i t DEPARTMENT OF PATHOLOGY y f G.M.E.R.S. MEDICAL COLLEGE JUNAGADH A Hoa, Near Majevadi Gate, Junagadh “4 avail: pathogmersiumagah atzmailecom Cutward No. Rathod —S0PL. — ay Denarihent 03104120) 5. Medical College a tal, Junagadn 93/04 / p09) Le, Sus, DAUGMRAUA SA Ady, yetiarg, Quaddady Aisa cttotat. Actiatett (OLD course & New: course) MlAaa ta Que aise Htetefla adel, A AAA UA GUasd Qua wuz wdald 3, len at Aud aad wldettal ests tele ude ARMARAel udewni ANAY Reusteu yet MAH tan tar MAA, Yett Sezer UIselell AAA, tet Keaelear utselell wt tet yet Vue wba, tat Aue eee BH UA MA Asia A Mscll ula MA, a eu uaa Alay aor wus tu Reicll e. BLO AE.. VaAy Rout DAL URAAALSA Dax, yatiaie. Asia: (2) Mads 242-01, yout MAMA, Yo Sealer mrsdlell a1gA2, Yett QUE eI (2) Mas sar-02, ta MAA, tal Kozel HIsaell a1eIctal, tet Aue wide. em BA Scanned with CamScanneree DEPARTMENT OF PATHOLOGY GMERS MEDICAL COLLEGE - JUNAGADH 2" M.B.B.S. Pathology SYLLABUS (Old Course) Department of Pathology S.AMERS, Medical College & Hospital Junagadh A & Head Ll ——— Scanned with CamScannerOBJECTIVES: A MIDS student atthe endl of tnin |. Understand the eoncepts of ell anal the boxly's capacity for healing, 2. Understand the normal homeostatic mechanisins, the derangements af effects on human systems 3. Understand the etiopathogeness, the pathological effects an the clinica ‘common infectious and noninfectious diseases 4. Understand the concept af neoplasi diagnosis and prognosis in differen in Pathology will he able to and changes proxticed therey in different sues and organs emechanism and the ogicat corel nof With reference to the etiology, gros and mictosenpic features Hes and organs af the body 5. Correlate normal and altered morphology (gross and microscopic) of different organ aye ‘ifferent diseases to the extent needed for understanding of disease processes a their cli significance 6. Have a knowledge of common immunological disorders and their resultant effects on the human body ~ Have an understanding of the common haematoto, diagnose them and determine their prognosis. 8. Perform and interpret in a proper manner the basic clinico-pathological procedures, ‘8. Know the principles of collection, handling and dispatch of clinical samples from patients in a Proper manner. ical disorders and the investigations necessary to COURSE CONTENTS (A) General Pathology |. Introduction to Pathology 2. Cell Injury a) Cell injury: Causes and Mechanism: Ischemic, Toxic +) Reversible cell injury : Types, morphology: Swelling, vacuol. ¢) Irreversible cell injury : Types of Necrosis ion, hyaline, fatty change. 3. Amyloidosis and Cakification a) Calcification : Dystrophic and Metastatic +) Amyloidosis: classification, Pathogenesis, Morphology 4, Inflammation and Repair a) Acute inflammation : Features, causes, vascular and cellular events. bb) Morphologic variants of acute inflammation c) Inflammatory cells and Mediators 4) Chronic inflammation : Causes, types, nonspecific and Granulomatous with examples «) Wound healing by primary and secondary union, factors promoting and delaying the process £) Healing at specific sites including bone healing 5. Circulatory Disturbances a) Edema : Pathogenesis and types 'b) Chronic venous congestion: Pathogenesis and changes in Lamng, Liver, Spleen ¢) Thrombosis and Embolim : Formation, Fate and Effects ; d) Infarction : Types, common sites, Gangrene ie ©) Shock : Pathogenesis, Types, Morphologic changes fj afitessor NOH Depart" ease Hospital reac MER EST gi ead Scanned with CamScannernoth Disturbances anit Neoplasia a) Atrophy. Hypertphy, Hyperplasia, Us poplasi, Metaptada, W)Nooplasia: Chositication, Histopen wnt Sarwoma Awrenats, Hy aplasia Ss Witopie Hetiviour Henign and Malignant, Cm ©) Malignant Neoplasia: Guades ani Stages, Focal aud A) Carcinogenesis: Hus iommental cateinoye ongapetes chemical, vial, caption, Heredity atl celta ©) Tumour anid Host Interactions : Syst immunology effects de fuding jaa niliatie syndionnes, Lunar £1) Laboratory diagnosis: Cytology, Hops, Lume markers 7. tenmunopathology 4) tovmune system : organisation, cell, antibodies and reyulation of im b) Primary immunodeticieney ©) Secondary Immumodeticieney inchding THY tnfection 4) Autosimmune isonfers like systemic lupus erythemntasis; organ specific aml a “organ specifi such as polyarteritis movosa, Hashimoto's disease, ©) Tumor Immunity 1 Organ transplantation: Immunologic basis of Rejection an Craft versus host reaction 8. Infections Diseases 8) Mycobacterial Diseases : ') Bacterial diseases : Py hold, Diphtheria, Gram negative infection, Bacillary dysentery, Syphilis ©) Viral : HBV, HPV, FICV infections 4) Fungal diseases and opportunistic infections ©) Parasitic Diseases : Malaria, Filarin, Amebiasis, Knla-tzar, Cysticercosis, Hydatid 1) AIDS : Actiology, modes of transmission, diagnostic procedures and handling of infected material and health education, Fubercuosis andl Leprosy 9. Miscellaneous Disorders ) Autosomal and sex-linked disorders with examples ) Metabolic disorders ¢) Protein energy malnutrition and vitamin deficiency disorders 4) Disorders of Pigment and Mineral metabolism such as bilirubin, melanin, hemosiderin (B) Systemic Pathology including Autopsy 1. Cardiovascular Pathology a) Rheumatic fever and Rheumatic Heart Disease : Pathogenesis, Morphology and effects 'b) Infective Endocarditis : Causes, Pathogenesis and Morphology ©) Atherosclerosis and Ischemic Heart Disease; Myocardial Infarction 4) Diseases of blood vessels other than atherosclerosis ¢) Hypertension and Hypertensive Heart Disease £) Congenital Heart Disease : ASD, VSD, Fallot's Bicuspid aortic valve, PDA 8) Pericarditis and other pericardial diseases 1h) Cardiomyopathy 2. Respiratory Pathology 4) Structure of Bronchial tree and alveolar walls, normal and altered lung function; concept of obstructive and restrictive lung disorders. Dea coteye & HOS! GMERS Pe adh Scanned with CamScannerf- . by tnflammatory ise ‘ses of bret chronic bronchitis, bron! obstructive ling disease ©) Proumonias :Lobar, Brwnche, tn a) Putononary sy ©) Patowonary D Emnphyser ‘wal acthna, bronchiectasis weestitial ‘Npuration including hing abscess 1 Hopathoxenesis ibereufosi Primary and Seven, Morph and Morphology Howe types Pes, pathogenesis len: Carcinoid, Mali nal lung disonters : Touling pteuritis ignants Squamous cell, Oat cell, Aden, etiopathogenesis Anthracosis, silicosis, asbestosis, mess 3. Urinary Tract Pathotogy 4) Renal structure, basis of imp omerulonephritis: C wired fiction, urine analysis fication, P Conudary Glomerulonephritis: SLUT 4) Nephrotie Syndrome ¢) Acute Renal Failure Acute tubul 4) Progressive renal failure nary Proliferative and Non Protiterative + Purpura, Polyarteritis, Amyloidosis, Diabetes lar and cortical necrosis and end stage renal disease ©) Pyelonephitis, Reflux Nephropathy, Intersil Nephrits ') Renal tumors : Renal cell carcinoma, Nephroblastoma ') Renal vascular disorders, kidney’ changes in Uypertension 4) Renal Malformations : Polycystic kidney 4. Pathology of the Gastro-Intestinal Tract 8) Lesions of Esophagus ©) Salivary sland tumors: Pleomorphic adenoma, wartin’s tumor, Adeno Carinoma ¢) Fentic ulcer etiopathogenesis and complications; estits: types €) Tumors of stomach: Benign: Plyp, Leiomyoma, Malignant; Adenocarcinoma, Lymphoma intestine : Typhoid, Tubereulosis, Crohn's, Appendictis dix and large intestine : Amocbic colitis, Bacillary dysentery, its €) Inflammatory diseases of small £) Inflammatory diseases of apper Ulcerative Ci 8) Malabsorption : Celiac disease, Tropical sprue and other causes h) Tumours and Tumor like con Carcinoma, Lymphoma ‘on of the large and small intestine : Polyps, Carcinoid, 5. Hematopathology 4) Constituents of blood and bone marrow, Regulation of hematopoiesis >) Anaemia lasification and clinical features; clinical and lab. approsch to diagnosis «) Nuvitionalansemias: Iron deficiency anaemia, Folic Aci/VitB 12 deficiency ansem including, pemicious anaemia 4) Hemolytic Anaemias : Classification and investigation ©) Hereditary hemolytic anaemias : Thalassemia, sickle cell anaemia £ Hereditary hemolytic anaemias: hereditary spherocytosis, G-6-PD deficiency £8) Acquired hemolytic anaemias 4) Aplastic Anaemia, PNH and Myelodysplastic syndrome ') Hemostatic disorders: Platelet deficiency; ITP, Drug induced, seconda }) Coagulopathes: Coagulation factor deficiency; hemophilia, DIC and anticoagulant contol ') Leukocytie disorders: Leukoeytosis, leukopenia, leukemoid reaction ') Acute and chronic Leukemia : Classification, Diagnosis '™) Myeloproliferative disorders: Polyeythemia, Myelofibrosis 1) Multiple myeloma and dysproteinemias ©) Blood transfusion : including HIV and hepatitis ing and cross matching, untoward reactions, transmissible infections Leto Provessor & Head Departaient of Bathatogy GMERS. f Scanned with CamScanner6. Liver and Biliary Tract Pathology 4 faa Types, Pathogenesis and Different b) Hepatitis : Acy Mhronie, T oor: feo And Chronic, Etiology, Pathogenesis an Pathology Ology; Postncerotic, Alcoholic, M [ : ote, Alcoholic, Metabolic, Pathology, Morphology (Maceonestutar Micronodular, Mixed), complications ieenee ages oe 7, Lymphoreticular System 4) Lymphadenitis: nonspecific, Grannlomatous }) Hodgkins and Non-Hodgkin's Lymphomas :Clasiietion, Morphology ©) Diseases ofthe spleen : Splenomegaly causes and effects 8. Reproductive System 2) Diseases of cervix cervicits, cervical carcinoma, etiology. types and cytologie diagnosis +) Hormonal influences and histological appearances f different phases of menstrual cycle and the abnormalities associated with it ©) Diseases of uterus: endometrtis, endometrial hyperplasia and carcinoma, adenomyosis, smooth ‘muscle tumors 4) Trophoblastic disease : Hydatidiform mole, Choriocarcinoma ©) Diseases of the breast: Masttis, abscess, Fibrocystic disease, Neoplastic lesions : Fibroadenoma, Carcinoma, Phyllodes tumor £) Prostate : Nodular Hyperplasia and Carcinoma ) Ovarian and testicular tumors hy) Pelvic inflammatory diseases including salpingitis i) Genital Tuberculosis 9. Osteopathology 4) Bone — general considerations, reactions to injury and he b) Osteomyelitis : Acute, Chronic, Tuberculous, Mycetoma ©) Tumors : Primary, Osteosarcoma, Osteoclastoma, Ewing’s Sarcoma, Chondrosarcoma; Metastatic 4) Arthritis : Rheumatoid, Osteo and tuberculous of fractures 10. Endocrine Pathology 4) Diabetes Mellitus : Types, Pathogenesis, pathology ») Nonneoplastic lesions of thyroid : lodine deficiency goiter, autoimmune thyroiditis, thyrotoxicosis, myxedema +) Tumors of thyroid ~ adenoma, carcinoma : Papillary, Follicular, Medullary, Anaplastic 4) Parathyroid hyperplasia and tumors and Hyperparathyroidism ©) Multiple endocrine neoplasia 1. Neuropathology 4) Structural Organization, specific cell types, and reaction patterns b) Inflammatory disorders: Pyogenic and tuberculous meningitis, brain abscess, tuberculoma ©) CNS tumors ~ primary : glioma and meningioma (excluding histopathology) and metastatic 4) CSF and its disturbances : cerebral edema, raised intracranial pressure ©) Cerebrovascular diseases : Atherosclerosis, thrombosis, embolism, aneurysm, Hypoxia, Infarction id Hemorrha and Hemorrhage drt? Trokesor & Heat Departarsr” of Pahalogy GIMERS. Neaice Coege & Hospital Junagaan Scanned with CamScanner(C) Practicnls 1) Mlentity and interpret the pu nie "DFE the pres anor microscopic features of common disorders as given ee ‘with accuracy and reliability basic haematological procedures such as haemoglobin estimation, total and dlifferential WAC count and peripheral blood smear staining, examinati an repo " 9 Clete the indices and interpret the relevant significance. A Reform the basi laboratory haematological tests ike bleding time and eating time ) Perform a complete examination of the urine and detect any abnormalities £) Grouping and cross matching of blood #) Collect and dispatch clinical samples from patients in a proper manner 10) Interpret abnormal biochemical laboratory values of common diseases. ‘TEACHING AND LEARNING METHODOLOGY Department stresses on teaching basic fundamentals of the disease process and the applied aspects relevant tothe clinical subjects. General Pathology ‘Taught withthe help of Didactic lectures, Small group discussions, tutorials, seminars & quiz on specific topics, followed by Practicals pertaining to that topic. Besides microscopic examination, fresh specimens ‘obtained at autopsy or surgical operations are shown, Systemic Pathology ‘The following tools are employed: i) Didactic lectures: discussing a particular topic at length in an one hour lecture ii) Small group discussions, tutorials, seminars & quiz. iii) Paractinical seminars: are conducted by a combined team of pathologist and a clinician who discuss the pathophysiology and iv) Case studies: The significant and common diseases are discussed in the form of a representative clinical case in which the clinical features, the course ofthe disease in that particular patient and relevant laboratory investigations are discussed in an interactive manner in small ‘groups. This is followed by demonstration of the gross and microscopic features ofthe disease in that ease. This is followed by clinico-pathologic correlation. v) Practicals Deals with demonstration of gross, and/or microscopic features ofthe disease entities. vi) Clinical case demonstration Patients ofa particular disease are demonstrated to the students by a clinical faculty in the ward, discussing the clinical features in the patient which provides them a real-life experience of studying a disease as it presents in patient, By a combination of above modalites/tols, student learns applied aspects ofthe disease process. ‘TEXT-BOOKS RECOMMENDED 1. Robbin’s Pathologic Basis of Diseases 2, Text-Book of Pathology by Harsh Mohan 3. Text-Book of Pathology by Vinay Kamal 4, Departmental Journal, Clinical Pathology & Histo pathology. 5. Autopsy Manual, y Lalli at cer af Pathology iecicalCuliege & Hospital Junagadh Scanned with CamScanner* The EXAMINATION AND. MARKS DistRInt | Total Marks: 159 Internal Assessm Professional (Uni TON | ‘ent: 30 (Theory 15, py : N ‘tactical 15) versity) Examinatio 20 (Theory 80, Viva 15, 1 actical 25) Pattern for internal asse 'ssment will be as follows mination | Total No. of Internal hr anion teat Marks Caleulation cory MIT Semesier First Interna io 25 E 100 25 | V Semester 00 L Examination a), | Tot is Practicals: II Semester rst Internal 50 25 | Examination IV Semester Second Internal [50 25 | Examination V Semester Prelim 50 10 Examination Total 15 | in Theory classes more than 75% Practical more than 75% if any one of above criteria is not fulfill students will be detained as per rules of University. hee Professor & Head Department of Pathology GMERS. Medical College & Hospital Junagadh Scanned with CamScannerProfessional (University) ’xamination; Theory: Paper I: (40 Marks) Topics: P, ‘opics: General Pathology, Immunopathology, Blood Transfusion, Hematopathology Paper Il: (40 Marks) Topi 'ystemic Pathology including Autopsy, Cytopathology, Histopathology techniques, clinical Pathology, Viva: (15 Marks) 1. Gross. specimen & General Pathology viva : 8 Marks 2. Clinical Pathology Viva : 7 Marks. Practicals: (25 Marks) Theory Papers: Comprise of Short notes, Short answered questions (SAQ), Autopsy. : js a Practicals: Conventional Urine & CSF examinations and viva, Hematology Exercises and vivi and Histopathology slides. olson Hed Department of Pathology GMERS Medical College & Hospital ° ‘Wunagadh a Scanned with CamScannerDEPARTMENT OF PATHOLOGY 2" M.B.B.S. EXAMINATION (Old Course) INTERNAL & EXTERNAL (UNIVERSITY) EXAMINATION MARKS DISTRIBUTION PATTERN G.M.E.R.S. MEDICAL COLLEGE, JUNAGADH Theory Internal xamination Theory MCQs| Viva |. Total | Practical Assessment Theory | Practical | 1Internal 60 20 20 100 50 25 25 Assessment 24 Internal 60 20 20 100 50 25 25 Assessment Preliminary Paper-I | Paper- Examination I _ 20 100 50 10 10 40 40 University Paper-l__ | Paper- Examination IL _ 1s 95 25 15 15 40 40 University Theory= Practical Examination | paper-I & Total-40 11(80), Viva(15), Internal Marks(15)- Total-110 © Theory Viva will be taken at the time of Pathology Practical Exam. 0 Head Depat int of Pathology Junagadh Scanned with CamScanner GILERS, Medical College & HospitalSeat No. Second Year M. B. B.S, Examination (Old Course) Pathology: Paper ~ 1 (€ ral Pathology, Immunology, Blood Transfusion , Hematology) 2 ours} [Total Marks: 40 Instruction: A. Write answers of each section separately. B. Draw neat & clean diagrams wherever necessary. C, Figures to the right indicate full marks. D. Irrelevant writing will reduce the marks. SECTION -1 (General Pathology including Neoplasia) 1 Write notes on: (Any Three) 12 a) b) °) da) 2 Answer in brief: (Any Four) 8 a) b) | °) d) e) SECTION -II (General Pathology, Immunology, Blood Transfusion , Hematology) 3 Write notes on: (Any three) : R a) b) Co) d) 4 Answer in brief: (Any Four) 8 a) | b) °) | d) i O} folessor k'Head Department of Pathology GMERS, Medical College & Hospital Sunagadh Scanned with CamScanner(Autopsy, Systemic Pat Seat No. Second Year M. B. 1. mination (Old Course) per =H , Histopathol Pathology, Museum Techniques) y Techniques, Clinical ‘Time: 2 Hours} [Total Marks: 40 Instruction: 2 Write answers of each seetion separately, Draw neat & clean diagrams wherever necessary. es to the right indicate full marks. SECTION -1 (Autopsy, Systemic Pathology) Write autopsy findings 8 (a) Write notes on: (Any Two) 8 a) » ° a) (b) Answer in brief: (2 marks each) 4 a) b) SECTION - II (Systemic Pathology, Cytopathology, Histopathology Techniques, Clinical Pathology, Museum Techniques) Write notes on: (Any Four) 2 a) b) °) d) °) Answer in brief: (Any Four) 8 a) b) °) da) °° rBhyssor § Head Department of Pathology GAMERS, Medical College & Hospital Junagadh Scanned with CamScanner