o Oxidizing agent is NADP+ forming NADPH
o Ribulose-5-phosphate: 5-carbon molecule
Coupled with the decarboxylation of 6-phosphogluconate
producing carbon dioxide (CO2)
Catalyzed by 6-phosphogluconate
o Not as important as G6P dehydrogenase
IV) APPENDIX
Figure 9. Overview of the pentose phosphate pathway (PPP) and the importance of NADPH and ribose-5-phosphate.
VI) REFERENCES
Nelson, D., & Cox, M. (2017). Lehninger Principles of
Biochemistry (7th ed.). New York: W.H Freeman and Company.