You are on page 1of 23

Accepted Manuscript

Helmholtz’s Critique of Goethe’s Theory of Color More than Meets the Eye

Curtis E. Margo, Lynn E. Harman

PII: S0039-6257(18)30148-6
DOI: 10.1016/j.survophthal.2018.10.004
Reference: SOP 6823

To appear in: Survey of Ophthalmology

Received Date: 12 June 2018


Revised Date: 29 September 2018
Accepted Date: 8 October 2018

Please cite this article as: Margo CE, Harman LE, Helmholtz’s Critique of Goethe’s Theory of
Color More than Meets the Eye, Survey of Ophthalmology (2018), doi: https://doi.org/10.1016/
j.survophthal.2018.10.004.

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to
our customers we are providing this early version of the manuscript. The manuscript will undergo
copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please
note that during the production process errors may be discovered which could affect the content, and all
legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Page 1

Helmholtz’s Critique of Goethe’s Theory of Color

More than Meets the Eye

PT
RI
SC
Curtis E. Margo Ϯ* and Lynn E. Harman*

U
AN
Ϯ Departments of Pathology and Cell Biology, and *Ophthalmology, Morsani
M

College of Medicine, University of South Florida, Tampa, Florida, U.S.A.


D

Conflicts of interest: none


TE

Corresponding author: Dr. Curtis E. Margo, 12901 Bruce B. Downs Blvd., Box 21,
EP

Department of Ophthalmology, University of South Florida, Tampa, FL, USA


C

E-mail address: cmargo@health.usf.edu


AC

Abstract 142; text 2,761; illustrations 4; references 32


ACCEPTED MANUSCRIPT
Page 2

Abstract

After arriving at the University of Königsberg in 1849, Hermann von Helmholtz started

investigating the trichromatic hypothesis of color perception proposed by Thomas Young. Four

PT
years later in 1853 he was invited to lecture to the German Society and used the opportunity to

RI
criticize harshly Johann Goethe’s Theory of Color published in 1810. Offending a revered

member of German society was an odd method of introducing the study of color to a learned

SC
audience. but the content and tone of the lecture suggested Helmholtz was more concerned

about dispelling misconceptions of experimental science than in imparting knowledge on the

U
nature of color. By 1860, Helmholtz’s color mixing experiments provided further evidence for
AN
the trichromatic hypothesis. Goethe’s ideas about color resonated intuitively with generations
M

of artists, but the imperviousness of his theory to experimental testing set it apart from the

arena of science.
D
TE
C EP
AC
ACCEPTED MANUSCRIPT
Page 3

“In the present case we assume a white and black already produced and fixed; and the
question is, how colour can be excited in them?” — Johann Goethe 5p206¶501

“The scientific Goethe was a disturbing figure from the outset because his strangely
capricious mind flittered like a butterfly over the diverse mysteries of nature that he endlessly
explored over and over again.” ─ Michel Meulders 14p107

PT
RI
SC
1. Introduction

In 1850, Hermann von Helmholtz (1821 – 1894) turned his attention to the study of

U
color. He would initially encounter difficulty in confirming the trichromatic hypothesis proposed
AN
by Thomas Young. In the spring of 1853, Helmholtz delivered a lecture before the German

Society of Königsberg “On Goethe’s Scientific Researches,” in which he assessed the venerated
M

poet’s explanation of color as “absolutely irrational” and the sum of this work an “egregious
D

failure.” 25p20-1 These were harsh words given the exalted position Johann Wolfgang Goethe
TE

(1749 – 1832) held in German-speaking society. It was, however, a rebuke tempered by

Helmholtz’s admission that Goethe was a talented writer and had contributed knowledge to
EP

the field of descriptive biology. Yet it seemed curious why Helmholtz would draw a dead poet
C

into a controversy over the nature of color given his own uncertainties on the subject. Did
AC

Helmholtz have another goal in mind? When viewed in context of traditional descriptive

biology, the lecture can be seen as an announcement that a “new” physiology has arrived: a

science built on the foundations of physics and chemistry.

2. Johann Wolfgang von Goethe


ACCEPTED MANUSCRIPT
Page 4

Much of Goethe’s reputation as a natural philosopher, which he took seriously, rested

on a two-volume work published in 1810, Theory of Color (Zur Farbenlehre). 5,6,A Portions of

Goethe’s treatise on color became infamous for its attack on Isaac Newton (1643 – 1727). In

PT
retrospect, the diatribe raised the profile of the book more that its scholarly contents did.
2p8,3,7,20

RI
Goethe had been interested in light and color for most of his adult life (Fig. 1). In school

SC
he learned the principles of Newtonian physics. 1,7,26 In the 1790s he published several essays

on the subject, including “Contributions to Optics and On Colored Shadows”.6 These works

U
were largely ignored by the academic community, but Goethe persisted in his investigations.
AN
He grew to resent the influence Newton had on natural philosophy and rejected Newton’s
M

attempt to reduce color to mathematics and mechanics. Goethe saw the act of splitting

sunlight into a spectrum of colors as a desecration of nature, which he expressed in a polemical


D

epigram by comparing it to dividing God into three. 26p260 Goethe’s enmity towards the long-
TE

deceased Newton intensified as he finalized Theory of Color. He was so offended by Newton’s


EP

mathematical treatment of light that he insinuated his research may have been fraudulent and

the product of an unstable mind. 26p262


C

When completed, Theory of Color was over 1,000 pages and consisted of three parts:
AC

didactic, polemical and historical.5,6,A,B The book included 16 color plates, some of which

became icons of future aesthetic movements. His major notion about color was that it was a

mixture of the polarities of lightness and darkness (Fig 2). In describing how polarities create

color, light and dark must interact at some distance from the eye. Then from that point of
ACCEPTED MANUSCRIPT
Page 5

interaction light travels across a turbid medium to reach the eye (Fig 3). (He considered the

prism a turbid medium.) The interaction of polarities with an infinite number of turbidities

creates an infinite number of colors. The didactic session was filled with demonstrations

PT
described as experiments whose outcomes reflected Goethe’s understanding of nature. He

proposed a color wheel and arranged colors in their “natural order,” including the idea of

RI
complementary colors. Goethe went on at length about the innate or temperamental

SC
overtones of color: red was beautiful, orange was noble, etc. Definitions were evasive or

circular. Color, for example, “is the law-like nature with respect to the senses of the eye.”22p173

U
No theory in the formal sense of the word was ever offered; rather his intuitive sense of color
AN
was the ultimate contribution.2,7,8,20 The impact of the book in the decades following its

publication is hard to measure, but the work carried the prestige of Goethe.
M

3. Brief History of Light and Color


D
TE

Since the time of antiquity when Greek painters argued over the minimum number of

primary colors needed to generate all colors, the subject of color has spawned controversy. Its
EP

relationship with light was equally baffling. By 1810, some prominent natural philosophers had

rejected the corpuscular theory of light proposed by Newton, favoring instead the undulatory
C

or wave theory as advocated by such luminaries as Robert Hooke, Christian Huygens, and
AC

Leonhard Euler. The influence that Newton exerted over the scientific community during the

18th and early 19th centuries, however, cannot be overstated.16,19 The Principia and Opticks

inspired confidence in inductive reasoning and mathematical verification. They also placed a

premium on careful experimentation. No single set of experiments embodied this


ACCEPTED MANUSCRIPT
Page 6

transformative period of natural philosophy better than Newton’s investigation of light with

prisms. After showing that sunlight could be broken down into a color spectrum then

reconstituted with a second prism to white light, he then studied the colored rings that formed

PT
between infinitesimally thinly separated layers of transparent glass. Newton discovered that

the pattern of colored rings was mathematically predictable. These two experiments generated

RI
a range of interpretations. A century would pass before fresh ideas advanced the conversation.

SC
In opening years of the 19th century, Thomas Young (1773 – 1829) presented persuasive

evidence that light was a wave and individual components of that wave could form the color

U
rings described by Newton.18,E,F He gleaned these insights first from a water ripple tank
AN
experiment where the constructive and destructive pattern of intersecting waves could be seen
M

analogous to light waves forming interference patterns. He then took the analogy further by

proposing that different wavelengths within white light could explain the color rings observed
D

between closely approximated layers of glass through the processes of refraction and
TE

reflection. Although analogy and geometric models were far from proof of the wave nature of
EP

light, Young went on to investigate color diffraction patterns created from a thin beam of

sunlight intersecting a thin strip of cardboard to test his hypothesis. Based on these
C

experimental measurements, he was able to calculate the wavelengths of distinct colors of


AC

light. Light and color was becoming increasingly comprehensible in terms of Newtonian physics,

but natural philosophers less comfortable with math remained skeptical of Young’s handiwork.

But Thomas Young had more to say about color. In 1801, he argued before the Royal

Society that the perception of color was mediated by retinal fibers sensitive to just three colors
ACCEPTED MANUSCRIPT
Page 7

of light.18,F All colors of the spectrum could be perceptive through the relative mixing of just

red, yellow, and blue. Although he would later change the selection of primaries to red, green,

and blue, Young rejected the corpuscular theory since it called for a prohibitively large number

PT
of different retinal receptors. If biological systems were designed for physiologic efficiency,

then the absorption of vibrating light waves was a model of parsimony. Young’s theory also

RI
highlighted the critical difference in the nature of light and the constitution of man: color is a

SC
sensory perception. When published the next year, Young’s synthesis of ideas was a creative

masterpiece, explained in brevity,18 but the trichromatic theory still stymied natural

U
philosophers because they did not fully comprehend the intricacies of color mixing. 16
AN
For nearly 50 years, various experiments with color mixing using color wheels, prisms
M

and lenses, and blended pigments were prone to misinterpretation. At the heart of this

problem was a failure to understand the difference in adding color lights and color pigments.
D
TE

4. Hermann von Helmholtz

By 1853, Helmholtz had been the Extraordinary Professor of Physiology at University of


EP

Königsberg for four years. Educated as a physician, he was a self-taught physicist in the modern

sense of the word. 4,12 Since his youth, Helmholtz had been interested in the interactions of
C

physical phenomenon and framing those relationships in terms of mathematics. He graduated


AC

from the premier medical school in Prussia in 1842 (Friedrich-Wilhelm-Institute, Berlin), and

trained under the leading physiologist in Europe, Johannes Müller (1801 – 1858). While in

Berlin, Helmholtz worked with a group of young physicians who challenged the widely held

belief that the processes of living systems could not be explained by the same laws that govern
ACCEPTED MANUSCRIPT
Page 8

the inorganic universe. 15 This notion was embodied in the term vitalism that viewed chemical

and physical laws incapable of understanding life.11 Although Müller was a passionate

experimenter and skilled anatomist, he never renounced vitalism. Helmholtz, his prize student,

PT
was among its most ardent dissenters. In 1847, Helmholtz initiated a major assault on vitalism

when he introduced the concept of conservation of force (a forerunner of the theory of

RI
conservation of energy). 14

SC
After accepting a teaching position at the University of Königsberg, he studied nerve

impulses, and soon determined the speed of nerve transmission between 24 and 29 meters per

U
second. The implications of this research were far reaching because it meant that electrical or
AN
chemical activities were involved with nerve transmission, and thus the process was governed
M

by natural laws. His colleagues in Berlin saw the research as a lethal blow to vitalism.
D

Barely a decade out of medical school, Helmholtz was on a trajectory to become the
TE

preeminent physiologist (if not scientist) of his generation. In 1850, he became intrigued by

Young’s three-color hypothesis of color perception and then initiated a series of experiments to
EP

test it. In his first paper on color mixing, Helmholtz made a clear distinction between colored

lights (additive mixing) and colored pigments (subtractive mixing). Since pigments absorb light,
C

when mixed they reflect less incident light. On the other hand, when colored lights of different
AC

frequencies are combined, they alter perceived color by other mechanisms, referred to as

additive. When Helmholtz completed his first mixing experiments, he concluded five primary

colors existed, not three. He thus initially disagreed with Young’s model. At roughly this time,

Helmholtz decided that Goethe would be the centerpiece of the German Society lecture.
ACCEPTED MANUSCRIPT
Page 9

5. The Lecture

The 1853 lecture focused its criticism on the celebrated poet’s idea of color. Helmholtz

complimented Goethe on his literary skills. He praised the work he had done describing a faint

PT
suture in the upper jaw, perhaps the vestigial remnant of an intermaxillary bone, and his

contributions to the doctrine of plant metamorphosis,25 but these tributes were overshadowed

RI
by faulting Goethe for his ignorance of available knowledge of light and color. He recounted

SC
how Goethe was dumbfounded when he first tried to visualize the colored spectrum by looking

through a borrowed glass prism and saw nothing but a white wall. A tutorial on basic optics

U
was kept short, as Helmholtz moved to the crux of his criticism. Goethe’s theory of color was
AN
not a theory at all because it presented no hypothesis to test. The poet held that “observed
M

facts shall be so arranged that one explains the other, and that thus we may attain an insight in

their connection without ever having to trust to anything but our senses.” 25p15 Color for
D

Goethe was understood instinctively; it was a perception, not a quality or quantity of light.
TE

Helmholtz argues that a legitimate theory must withstand scrutiny and rigorous testing, which
EP

in turn leads to confirmation or rejection.

This defining feature of science, falsifiability, would be expressed by Karl Popper a


C

century later.17 Popper would have called Goethe’s theory of color pseudoscience because it
AC

could never be refuted by empirical means. In other words, Goethe’s theory was supported by

any ad hoc explanation the poet deemed appropriate.

6. Why Goethe?
ACCEPTED MANUSCRIPT
Page 10

We don’t know why Helmholtz chose to use The Theory of Color as a counter point to

the role that Newtonian physics should play in biologic research, but there are several

possibilities. Goethe’s treatise is filled with misleading comments about physics, the acquisition

PT
of knowledge, and the study of human perception. Maybe Helmholtz just wanted to set the

record straight. In discussing the role of mathematics, for example, Goethe writes:

RI
The theory of colours, in particular, has suffered much, and its progress has been incalculably

SC
retarded by having been mixed up with optics generally, a science which cannot dispense with
mathematics; whereas the theory of colours, in strictness, may be investigated quite
independently of optics. 5¶725

U
Such thinking likely made Helmholtz bristle. But was there more than just correcting intellectual
AN
misguidance?

At the time he received the invitation for the German Society lecture, Helmholtz was
M

engaged in color research. It is possible that this experience showed him how many prominent
D

natural philosophers were misinformed by Goethe’s theory of color. 20 Helmholtz’s mentor,


TE

Johannes Müller, for instance, had praised Goethe’s work writing: “I, for one, have no

reservation in acknowledging how grateful I am to the inspiration of Goethe’s Color


EP

Theory.”5preface Favorable opinions were also offered by such notables as Hegel, Schelling and

Steffens.5preface Could Helmholtz have feared that aesthetic opinion might someday trump the
C

scientific method? Was there concern that theories might become invulnerable to evidentiary
AC

challenge, particularly in a boundary discipline of physiology and psychophysics?.

7. The Next Seven Years

In 1855, James Clerk Maxwell made his mark on color theory with a study that required

subjects to match mixtures of three colored lights with shades of gray.10,13,21 He was able to
ACCEPTED MANUSCRIPT
Page 11

quantify ratios of colors to match other colors, eventually concluding that three colors could be

used to create any other. It reinforced the idea that the human eye needed just three colored

rays to perceive color from whatever assortment of undulations might exist within white light.

PT
Helmholtz continued his investigations into color mixing after the Goethe lecture. He

RI
learned of Maxwell’s work and referenced it in his 1860 edition of Handbook of Physiologic

Optics. 24 His color mixing experiments became more technically sophisticated and eventually

SC
confirmed the findings of Young and Maxwell. Helmholtz added another insight to Young’s

theory, however. After plotting the absorption curves of red, green, and blue, he opined that

U
each of three retinal receptors receive input proportional to their spectral absorption
AN
sensitivities.23 It is this sensory amalgamation that determines perceived color.
M

8. Epilogue
D

The study of light and color embodies an aphorism attributed to Carl Sagan that
TE

“science is never finished.” C In 1905, when the scientific community was ready to fully

embrace the wave theory, Albert Einstein (1876 – 1954) interpreted the results of his
EP

photoelectric experiment as demonstrating that light can also behave as a particle. Fifty years

later, with the development of exquisitely precise spectrophotometers and electrophysiologic


C

recording techniques, researchers identify three mutually exclusive classes of cones with
AC

spectral sensitivities as predicted by Young.

Goethe’s reputation as a natural philosopher never recovered as biology was

progressively embraced in the same physical laws that govern the rest of the universe., but in

the late 19th and early 20th century, the moral and symbolic value that Goethe placed on colors
ACCEPTED MANUSCRIPT
Page 12

gained popularity among painters and other artisans. Artists were drawn to his opinions about

complementary and harmonious colors, and they likely influenced such notable painters as

Mondrian and Kandinsky.14p124 In the realms of philosophy and cognitive science debate

PT
continues about the nature of "qualia," or the individual instances of subjective, conscious

experience. D Even today, there are those who sympathize with the notion that one's subjective

RI
experiences cannot be reduced to electromagnetic waves or to particles in motion. As with

SC
Goethe’s “sense of color,” the notion of ‘qualia’ does not lend itself to empirical testing.

The controversy surrounding Helmholtz’s 1853 lecture has faded with time but is still

U
remembered as a call to arms during the nascent era of biology when a minority of educated
AN
elite saw science as establishing causal associations through hypothesis-driven
M

experimentation. 8,12 Ironically, 40 years after the German Society lecture, Helmholtz was

invited to speak to the general assembly of the Goethe Society in Weimer. The title of the talk
D

was “Goethe’s Presentiments about Future Ideas in Natural Science.” 14p203 The 71-year-old
TE

Helmholtz spoke deferentially about the poet, emphasizing how both he and Goethe shared the
EP

same desire to understand nature (Fig. 4). Although their methods may have differed, both

artist and scientist ultimately strive to achieve the same goal. 9


C

9. Method of literature search


AC

After reading Helmholtz’s lecture on Goethe’s Scientific Researches23, the subjects of

Goethe, his theory about color, and the German Society of Königsberg were initially

investigated through PubMed, Google, and Google Scholar. Goethe’s Theory of Colours was

read in translation both in hard copy and online versions. 5,A,B Various combinations of search
ACCEPTED MANUSCRIPT
Page 13

terms (Goethe, Helmholtz, color, theory of color, color perception, trichromatic theory, color

mixing, theory of light and the Goethe Society) were employed to find additional relevant

material. The book holdings on Johann von Goethe and Hermann von Helmholtz at the main

PT
and medical school libraries of University of South Florida were manually studied for related

material.

RI
10. Disclosures

SC
There are no conflicts of interest to declare.

U
AN
M
D
TE
C EP
AC
ACCEPTED MANUSCRIPT
Page 14

REFERENCES

1_Boerner P. Goethe, London, Haus Publishing, 2004. (translated by Nancy Boerner.)

2. Burwick F, The Damnation of Newton: Goethe’s Color Theory and Romantic Perception.

PT
Berlin, Walter de Gruyter, 1986.

RI
3. The Cambridge Companion to Goethe, Sharpe L (ed), Cambridge, Cambridge University Press,

SC
2002.

4. Cahan D. Helmholtz. A Life in Science. University of Chicago Press, Chicago, Il., 2018.

U
AN
5. Goethe JW. Goethe’s Theory of Colours (Illustrated Edition), Fairford, England, Echo Library,

2016. (Translated by Charles Eastlake.)


M

6. Goethe JW. Goethe’s Collected Works, vol X11. Scientific Studies. Miller D (ed). Princeton,
D

Princeton University Press, 1995. (Translated by Douglas Miller)


TE

7. Gray DD. Goethe the Alchemist. Cambridge, Cambridge University Press, 1952.

8. Hallet D. On the subject of Goethe: Hermann von Helmholtz on Goethe and scientific
EP

objectivity. J Hist Phil Sci 2009;3(1):178-94.


C

9. Hatfield G. Helmholtz and classicism: the science of aesthetics and aesthetics of science. In,
AC

Cahan D (ed), Hermann von Helmholtz and the Foundations of Nineteenth-century Science.

Berkeley, University of California Press, 1993.

10. Heesen R. The Young-(Helmholtz)-Maxwell theory of color vision. XXX015


ACCEPTED MANUSCRIPT
Page 15

11. Hunter GK. Vital Forces. The Discovery of the Molecular Basis of Life. San Diego, Academic

Press, 2000.

12. Kresselring J. Helmholtz and Goethe – controversies at the birth of modern neuroscience.

PT
Eur Neurol 2013;9:152-7.

RI
13. Longair MSL. Maxwell and the science of colour. Phil Trans R Soc A 2008;366:1685-96.

SC
14. Meulders M. Helmholtz. From Enlightenment to Neuroscience. Cambridge, MIT Press, 2010.

(Translated by Laurence Garey)

U
15. Otis L. Muller’s Lab. Oxford, Oxford University Press, 2007.
AN
16. Park D. The Fire within the Eye. A Historical Essay on the Nature and Meaning of Light.
M

Princeton, Princeton University Press, 1997.


D

17. Popper K. Conjectures and Refutations, Routledge, 1963


TE

18. Robinson A. The Last Man Who Knew Everything. New York, Pi Press, 2006.
EP

19. Ronchi V. The Nature of Light. An Historical Survey. Cambridge, MA, Harvard University

Press, 1980. (Translated by V Barocas.)


C

2018. Stepper DL, Goethe Contra Newton. Polemics and the Project for A New Science of Color.
AC

Cambridge, Cambridge University Press, 1988.

21. Sherman PD. Colour Vision in the Nineteenth Century. The Young-Helmholtz-Maxwell

Theory. Bristol, Adam Hilger, 1981.


ACCEPTED MANUSCRIPT
Page 16

220. Steuer D. In defense of experience: Goethe’s natural investigations and scientific culture.

In, The Cambridge Companion of Goethe, Sharpe L (ed), Cambridge, Cambridge University

Press, 2002.

PT
23. von Helmholtz H. Handbuch der Physiologischen Optik, New York, Dover Publications,

RI
(translated by James Southhall), 1962.

24. von Helmholtz H. Handbuch der Physiologischen Optik, 1860, Leipzig, Leopold Voss 1860

SC
(Translated by James Southhall).

U
25. von Helmholtz H. On Goethe’s scientific research. In, Popular Scientific Lectures by Hermann
AN
von Helmholtz, New York, Dover Books, 1962. (Translated by H W Eve.)
M

26. Williams JR. The Life of Goethe. A Critical Biography. Malden, MA, Blackwell Publishers,

1998.
D

OTHER CITED MATERIALS


TE

A. Goethe JW. Theory of Colour. http://sydney.edu.au/intellectual-


EP

history/documents/Goethe_Theory_of_Colours.pdf Last accessed 5/31/18.


C

B. Goethe JW. Theory of Colour. http://www.gutenberg.org/5/0/5/7/50572/. Last accessed


AC

6/8/18.

C. Carl Segan. http://saganist.blogspot.com/2008/09/science-is-never-finished.html. Accessed

5/1/18.
ACCEPTED MANUSCRIPT
Page 17

D. Qualia. Stanford Encyclopedia of Philosophy. https://plato.stanford.edu/entries/qualia/.

Accessed 6/6/18.

E. Young T. Experiments and calculation relative to physical optics Philosophical Transaction of

PT
the Royal Society, 1804.

RI
https://books.google.com/books?id=7AZGAAAAMAAJ&pg=PA1#v=onepage&q&f=false.

Accessed 5/14/18.

SC
F. Young T. The Bakerian lecture: on the theory of light and colours.

U
https://www.jstor.org/stable/107113?seq=1#page_scan_tab_contents. Accessed 4/2/18.
AN
M

Acknowledgement: Don B. Smith, MD critically reviewed the paper and provided valuable

insights into the intersection of philosophy and cognitive science.


D
TE

Legends
EP

Fig. 1- Johann Wolfgang Goethe roughly age 40. Print by Christian Friedrich Traugott Uhlemann.

Courtesy British Library.


C
AC

Fig. 2 – Plate 1 in The Theory of Color. This engraving was used to illustrate how light and dark

are the basis of all color. Its interpretative correspondence with the text is loose. Public

domain, Gutenberg Library.


ACCEPTED MANUSCRIPT
Page 18

Fig. 3 – Plate 4 in The Theory of Color. When Goethe looked through a glass prism at a white

wall for the first time and saw a white wall and knew immediately that Newton’s theory was

wrong. He intuitively understood that colors arise from the mixing of light and dark as its

PT
travels through turbid media such as a prism. Public domain, Gutenberg Library.

RI
Fig. 4 – Herman von Helmholtz about a year after the Goethe Society lecture. Courtesy of

British Library.

U SC
AN
M
D
TE
C EP
AC
ACCEPTED MANUSCRIPT

PT
RI
U SC
AN
M
D
TE
EP
C
AC
ACCEPTED MANUSCRIPT

PT
RI
U SC
AN
M
D
TE
EP
C
AC
ACCEPTED MANUSCRIPT

PT
RI
U SC
AN
M
D
TE
EP
C
AC
ACCEPTED MANUSCRIPT

PT
RI
U SC
AN
M
D
TE
EP
C
AC

You might also like