Effect of yoga on clinical outcomes and

quality of life in patients with vasovagal

syncope (live-yoga)
Authors – Sharma, G. et al., 2022

Presenter
Dr. Drishti Saini, BNYS
Trial Coordinator, AIIMS Rishikesh
Why Vasovagal Syncope? Why Yoga ?

Lifetime Positive
Common Prevalence of influence on
35% Cost effective
autonomic
system
Decrease in Frequency of
Quality of life recurrences
Recent studies-
benefits of yoga
in VVS
Existing
therapies –
largely ineffective
Introduction/ Background

Vasovagal Syncope

Yoga

Recent trials – effect of Yoga in autonomic

imbalance, investing it’s potential utility in VVS
 Pathophysiology Of Vasovagal Syncope

Fig 1. Pathophysiology of vasovagal syncope indicating the potential sites (orange arrows) of yoga-mediated modulation
(Sharma et al., 2022)
Aims & Objectives

Impact of yoga
therapy as adjunct Implication - yogic modality
to standard therapy for the VVS patients
on symptomatic
burden in patients To investigate the potential
with recurrent effect of yoga therapy in VVS
vasovagal syncope
Methodology

Pre-liminary Open Label

Single center RCT
phase II

➢ Sample size – 270

➢ Study center – AIIMS Delhi
➢ The trial was supported under the extramural research scheme by the
Ministry of AYUSH, Govt. of INDIA.
 Assessed for eligibility
(n= 270)

Excluded
(n= 215)

Randomized (n=55)

Control Group
Yoga intervention (n= 25)
(n= 30)

Completed 6 weeks visit Completed 6 weeks visit

Completed 6 months visit Completed 6 months visit
Completed 12 months visit Completed 12 months visit
(n=30) (n=25)
Statistical Analysis

Continuous
Mean ± SD
Student’s t-test

p – value
Variables < 0.05
Statistically significant

Categorical
Percentage
Chi-square test
 RESULTS

(A) (B)
Fig 2. A. Primary outcome event frequency , B. Primary outcomes – Episodes as MEAN ± SD (Sharma et al., 2022)
Table 1. Secondary Outcomes – QoL Scores (Sharma et al., 2022)
Discussion
Significant reduction in recurrent episodes of syncope and pre-syncope
during12 months follow up.

Significant improvement of Quality of Life to the patients in Yoga

Intervention group, during the study period by assessing SFSQ and
WHOQoL questionnaire.

No difference was observed in HUTT and HRV at 6 weeks, due to the

less duration of study as well as small no. of subjects.
Conclusion

Yoga – superior Cost-effective

to medical and safe
therapy in Improvement in intervention of
reduction of Quality of Life Yoga in
syncopal and pre- management of
syncopal events VVS
Study Limitations

Less no. in
Lack of sample
sham yoga subjects.
Open
Label. group.
SWOT Analysis
Strength Weakness
• Feasibility, • Lack of sham yoga group.
• Less no. in sample subjects
• Efficiency,
• Duration of the study is less
• Economic study design • Socio-demographic implications
• Socio-economic implications

Opportunity Threat
• Improvement of study design, • No significant threats found
• Show path to future studies on yoga
intervention therapy for neurovascular
diseases.
• Long duration study
• More no. of Subjects
Take Home Message

IN THE PRESENT SCENERIO OF

INADEQUANCIES WHY NOT A POCKET
FRIENDLY METHOD…
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