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Change in Outcomes For Trauma Patients Over Time Two Decades of A State Trauma System
Change in Outcomes For Trauma Patients Over Time Two Decades of A State Trauma System
Injury
journal homepage: www.elsevier.com/locate/injury
a r t i c l e i n f o a b s t r a c t
Article history: Background: Trauma center mortality rates are benchmarked to expected rates of death based on patient
Accepted 9 June 2022 and injury characteristics. The expected mortality rate is recalculated from pooled outcomes across a
trauma system each year, obscuring system-level change across years. We hypothesized that risk-adjusted
Keywords: mortality would decrease over time within a state-wide trauma system.
Trauma systems Methods: We identified adult trauma patients presenting to Level I and II Pennsylvania trauma centers,
Shock 1999–2018, using the Pennsylvania Trauma Outcomes Study. Multivariable logistic regression generated
risk-adjusted models for mortality in all patients, and in key subgroups: penetrating torso injury, blunt
multisystem trauma, and patients presenting in shock.
Results: Of 162,646 included patients, 123,518 (76.1%) were white and 108,936 (67.0%) were male. The
median age was 49 (interquartile range [IQR] 29–70), median injury severity score was 16 (IQR 10–24),
and 87.5% of injuries were blunt. Overall, 9.9% of patients died, and compared to 1999, no year had sig-
nificantly higher adjusted odds of mortality. Overall mortality was significantly lower in 20 07–20 09 and
2011–2018. Of patients with blunt, multisystem injuries, 17.7% died, and adjusted mortality improved over
time. Mortality rates were 24.9% for penetrating torso injury, and 56.9% for shock, with no significant
change. Mortality improved for patients with ISS < 25, but not for the most severely injured.
Conclusions: Over 20 years, Pennsylvania trauma centers demonstrated improved risk-adjusted mortality
rates overall, but improvement remains lacking in high-risk groups despite numerous innovations and
practice changes in this time period. Identifying change over time can help guide focus to these critical
gaps.
© 2022 Elsevier Ltd. All rights reserved.
https://doi.org/10.1016/j.injury.2022.06.011
0020-1383/© 2022 Elsevier Ltd. All rights reserved.
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E.J. Kaufman, P.M. Reilly, J.S. Hatchimonji et al. Injury 53 (2022) 2915–2922
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E.J. Kaufman, P.M. Reilly, J.S. Hatchimonji et al. Injury 53 (2022) 2915–2922
Table 1
Characteristics of patients treated at Pennsylvania trauma centers, 1999–2018.
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E.J. Kaufman, P.M. Reilly, J.S. Hatchimonji et al. Injury 53 (2022) 2915–2922
Fig. 2. Adjusted odds ratio of mortality for Pennsylvania trauma patients, 1999–2018
A: Overall mortality and blunt multisystem injury
B: Penetrating torso injury and patients presenting in shock.
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E.J. Kaufman, P.M. Reilly, J.S. Hatchimonji et al. Injury 53 (2022) 2915–2922
Fig. 3. Adjusted odds ratio of mortality for Pennsylvania trauma patients by injury severity, 1999–2018.
0.75 (95% CI 0.66, 0.86). As shown in Fig. 2A, in multivariable anal- tile range 21–38) and 89.9% were male. Firearm injuries accounted
ysis, odds of mortality were significantly lower than baseline in for 67.9% and cut or stab injuries for 28.9%. Median ISS was 16
20 07–20 09 and 2011–2018 compared to 1999. Additional factors (interquartile range 9–25). Unadjusted mortality was 24.9%, and
that were significantly associated with mortality in multivariable there was no significant change in adjusted mortality over time
analysis included patient age (OR 1.04, 95% CI 1.04–1.05), low GCS as shown in Fig. 2B. Factors that were independently associated
motor score, abnormal vital signs, and higher ISS. Patients trans- with odds of mortality in multivariable analysis were similar to the
ferred in had lower odds of death (OR 0.62, 95% CI 0.58–0.65), overall group. Compared to firearm injury, cut/stab injuries were
as did those with a mechanism of firearm injury or pedestrian associated with lower odds of mortality (OR 0.18, 95% CI 0.15–
struck. Comorbidities associated with higher odds of mortality in- 0.23).
cluded heart disease (OR 1.68, 95% CI 1.58–1.79), cancer (OR 2.16,
95% CI 1.89–2.46), and liver disease (OR 3.85, 95% CI 3.31–4.47).
Full regression results are included in the online supplementary Shock
material.
Overall, 11,186 patients (6.9%) presented in shock. The median
age was 37 (IQR 24–57) and 76.7% were male. The most common
Blunt multisystem injury
mechanism of injury was firearm (34.5%) followed by motor vehi-
cle crash (26.3) and median ISS was 21 (interquartile range 13–29).
We identified 20,303 patients with blunt multisystem injury
Of the 6362 (56.9) patients in shock who died, 3664 (57.1%) died
(12.5% of trauma patients). The median age was 43 (IQR 26–61)
within an hour of presentation, and another 1246 died between 1
and 68.4% were male. The most common mechanism of injury was
and 6 h. There was no consistent change in risk-adjusted mortality
motor vehicle crash (50.4) followed by fall (16.4%) and pedestrian
rates over time, but rates were higher in 2005 and 2016 as shown
struck (9.8%). Median ISS was 27 (interquartile range 22–34). Unad-
in Fig. 2B.
justed mortality was 17.7%. In multivariable analysis, adjusted odds
of mortality decreased during the study period, with an odds ra-
tio for 2018 of 0.68 (95% CI 0.50–0.91). Odds of mortality were Analysis stratified by injury severity
significantly below baseline in 2003 and in 2006–2018, as shown
in Fig. 2A. Factors independently associated with mortality in this Of the 80,006 (49.2%) of patients with mild to moderate in-
group were similar to those in the overall population, though the juries (ISS < 16), unadjusted mortality was 4.7%. For the 59,413
only mechanism independently associated with higher mortality (36.5%) with severe injuries (ISS 16–24), 10.0% died. Among the
was pedestrian struck (OR 1.69, 95% CI 1.43, 2.02). 23,227 (14.3%) with very severe injuries (ISS ≥ 25), 27.7% died.
In multivariable analysis, mortality declined significantly for mild-
Penetrating truncal injury moderate and severe injuries. For the very severe injuries, adjusted
odds of mortality were lower during the middle of the study pe-
We identified 17,058 patients (10.5%) with penetrating injury to riod, but returned to baseline between 2014 and 2016, as shown in
the neck, chest, or abdomen. The median age was 27 (interquar- Fig. 3.
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on October 12, 2023. For personal use only. No other uses without permission. Copyright ©2023. Elsevier Inc. All rights reserved.
E.J. Kaufman, P.M. Reilly, J.S. Hatchimonji et al. Injury 53 (2022) 2915–2922
2920
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E.J. Kaufman, P.M. Reilly, J.S. Hatchimonji et al. Injury 53 (2022) 2915–2922
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changed Despite Several In-Hospital Hemorrhage Control Advancements. Shock
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