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Synaptic Cleft
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Receptor Molecules and Neurotransmitters
• Neurotransmitter only "fits" in one receptor.
• Not all cells have receptors.
• Neurotransmitters are excitatory in some cells and inhibitory in
others.
• Some neurotransmitters (norepinephrine) attach to the
presynaptic terminal as well as postsynaptic and then inhibit the
release of more neurotransmitter.
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Neurotransmitters found in the nervous system
EXCITATORY
Acetylcholine
Aspartate
Dopamine
Histamine
Norepinephrine
Epinephrine
Glutamate
Serotonin
INHIBITORY
GABA
Glycine
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Neurotransmitters
• Chemicals used for neuronal communication
with the body and the brain
• 50 different neurotransmitters have been
identified
• Classified chemically and functionally
• Chemically:
• ACh, Biogenic amines, Peptides
• Functionally:
• Excitatory or inhibitory
• Direct/Ionotropic (open ion channels) or
Indirect/metabotropic (activate G-proteins) that create a
metabolic change in cell
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Chemical Neurotransmitters
• Acetylcholine (ACh)
• Biogenic amines
• Amino acids
• Peptides
• Novel messengers: ATP and dissolved gases NO and CO