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You may have heard the terms “Cold Laser” or “Low-Level Laser Therapy (LLLT)” before. In
general, such terms refer to “treatment using irradiation with light of low power intensity so
that the effects are a response to the light and not due to heat.”1 Many of the terms used to
commonly describe this process do not ideally reflect the mechanisms of action involved.
They also don’t adequately distinguish this type of therapy from the other laser-based thera-
pies that rely on heating tissue to achieve an effect. This lack of clarity has led to significant
confusion and a need for better nomenclature.
In September 2014, the North American Association for Light Therapy (NAALT) and the World
Association for Laser Therapy (WALT) convened to discuss this issue, and as a result of their
efforts, the term “Photobiomodulation Therapy” was added to the MeSH database. This term
more accurately reflects the process and better distinguishes it “from the popular use of light-
based devices for simple heating of tissues…or other applications of light energy that rely on
thermal effects for all or part of their mechanism of action.”2
TABLE OF CONTENTS
Did You Know? PG 1 - 6 How it Works
100 +
That laser therapy is the PG 7 Practical Applications
modality of choice in
professional and collegiate PG 8 - 10 Case Studies
athletics? LightForce Therapy Lasers (the human PG 11-12 Companion
counterpart to Companion) are utilized by over
100 professional and collegiate teams.
1. Ncbi.nlm.nih.gov. Low-Level Light Therapy – MeSH – NCBI. 2016. Available at: http://www.ncbi.nlm.nih.gov/mesh/?term=photobiomodulation. Accessed February 25, 2016.
2. Anders J, Lanzafame R, Arany P. Low-Level Light/Laser Therapy Versus Photobiomodulation Therapy. Photomedicine and Laser Surgery. 2015;33(4):183-184. doi:10.1089/
pho.2015.9848.
PG 1
http://www.LiteCureInfo.com/IntroToPBM
1. Anders JJ, Lanzafame RJ, Arany PR. Low-level light/laser therapy versus photobiomodulation therapy. Photomedicine and Laser Surgery. 2015; 33(4): 183-184.
2. Frydrych. The Evolution of Photobiomodulation link
3. Karu TI. Low power laser therapy. In: Vo-Dinh T, editor. Biomedical Photonics Handbook. Boca Raton (FL) CRC Press; 2003: 48-1-48-25.
4. Hamblin MR, Demidova TN. Mechanisms of low level light therapy. Proc. of SPIE. 2006; 6140: 612001-1-12.
PG 2
Class IIIb: IIIb lasers are hazardous to the eye treatment head is moved throughout the dura-
when viewed directly. For visible and infrared tion of the treatment to ensure a therapeutic
devices, emission power is limited to 0.5W. dose of energy is being delivered evenly to the
Protective eyewear, key switches, and safety entire target area and its associated tissues.
interlocks are required safety features. Class IV laser therapy can also be administered
using contact or non-contact treatment heads.
Class IV: Class IV includes all lasers that emit
powers in excess of the IIIB limitation of one Dosing Strategies: Relative to Class IV lasers,
half of one-watt. Eye protection is needed to Class IIIb lasers deliver a smaller dose of Joules
limit both direct and diffuse reflected exposure. to a smaller area of tissue. Typically treatments
Key switches and safety interlocks are also re- are confined to discrete points. A potential
quired safety features. The majority of scientific, weakness of this technique is the variability of
industrial, military, and surgical lasers are in this clinical results due to the exact placement of
category. the treatment points. The foundation of Class
IV laser therapy is based on the delivery of a
Power: Class IIIb lasers are limited to a maxi- therapeutic dose of Joules to a large area of
mum power of a 0.5 Watt. Class IV therapy target tissue, reducing variability in outcomes.
lasers typically enable the user to select from For example, on the lumbar spine of a large
powers of a 0.5W up to 15 Watts. Increased dog, to deliver an effective dose for arthritis of
power enables the clinician to treat a larger 10 Joules/cm2, a Class IV therapy laser set at 10
area in a shorter period of time, thus allowing Watts in continuous wave would deliver 6,000
an efficient delivery of a therapeutic dose to Joules of energy in a 10 minute treatment ses-
target tissues. sion. It would take a 0.5 Watt Class IIIb laser 200
minutes to deliver the same dose.
Treatment Strategies: Due to their power dif-
ferences, Class IIIb and Class IV laser treatment Wavelengths: Different therapeutic lasers of-
strategies vary. Class IIIb lasers are often used ten have different treatment wavelengths rang-
to treat single points or a group of small points ing from 700 nm to 980 nm. All wavelengths in
and are held in one place for the duration of this therapeutic window target the same photo-
the treatment time at each point. When treat- active chromophores. The main difference
ing with a Class IV therapy laser, the clinician between wavelengths is the absorption of the
may treat a much larger area, (ex. 300 cm2 for light by tissue components such as water and
the anatomical area of a large dog’s hip); the melanin.
PG 3
CLINICALCONCERNS
CLINICALCONCERNS
SEOTERRA/ THINKSTOCK
Laser focus
What to know about adding photobiomodulation therapy to your practice.
BY L U I S H . D E TA B O A DA , M S E E , A N D W E N DY S . F RY D RYC H , P H D
A
r focus
RE YOU CONFUSED BYfindings initiated research to understand (LEDs) are not included in the term
the effects of light on living cells and
MANUFACTURERS’ CLAIMS ABOUT even though an LED-based device may
the best laser therapy devices? the mechanisms involved. be able to deliver an LLLT response.
Are you skeptical of light therapy as a Hundreds of scientific studies have There was reluctance to adopt the
know about adding photobiomodulation therapy to your practice.
treatment modality? Your confusion CLINICALCONCERNS
is been conducted in vitro to characterize term photobiomodulation because it
understandable—there have been mixed the dosages needed to achieve a cellular was not a MeSH (Medical Subject
E TA B O A DA , M S Eand
messages E , unrealized
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Surg Med. 4
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11 Tedford CE,to adopt the S, Anders J.
CLINICALCONCERNS after invented in biomodulation” to describe the
17 Lasers are being used with great process In 2014, a consensus
DeLapp nomenclature
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2015;47(4):312-322. to the MeSH
unrealized claims about
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therapy (LLLT); however,
TABOADA , MSEE, ascontrolled
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laser therapy is an effective modality.13-
devices
Surg Med. usehas over 20 years’which
that 2010;42(6):450-466.
light-emitting diodes
experience consists of terms that
inby chromophores found arein used
the body, to
13 Conforti M, Fachinetti GP. High power laser
trigger nonthermal, non-harmful FDA approved the first Class 4 laser evidence is needed.
biological reactions that result in (greater than 0.5 watts) for the relief When the laser is used in gated
beneficial therapeutic outcomes.5 of minor muscle and joint pain. The mode, it is cycling its CW power on
higher powered lasers make it possible and off and consequently delivering a
Protocols for use to not only apply the benefits of lower average output power. In general,
Appropriate dose selection is critical to photobiomodulation superficially, but the use of pulsing decreases light
the safety and effectiveness of photobio- also to treat a greatly expanded range delivered to the target. On the other
modulation therapy. To get clinical of conditions by delivering a clinically hand, in instances where there is a
results, sufficient light must reach effective dose to target areas below the concern about heating tissue, such as
the target tissue. There are various skin (e.g., hamstring muscles), and in a in treatment of the brain, pulsing can
parameters to consider when calculating shorter period of time.9 be used to further control the output
dose, including power density or power of the laser. In a recent paper
irradiance, treatment time, wavelength, Optimal wavelength that looked at human cadaver brain
pulsing, and application technique.6 For light to produce beneficial thera- tissue, there were no differences
The therapeutic dose is measured in peutic outcomes, it must be delivered observed in light penetration between
joules (J) delivered per square inch of at an appropriate wavelength and of pulsed and CW laser light.11
surface area.3 Much of the research sufficient intensity to the target tissue.
conducted in the field has involved cell One range of wavelengths has been Implementation and application
or small animal studies in which low referred to as the “optical window” for As with any complicated technology,
power and small beam size were photobiomodulation therapy, where even if you don’t understand exactly
sufficient to treat the cells or muscles. there is minimal absorption from how it works, you should have a basic
A recent study published by Anders, different substances (e.g., water, grasp of the mechanisms involved. If
et al., reported the successful trans- hemoglobin, and melanin). you are using a laser that has prepro-
lation of in vitro results obtained in the The current understanding is that grammed protocols, understand the
petri dish by using those parameters to light in the visible range (600 to 800 differences between treatments when
treat surgically repaired peripheral nanometers) is absorbed more by your patient’s skin color is light or dark,
nerves in vivo.7 The researchers found hemoglobin and melanin, so these or their body size is small or large. For
an optimal dose for nerve repair in visible wavelengths are better suited for example, if the laser has a mix of 980
vitro to be 97.5 percent less than that superficial areas. To effectively treat and 810 nanometer light for treatment
required when delivered on the surface deeper musculoskeletal conditions, of light skin, it may switch to only 980
of the skin. CLINICALCONCERNS therapy lasers should be in the near- nanometer light to treat dark skin.
infrared range (800 to 1,000 Protocols for larger bodies will deliver
Power and density modulation, andnanometers).light-based devices Morimoto Y, Saito A, Tokuhashi Y. Low level
9 a larger dose compared to treatment of
laser therapy for sports injuries. Laser Ther.
The FDA regulates lasers for medical can be used to address a variety of
2013;22(1):17-20. a patient with a smaller build.
medical issues.12 When a compre-
use. Unlike surgical medical lasers, hensive treatment Understanding
approach is used, pulsed laser
Hashmi JT, Huang YY, Sharma SK, et al. Effect
10
Assessment
therapy
A, Bharati
of CS.
is an R,
S, Saxena
feasibility
effective
Mehta K.modality.13-
and efficacy of
Surg Med. 2010;42(6):450-466.
the clinical studies manager at medical
Photomed LaserlaserSurg.design, development,
2014;32(9):490-494.
segmental
References 6 Enwemeka
17 Lasers Intricacies
are beingofused in class
dose with lasergreat
11 Tedford CE, DeLapp S, Jacques S, Anders J.
LiteCure. Wendy has a BS in 15 Tumilty S, Baxter D. Effectiveness of class 4
power Major
inLeague
materials 16 Roberts D
laser therapy
6 Enwemeka is an ofeffective
CS. Intricacies modality.
dose in laser 13-
Medicine,
Photomed Medical
Laser Subject Headings. Available
Surg. 2014;32(9):490-494.
phototherapy
17 Lasersfor aretissue
beingrepair andwith
used pain relief.
great
11 Tedford CE, DeLapp the clinical studies
S, Jacques manager
S, Anders J. at from: http://www.nlm.nih.gov/mesh/mesh
15 Tumilty
science and Baseball
S, Baxter D. Effectiveness of class 4
engineering from the
lineup. ADVANCE. University
2014;June:21-22.
effectivene
Photomed Laser Surg. 2009;27(3):387-93. LiteCure.
Quantitative analysis Wendy hasand
of transcranial a BS in home.html. Updated Sept. 22, 2015. Accessed
success in chiropractic, veterinary lasers for Achilles tendinopathy. Lasersof Pennsylvania.
Surg She can be contacted at
7 Anders JJ, Moges H, Wu X, et al. In vitro and intraparenchymal light
physics penetration
from in
Pennsylvania human State Sept. 3, 2015.
Med. 2015;47(S26):38.
laser treatm
medicine, professional sports, and cadaver brain tissue. Lasersand Surg Med. in materials
DB, Kruse RJ, Stoll SF. The wendyf@litecure.com.
in vivo optimization of infrared laser treatment University a PhD 5 Anders JJ, Lanzafame RJ, Arany PR. Low-level
16 Roberts Med. 2013
2015;47(4):312-322.
PG 5
Anti-Inflammation
Laser therapy reduces inflammation with vasodilation, activation of the lymphatic drainage system,
and reduction of pro-inflammatory mediators. As a result, inflammation, erythema, bruising, and
edema are reduced.
Analgesic Effect
Laser therapy of diseased and damaged tissue produces a suppression of hypersensitive nociceptors,
normalization of the membrane firing threshold, and an increased release of tissue endorphins. The
result is a decreased patient perception of pain.
Immunoregulation
Therapy laser photons have an effect on the immune system’s status through stimulation of immuno-
globins, neutrophils, and lymphocytes.
There are many different types veterinary la- fective target dose of 10 Joules/cm2 is 3,000
ser therapy devices. Class IV, Class IIIB, Class Joules (300cm2 x 10 J/cm2 = 3,000 J). Below is
III, and even Class II lasers may be used for an example of how long it would take to deliver
therapy. One parameter that separates these 3,000 J of therapeutic energy with 4 different
lasers from one another is its available power. lasers of varying power capabilities:
What role does power play in achieving clinical
results for pet pain? • 5mW Laser = 10,000 minutes (166.7 hours)
• 500mW Laser = 100 minutes (1 hour 40 min.)
Power impacts the functional depth of pen- • 3W Laser = 16.7 minutes
etration of the laser light. The combination • 10W Laser = 5 minutes
of treatment time and power determines the
therapeutic dose of energy that is received Therefore, treating with a low-powered laser
by tissues at depth. If a therapy laser has low will deliver less than the identified therapeutic
power, the total number of Joules it can deliver dose of 3,000 Joules simply because the treat-
to relevant depths for treating most musculo- ment time is unrealistic. Companion Therapy
skeletal conditions in a realistic treatment time lasers enable you to deliver power from 500mW
is very low. up to 15 Watts giving you the flexibility you
need to give every condition the appropriate
For example, to treat the lumbar spine for therapeutic dose. Understand the difference
arthritis on a large dog with a treatment area between class IV laser therapy and other thera-
of 300 cm2, since it is a deep condition, an ef- py devices before you invest.
Your time is valuable – and providing your patients with the best care in
the most efficient amount of time is a priority. Class IV therapy lasers are a
great resource to maximize your staff’s efficiency in treating your patients.
Class IV laser therapy is often able to provide pain relief to pets suffering
from a variety of conditions such as arthritis and otitis. Flexibility of treat-
ment delivery gives the clinician the power to deliver therapy in either
contact or non-contact mode to maximize results based on the presenting
condition.
• Abscesses • Otitis
• Acral Lick Dermatitis • Post Surgical Pain Relief
• Acute Nephritis • Post-Operative Healing
• Acute Pain • Pyotraumatic Dermatitis
• Bacterial Infections • Skin Grafts
• Burns • Snake Bites
• Edema • Soft Tissue Trauma
• Fractures • Sprains & Strains
• Fungal Infections • And More...
• Mastitis
Presentation Presented on
after1/29.
being taken in by Animal Control,
Treatment Details: Started laser therapy Approximately 85%received singleskin
of total dose surface
of Ivermectin SC
treated for
injection and 2had received2Prednisone 20mg PO SID for unknown duration. DVM
total dose of 16,200 J at 6W over ~3,200 cmsteroids,
discontinued (5 J/cm ). Cephalexin and benzoyl peroxide bathing/shampoo, daily
started
Ivermectin PO and laser therapy.
Every other day treatment for 5 treatments, then weekly through 3/1 when all lesions resolved.
Started laser therapy on 1/29. Approximately 85% of total skin surface treated for total
Treatment Details
dose of 16,200 J at 6W CW over ~3,200 cm2 (5J/cm2).
Treatment Results: “Patient’s skin Every
lesions/disease
other day treatmentshowed rapid then
for 5 treatments, reduction in erythema,
weekly through 3/1 when all crusting, and
pruritis leading to marked improvement in patient’s comfort level while managing/treating general-
lesions resolved.
ized demodicosis/pyoderma.
Treatment Results Overall healing
“Patient’s process was
skin lesions/disease showed dramatically accelerated
rapid reduction in by laser
erythema, crusting, therapies
and pruritis
leading to marked improvement in patient’s comfort level while managing/treating
and most importantly comfort was generalized
makedlydemodicosis/pyoderma.
improved throughout laser therapy period.” – Dr. Sara
Overall healing progression was dramatically
Hogel accelerated by laser therapies and most importantly comfort was markedly improved
throughout laser therapy period.”—Dr. Sara Hogel
Presentation: Presented in 2009 with mild stomatitis. Treated over the next four years with a combi-
nation of steroids, diet change, antibiotics, homeopathy and multiple pharmacologic analgesics as
well as partial dental extraction. Patient also experienced feline hyperesthesia, constantly biting and
chewing his skin, and was treated with amitriptyline as well.
Secondary to the long term use of steroids for his stomatitis, Stewie’s skin was very thin and tore eas-
ily, resulting in four episodes of skin tears/ wounds created by normal grooming
Complications from suturing these wounds and the placement of Penrose drains in his thinned skin
resulted in further skin tearing. Despite extensive workup and therapies, Stewie’s stomatitis contin-
ued to worsen and by April 2013, he was anorexic and had experienced weight loss secondary to this.
Additionally, he was withdrawn and painful and the owners were considering euthanasia due to his
poor quality of life.
Dr. Smith outlined each problem and complication, adding that each new issue and its treatment
seemed to complicate or exacerbate his other problems. “For instance, each skin tear seemed to
increase the hyperesthesia, and Stewie’s attempts to deal with the hyperesthesia created more skin
tearing. It was difficult to orally medicate him because his mouth was so painful. Weight loss also
reduced his immune resistance. Stewie, who had been a lively, friendly cat, refused to get out of bed,
eat or interact with the owners or the other cat.”
Treatment Details: Stomatitis – Open Mouth = 186 Total Joules (at 3W), Closed Mouth = 360 Total
Joules (at 4W); Wound – 2×3 = 196 Total Joules to 45 cm2 area (4.35 J/cm2) at 2W
Stewie was initially treated 2 to 3 times weekly, decreasing treatment frequency as his condition im-
proved.
Treatment Results: By improving the quality of his skin and decreasing his somatic pain, his owners
felt his improved quality of life justified further [dental] extractions. …Laser treatment following his
oral procedures allowed the gingival, tonsillar and lingual lesions to heal.
“By removing most of the remaining problem teeth and following up with laser treatment for post-
extraction healing, Stewie’s appetite returned, he began to eat normally and put on weight. We were
able to significantly reduce pain medication and completely eliminate antibiotics and steroids.” – Dr.
Smith
PG 10
Photos and case courtesy of Dr. Jerri Smith and Christine Garbow, CVT, from BFF Veterinary Care in Minneapolis, Minnesota.
Innovation Outcomes
Whether you are considering adding laser Backed by scientific evidence and on-going
therapy, regenerative medicine, or another research you can achieve the best results with a
Companion rehabilitation product - Companion Companion Therapy Laser. On-going software
allows you to practice reliable, innovative medi- updates ensure you are always practicing the
cine. most current medicine.
You can elevate your standard of care with con- Achieve results on acute and chronic conditions
fidence. Keep a finger on the pulse of the most alike. Treat with ease with the most species-
innovative therapeutic solutions with Compan- specific protocols available on any therapy laser
ion. on the market.
Education ROI
Never be left behind - Companion provides you Realize ROI with the Companion CORE imple-
with the most current research and applications mentation program. The program includes
through a multi-channel education program. one-on-one consulting.
Versatility Education
Effectively treat a wide variety of clinical condi- Attend live events or monthly webinars for the
tions with a Companion product. latest applications.
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