Pharmacology Computations

DESIRED DOSE (D) X Volume (V) = Amount (A)

DRUG ON HAND (H)

PROBLEM 1 DOCTORS ORDERS: PROBLEM 2 DOCTORS ORDERS:

Administer 10.5mg/kg/day of ------- in 8 doses Administer 4mg/kg/day of ------- in 2 divided doses
Stock dose: 100 mg/20ml Stock dose: 500 mg/5ml
Patient's Weight: 44lbs Patient's Weight: 64lbs

How many mg is needed for 24 hrs.? What is the desired dose for the patient a day?
How many mg is needed for each dose? What is the desired dose for the patient per administration?

GIVEN: WT: 44 = 20 kg GIVEN: WT: 64 = 29.091 kg

2.2 2.2
D: 10.5 mg/kg/day D: 4 mg/kg/day
H: 100 mg H: 500 mg
V: 20 ml V: 5 ml

SOLUTION: SOLUTION:
Patient's dose Patient's dose
10.5 mg/kg/day x 20 kg = 210 mg /day 4 mg/kg/day x 29.091 kg = 116.36 mg /day

210 mg x 20 ml = 42 ml 116.36 mg x 5 ml = 1.16 ml

100 mg 8 500 mg 2

= 5.25 ml/dose = 0.58 ml/dose

 DESIRED DOSE (D) X Volume (V) = Amount (A) PROBLEM 4 DOCTORS ORDERS:

DRUG ON HAND (H) Administer 10.5mg of ------- Q8h in 7 days

Stock dose: 8 mg/20ml
PROBLEM 3 DOCTORS ORDERS:
Administer 0.75g of ------- Q12h in 3 days Compute Desired Amount to Administer
Stock dose: 1000 mg/500mg/vial
dilute in 10 ml saline GIVEN:
D: 10.5 mg
How many ml will you administer per dose? H: 8 mg
How many vial will you request to complete the course V: 20 ml
of treatment?
SOLUTION:
GIVEN: 10.5 mg x 20 ml = 26.25 ml
D: 0.75 x 1000 8 mg
750 mg
H: 1000 + 500 26.25 ml x 3 x 7 = 551.25 ml
1500 mg
V: 10 ml PROBLEM 5
Gentamicin in a Soluset to complete 100ml infusion.
SOLUTION:
750 mg x 10 ml = 5 ml /dose How many ml of PNSS will you add with Gentamicin?
1500 mg 100 ml - 40ml = 60ml of PNSS

5 ml x 2 x 3 = 30 ml What is the drop rate if it is infused in 100ml/hr?

100 ml x 60 gtts = 100 gtts
30 ml = 3 vials 60 ml
10 ml
 Flow rate = Total Volume (TV) X Drop rate (DR) Infusion rate = Total Volume Infusion Time = Total Volume
(FR) Minutes (IR) Hours (IT) Infusion rate

PROBLEM 6 PROBLEM 7
Start IVF D51MB 1/2 L in 8 hrs via microset Start IVF D5lr 1 L in 12 hrs via macroset

What is the Infusion rate What is the Infusion rate

What is the Flow rate What is the Flow rate

GIVEN: TV: 1/2 L GIVEN: TV: 1 L 1000 ml

1/2 X 1000 500 ml
DR: 60 gtts DR: 20 gtts
Time 8 hrs. Time 12 hrs.
8 x 60 480 min. 12 x 60 720 min.

SOLUTION: SOLUTION:
Infusion rate = 500 ml Infusion rate
= 1000 ml
8 gtts 12 hrs.

= 62.5 ml/hr = 83.33 ml/hr

Flow rate = 500 x 60 gtts Flow rate = 1000 x 20 gtts

480 min. 720 min.
= 30000 gtts = 20000 gtts
480 min. 720 min.

= 62.5 gtts/min. = 27.78 gtts/min.

 PROBLEM 8

Start IVF D5W 1 1/2 L in 12 hrs for pt. G 35 year old male

What is the Infusion rate IV level by 1500H If it started at 0900H

What is the Flow rate
1500H 125.00 ml/hr
GIVEN: TV: 1 1/2 L - 0900H X 6 hrs.
1500 ml 0600H 750 ml
DR: 20 gtts
Time 12 hrs. 1500 ml
12 x 60 720 min. - 750 ml
750 ml
SOLUTION:
Infusion rate = 1500 ml
12 hrs. When is the expected time of consumption of IV?

= 125.00 ml/hr 0900H

+ 1200H
Flow rate = 1500 x 20 gtts 2100H OR 9PM
720 min.
= 30000 gtts
720 min.

= 41.67 gtts/min.
tal Volume
usion rate