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  • تأشيرات دوائيات عملي

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    تأشيرات دوائيات عملي (1)

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    7 views9 pages

    تأشيرات دوائيات عملي

    Uploaded by

    ma22mdmm

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    of 9
    AP eed Pharmacology Dr.Lab upplicd with blood and lymph nis, on hand, is wells! ermeable to both lipid-soluble and watef- of the skin by Jipid-insoluble accomplished by diffusion robably st plands, or sebaceous glands. Distribution r suphout the body or to reach an organ, ‘0 other body compartments. Most water, in part bound d and int n part dissolved in body sues. Distribution for drugs may bind selectively to plasma c tissue proteins or be localized within _ the site of localization of a drug is likely to. t crosses the blood-brain barrier to — particular organs. Cl nfluence its action, e.g. whether i enter the brain; the extent (amount) and strength (tenacity) of protein or tissue binding (stored drug) will affect the time it spends in the body and thereby its duration of action. 3 ———=—— tt Pharmaneledy ae cologically active toa an inactive Un carly) sles rmacologically active to another active a SoS hse HE METABOLIC PROCESSES 3 S 1 shards StaMlols ce pes netapolizing ‘organ, Pavey] rary je KR, gut musdsa, “Vax ct hott Sie Ax s i c a the drug molecule by ox! F ag ; ogee Se erdup of Teactiony aye et wakes cea Sast st important Caaee a eae “Hin f y ra of: ee P450 enzymes eb Perrys aay Dr,Labe 2 ee Lajteaat involved in the biot Section one @A Ais si 9 outside, the liver sl drugs: Gti ains poo OP \ vais of ofiany _ UN dieganee » vai “Phase metabolism involves nfoti of the SA fer-soluble) end sis lect tak os rl yey MG ba ee Cee Say ary olism, to formals water-soluble conte it “se 5 i Yea) Salt yp WD \ nil phave ir méabotism! = sith ns of: aenat eo ob) Ses itl t ial bf o-0-pot 1pm Joye ests Al all eh all ay i Sod enters the clomerulus by the afferent arteriole atthe — « Gle merular Fill. z bee ee ect ieee l glon _ Ae je i Pple ego pa! Lh a wa bularsé Mist er gens sees tpi goed gfliceeeetl A) ce an4 Date els Od Lae nb Gaal ped pl et cyl, gyiel Als eth abe 1 A pd pt ABPR aby Sab eh Papp Se ag NY A A ot il et eal hormone from the adrenal cortex, promotes sodium-potassium exchange mainly in the distal tubule and collecting ducts. Thus, Idosterone promotes sodium reabsorption and potassium .Malbulare (enbe Se Pion oa ol ttn fice eae Cay iclmo dined esd Yow cepilcy ee “as! a Stabe SLE Se Lin Spi pA Lee l ses » ast a Gk bad poe ed Malad eae | Phé Paes \ ela Bes tla A Sale sil Bulag —elierinad des Mad iG ae e anit «Lene SN Shee. ; Pulmonary elinineds'on.—— ledges: A | -enale JAR phate ONT: wore — Dr ug interaction ? Ws eblast & $ may interact, but me +5 5) ees ic Mec Lik as ' poeas | he GIT absorptions ow Peal as i : face area upon which the drug cen, ie Nessie dt iba (eter castrointestinal motility, or (S) 2ffect transport proteins : ach as P-glycoprotein, petition for plasma protein binding, : lacement from tissue binding sites, a ——_ Pharmacology w ytd puso ion (stimulation) of cya chro can bé catised by Gnigs|barbinuranes th phenytoin, Fizampin, vince Lnnetabonisn Induct Dhol hibition of metabolism > induction ahd m S53 - aT aa =e Sk [Pharmacody namic Mechanisms _. |When drugs with similar phermecologic effects are aém ay concurrently, an additive cr synergistic response is usuz a two drugs may or may not act 02 the same receptor to | effects, Conversely, drugs with opposing pharmacolo reduce the response to one OF oth drugs, Pharm: interactions are relatively common in clinical armacolog . Pas i ay Or,Labeeb ie Poisoning Nic LO Vay Blass 4) 2d Ea lek est) ity Kan n tobiéeo smoke Nicotine ss es =e NL a a “ Nes eof the other sitios fourrd in cigarettes Carbon monoxide | | onia (household cleaning agent) | one (nail polish remover) ; b e (mothballs) i | anol (rocket fuel) | raldehyde (which preserves the dead) | ol (disinfectant), gen cyanide (tle = te s (76 metals including arsenic, cadmium, Mee oactive compounds (polonium-210) acetic acid (vinegar) oluene (industrial Solvent) oS Veter uae

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