Malaria is a mosquito-bome disease accounting for 241 million cases in 2020and has become a public health burden. Several methods have been employed in an attempt to control this Disease with the most recent being vaccines. WHO has begun administration of RTS,S as the first generation This review aims to analyze effi ne in children ant Tnrature from search engines PubMed, Google Scholar, and Science rect using key words “RTS,S/ASO1 malaria. vaccine”, ‘Efficacy” and “Children”, Publications were limited to English Manuscripts published within the last 10 years Inclusion criteria were RTS,S/ASO1 malaria vaccine as A total of 6 studies with 33,840 study 2 intervention and children as study population. We excluded were identified. Based on JADAD assessment, all ee eames ea ere reread 6 studies were of good quality. All 6 studies meta-analyses. A ttl of 8 studies were identified suitable for showed that RTS,S/ASO1 were protective against review. All studies were evalused and scored using 7 JADAD scale. clinical malaria. Two studies showed that ef declined after 3-4 years. review found that the RTS,S/ASO1 malaria vaccine had good efficacy among children. Further research and data collections are required in order to determine the need for booster and safety as preventive efforts for malaria, especially in endemic counti