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The Clinical Neuropsychologist, 18: 559572, 2004

Copyright # Taylor and Francis Ltd.


ISSN: 1385-4046
DOI: 10.1080/13854040490888530

Similarities and Differences in Wechsler Intelligence Scale


for Children—Third Edition (WISC-III) Profiles: Support
for Subtest Analysis in Clinical Referrals
Susan Dickerson Mayes and Susan L. Calhoun
Department of Psychiatry, The Penn State College of Medicine, Hershey, PA, USA

Our study supports the reliability and validity of profile analysis in children with neurobiological
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disorders. Three mutually exclusive WISC-III profiles were identified that characterized the
majority of children with autism (low coding or Freedom from Distractibility Index with low Com-
prehension), attention deficit hyperactivity disorder and learning disability (low Coding or FDI
without low comprehension), and brain injury (low Performance without low Coding or FDI).
The profiles suggest attention, writing, and performance speed deficits in autism, ADHD, and
LD; global visual-motor problems in brain injury; and specific difficulty with language comprehen-
sion and social reasoning in autism. Children with anxiety, depression, and behavior disorders did
not exhibit distinct profiles. Our profile analysis is based on the simple rank ordering of standard
scores. The profiles are clinically useful because they may alert clinicians to certain diagnostic pos-
sibilities, they reveal characteristic strengths and weaknesses that have implications for educational
intervention, and they are consistent with preliminary WISC-IV data.
Keywords: WISC-III profiles, ADHD, Autism, Brain Injury, Anxiety, Depression, Oppositional-
Defiant Disorder, LD

Profile analysis is a popular practice among researchers maintain that only Full Scale IQ
school, neuro-, and clinical psychologists (an estimate of g) is meaningful, and they
(Anastasi & Urbina, 1998; Fiorello, Hale, oppose the analysis of subtest or factor scores
McGrath, & Quinn, 2002; Pfeiffer, Reddy, (Bray, Kehle, & Hintze, 1998). Others argue
Kletzel, Schmelzler, & Boyer, 2000). How- that composite scores (i.e., index or factor
ever, much controversy exists regarding its scores) are reliable and meaningful and can
validity. Stanton and Reynolds (2000) con- be used in profile analysis with corroborating
tend that ‘‘clinicians who focus on the evidence from other sources (Donders, 1996;
relationship between groups of participants Glutting, McDermott, Prifitera, & McGrath,
appear to support the clinical practice of pro- 1994; McDermott, Fantuzzo, & Glutting,
file analysis, whereas statisticians who focus 1990; Oh, Glutting, & McDermott, 1999).
on the relation between variables strongly Still others argue that profile analysis at the
oppose the practice’’ (p. 434). subtest level with supporting data is useful
The literature is replete with various posi- in understanding a child’s strengths and
tions on profile analysis. Some clinicians and weaknesses and in guiding treatment and

Address correspondence to: Susan Dickerson Mayes, Ph.D., Department of Psychiatry H073, Milton S.
Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA. Tel.: þ1-717- 531-6201. Fax: þ1-717-
531-3662. E-mail: smayes@psu.edu
Accepted for publication: July 27, 2004.
560 SUSAN DICKERSON MAYES AND SUSAN L. CALHOUN

educational programming (Hale, Fiorello, More important, some distinct and reliable
Kavanagh, Hoeppner, & Gaither, 2001; subtest and index profiles have been found
Kaufman, 1994; Sattler, 2002). Supporters of across studies for specific clinical groups. Stu-
subtest analysis argue that subtest scores dies using the WISC-III have reported lower
provide specific information that is lost if Freedom from Distractibility and Processing
analyses are based only on factor or index Speed than Verbal Comprehension and
scores (Kramer, 1993; Nyden, Billstedt, Perceptual Organization Index mean scores
Hjelmquist, & Gillberg, 2001). According to in children with ADHD, LD, and autism
Kaufman (1994) and Sattler (2002), most (Mayes et al., 1998a, 1998b, 2003; Mealer,
WISC-III subtests have sufficient specificity Morgan, & Luscomb, 1996; Naglieri, Goldstein,
(i.e., reliability and distinctiveness) to justify Iseman, & Schwebach, 2003; Newby, Recht,
subtest analysis. Caldwell, & Schaefer, 1993; Nyden et al.,
The most common method of intraindivi- 2001; Prifitera & Dersh, 1993; Saklofske,
dual profile analysis is the ipsative approach Schwean, Yackulic, & Quinn, 1994; Schwean,
whereby specific subtest scores are compared Saklofske, Yackulic, & Quinn, 1993; Snow &
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with a composite score. Critical values for the Sapp, 2000; Wechsler, 1991). In the aforemen-
statistical significance of differences between tioned studies reporting mean subtest scores,
subtest and composite scores are found in Coding was the lowest of the six nonverbal
tables in multiple sources (e.g., Kaufman, subtests, followed by Symbol Search.
1994; Sattler, 2002; Wechsler, 1991). A mean Another consistent profile finding across
difference of 34 points is required for WISC-R and WISC-III studies is lower Per-
significance at .05 when a subtest score is formance relative to Verbal IQ in children
compared with the mean of the subtest with acquired brain injury. This includes
scores. Another method of subtest analysis children with severe traumatic brain injury
is a variant of configural frequency analysis (Donders & Warschausky, 1997; Hoffman,
(Stanton & Reynolds, 2000). This procedure Donders, & Thompson, 2000; Kay &
simultaneously compares multiple subtest Warschausky, 1999; Kinsella et al., 1995;
scores (ipsative comparisons dichotomized Mayes, Pelco, & Campbell, 1989; Tremont,
as significantly different or not for each sub- Mittenberg, & Miller, 1999) and children with
test) and uses multivariate statistics to com- spina bifida with hydrocephalus (Fletcher
pare the expected with observed frequencies et al., 1992; Friedrich, Lovejoy, Shaffer,
for the subtest patterns. Shurtleff, & Beilke, 1991; Jacobs, Northam, &
Studies of clinical children show signifi- Anderson, 2001).
cant differences between diagnostic groups Eight independent studies of children with
in WISC-R and WISC-III subtest scores. autism reported the same WISC-III and
Differences have been found between chil- WISC-R subtest profiles (Allen, Lincoln, &
dren with attention deficit hyperactivity dis- Kaufman, 1991; Asarnow et al., 1987;
order (ADHD) and emotional disturbance Ehlers et al., 1997; Happe, 1994; Lincoln,
(Lufi, Cohen, & Parish-Plass, 1990), ADHD Courchesne, Kilman, Elmasian, & Allen,
and autism (Ehlers et al., 1997), ADHD 1988; Mayes & Calhoun, 2003; Nyden et al.,
and other clinical disorders (Mayes, 2001; Siegel, Minshew, & Goldstein, 1996).
Calhoun, & Crowell, 1998a), high-function- In all of these studies, the mean Comprehen-
ing autism and schizophrenia (Asarnow, sion subtest score was lower than the other
Tanguay, Bott, & Freeman, 1987), learning subtests that comprise the Verbal Compre-
disability (LD) and clinical children without hension Index, and Block Design was the high-
LD (Mayes, Calhoun, & Crowell, 1998b), est of the Performance subtests.
and reading disability and comorbid The purpose of our study is to (a) indepen-
reading and math disabilities (Ackerman & dently replicate the profiles reported in pre-
Dykman, 1995). vious studies, (b) describe profile similarities
SUPPORT FOR SUBTEST ANALYSIS 561

and differences for clinical children, and ADHD and autism were in previous research
(c) determine the accuracy of WISC-III studies by the authors. The children with ADHD
profile types in differentiating children with who were prescribed medication were off medi-
cation for testing, and none had a head injury with
specific clinical disorders. Our study is unique
loss of consciousness. In the ADHD group, 183
because it simultaneously analyzes profiles children had ADHD combined type without a
for several different clinical groups, including comorbid mood or behavior disorder, 312 had
ADHD, LD, autism, brain injury, anxiety, ADHD combined type with a comorbid disorder
depression, oppositional-defiant disorder, (e.g., oppositional-defiant disorder), 103 had
and adjustment disorder. As in previous ADHD predominantly inattentive type without a
research, our study describes profiles based comorbid mood or behavior disorder, and 32 had
ADHD predominantly inattentive type with a
on group mean scores. Unlike previous
comorbid disorder. The brain injury group com-
studies, ours also determines the predictive prised 19 children with spina bifida with hydro-
validity of profile types in identifying indi- cephalus, 16 with severe closed head injury, 5
vidual children with different clinical disor- with a brain tumor, 4 with a stroke, 2 with anoxic
ders. A strength of our profile analysis is its brain injury, 1 with encephalitis, and 1 with a
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clinical utility. The analysis is based on the gunshot wound to the brain. Time post-injury for
simple rank ordering of subtest and index children with acquired injuries was 1 month to 16
years.
scores and does not require mathematical
Children ranged in age from 6 to 16 years with a
calculations or statistical procedures. mean of 9 years and an SD of 3. The mean IQ was
103 (SD ¼ 14), with a range of 80 to 150. Twenty-
six percent of the children were female, 92% were
METHOD White, and 8% were Black, Hispanic, or Asian.
For 37% of the children, one or both parents had
Sample and Procedure a professional or managerial occupation. The diag-
The sample comprised 809 clinical children with an nostic subgroups did not differ significantly
IQ of 80 or higher evaluated in our Department of (p > .05) in IQ (F ¼ 2.9), race (v2 ¼ 7.3), and
Psychiatry diagnostic clinic, which is in a suburban occupation (v2 ¼ 7.9). As expected, children with
setting. Most children were referred for learning, ADHD and autism were younger (Bonferroni
attention, and=or behavior problems, Only chil- p < .0001) than children with mood and behavior
dren with DSM-IV diagnoses agreed upon by both disorders, and they had a higher percentage of
a child psychologist and child psychiatrist were males than the other subgroups (v2 ¼ 34.5,
included in the sample, so that there was 100% p < .0001). These differences were expected
diagnostic agreement. Components of the psycho- because ADHD and autism are congenital disor-
logical evaluation included (a) IQ, achievement, ders (unlike mood and behavior disorders, which
and neuropsychological tests; (b) teacher and par- have a later onset) and because the incidence of
ent questionnaires and rating scales (Pediatric ADHD and autism is far greater in males than in
Behavior Scale; Lindgren & Koeppl, 1987); females.
(c) child interview and self-report scale; (d) clinical
observations of the child; and (e) review of the
child’s developmental history, school transcripts Instruments
from kindergarten to the present, and previous All children completed the 12 WISC-III subtests
evaluations. The psychiatric evaluation was based comprising the four Indexes, Verbal Comprehen-
on independent semistructured interviews with sion (VCI), Perceptual Organization (POI), Free-
the parent and child and on a review of the records dom from Distractibility (FDI), and Processing
and questionnaire and rating scale data obtained Speed (PSI), and the Wechsler Individual
from the parents and teachers used in the psycho- Achievement Test (WIAT) Basic Reading, Reading
logical evaluation. Comprehension, Numerical Operations, and
Sample sizes and clinical diagnoses included: Written Expression subtests.
630 children with ADHD, 93 children with autism,
48 children with brain injury, and 38 children with Learning Disability Definition
mood and behavior disorders (anxiety disorder, All of the children in the study had a diagnosis of
depression, oppositional-defiant disorder, and=or ADHD, autism, brain injury, or mood and beha-
adjustment disorder). Some of the children with vior disorder. Within each of these groups,
562 SUSAN DICKERSON MAYES AND SUSAN L. CALHOUN

children were classified as having or not having a having a specific diagnosis (i.e., number of children
learning disability (LD). LD percentages were with both the diagnosis and the corresponding pro-
76% for ADHD, 75% for autism, 67% for brain file type divided by the total number with the diag-
injury, and 32% for mood and behavior disorders. nosis), specificity or percentage correctly classified
LD was defined as a WIAT word reading, reading as not having the diagnosis (number without the
comprehension, math, or written expression diagnosis who do not have that diagnostic profile
subtest score significantly lower (p < .05) than type divided by the total number without the diag-
predicted based on the child’s WISC-III Full Scale nosis), positive predictive power (number who
IQ using the predicted achievement method speci- have both the diagnosis and the corresponding
fied in the WIAT manual (Wechsler, 1992). The profile type divided by the total number with that
WISC-III and WIAT have a co-normed linking profile type), and negative predictive power (num-
sample allowing for direct comparison of standard ber without the diagnosis who do not have that
scores on the two tests (vs. comparing IQ and diagnostic profile type divided by the total number
achievement test scores on different tests normed who do not have that profile type).
on different children at different times). The
WISC-III and WIAT regression equation controls
for the correlation between tests, measurement RESULTS
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error, and regression to the mean (Glutting et al.,


1994). The predicted achievement method Group Means and Profiles
(vs. simple discrepancy) is recommended so that As shown in Table 1, the pattern of mean
children with high IQs are not overidentified as scores for each diagnostic group is consistent
having LD. All children identified with LD had
one or more WIAT standard score that was below
with profiles previously reported in the litera-
the normal mean of 100. The ability-achievement ture. FDI and PSI were the lowest Index
discrepancy definition used in our study is consi- scores for children with ADHD, LD with
stent with the Individuals with Disabilities Edu- mood and behavior disorders, and autism,
cation Act (Federal Register, 1999) and is the but not for children with brain injury or mood
most conventional way to define LD (American and behavior disorders without LD. Of the
Psychiatric Association, 1994; Fessler, Rosenberg, six nonverbal or performance subtest scores,
& Rosenberg, 1991; Fletcher, Shaywitz, & Shaywitz,
1999; Frankenberger & Fronzaglio, 1991; Glassberg,
Coding was the lowest and Symbol Search
Hooper, & Mattison, 1999; Gresham, MacMillan, & was the second lowest for children with
Bocian, 1996; Hoskyn & Swanson, 2000; Kavale, ADHD, LD, and autism, but not for the
Fuchs, & Scruggs, 1994; Sattler, 2002; Schuerholz other groups. For children in the brain injury
et al., 1995; Tannock & Brown, 2000; Ward, Ward, group, Performance scores (POI and PSI) were
Glutting, & Hatt, 1999). lower than Verbal scores (VCI and FDI). In
the autism group, Comprehension was lower
Data Analyses than the other VCI subtests, and Block Design
Our profile analysis was based on simple visual was the highest of the POI subtests.
inspection and rank ordering of standard scores
without the need for mathematic computations Low Coding and FDI Profile
or statistical procedures. Profile types were The majority of children with ADHD,
determined by ranking the Index and the subtest
scores from lowest to highest for each child with- autism, and LD had the low Coding profile
out considering the magnitude of differences (coding score  Picture Completion, Picture
between scores. The significance of differences in Arrangement, and Block Design), as shown
the frequency of profile types between clinical in Table 2. The percentage of children with
groups was determined using chi-square and risk ADHD, autism, and LD who had low Coding
and odds ratios. To compare the proportion of was approximately three times greater than
clinical children with specific profiles with chance the norm or chance expectation (z ¼ 20.1,
expectancy (based on a normal mean standard
score of 100), z-scores were calculated. The accu- 10.1, and 6.8, p < .0001). In contrast, the per-
racy of profile types in predicting group member- centage of children with other diagnoses who
ship was determined by calculating sensitivity had the low Coding profile did not differ sig-
or percentage of children correctly identified as nificantly from the norm (z ¼ 2.1, p ¼ .04).
SUPPORT FOR SUBTEST ANALYSIS 563

Table 1. Mean Standard Scores for the Clinical Groups (N ¼ 809).

ADHD Autism Brain LD, mood, Mood, behavior,


injury behavior no LD

Full Scale IQ 104 103 95 92 104


Verbal Comprehension 107 107 102 93 108
Perceptual Organization 105 105 92 98 101
Freedom from Distractibility 93 95 95 90 106
Processing Speed 98 92 90 87 103
Information 10.8 11.8 10.0 8.0 10.7
Similarities 11.6 12.2 11.0 9.1 12.6
Vocabulary 11.0 11.4 10.9 8.8 10.9
Comprehension 11.4 9.0 9.5 9.1 11.4
Picture Completion 11.1 11.0 9.5 10.4 10.9
Picture Arrangement 10.4 10.0 7.7 8.8 9.2
Block Design 10.9 11.6 8.7 9.3 10.8
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Object Assembly 10.5 10.4 7.9 9.5 9.5


Arithmetic 8.7 9.0 8.7 7.2 10.1
Digit Span 8.5 8.9 9.1 9.0 11.7
Coding 9.0 7.5 7.4 7.1 10.2
Symbol Search 10.0 9.2 8.3 7.5 10.5

Note. Mood=behavior disorders include anxiety, depression, oppositional-defiant, and adjustment dis-
orders. ADHD (attention deficit hyperactivity disorder), autism, and brain injury include both
children with and without LD (learning disability).

Table 2. Percentage of Children with Low Coding and Freedom from Distractibility Index (FDI) Scores.

Low codinga Low FDIb Low coding or FDI

ADHD (with or without LD) 52 57 84


Autism (with or without LD) 62 31 75
LD with mood=behavior or brain injury 70 20 73
Mood=behavior or brain injury no LD 34 20 49
Chance expectancy based on the norm 20 25 40

Note. ADHD ¼ attention deficit hyperactivity disorder, LD ¼ learning disability.


a
Coding  Picture Completion, Picture Arrangement, Object Assembly, and Block Design.
b
FDI (Freedom from Distractibility)  Verbal Comprehension, Perceptual Organization, and
Processing Speed.

Children with ADHD, autism, and LD had a p ¼ .0001), and other diagnoses (v2 ¼ 18.0,
two times greater risk of having the low Cod- p < .0001). The low FDI profile was two
ing profile than children with other diagnoses times more common in ADHD than the
(odds ratio ¼ 2.2, v2 ¼ 5.1, p ¼ .01). norm (z ¼ 18.5, p < .0001), but was not sig-
The low FDI profile was relatively unique nificantly more common than chance expec-
to children with ADHD. This profile was two tation in the other groups (z ¼ 0.61.3,
times more common in ADHD than in other p > .18).
diagnoses (odds ratio ¼ 3.6, v2 ¼ 45.7, Overall, 83% of children with ADHD, aut-
p < .0001). Differences in frequencies were ism, and LD had either the low Coding or low
significant when children with ADHD were FDI profile, whereas only 49% of children
compared to children with autism with other diagnoses had one or both of these
(v2 ¼ 21.2, p < .0001), LD (v2 ¼ 15.6, profiles (odds ratio ¼ 5.1, v2 ¼ 25.6,
564 SUSAN DICKERSON MAYES AND SUSAN L. CALHOUN

Table 3. Percentage of Children with Low Performance Scores.

Low performancea

Brain injury (with or without LD) 77


ADHD (with or without LD) 46
Autism (with or without LD) 58
LD with mood=behavior disorder 58
Mood=behavior disorder without LD 69
Chance expectancy based on the norm 50

Note. ADHD ¼ attention deficit hyperactivity disorder, LD ¼ learning disability.


a
Perceptual organization plus processing speed  verbal comprehension plus Freedom from
Distractibility.

p < .0001). The proportion of children with autism (z ¼ 10.2, p < .0001) and brain injury
either of these profiles significantly exceeded (z ¼ 4.0, p ¼ .0001). However, significantly
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chance expectation for children with ADHD, more children with autism had low Compre-
autism, and LD (z ¼ 22.0, 6.9, and 3.7, hension than children with brain injury
p < .001), but not for children with other (v2 ¼ 6.0, p < .01). The low Comprehension
diagnoses (z ¼ 1.1, p ¼ .26). profile did not differ significantly from
chance occurrence for children with ADHD
Low Performance Profile (z ¼ 2.3, p ¼ .02), LD (z ¼ 0.6, p ¼ .52), and
As seen in Table 3, 77% of children with mood and behavior disorders (z ¼ 0.2,
brain injury had lower scores on the Perform- p ¼ .81).
ance than on the Verbal subtests, indicating a
global visual-motor weakness (in contrast to Classification Accuracy Using Profile Types
the specific Coding weakness for children with Three mutually exclusive composite pro-
ADHD, LD, and autism). The low Perform- files were created based on study findings
ance profile was two times more common in (Table 5). The majority of children with
children with brain injury than in children ADHD (but not other groups) had low Cod-
with other diagnoses (odds ratio ¼ 3.6, ing or low FDI without low Comprehension.
v2 ¼ 14.6, p ¼ .0001). The percentage of chil- The majority of children with autism (but
dren with brain injury who had the low Per- not other diagnoses) exhibited low Coding
formance profile was significantly greater or low FDI with low Comprehension. The
than chance (z ¼ 3.8, p ¼ .0002), which was majority of children with brain injury without
not the case for children with ADHD, autism, LD (but not other children) had low Perform-
LD, and other diagnoses (z ¼ 2.0, 1.5, 0.6, ance without low Coding or low FDI. The
and 1.9, p > .05). frequency of these profile types in the
corresponding diagnostic subgroups did not
Low Comprehension and High Block differ significantly for children with below
Design Profile average (IQ < 100) versus above average
Both the low Comprehension and high block (IQ  100) intelligence (v2 ¼ 4.4 for ADHD,
Design profiles were more common in autism 0.2 for autism, and 0.1 for brain injury,
than in other diagnoses, but only low Compre- p > .05).
hension was found in the majority of children Children with LD (with mood or behavior
with autism (Table 4). The low Comprehen- disorders or brain injury) were more likely
sion profile was two times more prevalent in to have the low Coding or FDI without low
autism than in other diagnoses (odds Comprehension profile than the two other
ratio ¼ 5.7, v2 ¼ 60.3, p < .0001) and signifi- profile types. Therefore, children with LD were
cantly exceeded chance expectation for combined with children with ADHD for the
SUPPORT FOR SUBTEST ANALYSIS 565

Table 4. Percentage of Children with Low Comprehension and High Block Design Scores.

Low Comprehensiona High Block Designb

Autism (with or without LD) 71 47


ADHD (with or without LD) 29 34
Brain injury (with or without LD) 50 38
LD with mood=behavior disorder 33 33
Mood=behavior disorder without LD 23 42
Chance expectancy based on the norm 25 25

Note. ADHD ¼ attention deficit hyperactivity disorder, LD ¼ learning disability.


a
Comprehension  Information, Similarities, and Vocabulary.
b
Block Design  Picture Completion, Picture Arrangement, and Object Assembly.

Table 5. Percentage of Children with Specific Profile Types.


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Low coding Low coding Low performance


or FDI with or FDI without without low coding
low comprehension low comprehension or FDI

ADHD (with or without LD) 24 60 13


Autism (with or without LD) 56 19 19
Brain injury without LD 22 0 67
LD with mood=behavior or brain injury 30 43 20
Mood=behavior without LD 15 42 35
Chance expectancy 10 30 30

Note. FDI ¼ Freedom from Distractibility Index, ADHD ¼ attention deficit hyperactivity disorder,
LD ¼ learning disability.

predictive validity analysis. The low Coding or p < .0001) and correctly classified 67% with
FDI without low Comprehension profile was brain injury and 86% without brain injury.
three times more common in the ADHD=LD PPP was 5%, and NPP was 100%.
group than in all other diagnostic groups (odds
ratio ¼ 5.0, v2 ¼ 57.7, p < .0001). This profile
correctly classified 59% of children as having DISCUSSION
ADHD or LD (sensitivity) and 77% as not hav-
ing ADHD or LD (specificity). Positive predic- Clinical Profiles
tive power (PPP) was 93%, and negative The profiles found in our study are consistent
predictive power (NPP) was 27%. with those previously reported for children
The low Coding or FDI with low Compre- with ADHD, LD, autism, and brain injury,
hension profile was twice as common in aut- demonstrating reliability across studies. Our
ism (with or without LD) as in all other study also supports the validity of these pro-
diagnoses (odds ratio ¼ 4.0, v2 ¼ 41.1, files because of their significant association
p < .0001) and correctly classified 56% of with specific diagnoses. Children with neuro-
children with autism and 76% without aut- biological disorders (ADHD, LD, autism,
ism. PPP was 24%, and NPP was 93%. Last, and brain injury) had distinctive profiles,
the low Performance without low Coding or whereas children with mood and behavior
FDI profile was five times more prevalent disorders (anxiety, depression, oppositional-
in brain injury without LD than in all other defiant, and adjustment disorder) did not.
diagnoses (odds ratio ¼ 11.9, v2 ¼ 19.1, Further, none of the mean WISC-III Index
566 SUSAN DICKERSON MAYES AND SUSAN L. CALHOUN

scores for these children fell below 100, which with the low Coding or FDI with low Compre-
was not the case for children with neurobiolo- hension profile had diagnoses other than aut-
gical disorders. ism. Similarly, NPP was very high for brain
injury without LD. Almost all (99.6%) of
Predictive Validity those without the low Performance profile
Our profile analysis was based on simple vis- did not have brain injury without LD. How-
ual inspection and rank ordering of standard ever, PPP was low (95% of children with this
scores without the need for mathematic com- profile had diagnoses other than brain
putations or statistical procedures. Profile injury). Therefore, the profile types are most
types were determined by the relative rank useful in ruling in ADHD=LD (93% accu-
of certain scores, not the magnitude of differ- racy) and ruling out autism and brain injury
ences between scores. The analysis is easy (93% and 99.6% accuracies).
and practical and can be accomplished by
clinicians in only a few moments. Three pro- Clinical Implications
file types were identified that characterize the The presence or absence of profile types cer-
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majority of children with specific disorders, tainly should not be the basis for making a
but not children with other disorders. These diagnosis. Profiles are clinically useful
were (a) low Coding or FDI without low Com- because they may alert a clinician to certain
prehension, which characterized children diagnostic possibilities and they provide
with ADHD or LD, (b) low Coding or FDI knowledge about the pattern of strengths
with low Comprehension, prominent in chil- and weaknesses that characterize certain dis-
dren with autism, and (c) low Performance orders, which has implications for edu-
without low Coding or FDI, typical of children cational intervention. Our results and those
with brain injury who did not have LD. These of others indicate that children with ADHD,
profiles correctly classified children as having LD, and autism score low on FDI and PSI
versus not having ADHD=LD with 62% relative to other Index scores and that Coding
accuracy, autism with 73% accuracy, and is the lowest of the six nonverbal subtests, fol-
brain injury without LD with 85% accuracy. lowed by Symbol Search. These findings sug-
Although overall classification accuracy gest attention, writing, and performance
was relatively high for the three profiles and speed weaknesses in children with ADHD,
their corresponding diagnoses, sensitivity, LD, and autism. Children with brain injury
specificity, and positive and negative predic- score lower on the Performance than on Ver-
tive power differed between profiles. Speci- bal subtests, indicating a global problem with
ficity ranged from 76% to 86% for the three visual-motor skills not limited to writing.
diagnostic subgroups, but sensitivity was However, even in this group, the mean Coding
lower at 56% to 67%. PPP was high for chil- score is lower than the other nonverbal subt-
dren with ADHD=LD. If the low Coding or est scores. Psychologists should be aware of
FDI without low Comprehension profile was the likelihood of attention, writing, and per-
present, these children had a 93% chance of formance speed problems in children with
having ADHD=LD. However, if the profile neurobiological disorders to insure that these
was not present, ADHD=LD could not be areas are properly assessed and that inter-
ruled out because 73% of children without vention is provided if needed.
the profile had ADHD=LD. The opposite In contrast to attention, writing, and per-
pattern was found for children with autism formance speed weaknesses, children with
and brain injury. NPP was high in autism. If neurobiological disorders tend to have
the low coding or FDI with low Comprehen- strengths in verbal and visual reasoning (i.e.,
sion profile was not present, the likelihood higher scores on VCI and POI than FDI
of the child not having autism was 93%. How- and PSI). Because the weaknesses are neuro-
ever, PPP was low because 76% of children logically based, they are likely to persist over
SUPPORT FOR SUBTEST ANALYSIS 567

time. Therefore, it is important to teach to amount of time doing schoolwork as the


the verbal and visual strengths and bypass, child’s classmates, and two sets of textbooks
compensate for, and remediate (to the great- (one for school and one for home) if the child
est extent possible) the attention, writing, and has difficulty remembering which books to
performance speed weaknesses. Many bring home each day for homework.
accommodations and interventions are avail- In addition to low Coding, Symbol Search,
able to assist with writing problems. These and FDI, children with autism have relatively
include using a keyboard and word processor low scores on comprehension (measuring lan-
for written work, providing class notes and guage Comprehension and social reasoning)
outlines so the students do not need to rely and high scores on Block Design (assessing
solely on their own note taking, and teaching visual-motor manipulative skills). Numerous
structured writing strategies (Danoff, resources provide educational strategies
Harris, & Graham, 1993; Graham, 1990; and interventions for students with autism to
Graham, Harris, & Larsen, 2001; Lane & address the language, social, attention, and
Lewandowski, 1994; MacArthur, 1996, 2000; writing problems (Attwood, 1998, 2000; Bau-
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McNaughton, Hughes, & Ofiesh, 1997; minger, 2002; Gray & Garand, 1993; Jordan,
Sawyer, Graham, & Harris, 1992; Vaughn, 2003; Kunce, 2003; Manjiviona, 2003; Mesibov,
Gersten, & Chard, 2000). 1992; National Research Council, 2001;
Effective interventions also exist for stu- Shaked &Yirmiya, 2003; Williams, 1995).
dents who have attention problems. A recent
study funded by the National Institute of Study Limitations
Mental Health and U.S. Department of Edu- Limitations of the study include the differing
cation showed that stimulant medication sample sizes of the diagnostic subgroups and
(alone or in combination with behavior ther- the fact that 74% of the participants were
apy and counseling) was significantly more male and 92% were White. Therefore, our
effective in decreasing ADHD symptoms findings may not generalize to more diverse
than intensive behavior intervention and clinical samples. Another limitation is the
counseling or routine community care very small number of children with LD who
(MTA, 1999). Studies also demonstrate that did not have ADHD, autism, or brain injury
stimulant medication can improve attention and the absence of a pure LD subgroup with-
in children with autism (Birmaher, Quintana, out comorbidity. Future research is needed to
& Greenhill, 1988; Handen, Johnson, & determine if children with different types of
Lubetsky, 2000; Quintana et al., 1995; LD can be distinguished from other diag-
Strayhorn, Rapp, Donina, & Strain, 1988). noses using ability profiles or if children with
Students who have attention problems LD have profiles similar to those of children
may also benefit from adaptations in school, with ADHD, as suggested in our study. Pre-
which are described in several publications vious research indicates that children with
(Barkley, 1994; Fowler, 1990; Gordon, 1991; LD have some degree of attention problem
McCarney, 1989; Parker, 1988; Prior, 2003). (as measured by rating scales and psycho-
Accommodations might include: preferential metric tests of attention) even if they do
seating near the teacher and between peers not meet diagnostic criteria for ADHD
who are attentive, breaking tasks into small (Barkley & Grodzinsky, 1994; Dainer et al.,
manageable segments, teaching organiza- 1981; Mayes, Calhoun, & Crowell, 1998b,
tional and study skills, backpack check at 2000; Robins, 1992, Swanson, 1981, 1983;
the end of each school day and before school Tarnowski, Prinz, & Nay, 1986).
to insure that the child does not forget assign-
ments and materials, a reasonable time limit Implications for the WISC-IV
on homework and a reduction in classroom Our findings may apply to the WISC-IV,
assignments so that the child spends the same which has retained the subtests and indexes
568 SUSAN DICKERSON MAYES AND SUSAN L. CALHOUN

that are key to the three clinical profile types. functioning for either typical children with
These include Coding, Comprehension, VCI, significant profile variability or children with
POI (now called Perceptual Reasoning Index disabilities’’ (p. 115) and that VCI and POI
or PRI), PSI, and FDI (now called Working accounted for the majority of FSIQ variance
Memory Index or WMI). The WISC-IV mod- in children with ADHD, LD, and uneven
ifications may actually strengthen profile subtest profiles. This finding may be even
findings. Letter-Number Sequencing replaces more pronounced for the WISC-IV than
arithmetic on WMI. Therefore, WMI may for the WISC-III. Our study suggests that
be more sensitive to attention problems than FSIQ on the WISC-IV may be lower than
FDI because it is no longer confounded by on the WISC-III for children with ADHD,
math ability. A potential improvement for LD, and autism because all four of the
subtest analysis is that the WISC-IV has two WMI and PSI subtests are used in the calcu-
untimed motor-free estimates of visual lation of the FSIQ, whereas only two of the
reasoning (Picture Concepts and Matrix four FDI and PSI subtests were used on the
Reasoning). Block Design is retained as a vis- WISC-III. Therefore, FSIQ on the WISC-IV
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ual-motor subtest, and Object Assembly, Pic- may not be the best indicator of global
ture completion, and picture arrangement intelligence for children with neurobiological
are deleted. Thus, PRI on the WISC-IV has disorders.
only one timed visual-motor subtest, versus
three on the WISC-III POI. Now that fine
motor coordination and performance speed ACKNOWLEDGEMENT
will have less influence on PRI, this index
may be even more distinct from PSI than We wish to thank the Wells Foundation,
was POI on the WISC-III. Oxford Foundation, Spencer Foundation,
Future research will be needed to determine Children’s Miracle Network, and Penn State
how the substantial WISC-IV changes will Children, Youth, and Family Consortium
affect profile analysis. However, preliminary for their generous support of our research.
WISC-IV profile analysis data (Wechsler,
2003) on small samples of clinical children
(n ¼ 1989) are consistent with our WISC-III
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