NON-SURGICAL SOLUTION

FOR THE TREATMENT

OF PERIODONTAL POCKETS
WHAT IT IS:
CHLOSITE IS A XANTHANE GEL WITH BI-CHLOREXIDINE, RESULT OF GHIMAS RESEARCH, ADJUVANT
IN THE TREATMENT OF PERIMPLANTITIS AND PERIODONTITIS ABLE TO PREVENT, FOR AT LEAST
TWO WEEKS, THE BACTERIAL RECOLONIZATION AT THE APPLICATION SITE.

HOW IT WORKS:
THE PRODUCT REMAINS AT THE APPLICATION SITE, ADHERING TO THE TISSUE OF THE POCKET.
IT IS PROGRESSIVELY REMOVED BY THE PROCESS OF IMBIBITION FROM 15 TO 30 DAYS.
 Monomeric structure
of Xanthan

XANTHAN+BI-CHLOREXIDINE
Xanthan is a polymer that forms a three-dimensional pseudo-plastic
reticulum, capable of holding and maintaining in suspension various
substances, that are then gradually released on the basis of their physical
and chemical characteristics. These properties make Xanthan an excellent
substrate for the formation of a stable gel and a carrier for the chlorhexidine.

Chlorhexidine protects the application site from bacterial contamination. In

Chlo-site, bi-chlorexidine is present in a concentration of 1.5%, of which:

• 0.5% is in the form of di-gluconate

• 1% is in the form of di-hydrochloride

The association of the two substances gives the gel its mucoadhesive
property.

Bacteria, unable to adhere to the pocket wall, cannot proliferate and have
toxic effects on the gingiva.

Image of a cross-linked Xanthan

polysaccharide.
Dimensions: 1.5 μm x 1.5 μm
USED AFTER SCALING AND ROOT PLANING IT IS A WINNING
COMBINATION FOR THE TREATMENT AND CLINICAL
CONTROL OF CHRONIC PERIODONTITIS
The randomized multicenter
study by Paolantonio et Al. (J
Periodontal 2009; 80: 1479-
1492) studied the effects of
xanthan gel combined with
chlorhexidine (CHLO-SITE), used
as an adjunct therapy to scaling
and root planing (SRP) in the
treatment of chronic periodon-
titis. The study demonstrates
that the group being treated
with SRP+ CHLO-SITE showed
greater improvements than the
SRP ALONE in terms of pocket
depth at both 3 and 6 months
(statistical analysis shows that
the difference between the two
Pocket depth (PD) at the beginning
and after 3 and 6 months
groups are high and clinically improvement was also similar
relevant: P <0.001). in the subgroup with pocket
depths greater than 7 mm. In
The differences between the
other words, in cases of severe
two treatment groups in the
periodontitis the use of CHLO-
reduction of pocket depth
SITE combined with mechani-
were respectively 0.87 mm at
cal debridement is capable of
3 months and 0.83 mm at 6
restoring periodontal disease to
months (the statistical analy-
mild/moderate levels.
sis shows that the difference
between the two groups is
high and clinically relevant: P
<0.001). The same considera-
tions were made for the clinical
attachment level, 0.94 mm and
0.90 mm, respectively at 3
and 6 months (P <0.001). This
A - all pockets (n = 98)
B - pockets initially with PD  7 mm (n = 25).
All within-group time comparisons were statistically
significant (p = 0.000).
Statistical significance between groups at the same time
as control: † p <0.01, ‡ p <0.001.
ALLOWS THE DENTIST TO SAFELY
MANAGE PERIODONTAL DISEASE,
CHECKING PATIENTS EVERY 3-4 MONTHS.

The percentage of positive
sites for bleeding on probing
(BOP) was similar for both
treatments during each check.
The comparison between the
two groups, shows relevant
differences in favor of the
SRP + CHLO-SITE group after
3 months. Moreover, a greater
reduction was noticed in the
percentages of positive sites
for periodontopathic bacteria
strains in the SRP + CHLO-SITE
group when compared to the
SRP alone group.
In conclusion, the use of SRP
+ CHLO-SITE determines
a greater reduction of the
pocket depths and improves
the clinical attachment level
when compared to the SRP
only group.
These results are confirmed
by both chemical and biolo-
gical analyses up to 3 months
after treatment, considering
the different pocket depths
and pockets with the depth
greater than 7 mm only.
This data confirms the clinical
effectiveness of CHLO-SITE
and proves that periodontal
diseases can be safely
managed by the dentist if
the patient is checked every
3-4 months by supragingival
hygiene and periodontal visits
(with probing of the pockets
and SRP + CHLO-SITE
treatment for pockets with
a depth up to 4 mm).

Clinical Attachment Level (CAL)

at t=0 and after 3 and 6 months

PD (A and B), CAL (C and D), and GR (E and F) at baseline and 3 and 6
months for all pockets (n = 98) and for pockets ‡7 mm(n = 25). Data
are mean – SEM. The pairwise comparisons between 3 and 6 months
and baseline within each treatment (not shown) were statistically
significant at P = 0.000. Statistical significance of the differences
between the groups at each time point: *P <0.001; †P <0.01.
 EASY SIMPLE
After mechanical removal
it can be stored at room of the plaque, it is extruded
temperature, it is ready directly into the site
for use, and is applied starting from the deepest
directly from the syringe portion of the pocket, and
into the pocket thanks to progressively withdrawing it
the thin needle with blunt up until the gingival margin
tip and side exits.

EFFICIENT
RESULTS It produces an occluding barrier SPECIAL
GUARANTEED at the application site for at
least 15 days. Unlike topical ATRAUMATIC
IN A SHORT TIME
treatments with antibiotics,
CHLO-SITE does not induce NEEDLE
bacterial resistance.

SINCE 2004
MORE THAN

MORE THAN
1,5
MILLION

3.000
POCKETS
TREATED SOLD IN
MORE THAN

PROFESSIONALS
HAVE USED THE PRODUCT WITH SUCCESS
35
COUNTRIES
AROUND THE WORLD
APPLICATION METHOD
Periodontal
probing
F.A.Q.
Is Chlo-site an antibiotic?
No, it is an antiseptic,
Di-Hydrochloric
Chlorhexidine 1.0%
and Degluconate 0.5%
Does Chlo-site create
bacterial resistance after
repeated applications?
No, it doesn’t create
resistance
Is Chlo-site effective on
anaerobic bacteria?
Chlorhexidine is not only
active on aerobic and
anaerobic bacteria,
but also on gram positive
and gram-negative
bacteria.
Application Application of Chlo-site into the periodontal pocket
of Chlo-site
How long does it remain
in the contaminated
periodontal pocket?
Thanks to Xanthan, it
remains at the site for
at least 15 days. The
Xanthan is resistant but
water-soluble, with the
help of crevicular fluids
it is removed from the
pocket.
Is it possible to use
Chlo-site for multiple
applications?
Yes, if necessary,
it is possible to use
Chlo-site for up to three
applications, every
15 days.
Dr. Magda
Is it possible to use Chlo- Is there a risk of damage
site in mild to severe to the tissues during the
cases of periodontitis/ application?
peri-implantitis ?
Thanks to the needle
Yes, currently in the with blunt tip and
mild forms we have lateral holes, it is the
good satisfying results. only product totally
In severe forms it is atraumatic.
supportive to others
therapies.
Is it possible to apply
Chlo-site in the hole of
the implant before the
screwing cap?
Yes, it is possible to
apply the product on the
threads of the healing
cap.
 Available in 3 different versions:

BOX WITH 1 SYRINGE CONTAINING 1 ML OF PRODUCT

BOX WITH 4 SYRINGES EACH CONTAINING 1 ML OF PRODUCT

BOX WITH 6 SYRINGES EACH CONTAINING 0.25 ML OF PRODUCT

VIDEO DEMONSTRATING

THE APPLICATION OF CHLOSITE

VIA CIMAROSA, 85 40033 CASALECCHIO DI RENO (BO) ITALIA

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E-Mail: info@ghimas.it - www.ghimas.it

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