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Worldwide
46 million people around the world, including 4.4%
of the U.S. population, have bipolar disorder.
Onset
Bipolar II disorder can begin in late adolescence and throughout adulthood,
average age at onset is the mid-20s, which is slightly later than for bipolar I
disorder but earlier than for major depressive disorder.
The illness most often begins with a depressive episode and is not recognized
as bipolar II disorder until a hypomanic episode occurs; this happens in about
12% of individuals with the initial diagnosis of major depressive disorder.
About 5%–15% of individuals with bipolar II disorder will ultimately develop a
manic episode, which changes the diagnosis to bipolar I disorder, regardless of
subsequent course.
Youth with bipolar II disorder spend less time hypomanic compared to those
with bipolar I disorder, and the initial presenting episode is typically
depression. Compared with adult onset of bipolar II disorder, childhood or
adolescent onset of the disorder may be associated with a more severe lifetime
course.
Risk and Causal Factors
GENETIC AND PHYSIOLOGICAL FACTORS
Individuals with relatives with Bipolar II has higher risk of developing
bipolar II. Genetic factors also influence the onset of the disorder.
There is a growing evidence of a partial distinction in the genetic
architecture of Bipolar II from Bipolar I and Schizophrenia
BIOLOGICAL TRAITS
Research suggests that imbalances in neurotransmitters or
hormones that affect the brain may play a role.
ENVIRONMENTAL FACTORS
Life events, such as abuse, mental stress, a “significant loss,” or
another traumatic event, may trigger an initial episode in a
susceptible person.
Suicide Risk
Suicide risk for both Bipolar 1 and 2 are higher than the general
population.
1/3 of individuals with Bipolar 2 report a lifetime history of suicide
attempts.
Risk and incidence of suicide in Bipolar 1 and 2 does not differ
Treatment and therapies
Treatment of Bipolar 2 aims to regulate the person’s mood, reduce
symptoms and improve quality of life.