:10119103 I

Course Code
.No. M2345

RESEARCH FOUNDATION, SALEM.

VINAYAKA MISSION'S

(Deemed to be University)
-

EXAMINATION June 2021

FIRST MBBS DEGREE
BIOCHEMISTRY - I

Time: Three hours

Maximum: 100 marks

Answer ALL Questions

Answer Section A in the Answer Sheet attached for 20 marks
Afier 20 minutes to be handed over to the invigilator immediately Section A
Answer all the question of Section B in the main answer book provided

Time: 2 hours 40 minutes SECTION - B Maximum: 80 marks

L. Long Answer Questions (LAQ): (2 x 15-30)

1. A pre-term male child born 4 days ago developed yellowish discolouration. of

eyes and all over the body which was increasing gradually and then after 2 days
it subsided. The child was given phototherapy. The laboratory reports of the
child are given below:
Day Total Serum Bilirubin Conjugated Bilirubin
1st day 2mg% 0.5mg%
3rd day ómg% 2.0mg%
5th day 5mg% 3.0mg%
7th day 1.6 mg% 1.0mg%
a. What is the probable diagnosis? What is it due to? (1+1)
b. What is Bilirubin? How is bilirubin synthesised, transported and
excreted? (1+2+2+2)
c. What are the normal values Bilirubin - total & fractions?
(2)
d. Mention the types and causes of Hyperbilirubinemia (4)
2. Describe the site and process of Beta oxidation of fatty acids..Add a note on role
of carnitine. Write down the energetic when palmitic acid is oxidized. Oxidation
of odd chain fatty acids. Refsum discase. (1+5+2+2+3+2)
 -(2)

Questions (SAQ):
Answer
1. Short

Oral Ghucose
Tolerance
is
1 thehat
proccdure adopted.
1Test? Describe the
Add a note on ils clinical uge (6 5 30
ycerides aro
4 How endogenous metaboliz. ed? preparaliom of patient
cumulation in liver? Name two causes
for i. What is the and
What are Isocnzymes? Give two disordeder caused(-22
cxamples and discuss
mportance. their hy
6. Sourees, biochemical functions, daily requirement (2:1 2its
pyridoxine and defi
A 30-year-old male presenied al clinic with histo deficiency manifestatio(2ns 3)of
and episodes fusionand
psychiatric problems.
increasc of urinary 0-aminolevulinate and pornho Lahorat
revealeda
a mutation in the gene for
aboratory tdominal n dbdominal
a. What is the probable diagnosis? uroporphyrinogen Mutational.wealed
h What is the cause of abdominal
pain and
Synthase. 1alysis
c. Thedisorder concern with which psychiatrio
atrie
d. Name some other disorders
to same
metabolic pathway. problem?
related (1)
8. Protein energy malnutrition. pathway (1)
()
(2)
II. Brief Answer Questions (BAQ: 5)
9. Name any four
GlycOsaminoglycans
10. Deficiency of G 6 PD leads to with their
functions (10x2 20)
11. Name the major hemolysis. Explain.
regulatory enzyme of lipog
enzyme.
12. Give two
Mention the activator
of
examples competitive inhibition of this
for thi
13. What are the dietary sources and enzymes
name of folic acid. coenzymic formbrms of folic
14. Which are the serum acid? Give the other
15. How is enzymes that get elevated in
acute
16. Total
obesity measured and give its
nutrition
parenteral and
reference interval?pancreatitis
17. its
Cytochromes in ETC. importance.
18. Name the
powerhouse
found in mitochondria
of the cell,
why is it called so?
Explain the major pathway
*****

(SI.No. M2345)
 Sub. Code: 1010103
SI.No: M10503

M B B S D E G R E EK Y A M I N A Í I O N . 1010103
ON- AUGUST 20
FTRST VEAR

BIOCHEMISTRY - PAPERI

Three hourN Maximum: 50 marks

Time Answer ALL questions
SECTION- A

1. Answer briefly:
(10x1-10)
1. Name
the epimers ofglucose.
essential
acids.
fatty
2. Name the of glucose in the
mechanism of absorpion gut?
What is the
3. accumulation causes fatty liver?
4. Which lipid
in TCA cycle is inhibited by Arsenite?2
5. Which enzyme
6, Which serum electrolytes are measured using flamephotometer
HbS?
7. What is the defect in
8. Define Km value.
9. Name the active form of Vitamin D.
10. What is cardiolipin?

SECTION - B

II. Write briefly:

(5x2-10)
11. Mention the complexes in Electron transport chain.
12. What are mucopolysaccharides? Give two
13. What is Vitamin 'K' cycle?
examples.
14. Name the coenzymes for
Pyruvate
15. Write the enzyme defect and two dehydrogenase complex. Mention its function.
symptoms of Acute Intermittent porphyTnia.
SECTION-C
Ill. Write short notes
on:
(3x5 15)
16. Galactosemia.
17.
6.
Ketogenesis and the conditions to Ketosis.
Detine lsoenzymes. Mention twoleading
enzymes with their isoforms
significance. anu

IV. Write SECTION-D

Essays on: (8+7-15)
19.
on
Explain the pathway of
familial hypercholesterolemia.
cholesterol synthesis and its regulation. Add a note o
20. Write in 8
detail the structure, souree and
deficiency
symptoms of Thiamin. biochemical functions, RDA, ()
 FIRST YEAR GUST 200
AUGUST 2009 \010104 (
-

BIOCHEMISTRY PAPER I
Time: Three hours
Answer ALL questions
SECTION - A n: 50 marks
Maximum: 50 marks
I. Answer briefly:

. What is Garrod's tctrad?

2. How bilirubin is detoxified in the body? (10xl=10)
What is active sulphale and write its functions?
4 Mention the enzymes deficient in orotic aciduria
Mention the end products ot pyrimidine metabolism.
6. Name any five hormones acting through cyclic
7.
AMP
Mention the applications of molecular cloning in
8. Raw egg is used as an antidote for medicina
ine.
9.
mercury poisoning.
What is the normal serum sodium level
and Why?
10. Name the heterocyclic amino acids and the mention the causes of
these amino acids. hy- natremia?
important compounds nypopo natremia?
forme
SECTION B
IL Write briefly:

11. TATA Box.

12. Alaptonuria. (5x2=10)
13. Mitochondrial DNA.
14. Salient features of
15. genetic code.
Enzyme linked immuno sorbent
assay.

SECTION-C
III. Write short
notes on:
16. Renal
regulation of pH. (3x5-15)
17.
Regulation
18. PCR of blood calcium level.
techniques and its applications.

IV. Write
SECTION- D
Essays on:
19. Discuss (8+7-15)
in detail about the
ine metabolism and add a noteon
methionine
20. Homocystinuria. metabolism
Discuss in detail (8)
diseasts
about the DNA
NA repair mechanism and add a note on e
associated with DNA nechanism and (7)
repair.
*** *
 MBBS DEGREEE
Gk EXAMINATIO
FIRST YEAR -
EXAMINATIO
FIRST YEA ON ourse Code: : 1010103
AUGUSTST 2009
2009
BIOCHEMISTRY - PAPE
Time: Three hours
Answer ALL questions
SECTION- A
50 marks
Maximum. 50 marks
I. Answer briefly:

. Name the antioxidant Vitamins.

2. Name the key enzy mes or giuco neo
genesis, (10x1=10)
3. Hyper uricemia in on Gierke s disease.
4. Glucose and Fructose gives the same Why?
5. Intake of raw egg leads to biotin osasone
crystals. Whu
deficiency. Why? Why?
6. What are uncouplers? Name the
7. Name the ring structure in
choleste physiological uncoupl
8. Name the marker in
enzyme cellular
and the compounds ds far
9. organelles 1like Ivsnc.
Methotrexate is used as an anti cancerous formed from
10. Nanie the enzyme deficient in acute agent. Why? lysosome and
and golgi bodi
golgi cholesterol.
intermittent bodies.
erythropoetic porphyria. porphyria and cone
congenital
SECTION - B
II. Write briefly:
11. Essential pentasuria.
12. Essential
fatty acids. (5x2-10)
13. Functions of
Vitamin C.
14. of TCA
15.
Energetics cycle.
Significance of HMP shut pathway.

II. Write
SECTION-C
short notes on:
16.
17. Isoenzymes and its (3x5-15)
Formation
18. Fatty and fate of significance.
liver and pyruvate.
lipodtropic factors.
IV. SECTION - D
Write Essays on:
19. (8+7-15)
Discuss in
20. Discuss detail about
in detail hyper (8)
about
bout bilirubinemias. (7)
glycogen metabolism and its
metabolism and regulation.
 YEAR UGUS
UST
2009
BIOCHEMISTRY -PAPERI
Time: 1hree hours
Answer ALL questions
SECTION A Maximum 50 marks
I. Answer briefly:

. Name the antioxidant Vitamins.

2. Name the key enzymes of gluco neo genesis. (10x1=10y
3. Hyper uricemia in Von Gierke s disease. Why?
4 Glucose and Fructose gives the same osasone crystals.
Intake of raw egg leads to biotin deticiency. Why?
. What are uncouplers? Name the
Why?
physiological
Name the ring structure in cholesterol and the uncouplers,
8. Name the marker enzyme in cellular compounds formed
organelles like from cholesteroi
9 Methotrexate is used as an anti cancerous lysosomeand om
10. Name the enzyme deficient in acute
agent. Why? golgi cholesterol
bodies.
termittent porphyria and
erythropoetic porphyria. congenital
SECTION- B
II. Write briefly:
11. Essential pentasuria. (5x2=10)
12. Essential fatty acids.
13. Functions
of Vitamin C.
14. Energetics
of TCA cycle.
15.Significance of HMP shut pathway.

SECTION- C
III. Write short
notes on:
16.
(3x5-15)
Isoenzymes and its
17. Formation and
fate of
significance.
18. Fatty liver and pyruvate.
lipodtropic factors
SECTION-D
IV.
(8+7-15)
Write Essays on:
19. Discuss in
20.
detail about
hyper (8)
Discuss in detail about bilirubinemias. (7)
glycogen metabolism and its
reguiatation.
 Si.No: M9004 Sub. de: 101010
- -

EXAMINATION FEBRU 104

MBBS DEGREE FIRST YEAR
ARY 2009
BIOCHEMISTRY - PAPER II

Time: Three hours

SECTION - A
Maximum: 50 marks
in one or two sentences:
one word or
I. Answer briefly in

non protcin amino acids.

(10x1=10)
1. Name the
Name the biologically active peptides.
What is transamination?
What are the important substances formed from phenyl alanine?
5. What is the metabolic role of Selenium?
6. What is meant by anion gap?
Name the second messengers.
8. Name the synthetic analogues of purines.
9. Name the clearance tests.
10. Name the methods of separation of Proteins.

SECTION-B
II. Write briefly:
(5x2-10)
11. Gamma glutamyl cycle.
12. Amino acidsuria.
13. Transcription.
14. Tumour markers.
15. Isotopes in Medicine.

SECTION-C
II. Write short notes on: (3x5-15)
16. One carbon
metabolism.
17. Purine catabolismn.
l6. How 1s the estimation of NPN substances in blood useful in clinical aagn

SECTION - D

IV.Write Essays on: (8+7-15)

19. (8)
Describe in detail the
20. Write thes metabolism of glycine.
biochemical
functions and deiciene(7)
requirement, absorption,
manifestations
manifestations ef
of Calcium.
 SI.No: M9003 Sub. ode: 1010103
EXAMINATION-
DEGREE
MBBS FIRST YEAR EBRUAR 2009

BIOCHEMISTRY - PAPER
Time: 1hree hours

SECTION-A
Maximum: 50 marks
o r in o n e o r two sentences
one word
1. Answer briefly in

chemical composition of cell membrane. (10x1=10)

i. Give the
alcohols responsible for cataracts.
2. Name the sugar
importance of 2,3,BPG?
3. What is the
Eicosanoids?
4. What are
Michaelis-Menton constant?
5. What is
marker of Thiamine deficiency,
6. Name the biochemical
Name the different forms of Vitamin A.
7.
anemia due to?
8. What is sickle cell
9. Mention the major Nutritional deficiency disorder in developing intries.
10. Name the physiological uncouplers of Oxidative phosphorylation,

SECTION - B

IL Write briefly:
11. Galactosemia.
(512-10)
12. Visual cycle.
13. Heme synthesis.
14. Sphingomyelins.
15. Specific dynamic action of foods.
SECTION-C
II. Write short notes on:
(3x5-15)
16. Explain competitive inhibition and its usefulness in
17. therapeutics.
Gluconeogenesis and its regulation.
18. Write the sources, RDA, biochemical functions and deficiency maniresauouo
Vitamin D. o

SECTION - D
IV. Write
Essays on: (8+7-15)

19.Outline (8)
20.
the metabolic derangements in diabetes
Explain the biochemical melitus. (7)
basis for anaemias in different Vitamin deficiencies

*****
 Sub.b. Code: 11010104
FIRST MBBS DE REE 1010104
BIOCHEMI: TRY
EXAMINATION -

PAPER II
Time: Three hours

SEC ION -

A
Maximum: 50 1marks
I. Answer briefly:

semiessential aminoacids
I. Name the (10x1-10)
2. Name the polyamines
leads to Al:.i ism?
3. Which enzyme deficiency
Name the antithyroid drugs
What is Lesch Nyhan syndrome?
b. whai is the predomnant anion in the in racellular fluid?
Which enzyme def+ciency leads to hypc iricemia?
8. Write the stop codons.
9. Name the enzyme that is used for PCR.
10. What is the normal inulin clearance leve 1?

SEC ION B
II. Write briefly:
1. Secondary structure of protein (5x2-10)
12. Second Messenger
13. Homocystinurias
14. Catabolism of Purines
15. Blotting techniques

SEC ION-C

on:
II. Write short notes
16. Chromatography (3 x5 15)
17.Phase Two Detoxification
18. Recombinant
DNA technology

SECT ON- D
IV. Write
Essays on: (8+7 15)
19. What is the
normal blood pH? Discuss t e mechanism involved in its regulation.
(8)
0.Wnte n detail about the absorption, tran:
manifestation of Iron. port, daily requirement and deficieney
(7)

*} k**
 FIRST MBBS DEGREE Sub
EXAMINATATION Code: 1010103
BIOCHEMIST - PAPER-1
Time: Three hours

SECTION- A Aaximum: 50 marks

I. Answer briefly:

I. Name two Enzymes present in peroxisomes.

2. Nane the 4 Epimer of glucose.
3. What is the rate limiting Enzyme of
holesterol
(10x1=10)
4. Name the enzyme that is specifically
in
increased biosynthesis
5. Name any Two Folic acid antagonist. prostate
cancer
6. Name any Two High Energy
7. How many kilocalories are
Compounds.
produced from one gram of
8. What is the normal level of Serum fat?
bilirubin?
9 Which type of
Porphyria isinherited as
10. Name the autosomal
diagnostic test for Thiamine deficiency. recessive?

SECTION - B
i. Write briefly:
11. Name the bile salts. What is
its use?
12. Define 5x2-10)
coenzymes. Give two examples.
13. Laboratory
14. Biochemical
findings in a case of hemolytic Jaundice.
functions of Thiamine.
15. Absorption of Carbohydrates.

SECTION-C
III. Write short notes
on:
16. Galactosemia.
(3x5-15)
17. Inhibitors and
18. Dietary fiber. uncouplers of oxidative Phosphorylation.

SECTION-D
IV. Write
Essays on:
19. What 8+7-15)
are Ketone bodies? Write in
Keto acidosis. detail about Ketone body Synthesis. Add a note on
20. What is the Aa (8)
Homeostasis of bloodlevel of fasting and Post Prandial blood sugar? Write in detal ap
sugar. (7)

*****
 Sub.
ib. Code:
Code:101010104
FIRST MBBS DEGREE
EXAMINAiATION 1010104
RIOCHEMISTRY- PAPER 1
me Three honrs

SECTION A
Maximum.
)marks
. Answer briefly:

Name the semiessential aminoacids

Name the polyamines
(10%1-10)
Which enzyme deficiency leads to Albinism?
Name the antithyroid drugs
What is lesch Nyhan syndrome?
What is the predominant anion in the
intracellular fluido
Which cnzyme deficiency leads to hypouricemia
8 Wnte the stop codons.
Name the cnzyme that is used for PCR.
10. What is the nomal inulin clearance level?

SECTION B
I. Write briefly:
11. Secondary structure of protein (5x2-10)
12. Second Messenger
13. Homocystinurias
14. Catabolism
of Purines
15. Blotting techniques

SECTION - C

IlI. Write short notes on:

( 3 5 15)
16. ChromatographyY
17. Phase Two
Detoxification
18. Recombinant DNA
technology
SECTION- D

IV. Write (8+7 15)

Essays on:
. What in 13
is the normal blood DH? DiscuSs the nechanism involved E (8)
20. Write in detail about the absorption, transport, daily requirement anddelicien
(7)
manifestation of Iron.
l
 Si.No: M7005 Sub. Code 1010103
FIRSTMBBS D GREE EXAMINATION
-

BIOCHEl1ISTRY PAPER
Timc: Three hours
Maximum: 50 marks
SECTION - A

I. Answer briefly:

What is the key enzyme for glycoge 1olysis?

(10x1-10
2. What is ionophores? Give example
3. Write the substrate level phosphoryl ition reaction in TCA cvcle
4. Define Lipotropic factors. Give exe nples.
5. Name the enzyme used for the treat ient of leukemia.
Name the sulphur containing Vitam as.
Howprostaglandins are synthesize3'
8. How much iron is present in each gi m of hemoglobin?
9 What are dietary fibres? Give exam bles.
10. Name the coenzyme of Pantothenic 1cid.

S CTION - B

II. Write briefly:

5x2 10)
11. Mucopolysaccharides
12. Phospholipids
13. Calcitriol
14. Nitrogen balance
15. Acute intermittent porphyria

SCCTION-C
III. Write short notes on: (3x5 15)
16. Explain the influence of various fact rs on enzyme activity.
17. Glycogen storage diseases.
18. Wrnte the sources, daily requirement biochemical function and deficiency
manifestation of Niacin.
SICTION - D

(8+7 15)
IV. Write Essays on: t chain.
19. Describe the components, complexe: and inhibitors of Eiceu
20. Write in detail how cholestero is in our
about synthesizedbouy
****
 SI.No: M8506

FIRSTMBBS DEGREE
sub. Code
EXAMINATION 10104
BIOCHEMISTRY-PAPER- II
Time: Three hours

SECTION - A Maximum: 50 marks

I. Answer briefly:
1. Name the Sulphur containing essential amino acid.
2. Name the polyamines.
(10x1=10)
Name the Enzyme deficient in Lesch Nyhan Syndromne
4. Write any two uses of PCR.
5. Define anion gap. What is the normal anion gap?
6. What is the normal level of Phosphorous.
7. Write any two causes of hyperkalemia.
8. Name the Enzyme used in ELISA.
9. Expand RFLP.
10. Write stop codons.

SECTION - B

II. Write briefly:

11. Quarternary structure of

Proteins with examples. 5x2=10)
12. Define metabolic acidosis. Give two
13. Name 2 Pruine 2, 2 examples.
14. Creatinine clearance.
Pyrimide analogs.
15. Southern-blotting Technique.

SECTION-C
FII. Write short notes
on:
16. Phenyl Ketonuria. (3x5-15)
17. DNA
repair mechanism.
1&Salvage Pathway of Purines.

SECTION-D
IV. Write
Essays on: (8+7 15)
19.What s the
normal level
urea cycle disorders. of urea? Write in detail about it's synthesis.
1+5+2 (8)
20. Write in detail
about the Calcium (7)
Homeostasis.
 ub. Code: 1010104
S I N o : M18006

FIRST MRRS DEGREE EXAMINATION

BIOCHEMISTRY - PAPER I

7hree hours
Time Maximum. 50 marks
SECTION - A

1. Answer briefly
(10x1-10)
amino acids
Name the aromatic
is essential for Transaminases?
Which coenzyme
for creatinine
synthesie
Name the amino acids which are essential
What is the source
of C4, Cs2 N7 in a Purine ring?
5. Name the Enzyme deficient in severe combined Immuno deficienas.
TCA cyle?
6. How is urea cycle connected to
7. What type of RNA has unusual bases?
8. What is the most common form of DNA?
9. What is the normal level of Serum Calcium?
10. What is the normal pH?

SECTION - B

IL Write briefly:
11.
Sx2-10)
Nameany four compounds derived from glycine.
12. Name the amino acids that are excreted in
13. Orotic aciduria
Cystinuria.
14. anion gap
15. Hartnup disease

SECTION-C
II. Write short notes on:

16. Tumour markers

(3 x5 15)
17. Metabolic acidosis
18. Creatinine clearance

SECTION- D
IV. Write
Essays on: (8+7 15)
19. Write in detail about
the catabolism of Tvrosin? Add a note on
Important Blo (8)
20. What is thecompounds derived from Tyrosin.
normal pH? How is it
regulated in the boay (7)
 FIO
F X A M I r i A
FXA MIIA JieiN
nEr,HE

M P n s

n t o H E M I S I R V P A P E R

PAPE
RS
MAimmm m1ark

SECTON A

10119)

tsones
erox
n
present
b i o s y n t h e s i s

n z n e s

o
glucOse C h o l e s t e r o l

of cance
WRr Fpnci of prostatc
ihe lnzyme IP
Name
4 limiting inercasgd
rate spccifically

W h a t i t h e

s
enzype.tlhat a n t a g o n i s t .

Name
the acid
C o m p o u n d s .
Folic
Two of fat?
any one gram
Name Energy irom
Two High produced
6 N a m e any are bilirubin?
k i l o c a l o r i e s

recessive?
How many Serum
of autosoinal
level
normal
s
the inlieritedas
A7a deficiency.
Porphyriais Thiamine

7ch ype of test for

diagnostic
a i n c t h e

SECTION - B

(529
Write briefly:
use?
What is its
IName
the bile salts.
Give two examples.
coenzymes. Jaundice.
2 . Deiine
a case of hemolytic
ILaboratory
findings in
Biochemical
functions of Thiamine.
14
Carbohydrates.
5. Absorpiion of
SECTION - C

3x5=15)
Write shert motes oh
i6 Galnctosemia.
7. Inhibitors and uncouplers of oxidative PhosphorylatiOn.
18 Dictary fiber.

SECTION - D

(8+7-15)
PV. Write Essays O
On
19.Whatare Ketone bodies? Write in detail about Ketone body Syntne1S. (8)
Keio acidosis.
1a level of fasting and Post Prandial blood sugar? * w e (7)
Homeostasis of blood sugar.
 SI.No. 5754

FIRST MBBS EXAMINATION Sub. Code. 1010103

BIOCHEMISTRY
PAPER-1
Time: Two hours

Draw diagrams wherever Maximum: 50 marks

necessary.
SECTION- A
I. Write about the enzymes in
(a) Definition
following headings:
(b) Classification of enzymes as
(c) What
are enzyme inhibitors?
adopted by IUB.
How
(d) Competitive inhibitors salient they are classified? (1)
features and their role
inin therapeutics. (2)
2 What is the principle of Vanden (2)
Name the conditions where the Berg reaction, and the reagents (3
unconjugated used?
bilirubin is increased.
3. What are the
components of ETC? (3)
Name the inhibitors of electron transport chain at
various sites.
44. What is oxidative 2)
Name the phosphorylation? Give with examples.
uncouplers of oxidative
phosphorylation.
5. What is the normal plasma fasting (2)
Name the hormones that glucose level?
to
What is the mechanism ofhelp maintain the plasma
action of Insulin? glucose level.
6. Where the Rapaport (3)
What is the Lubering cycle takes place?
significance of this cycle?
7. What are marker (2)
enzymes? Name the marker enzyme for
8 Lysosomes. (2)
Define
gluconeogenesis. What are the substrates for
9. Gluconeogenesis? (1)
Normally which isoenzyme of LDH is
present in plasma? (1)
10. What test
is done to assess
the excretory function of Liver? (1)

(p.t.o.)
 (2)

SECTION

under following headings:

Write about ketogenesis
(n)Emumerate the ketone bodies and their normal plasma levet
(b) Organ in which it is synthesized and where it is utilized
(c)Pathway of synthesis and utilization. (2)
occurs. ()
(d) Conditions where ketonuria
(4)
12. What are Lipoproteins? Name the difterent methods of seperation ()
What is the ecomposition and function of chylomicrons?

13. Name the bile salts. What is it's function? (3)

14. Define pH. What is the normal range of plasma pH? 2)

What are the important buffers in blood?

15. What biochemical parameters are routinely done in (3)

What is the normal CSF Glucose level and in which
cerebrospinal fluid?
condition is it reducedo
16. Name the
2)
lipolytic enzymes present in pancreatic juice.
(1)
17. What is anion gap? Name in which condition it will be
increased?
2)
18 What is the enzyme defective in
(a) Niemann-pick disease
following disorders?
(b) Gaucher's disease
(2)
19. What is the enzyme
catalysing the regulatory step in cholesterol synthesis?
Name the hypolipedemic drug that acts
by blocking the absorption of cholesterol
from gastrointestinal tract.
2)
*****

(SI.No. 5754)
 EAMINATION
FEBRU ARY
MRBSDGRETNEWREGULAT1ONS) 2014
FIRSTVTAR

BIOCHEMISTRY PAPER
A.Y.MC
ORONUTC
1hrer hour Mavimum: 80 mark
Tme:
Ansner ALL qneetinns
Draw diagrams w herever neceseary
SECTION A

Write cksan on (10-10)

Define ghuconcopcnesis. Name the substrates for gluconcogenesis. Trace the

phconcogenesis
from Lactate.
pathway ol

1. r i t e short notes on: (45-20)

ormation. biochemical functions and dcliciency manifestations ofia
Galactosemia.
Name the complexes of Electron 1 ransport chain and write about its inhibitors

sEaplain 1CA cycle as an amphibolic pathway.

1. Anscr bricfly (512 10)
6. Peroxisomes
Nomal level of HbA,C and its clinical significance.
8. Name any two antivitamins of folic acid and Vitamin K.
9 Glucose 6 phosphate dehydrogenase deficiency.
10 Met-hemoglobin
SECTION - B

I. Write essay on: (lx1010)

11. Define ß oxidation. Write in detail about the ß oxidation of palmitie acid. Add
a note on its energetics and clinical significance.

II. Write short notes on: (4x5-20)

12 Protein energy malnutrilion.

13. Isoenzymes
14. Fatty liver
15. Heme synthesis.
(52-10)
III. Answer briefly:

16. Write 4 clinical applications of prostaglandins.

17. Surfactant
18. Reverse cholesterol transport.
use zymes.
19 Can liver
ketone bodies as
fuel? Why? inhibition
20. ive two npetitive
ofenzym
examples of competitive and non
*
 S u b . C o d e : 1 0 1 0 1 2 6

1.INO.
o: M150006 InIIVERSIT Y

VINAYAKA a5
- F E B R U A R Y
UNIVERSITY,SA
AMINA'TION
MBBS DEGREEMISIONS
PXA
(NEW REGULATIONS)
FIRST YEAR
BIOCHEMISTRY- PAPER IT Maximum: 80 marks

Time: Three hours

Answer ALL questions
necessary
wherever
Draw diagrams
SECTION - A (1x10=10)

1. Write essay on:

Write in detail about disposal of ammonia. (4x5-20)

II. Write short

notes on:

2. Calcium Homeostasis
3. Gout
4. Cytochrome P4so
Enumerate the liver function tests.
Add a note on Vandenocig
(5x2-10)

II. Answer briefly:

Tyrosine.
derived from
important compounds
a m e the biologically nucleotide analogs.
7. Write any four synthetic
8. Quaternary structure of proteins
through cyclic Amp.
9. Name any four hormones acting and alkaptonuria.
deficient in phenylketonuria
10. Name the enzyme
SECTION - B
(1x10=10)
I. Write essay on:
detail about the renal
serum pH? Explain in
11. Define pH. What is the normal (1+1+4+4)
acidosis.
Add a note on metabolic
regulation of pH.
(4x5-20)
II. Write short notes on:

modifications
12. Post transcriptional
13. Paper chromatography
14. Lac-operon
15. Mutation

III. Answer briefly: 512 10)

16. What is the normal level of Potassium? Write any two causes of hyperkalemia.
17. Define oncosuppressor gene. Give two examples
18. Southern blot technique
19 Name two hormones that act as tumour markers and the cancer in which it is
increased.
20 Define micro-albuminuria. Write its clinical significance.
*****
 s B S DEGREE EXAMIN,
FIRST YEAR

BIOCHEMISTRY PAPER II Maximum: 50 marks

Time: Three hours

Answer ALL questions
necessar
wherever
Draw diagrams
SECTION - A
(1x8-8)

or
formation
I. Write and
essay on: aminoacids
from
Write in detail about the removal of nitrogen
urea. (4x3-12)

I1. Write short notes on:

2. Sources of atoms of purines and pyrimidines

3. Glomerular function tests.
4. Absorption of iron and its transport
5. Polymerase chain reaction.
(5x1-5)
II. Answer briefly:
derived from Glycine.
6. Write four special products
7. Write two causes for hyperuricemia
8. List four tumor markers.
endonuclease?
9. What is restriction cofactor.
T0. List two enzymes requiring
copper as
SECTION - B
(1x8-8)
I. Write essay on:
a note on
metabolic acidosis.
is maintained and add
11. Explain how the plasma pH

II. Write short notes on:

(4x3-12)
12. Nucleosome
13. Lac Operon
14. Characteristics of genetic code.
15. Post translational modifications.

I1. Answer briely: (5x1=5)

16. List four essential aminoacids.
17. What is transmethylation reaction?
18. Name two modified bases in tRNA.
19. What is southern blot technique?
20. Name the enzyme deficient in
phenylketonuria and tests used for the diagnosils.
*****
N S R E S E A R C HF O U N D A
2021
T s i v o r s i t y )

: 1 0 1 1 9 1 0 3
-

I
CourseCode
S.No. M2041
FOUNDATION,
SALEM
RESEARCH

INAYAKA MISSION'S University)

( D e e m o d to
be 2021
February
EXAMINATION-

RST MBBS DE;REE

BIOCHEMISTRY - I
Maximum: 100marks

Time : 1hree hours

Answer ALL Questions marks
attached for 20
Answer Sheet Section A
Scction A in the immediately
Aswer the invigilator
handed o v e r to
r 20 niutes to be book providedd
answer

Answer Section B in the main

Maximum: 80 marks
SECTTON-B3
me: 2 hours 40 minutes
(2 x 15 30)
I. Long Answer Questions:
on the
developed jaundice
. A second child born to a Rh
incompatible parents and
Child was admitted
in the neonatal ICU
2nd day of delivery. child of the couple"
revealed that the first
was given. History
phototherapy child's blood showed
increased
during delivery. This
had no such problems
bilirubin and unconjugated
bilirubin.
level of total
(2)
a. What is this due to? Give your probable diagnosis.
values of total and
b. What is Bilirubin? What are the normal
unconjugated bilirubin? (1+2)
c. What is jaundice?(2) What are the various types of Jaundice? (2)
d. Discuss the causes and biochemical features of each type (6)
2. What is the normal plasma lipid profilc? Classify the lipoproteins and
tabulate the compositions and functions of 4 lipoproteins. Explain the
metabolism of HDL in detail. Give an account of the hyperlipoprotcinemias.
(2+1424+2+4+4

(p.
 -(2)- (6x 5-30)

(3+2)
I1. Short Answer Questions:
metabolism of low density
in 5)
of LDL
rCcentors

s c u s s the rolc
by its deteet.
and the disease causcd
clinical

and
(1+242)
metabolism? defects

liver in fat their

What is the role of
with
4. porphyrias,

note o n three types of

m y o c a r d i a l

TOte a after a an
e s t i m a t e d
after

manifestations. only
commo niy
c the cardiac
e n z y m e s

(2+3)
most
markers,
State the cardiac shown by
6. of the pattern
d i a g n o s t i c

Give details their (2+3)

infarct. and
discuss

mples (3+2)
infarct. mes?'Give
two
stuffs?

7. What are Isoenzym food

20)
2=
d i f f e r e n t

of x
the
SDA (10
importance. SDA.
W h a t is
note on
8. Write a
liver?

by the
s
sood
di um
iu m
Questions:
Answer fuel w
with
h
Brief a mi
m ix
xeed
d
III. used a s is
cannot be e s t i m a t i o n
e s t i m a t i o n

bodies
ketone glucose Explain.
Why for
for
9. patient
patient function?

from a their
collected
What is
Blood
10. oxalate.

potassium
from
i n t o l e r a n c e .

and
fluoride
lactose jaundice
features of h e p a t o c e l l u l a r

c a u s e s
&
the between

11. List differentiate

would you
How
12.
obstructive jaundice? explain?
and
pattern

flipping ofLDH purposes.

the
W h a t is
therapeutic

13. used
for
enzymes i m p o r t a n c e .

two s i g n i f i c a n c e ?

14.
Name
and its is its
nutrition What

15.
Total
parenteral

action
(SDA) offoods?
dynamic pulses?
specific and
W h a t is
cereals
example. of
16. Give
one c o m b i n a t i o n

ionophores. a
ingesting
Define
basis for
17. nutritional
(SI.No. M2041)

is the
*****

What
18.
SLNo. M2041 Course Code:10119103 - I

VINAYAKA MISSION'S RESEARCH FoUNDATION, SALPM.

(Deemed to be University)
IRST MBBS DEGREE EXAMINATION - February 2021

BIOCHEMISTRY -I
Time Three hours Maximum: 100 marks

Answer ALL Questions

marks
Answer Section.A in the Answer Sheet attached for 20
Atter 20 minutes to be handed over to the invigilator immediately Section A
nswer Section B in the main answer book provided

Time: 2 hours 40 minutes SECTION-B Maximum: 80 marks

L. Long Answer Questions: (2 x 15 30)

. A second child born to a Rh incompatible parents developed jaundice on the

2nd day of delivery. Child was admitted in the neonatal ICU and
phototherapy was given. History revealed that the first child of the couple"
had no such problems during delivery. This child's blood showed increased
level of total bilirubin and unconjugated bilirubin.
a. What is this due to? Give your
probable diagnosis. (2)
b. What is Bilirubin? What are the normal values of total and
unconjugated bilirubin? (1+2)
c. What is jaundice?(2) What are the various types of Jaundice?
d. Discuss the causes and biochemical features of each
(2)
type (6)
2. What is the normal
plasma lipid profile? Classify the lipoproteins and
tabulate the compositions and functions of 4
lipoproteins. Explan the
metabolism of HDL in detail. Give an account of the
hyperlipoproteinemias-
(2+1+2+2+444

p.
 - (2) -

II. Short Answer Qucstions

3. Discuss the role ofLDL
receptors in
metabolis
and the disease caused by its defect. of low 6x.5- 30)
density
What
4. What is the röle ofliver in fat
thero metabolism? lipoproteins
5. Wrotea note on thrce
manifestations.
etypes of porphyrias,
types of
porphyrias, with
vith their . 3-2)
defects and and clinical (5)
6. State the cardiac
markers, most
infarct. Give details of the commonly
estimate after a
infarct.
pattern shown bythe
cardiac myoardial (14242)
7. What are
Isoenzymes? two
enzymes after an
importance. examples and discuss
uss their
their diagnostic (243)
.

8. Write note a
s*

SDA. What is the SDA

on
diagnostic
of different food
II. Brief Answer stuffs? (2+3)
Questions: (3+2)
9. Why ketone bodies cannot be used as a (10 x 2 20)
fuel by the
10. Blood collected from a liver?
patient for giucose estimation is
fluoride and potassium mixed with sodum
oxalate. What is their function?
11. List the causes &
features of lactose intoleránce. Explain.
12. How would you
differentiate between hepatocellular
obstructive jaundice? jaundice from
13. What is
the flipping of LDH
patterm and explain?
14. Name two
enzymes used for therapeutic
15. Total purposes.
parenteral nutrition and its
importance.
6. What is specific dynamic action(SDA) of foods?
What is its
. Define
ionophores. Give one example. signifcance!
What is the nutrition al basis for
ingesting a combination o f cereals and plse>
*** **

(SI.No. M241)
 SI.No: M16505 Sub. Code: 1010125

INAYAKA MISSIONS UNIVERSITY, SATEM

2016
MBBS DEGREE EXAMINATION - August
FRST YEAR

BIOCHEMISTRY PAPERT Maximum: 80 marks

Time: 1hree hours

Answer ALL questions
wherever necessary
Draw diagrams
SECTION - A
(1x10-10)

1. Write the steps

essay on: Write
down
stored.
1. Name the ynthesised
and
hormones whicn nep
organs where g Add a note
on the (1+4+2+3)

with suitable diagrams,

i 1n e nolysis
the Glycogenolysis and their mode
of action.
(4x5-20)

lI. Write short notes on:

Inhibitors and uncouplers of Electron

transport chain.
anemia
3. Cellular and molecular aspects
of sickle cell
4. Peroxisome
D
5. Synthesis and functions of Vitamin (5x2-10)

III Answer briefly:

6. Glucose transporters (GLUTD significance
mucopolysaccharidosis
and their clinical
1. Mention any two
8. Reference range and
clinical significance of HbAlc metabolism?
helps in carbohydrate
B1 (thiamine)
9. Mention how Vitamin How it acts as
Antidote?
warfarin over dosage.
10. Name the Antidote for

SECTION- B
(1x10=10)
I. Write essay on:
cholesterol with suitable
metabolism and its role in reverse
11. Writein detail the HDL (7+3)
other functions of HDL.
diagram. Add a note on
(4x5-20)
IL Write short notes on:

12. BMR
13. Explain the covalent modification
14. Fatty liver
15. Isoenzymes

II. Answer briefly: (5x2=10)

16. Name the storage form of lipid and its storage site.
17. Name the biological compounds derived from cholesterol.
18. Type I and II hyperlipoproteinemia
19. How obesity is measured and its reference interval?
20. Define active site, Allosteric site, Km and Vmax.
*****