United States of America v. Karl Brandt, et al.

KARL BRAND WAS TRIALED FOR COMMITING CRIMES AGAINST HUMANITY BY

PERFORMING EXPERIMENTS ON SUBJECTS SUCH AS EXPERIMENTS CONCERNING THE
EFFECTS AND TREATMENT FOR FREEZING,MALARIA,POISON GAS.
THESE EXPERIMENTS WERE CONDUCTED ON CONCENTRATION CAMP INMATES.

Tuskegee study.

THE TUSKEGEE EXPERIMENT BEGAN IN 1932. THERE WAS NO CURE FOR SYPHILLIS AT
THE TIME. 600 AFRICAN AMERICAM MEN WERE PROMISED
FREE HEALTHCARE IF THEY VOLUNTEED. THE PURPOSE OF THE STUDY WAS TO
DETERMINE WHETHER PENICILLIN COULD PREVENT NOT JUST CURE
SYPHILLIS.

Elixir Sulfanilamide.

THE ELIXIR SULFANILAMIDE DISASTER OF 1937 WAS ONE OF THE MOST

CONSEQUENTIAL MASS POISONINGS OF THE 20TH CENTURY. SULFANILAMIDE AN ANTI-
BACTERIAL DRUG WAS FIRST USED
SAFELY IN THE TREATMENT OF STREPTOCOCCAL INFECTIONS. OVER 100 PEOPLE DIED
AFTER TAKING A LIQUEFIED VERSION SWETTENED WITH GLYCOL.THIS TRADEGY
PROVIDED A CATALYST FOR
THE FDA COSMETIC ACT 1938.

Declaration of Helsinki 4th revision 1996.

THE AIDS CLINICAL TRIALS GROUP(ACTG) STUDY 076 OF 100 ZIDOVUDINE IN

MATERNAL-INFANT TRANSMISSION OF HIV HAD BEEN PUBLISHED IN 1994.THIS WAS A
PLACEBO CONTROLLED TRIAL
WHICH SHOWED A REDUCTION OF NEARLY 70% IN THE RISK OF TRANSMISSION AND
ZIDOVUDINE BECAME A DE FACTO STANDARD OF CARE.

Directive 2001/20/EC of 4 April 2001

ON 4TH APRIL 2001 THE EUROPEAN PARLIAMENT AND COUNCIL ENACTED DIRECTIVE
2001/20/EC WHICH HAD TO BE IMPLEMENTED IN THE NATIONAL LAW OF THE
EUROPEAN UNION MEMBER STATES
BY MAY 2004. ITS AIM WAS TO IMPROVE THE QUALITY OF CLINICAL TROIALS AND
TO ASSURE THE SAFETY AND WELL BEING OF TRIAL SUBJECTS.

TeGenero trial (TGN1412)

ORIGINALLY INTENDED FOR THE TREATMENT OF B CELL CHRONIC LYMPHOCYTIC

LEUKEMIA (B-CLL) AND RHEUMATOID ARTHRITIS,TGN1412 IS A HUMANISED
MONOCLONAL ANTIBODY THAT NOT ONLY BINDS TO BUT IS A STRONG AGONIST FOR
THE CD28 RECEPTOR OF THE IMMUNE SYSTEM'S T-CELLS.