TRATAT DE FARMACOLOGIE EDITIAT Sub redactia: Prof. Dr. AURELIA NICOLETA CRISTEA Mente Acie de tne Medel Mates Annan de arms a Fran EDITURAMEDICALA ‘BUCURESTI 2006,sig wawut ain (opr ADRIAN CONSTANTINESCU CS AUTORI (Erectul de obignuingd si Efectal rebound) Prof. dr, Aurela Nicolets Crises ofl dr, Simona Nesey ‘Concepfn: Prof Dr. Aurelia Nolet Cristea Ase univ, Citi Daniela Marne ‘Graf: Farm. Dare Joean ‘Asis uni. una Laur Turcale ‘Asis univ. Corel Chics (Conk. act Alexandey Bring ‘UME os Be Bes Fi ee a Fame Conf. Florin Dan Popes UML al Davia Bares Pat e Mes, Cae eas ‘Alsace Prof. de. Mires Paveesce Prof Anan Hrscu ‘UME... Popa Fite ema, Go msg Fmt Pro. de Maria Tite Dogars ‘Sef ure de Cail EV “Tatat de farmacoogie ob rea prof, de. Aurelia Nesleta ‘UME. Tage ese eae, Ce emis (Cesta ~ Bocuret: Eitan Medien, 2006 [SBN (10) 973-39-0590-; ISBN (13) 978973-39.0890-5 Sefer de, Cision Mogogan UME be aig” Cs ges, ele Fmaci, Cee em 1. urea Niele Cres (oondonte) Pro dr. Foie Popes LUNE. Cr ais ara Cr ee 615.01 035) a) =e Cont. Caren Cfsesea SS ‘UNE. Tn Fade Ppt a de Poole Fama it Pf dr. Gbeorghe Tangs ae Ic \ aersiste Ovi” Cons, Fai de Seapets, Cn | FempePREFATA dew cre eer dein dame Fors Farmactap co pte et inte nostro formar nani Cr ee tine” prcun yin pasieriter i perecnre Se bel fd tree ri Se dr er eg de rine, coi te devo apaina oe et ae bate fomacotp et 3! He apa ar nt ie corte cx ane ai den. dpe neni dona, frmcdaame yf amacooresbgi) cpt de fee Cer chic ce bovanjorm redone pram ets ee Scr fms achat gece Apel open ra ic macopate orescence concern ite pe hs mesos rier heel optional a eS fe care medsamontr, Peters fl 0 ‘Jace hp ove ene sed pares Seema eins Be mL techie le usanier mecomesaze rt pres fer, gpa coon it nce in neering ar dre ce 3 ee, Canes ee lncel comer cpr mu i Tier at care pr complere a “sce oe pric graf selene sec 62 igre ral fr Se ae ere ccs mesonen, ox dour chine meron irene ‘ean anna ected man ie dee poe» ams nalic-conpaat, dnl pe noes Ge treo reals ope ce mca. Pe eth fomacoe TERETE esc enc sf cma re fraps preted. De ERSTE crm copra a fb foresee mesa SEDT SG Apacer" peng pete ed Freee cnn fart mnmes nx spa seeps Win ec nal somes de nl fH utemaaes sere: Je conic ered arta 900 de mean ea eematare devine dn ine onde cant. spe iit erie cen dra me @ Sade omer nme ties ale made fc dr dereeter cme de cit sce eich. pan rate s,s, ‘Copeni eT sia! ocr are 9 and Ys) cial ale 4 Scone pa pe arcane ey. rae fae coro dire sole foncte ee ond age 0 ed neem pind i ‘Sivan madsen tate ct denn come afin OCD 0 [raindorfrmaceice dennis eurce fone comerte ga asta cer omc alinetce ‘ete pet informants i dome gr biog, eo stot ingly wd Sons rem de hy com eat a Soma Joma me matron mi! pene fds Sona wa st ‘po oa ger re Deb om sat pr ler dn a oe de Fermacage ih nek are tars lr armbar ne propane sh exile ‘icin Se or mate coe dc tee Miele cede rned de Feral ni i el man fs oe, ced ert ke Frat relate abel peti ew cy Joti cate aches in opp oan Comte Unoersare n Rmn far hl. Te Moe, Dagar Cora Couronne sabes Imes tcp al one pin pres pone porter ogra de Vomit a mix ma pp ert conan, ‘hc elt lt pin, re atc pomenent 0 ee A shee acer ele mae clio en ers asad ee cnr dene "Bee crt ecard De ce, rin marines, sealant oes prin edie Pr Dr A ta Cee CUPRINS “amauame capac et ae —— Slee suaceereussaeee sereceees,4SEN835 B2EERESEETSS LOQSRRSSERGER: eeedueegesenaayee: egugueeasSiete Sibystaaccinavica nce ideahepaara thea cain nant eee oo v-uMOTERATA STNEORLAIK eo LT ot A Bt). ‘Shoes mnt : = Oia em - teeChie) Coe hte a == St ae ————— ———— geEseegegegevenssons IMOTICESLCHIMIOTERAMCE ATTCROMINE of ree ‘oerannge ——— = GdaggevesagaegesssissaseePRESCURTARI a nT Conant {5 Mesewraryoeetmendecoand apse ——— pu armor nTanesTAEMERCRTON Ori n= ‘eae ea I 1 eo 5 i Serato ‘Sesame sd mt ein) OOgaPaPesabageS? REGERE*AEEE sexs - cases wroiowdrerinn b FENCE Mg hs ttn Sareea tr £5, es ot A a at aeasean gg Hddat eee?TEETTB LEERY sent grrenrggss BBE vo mngereage aE t Sa ecmees = ERSSSES SES arty g BF eee pybpeerarsa ¥ i i nagpertscge i» mci 1, FARMACOLOGIA SNC Sectiunea 4. BAZE FIZIO-PATOLOGICE $I FARMACODINAMICE 1.1. BAZE FIZIO-PATOLOGICE DDOMENILE COLINERGIC,ADRENERCIC, DOPAMINERGIC, SEROTONINERGIC. ‘oat taGIe, cLUTANATEROIC, OPODERETC Vac tocsin upc rendre # anouDlopafed AN, Ce, 198.26). ei 4.2.BAZE FARMACODINAMICE = sat CLASIFICAREA MEDICAMENTELOR CU ACTIUNE LA NIVELUL SNC Tine san od copa coun ite SHE colonies pcieate yates armas Repeat 2 tr setee pel tptie ee ‘Seaman Re Cr ae pihepearaesmerene evi ‘ee roe pi, wm oii oh ine CARHOTRO cere fan moran cae anicvckn,mpatisnen, wea nce esingon eta co ee el ‘Secs ks fa om mae rin Sess an sem ea ei) ‘Ceocaren pity pei reine eles male ses ‘ues ptaamimcce cae 15D) ‘iaiepce bom mbt (le se xine por)een ate nt slo pee a my Colinergiele cesta baal Alzheimer aac (sitosimainte conse arenes ipenteanay, Pa a yarn ovine serene eri ae rete SEE het ean oi es + DowEtut borane cnommare PEM, a Steer SS a en Fe ee epee Se Ane het seat CADRE + omextuccuutstat eee me Pe Antagonista recep lcine (excate medulare, tip tring) * ee ane — iced mason » 2. ANESTEZICE GENERALE 2.1. BAZE FARMACOLOGICE 2.44. Deftnitio Ante: ining n= =e 7 “ina dace popmand a cpremror SAG, arer ved ope ‘apo snr ece ste oi thea rasa, (tines apend + wnarer fet ale SNC", non etn vole eed tempore sea hd er nes leaden ese urs Sr il aba (wr rn) ee prope rept "Pope ual noes peal ele Sn nite tir rope chin tae mein: nore een ‘hen nel a wedcamenle oct a ic ase {SS petemen ig ‘ene mt hte ee as acd aan a ase, ‘arate demons acl), 24.2. Clasiiere fs fn ck de ndnintrare propre aici tratr chine Naor ra rn Sopp eb SE anton een SE angen mo Scere eee sta Te Ee Tsar sfieieg bene eon a a arch era rea wees eames fees eee Sooo erate cnet arnPy Fema 2.1.8 Farmacodinamie 21.3.1. Mecanism do acisne eS SN per se i pr eel ei ‘nace ele senor ope cree degree» acee (Angel Ax 153) ‘esse emi chon ania sae erst cl Free rmbt es teers pr ree com, ee Ct Seep, ie ‘canbe ee ers "Soper muta mena €F pin hres dhe clr cy, ‘cia 2 acne sammie sitowe GABA. pi tae wr ‘Geto penpals GABA er trina mene ‘Take snstir gem (ona pel pace fee {ethan ery ‘ews pment de NUCH ats nh ass ‘can faite, een prt ROA ae el ieee hn membre ri foe eircom eo ‘ctcen acs anne ce gicsrge, pn sma espe init lex oneseseeesir (ane ©. S's es 19) fame ‘esesee pnd mewn (Bs cal 19, Maal ME a 6 Scere coir See sents nl in eee eX de tp STMAY, ip TASL floam efrn). TASK? Caan ity can, eter, tem) TASK Stn TREK (tem, Isamu TREK? (loro haiti, fan) (Aland SPH sa oon Cine ep MAP bp TSK, so com ie emcee: ‘Ct dep DF i TREK Cai an ei cho a ae par ch ‘ong oa a eh ep rc cri pie ie pe ‘ety sag cl 199 “ oe te et ti eet pipe le Tear pace i Feats pc blot fap tamale geese pot introns mu mic lipdie mere doweniebarfoe se ocnce orn St ststlcami nce nombre mda epee Mp Ls W980. ‘SE's mrporor scat pcr pty ase ean reco inverse mn pr GABA Ee Se ek ML Ein amass 2.13.2, Fazele anestezei generale (nareozel Pena de ence Pes de mage ‘hie aor coal de area elo 2a some, tl ‘tens din momen nse pn I pri eine 12 bendeectae ounce! cnr coil felted ib cot» cero ‘Pia cen mirc, tri atcmate shinee le hb ocla ‘vena HTA rapes pines, Sten monrl pere csi pe sre rope rete ‘tere lene pt Sea piel en ome ce pte 1 rei ge oars fetus cope en scoala xing spre ave siti (Sit ie solce clr tba pines tate ‘mses pres (Sow oases tl “Goins uur etl (omen, oa iinare sar (fen eon Foose ey mie wo TAM nen ‘cnr eet rai, oe Test rises ona es spar ade, 113 Fen deola grat "pare rogein sea cs, cere il rept "econ a ie apna en tc emi val ult (ep # vam) ‘She reel able pos prep midiadimens; pike puh ee 9 ‘tes! np na cess moe ae open espe Anepre pee 3 mines momen Iocan esis tne le imeweni de en reine mit. Fst irc du ta de econ, ie ue ft ‘el pe tp ee tr {Snes dren greatest terpods dp aac aii el dor epee cee ee tls ema eames SNE ena) ae “ed vie dene de rs wn paneer, ae op ga, ces mee ae ie a ce i i 2.14, Farmacoterapie mts a a ctcmuey 4 cme teo re corer ee Sera erees eager ipa ee Ses soe See rine Eerie CLT et tte ree Gaieare center Sopp atta ta Sonat oe SAE me ne Cmamtee er t sete r ora heeree rie eel ee ae ee ae eueptic eoirn (lorpomasing et. aE ee pe pt pte Sica eee ee Fimmaeeeaent bre norma pari ei ein mule inn cr enc de bone (Gooey soe ee en ew : tngenscoane Cepeda isle. Prawn a th no a ein 2.1. Farmacotoxicologe ¢farmacoepidemiotogle "Brett dkny morte n prea sees pena, Sao SE cmneyn Sareea eS en re eeierenmmenesn regs SEES cen tat etter te Se epinge. permis SERRE El cae nto oer ma oo rot tlie vie SAC atin, 2m. ‘romney cect bee ate de ae [SIC imeem yen encore eu anesrle arte sg reren fake eae ces pape on at rn) in higenea reps feng ca 23 sips’ nie, AMEE ate mh oa he set necro ie en Sng oe eau rin (a mai cae me ia 1 Teron eA faite de ca chal webu aa a ade ef Shen eA emg, pom By cols ce potent ‘arte bigness sree domed comm, 2.4.6 Interafiuni Sten Torte eeu ermine SNC pause SNC “iene gente sel pe opr SNC noi pean seal gma cu snout NTA ech ‘See cane arama) pee whl com ‘unr ur ance pelo sce macs gree (coop, i) 2 min ADR) ote eco ‘isa fie eral ay mete ele io AB ace 9c ea cil es st Transeo)2.2, ANESTEZICE GENERALE INHALATORII 2.2.1. Bazofermacologice Sper pneu cide wll, Une un epee clap, ae ie) dna wml icone fers, sea sta ‘nal perio ite fica pn aes becenstel oxo crue ap {eee ia enue ve ert ata eae cama a pe fro en vit tA Sta exten pe csr et Epes ip coi bare cps eo ‘a ra dag vee on nes ps 2.21.1. Fermacocinetca Cs de sine oe cn lie Abr lee act lt cpr tna fe manish Daa irene i opt npr mc eit ers rc ih Femelle iunal 231) "Baranfoearea con Su i cmb ue het ope ean cot fos cnet poe metre Tete res. po teatnnsts oda: lam sar israel od ‘Suns al ter erence frat nas Se go ‘Fon ul an nee eshte ue pe crm rotenone mature ies ol ce ie 9 nine) reson part nonce la ee pit spite tena ssn soe ei le, er ig nd gs ps eb ar contin organ sigs pesuns pas asesecvl amend ala de pore sing “gee gra int oneal ge nce snesoed uty. es de wie pnd det ce es Set ine Aca cece oe Jeet at encase ears renin dit wes seldom ep uct on ere pen nga rere pen n> fr>en > hc creeps site ce 20 mar) ase GeO pees ar ‘rectal de uss fal cepa its retaea Goes ape Poy mel deans cmpat cama eee ola su ge ‘Caste de pore l= ae xg slates west pe 9 lenennt men data cpu ts jena dene Pome » Cc eo pri sng at, rt poi ies, pees Pi sels ra ee in pt emai gre De ota “==Teunl poste para dn ace math ca von pi a ane shatbores nf ie ce ep ve emi eae etn gs aera Gc ie scorn pir ofc te pri se coy roe ult at tesa Ae ae ‘Stee aa ity se amar i tl ips roe 0 ‘mmarated nl oth en scp dep eer Ha eV in retinas mee see re er | aie aoe oe ee leaeleceieemlee (22.1.2. Farmacodinamie conc sesh iO ce pie extent ‘Sn end ein ceo MAC oe opine rece (eel e oa. ‘me hatte ac MAC 0 cpt ce mst papa x Fa a, “tame pt xo ne onset nt SMMC orate (pea pal aman val) ee concn alia ‘was ct pede opt Sot ape comm veal 35d «E50 rs menor) ot cece shee cae sap cain meme 5 np acs ac teste C0 amar) WAC tenn a ore ige Secaie et ds, ape pda dr er ‘nia ere, Ti incr 22.1.3, Farmacotorcalogia fae tric tl rei pl de ie enn tir He osicrae topo provera e mess poe ae “age crc ce esccte to ea ca ers wt sum dma Sepa mh a Sep aes eal maa ns {Emi ice ours sear soe een (aren bata. yuu hee cused enn st aint ngtaninntie td scepter veer Ge mr cee cl wt nc ane on open et © conc ima simp Ge ese ia IO ean) Degrees aie een ropa) prem ce cee Fy mere nc ceteris "onicaten bepac ee prude hen (ie mt ican (era Inca ee on aor prea cen le ease a at ds grr come mnie eb ges need foe Ge ‘Goda cared ene coca sunt pee Re hepa ‘io sur met esate bane sds ca (rua, ‘aiiaracne eel ie doe oma ncn oe poe gpa 1h cera sinned, rots pon eenh ose pele Schritte i mm num co pin oho Tiperermis mapnd pa 6 ova de ce ates Mingo On, cor ean op feta ns x nl ahs ae [hae rated ice, ford wm rear cue an gem cet ‘recpon! yams. ce cota aml eau c cour bowel ET rie comin eno nd ei om oe roc shee eg {nd rare docu + ue, ctr, amare pron ‘em tes ros sing Are dae me epg Fact ‘ian meee em on msm, sore caren meen ESE Se Bendigo coe stro noon Fama » 22.14, Farmacolerapie, armacograte. a Fearn tee crs saseiuanesget rnoenat, cud fpbel ee rae, ‘Spa rexpsnor great ponoperie) @ mon ran one rec el), ‘eels yoegutn ga oscaeinenb omg se, wae Rp en eo nl erenoge sie mina acl “en pea epepmpscateisiea Denese te ries chm nui pace uel covara DESFLURAN ‘rot aac rf Ui ecient, i ina 9 ei pe compere pram de, ‘eave er race epee 9 brnlspasm,Fama 23, ANESTEZICE GENERALE LV. (osteeleyowl veer iat pny nce aes ce ‘sheer mcf etm meres peare ee aon Puen tt oe aed feu meses sh cen Pmt tome thee ae ce pee mera mica snes seta A aes 22.1 oarturce 7 omserong Sta i ett ee Ee Ez Topenial* | —H ~¢ —onc Oe = ee ecens | ay} may O oo wat | 04] oysor-og| OE a TOPENTAL ‘Se him: data ase aie ie eget a tote Secs Trace mec erase ste aga a 9 Fins dite bcs (titure sea fe SNC, arm de ie gina aim de. ee anit CARA, cv cies cone Sod C9 "te ra scan (ming 4-7 mn) —— Femi % Feige Er men meee ret eee agp ete Sa orc 2.3.2. Benzodiazepine oazo.aM ‘Shims det 2-1 enadincpin cE et, mon tama pee See eels mates aman ome "re cs ane omentieas% Pema 23.3. Alte structur KETANNA Stim: xodntnrea dl fence: dc erie ma re Bl Pee ew i aie, ceo pro Chen par, ‘ip ce crn ste fs ie "Sidhe sce sae cn et dei "ee 2-5 min ee ar $10 in tae in ina deer sera cl x inp, nt 0 esi ev tance peas nee dene "Fnac apn cc. ox i Fee 3. HIPNOTICE $1 SEDATIVE 3. BAZE FIZIOPATOLOGICE $1 FARMACOLOGICE 3.1.1. Baz falopatologioe 3.1.1.1. Somnul ologic Soul pen sede pes ergs ce ane pin co ae seg cad bt veh oer een) °c pe, ml 9 ves couprt rou So abe ce st pt Ue tonne acta el cs ss ace (44), apes prance Pn) Sal eee oie peacoat esl be Sea ‘hire ed Meine ace fos impel sme lg tone seemless a itt Sa pn a i oe relent du alee ee sn xi eee wt ‘Prone oan er emi ” ei i et er ea, enol co omer, pte at, ‘ese excise cera repinioe adp co aur de COs seg # ‘es none een oun vin S (rfeph CI elena ita clipes Ae! iri cnt dese. re feo Ss ea ‘A iogene fabian "> Ca oie rl nea Intec eat 8 ace cv le os mi fe pete TD mp ‘Siena ee de cna git Tansee aeum ses Fees ei ‘cLoRDUZEPOXID ‘Pr emaclpe meta dsp cs nol dai ‘Rouge peat =e pe nt th pn ele ite 15 pn omy wi pa mei cg EAS vom et ce eh ra 3 he er ae a Insc ssi pr ode 2040 my repro 24 pa ye ee ie {bd mpi eves dene ma tn (10 apn cop hy de S10 SPacsieg Booey nantes mek pct i, EDAZEPAM Fronttrmesoe ert Ser bet ei Dlsrvtrmars ds SH pen (S00 i ei a 90 Ae imine rn pl.) comp pe lps sat, rata aceasta foe sae al teal a A vn mnie a rma dc se ‘rfp nae cease perce Ome 23 Prof armen ent dati pone find male hts i ap 1030 ty bso se 36 pn ma Fe teen mS rin Dee ii et mg cxonazerar ‘rt trees sent zee ceumtioen done aco srrats chelsea Uocemase el esdate h ‘Stole tp ahr ph THD. oa a cra oc str eam a mre oseded Se faa coma ane“ Poms Pom Dea ie a ca 1030 mpi ais cts in, pr ol SD pes im pc Do ie ted sige sae dear, ne td 9 ‘btwn de eee, 810 mp Leap (pte 207 a, mame Saas 42.7.2, Benzodiazepine tp oxazepam (him 3 or: mie Sipe ce epee FU Gemeente Sc mes Ps ni TP oxazerant Fela: Noemie dit bs seat ghewamcg int went de ‘sommes eae “ir ar denne mec (12 = 10a) Hef RAs on meer. Insts a sla Wnt Da ec at 30-120 min pri Lonazenaw ro rma Scarpa rc abrupt ma fle. 12 tia ae oe 10 oe ‘amtaha c 90120 iran ie 4273. Benzodiazepine tip alprazolam Sci {2-4 bene Fr rma for om el a tot 9 re sexed me eins ste eo pit comple: Mawar pet rin i shia ria Yea pe ce et mt petal nai aa at de aie ey ne ‘iver des ate ‘ona ft nape, ce wine We, se Phe erat: (nS ire wast al dpi Fema HC « resent tng rato ofeach oman amare aa Beret ain anomemensoceraane ot Samat 4.2.74 Benzodiazepine tip tlsopam ct cin 23 rie Pra tamer Bocaire I neublt faci, TH dt de aie ‘orsoPAM elas sb os pi compl frm hepatic ei mi a Tiare de its mcrae Dele tn ani miei Ecc alts, eon don de 0m dees Fonsi see 43, TRANCHILIZANTE AGONIST 5 HTsx fir chim: idee [penning pron epics. spon ‘Mn de acne ldece apni af rrr 5. presnaytt,e eum lbri fiviawe py oie "ret recede est de menial de mine bee seen ita core ntetaeme fume tae hgh moar jens mln ln dh un eta peo spin tet alsa BuSPRONA Sec ie oe ps ox mc Doni il im i ot ‘Amite il noe erie few fl ae spins) Ms pore neo img Sh weet ose ret ua2abrpl dae bing Maton nt Syne Bosman Slaueba“ Po oe Fis [Sine aes ee erin SNC in ho em pt ie even woe dscns ea f ee Hg E0 oy Foy oem oy Merona a oo Co bina 44, ALTE TRANCHILIZANTE onoxzn ifartontaton ioeeigas eeereere cena aes ‘per pac dd Bmp 1h 1 sl ab Ba 252 mg 13 Fama « MePROSAMAT ain Po: eee gm Rec ten ost norma secre Songs shee pin i me Fe BE att 400120 meade 19 an 0000.4 5, NEUROLEPTICE (ANTIPSIHOTICE) 15.1. BAZE FIZIOPATOLOGIGE $1 FARMACOLOGICE 5,.1. Baze flopatologice 51.1.1, Psnoz dere (hfe pei st et de on ain le cr pte lel oe etn dl “Gnferspetor cor ee Sine, ici ri) cae heme spun eons at use pene a i hone tnpootloe, at ah ah ir esc oem pi a ce ec, esc (uml pa st: ott Witlog ptr rpc izes imp: ‘Spccivhowe mesos purine, special dese lol meso ‘ecient ecole Ds moc co inp ‘truce preci Son Sic ore eves nae! (ue ae ee iS pesce ae inp hpeciin dope 5.1.12, Bazo nowochimice 1 senpengnis por srt laminate Merce dopmiongch cong Retna dpi AFan err panies te ne ester eo fai by ina AC, sn pein Gs eo psa Dy Dik faye A ie gna PD Poms Dm esas (AC), ree oan irc de AM, Pani Dy inhi bestia AC), sade oa arc de AMP, int wn dex dod eo oni ee Se “Snes spa poun Sogumins stmt pn reel Dy (ce, wna tp mele Duran cpr paar! DD, nei De nscren snr De pcg Nema Dima, Spe sit spc, ats plat nel sean besa lt pam: De ‘Shes foe ea cer mr “ot memes spa Ds pomorinseei Seams ences espns “Aap nn eli po ys ‘ss marae) nla nee props st ‘i see senctcmanoy posh hap: LSD tie ai ep) eon “ran eae: Nironedan nne soci (Shiospanin = ST Respen S179 ‘en st npn itd poms, 5.4.2. Clastiare 1 Infonet oti ogrmasne, srs, Inonganin, lori: i ‘im poi pec poe pecloperan, i pei ‘Serpe pono 32 =z ee ‘Sone clarence penn pen one, cen pera empl eta deal ‘Sieber inna tarps perry “nema apap ‘Shee dbewctacone eens, deuotarie oa: dan ‘ain i Cie ‘mss eri ‘ea spermine als ant eae: rac dt (gc mos pohng) wt cH sop csi scsi ntiet tre doar (3st) entice 2 sen i ala (pi) peta dent ph Pama ® ups son (spt peril cc (a) line de mci ees ester de coesonne DANA, ADB) rik ‘gi pennant Spee Deere Ce. ts apd npn lc Doty pes et crema: rat downey saonnerbe HF 2 (apo ae SH 2/D2 > 1 Peep nore ip) ce rps (npn 07 2/2, yor rats pn 8 ca tp 3, Ds, Ds ‘leaned pal acd tans farce: reeSlgetd etre eanacete sericea, capes "lene (sia pm tome miei (Sapo eet tec ni amines prod sme “tin pc cit ar «+ Novotel Bena esp; fren oh Sein ened moss tase pipe (oles ‘Shouse partie ene ters tampon nome pote "rien ‘ea ein gol mate, Ae ite dnperlr eee le sabes epi ini nd tepate rls ‘Then pot role plik acre it a ‘Susie pec sso cer eee, 5.1.2. Definite vei to nn rn ti et 4 Amgen cease pena 3 oeinewsopee _Serrgaoneaceagemae mers eres 5.4.4, Farmacocineticd rolfreaain eta ron bere o esiine mve xcept: gh epsom ‘Sharma tet SOME ‘Mute et ser fa ce nce Suma fehl cn exit ain in» Fem 5.15. Farmacodinamio 5.1.5.1. Rene neuroleptcd 2 Ace a is mai nell eter eat: 1 fer rca major a rane tare Nees ‘pr sneer poorer es yom ‘eagle fooler adam a or ‘Come cl png els ep sees eral Moet {Se eee opr al ane ac te coe pment mas tne pa esi) ‘use atanfsoned gone min Cov oes ‘Gc es ops peo f era ace ar ‘Aneto fi irae dpi et ou ac 0m ion ‘conor sin ods eshnee ‘acon nce ante an tpt: ln te pane ene “ST PAR pe or pe ct © Atnt nearepe ese eps apc caeatanin opis rae, rales rei ‘tego ranger pe cpr Dy fy an pias ‘Seep nar sea gece nection ci “ipmitarie metre eve, sel arlene 2) be ‘ougenlon preemie fe ep. Ripon. pin: ‘jae siti ec cre co cl 341 I ct Reale wo tatpe gal orleans singe int nag rain Dy tbs esa pe npn piv eee ‘then! dies empoislaty.bslroe ‘Ernie pease nip tro) race ” Anas donna 51 seen peop single ai ae ‘Siete ite, poae mrt ex open S22 8) (esse acne J sewcop at pe gpis porta D2, plea i min 1m ele pes tc en es ic ‘idognncye nyc prm neper wbe 3) ‘oe Sac» a ct ea nce ok ees cna fone canspin our (4> D2 >), er clsapina D> Bison son pe as rr ae ee egctrine e lo ea RP | so eS ee nce a pn 5.18. Ate actu’ ale neuroleptielor ct pi el sl aon, et, vet, ener * nein eens pe oe espe D2, damon tb cence She pe ie tt Sin pe eri aia tein, oem, ‘wn wcsn mrance ry : : SOASESSRET Sfmt ora els nolo) pte orl pre SSR a eee pone ‘Sr ep pion Alt emi poral, oie id iu, dtr (ace soon wtinscrvnc dan deta mer ero abr ‘elm cose comme Hypnos ‘Sonja tes nnn omomasn, cman Ci2 Acre wisi Home, pn cin amp: Acie ecg po pa caer beni. Aleisha herve meen nha 5.1.8, Farmacotoxlcologle ut ce cana ‘hint pre eric a -hogen. Depend ee mans pn ener cert pn ion «ide exten, ml reps tte dea rake pence "Cheap cana oa tee newton. Se tp eeepemmt mine we sulin 1) ‘pine oper cg: wet cu bene mk, Hai epee enone) (Goats Te ny ‘7 Rpetiene eg esd: ron prio (ipo, pokes, er min 9 Sc etme a i a pt min ‘cece bt ph main i » Ampere inp st eso, ede seen temas Se eee) eee econ ee netic, ced iment (Gene oo Scan shod perl ex rie ‘sn dpa Aaj rape sor en ‘amecourei adroit arp mate ‘Escunsnton Serine cane sitar, TA sah pte, ceca pa ‘es ee nen at pea ne Sot ‘Seats Goch Seng D2 ce rien pote spam ina repr Goose nepaia amarok 5.1.6.2, Becta painice ste eect wear ont ice at pil (fn bln cejeyenioail, cla oi ier wget, ce dpa eps sn “resend samt ml pl ol ne (Goro snot carom Sifom Spe ase owe, aa oh it mle» Fem 5.18..Etece vegetative tupac de - vese (eine alciice ype ‘etaone situates festa) a semosmpnclne ei ‘Stes pen soma sie Aninearince pais Govtasue ieee pitied ‘Se. p ae Ngee come 5.1.64, Electe endoctine ‘bat tir sna Conc prone Tein segra ace Ge pon co aie ci mesa, menor, fewer 5.1.6.5. Ato oloco adverse ip mine in tl agai oss dec et, Snes enctae Ppec clorponatn {Saas ie, wr rb. nr sh mae eo "epi tre re mmc in ‘Sours int | smi 54 -armacoteraple $i farmacograie. Indies eTown par ez pana ani i mide, Schnee ms psc eps, yea ancl Per 1 mai csameeive nate mace deve ‘Route pee seme mane Gena) iW nctnngi tae de mene pea ees arr eae niet reps) Cc armuterapeti parker ‘her igre martes apt Nei sdetrenkpe au mpi, maf ac ini pions ese soon ome: ee eu aus {etree da de een sms poi se ‘Seon de ne bine eae tran seer mnie Fer toi mip eto efx aimesaa hone are eee Nets wolewe mig ST 2 dei Im wel Siganr puns shane pte sags i). -Retlgeclc epr ein ase conc ‘yma aor epi oe ead orm rma: septate riot onto Seaplane ‘mieten ex npn pd sae de xno ame Sanam epts ou deere inp ma gt su a sponse ape Se bee pe mim 3a Penlopeerspir en xeecpatn Cent ace yr cinerea (0) tla ell pa, (ng kd a fea crn spo e180 anne pn ee 83D gn oyna Fol 0.cr ge bei 0-150 pn {Foam mre (10-5 fps tne mil dS 20'mpe (ioe, lem, tar pers Spin. Pot ima (i erpigy te miedo? Km ie spon 5.1.8. Farmacoepidemioiogie Panini elec 652, NEUROLEPTICE FENOTIAZINICE ‘5.2.1, Relaistructurd chimied- prof farmacologic Neopets pit: ci emai ee ih ‘aba pone?Famine COOL y " % iar 5 — — epee Cin = (thy =a Teron =H Ny 7 conn) EO | a oy ‘ Dee pio = | oa seh Pee ors )-on Dea pipe pmonme | ~- WHom a, remo | =X mony or rammmane | — eK yey [ene za ropecimn | “CK Wench on| cry ramon | OK Sear enol Pama s8 7 ad pap Ste Sa (exponen x, Ionronasi tchtgun ano tot dt Gee sto ecto de an in 0 “Ga de om econ ee ares pea esi itn) See a eo tn Os dea a pot: unum fed ies ai porsche cae “i ie ne ea mm aie eat Chaticare nose arlene aa psa cic stay ie if fer leona, praise ‘Sin sa ese nae omen, entice sane pietasi, pei, rime Presi eam an ern ee 52.2, Farmacodinamie ps de i emote ips mirt compere sn (Sivan pst ‘us eubcne (a ppertil ‘Sn amos pe cepa vel pare at, "Shue Spans pn cpm centlatomse ne mire erie Seta perc ‘hs vege ete puri, cat ro cnr gach ae lia tian eine sete cane. ne de sna chink. 5:23, Formacoteraple Inca tn de poi mai fst bg ie 1 Femtaineambociieepranan ivopena®) rst rma an inet ste emi fe peeve festa (males bone renin) litem etal hilar el Inde toxin singin ach posi ene nee poneFence pps ip: ern petit) ate iin wr a lb pgs, Hes epsh mas ct state en pipet, tte wlnew ener) 9h peta), tne epi ansoat ca advan al atepreielor, Fentaneppranchiice ep: precopenit senad) Pretty: et ea rt ay Jet en oni othr annie Santen ste mrt cpm ema ep dines coma sso inher cer ea pe, ne epe date epee ‘naa ches man ‘pete son pelo 5.24. Interactiunt ie cel api SC {tens ncn be Eig io matin ‘Shee rane pein: ine) anes ‘Sinn sol wpe Speirs Joo a =e 5.25. Influentarea tostolor de laborator ota ope ebb onl, note 53, NEUROLEPTICE TIOKANTENE Repremtan cree cpio apathetic es Fone dp dope deca apoio "nf ales ec 1 peo it eta nr de a pout 10 CHa eee i cs Corpo Nery =a Sate Ciena Kye eo -a a rena | _cihy~cHy-O8 ory Tota =805—NHsp acpi nmaral 2) a peta Prt rman interred "Sade cree eves ie pl pe e C10 ar ‘ect dae (ds ami im coe cron 9 eh peas SiS Some cena +e nel cra pipemsescom totem ‘5.4, NEUROLEPTICE BUTIROFENONE eperente priil spil Paper doze Prt rma "tesa oe pene, ‘Shane nn dela ett pollo: fc antic anthain ‘erreurs fore ea ott ado ur erpoone fare ree ties pure spice ate oe tse ah ‘nag ee een ne) apes sl dlaPramas DROPERIDOL ate dt sce mn 9 spy 9m see Toa re ua: coupe 4 comers a iuwoet | Xe i ip see te ne nae ‘55. NEUROLEPTICE DIFENILBUTILPIPERIDINE eprint noi pine, ai, Frame: owls pean recs de baeer ‘eel ne rane ok da hg tac Tap ty - noe — Dagon Don praia Tel edt ak an pt eet pe nine ToL ft ona cnt fae et 657. NEUROLEPTICE DIBENZAZEPINE "ecm: ha eos lp ncouayin lp hessPret aac: nrc apes (emai lec cpains Dy DD fi Tm al meee sottrid Sue Meese fn cer macarinis ‘Serr alta? hen pcm tinge apne ea pes ‘spo af i sume eal ee pedo ese ipas alrite A eis gulch it inv fee ane we: de aie hematoma remiss sb el rv ‘au eo ecen S25 (impr moodewes iene dex Si ‘Ste site Se ree pen a are ‘state plo (te ti pe igo psi “Dok” ce pe oe ‘Souio ccc ales sigma neve secu “oe eset r OO OO — Fe Neri amet ie Pace 8 5.8, NEUROLEPTICE BENZIZOXAZOUL “ANTAGONIST! PREDOMINANT 5-H ezine) aaa epee doen se eae duis Dy ‘Se seo da pose a pn cpr vomit Sa emp mete ‘See ee eee FISPEROON Hae acquis Sean ee atu in 9a 950 te ae mt tm sm SE ln 1, ra re yD 2 i tS os mt SS ain arom nen nonin Soe ames neprmntngs ees taeptnlne eect ates etna eae a cecomes a acc men Cem, ee a See Tas een Faget oma el amon Ila cies meted pobole oe, wane pe eect, Hee ce keeeer a geet ap Tah a ieoninacs 59, ALKALOVZIDIN RAUWOLFIA eprint ci, NS Si pnt teen ADR D. tec np ne a TA: eclipsePamecage 6. ANTIDEPRESIVE (Psihoanaleptice) 6.1. BAZE PSIHOPATOLOGICE $I FARMACOLOGICE 6.1.1. Baze psihopatologice 6.1.1.1. Dopresia Chace adept: ‘Sar pone eta: nate. Sissons et le fmm. 2 Gna pee sf npc eal, We te pcs aa corp aan pon; Sets crepe sb enc) ater eer nag, pe re hes a el ope td eye eoet Cana net aa chine pene, x npc de 2 ‘crete bien 8 tes Soecle cated on bin dene Spl, de sonic e158 Clears to cede ign poy. ark ‘Ses tee ag ce Dobe, 190) ‘ispane ce siepune sot ‘Sil cd: dea mu oa pei x hep esha ie re Meth oi nd en ia cee gree, pt emi hoe once Scot eine is Pam s8C ‘ub canter Ge ne Coal, mie ei. ane; vere Seca ela eae pend y sane bese Ney dt mais, hein ove npc evi Teac tye Sel eso Ope mien emi) are sal ih das pumas pee “spa apes sae become ‘sini api senate dia io) Se mala pacar dart sone. pre ‘eel ts yw ee tte: ‘eee it ‘pee ingot: tet see nail pte cin ripe ecb bes sp 6.1.1.2. Baze neurochimice ac SEAR Sg 16) wa el ee ee Seda el Scoone ‘ion AAO eam mbps A) ote ecm mimi ipend shgenn “un degrade nspectc de cle MAO (at de supa A, ct i de ‘epi nee 6.4.2, Definiiaantidepresivelor cottage et See § fc. syst sch “maps a paper Fier eke Srl acer nee “Inde i ced po reer psorane acae NC; mec 3. Clasficarea antidepresivelor 6.1.8.1. Clasfiargaantdeoresveor,funtie de ctrl Tamacotorapeute + Tintin, efter i ime (pone. Se cla ‘piece ee (rtp vicPomc ‘Toi et et ei pt Seca te h ICH MCH —c Trimipran a I Ha NCH Cry oe spins SSO NCH a eee Chg {ety MH-CHy HCMC ne cs "ie Sr na ele pn 6.1.22, Clasioara timolopticeor, func de stuctura chink She Smee mam nie et wh rant, ee (nami, cana, weiranin, depein, Seren, ropes aio nce ou SEES pene pace eli, ont tipi, jaiewonree Goer ierbalnie api) eta evra pti in 6.1.3.3, Casfcarea terol, ural de selectivstea acing fe Seas des ail se elon lal lcapopnine em)« Fac MAO cnc mali alii ti oN imeem lee AOR tems (sie) 6.1.34, Claicareatimolepicelorcasice, pice, ese tetracicle, {ung de citer terapeutt (componentapsinomotri) (dupa Kieholtz $9 Poldnger, 1963; MutscherE. s Derendor H, 1988; completa 1+ Thule eft pre scr, et ne expan Spm ‘nen pa, ea, upon + Tepper Sp pai On, eee + Tepe ecapsen pilose ad sith, eine 8 ‘Sb perp (aiiptng separa) 6.1.36. Clasitearea anidopresvolor, tune de mecarismul de agiune: ee ale cap i sp, elaine (MA, ADR)! ening Shree mepoter 2 pila ma es-sp agea tinge essen {else se MAD ace seve IMAG) su mde ve MAO GMAO- W Ae meni: deesenp igi S72 (maser. ‘Tonite reaped NA ee eS pt NASH: oie ah an Ine lene ale reap NA: sgn mapa cup, is treme ct ae pan Sy aces aS {eine neccive abe le rcap NA a $397 ape) cs a ib epic DA conta! Se ane lt we wt NA at 0 ie ca a noc me iam! se mate cag NA wn S17, soe! Sa tre serene once hoes coe eer in ingle fet cao rina ese amar pr ceo mode desi vcore pty uo ‘pst der nip Se catamaran Se Tips eeande ae ese afc nee madere se fer af reap np ‘comand Gong agence se ner 1D nase py ce epee ng we? “Soy gee ines ear i ee in {iced ere claws SH chap sage ee ‘Sue pea Pama ® nt ee seca de sims pe sins acral a ep Sy (Geta rtiomoors) yn mepio Si, ge vn donner tose See meen ‘MAO coe oe msn ce elas sce NA iS Wf By ayeg © Ming A Nodes 8) Sewik (0) sng eam a Sg)° Pome cna AO si capac 401 pit ceoftes cnt senior (Na, SH DA) ie hepa he Feri a et en pm caes ‘tao coe Gok ue up on tant de mame sie, dre nies eas de Gp heap Treat AO nonethe x event, wove carl ein ope ett Sc nr avast ina ce ptt kop noma 6.1.36, Clasficarea antidepresivelor tmoleptc tpce gi atooe, unctie {de profil farmacctoxclog, In corelaje eu mecanismele do acne: clit, tint ntti die, ain cece wt ot Tecan ein (TA ras, ct, wil toe AY) ssi al ot uma pn un ccs tl case, ee une. ‘pete rp apn eee ol eam: Umber siete se rengart NA ip depron {Diihsowel ses rapa Na Sip miami Br Atipee tape mt, erate de oe px iol mance eave eee em feraeat iracagi pr feu etcamer i spe crepe pune eae mca cu owe steche sea Spare RS oni: Tepe se molt lees NA) 125) thbeoue sab se cap SH ren top dn 125) Shwe etn sl rap aps fom et ea ey or vepet moe fae era ‘oayehbatue si apt Sf mane DA Gen 13 nmr ters DA yt seep NA ata sy emguni bar) nat src SITE te (mr). 16.44 Rolafi structurh chimlcs-mecaniem de actune si clasificare Majin siecle vine apa pole merece pce peor abn nuaine (WAT mt area tpeeo ote ame (tle scm (ei, iin, aie, sap) ssi ace (Goan pment Tone nope cx wine supa pine wuss specie eo aber serie (SITET) raw sesepeste spe, sre bce fa a eon sede cu tine stp pte amore cc ‘Pant srerans (QD serene toe “cane ora alors NAT Gh rp co SHTT) 0 ei oe Fila saps etpenve tp, ain tcl mde 9 Fam » asin (ety py Hr weve co mal miko a deena ee pet tet ot) mp Conti ne tne fle hte cera ae gee WAT 3 mae eh Init sc depp (tier cae ein) Smt ch dpa ssp pene eel era) mie {tee + to toqe eae eset angen pte wanna pce Pores (tar mere ae "Sent wsotce ie ale wape scrone (SRS) ae eta ce Teeth elin ei pr, ta Racists re ees na mow sia pent hore apes ST rat in emo ona soso a erin ree tN in ale pene SIE maven ies ‘inne demesne, i sce izes natu ome apopiann tt ep ise ‘inch psoralen epee) (Esme SITET na mu a rat oben, wm ondont ‘con eg eden a i Ee oo 0] — ara Fame 7 Parent’) | erm a sera — Sr] ieee ee pte a aia 6.1.5. Farmacoteraple Pepe ram Foi tue 2 eprom manne cu pb eas cael ci ca a et it idee ttl ti ante ae 9 at (itr Scateeapaat de mete cal se wc ‘ec hint men wen sss a) {Bens ser Se cai un esses ioc, mnie gr oc ‘MAD aan msi ss active ca amie wiokie sue ict sco ane sie wwe uc HA cre NAO pee a eg ‘el ens 1ake de anpors omc rie 6am fe Meecipk en pers Ces tenn ert Sic, amte osc poate face RAs op ecole (En aco, ‘uml is pret 3 row dnl ame el Si doe ‘ESI Less per btamoce see ei nen! te Ste mc Fama si * nes nog shinseich eee etme ete i ICecreporngs iee fie ie et aj ear imran ice esata espero pensar ens ow 6.16. Farmacotoxicologle "ies Spe einen refine» RA, pei ae ead a areca ch onpnce ys seen Ra ane ec “inate ria gee toed mbna cs iene mv rn dg ee se A pr a eae irc pen apes arcn male aro snp 64.7. Interayiunt Sern: eel past eink ‘Mics’ patgats ce elec epi: te! DMAO aoc fetal tnttinceiee ap eecpia Sa nace ce ele cin pos te tui pe de ‘nee ptaeag Seon a itso cert Fence tl ante Se SRT MoS pia despa ee Sirens eer mou opie din pe da ‘ee peice sorceress octane ce “i po ta on uo) pe cae pre hee ‘fet ema le het Sc ecco WihOA mere nlc 7 rete (ip melon) a av ac of nado dot ith Brie ed ata eos erat a “ko pa eos same agin ymin SN eel din et ener, ‘epee Gi ce Steer, pi tee pa combine: Tein de eres Sse (oe, pein pot (6.2, INHIBITOR RECAPTARII NORADRENALINEI (NA) ‘SI SEROTONINE! (5-47) 162.1. Antidepresive tipic, amine trcilice gi tetraciclice Chae mann ve clfewe eevee, pe 3~ Pama oo eae on ett _sucuronocojupare. Meusbotit monodemetiag unt atv, d¢ ch deipramica (sme ome ee mel ae Oo ~ oO. Eye OH NOH bay ert 30 = TT os = ome BNO ny cH-o- my amc sve vs Sites po. ee et abl, Or tp Np tua ve comin psi Sn en ne ee ae ‘ial pil peta concrete 62.12, Famacodiramie Acfunte armcadnmle al timer lise pe, amine ie 4 ps feo NA 5. SHC pes “Poss etl sinpmonet (ove per), ine ink bee sn (et ima, ote ei snr se eft up NC acer ining, apocrine erin angie pn ioe ine ‘eri rin ee ml enc mer att retard NAW DA vei pets tid ae done vera fer asclepe pete! spn calpain man, ‘mil el ee, mn cc omy nd e- "png, sonee expen magnet vena Je si sa, tenrn xeremors, pecan toe perfor le ACH Ine Scee ‘gars TA eich she eek (ed aii opi sere te ‘rn rap erp (lec ony cv adver ante dee amid ico oneal SNC apoio cat ce Inet ei elec ome ex apr Parser ents seal epee, ag (3 sin inseam, po viet tem tn 6.21.3, Famacotoxicologl I farmacoepidemiologie bani nso pi nef clip fe ae m Sipe el aire Teh hee (as 1% nah 3% te ly ena contest de ons ae des Aces oa to ‘stn lawn coue vm man aml ice rae ‘Sn Sein, "RA retreat oeptlr dee nin tceprce ct ge te cones NAS), Poa enn mri einem tierce aac dp dean (epeconaaseN) seu caopne meal pe ion ue:% Fame sii cc in sb fo el sane ‘Spc ard x inne pis de tac, Nocti) ie ce cite atcolneg (me evenguant Son) C: com. pews depos ree wa une pi wa ei ‘hen ce cinder wes ar ans Ho AV NTA oo sa sali at ns tre eum rae ee Gian oni ‘Rou onan ssptin, denep), compar ee nae (sei, een min mh ope mei wes ‘See no one inc gt te cundare pie vit carina carers ns (seve dp com sea Di ehce mendes pris amare (aia, papa, aril) Seoltcesta A ese tt crim sarin sir eit i hae Ua pile ae ‘sk aml (grime oe conc er cae 1 ta nic. La pane pt ries ical se pte Pee aie ‘ome int cte coe Oa iio iin evr eh he (Che de learnt es, com gh ei ee ines Sra or ponte! un gn our dea pie 6.2.1.4 Farmacoterapo gi fermacograie Inet dre me na (ee eam pani we hc (0s) (mye 2: spp aan ne: pe (ue cbse amblar T0mas apace so cae pe ie2 ep pe dec oma 10 mg aires nse {23 Rene! alten de Gude coeur avin sea ‘Deze ene i 12 a a pa lrg, ea ee: pane, Lae) ee fed Fem 8 . ze : = lees* Poms 6.2.2. Anidepresive atipioe Repent pop chin hgen ean ce ir nto ane ‘ssf tape snp vou fen. sme, mE eile nie cnn sage ada tmaeie ‘Mec eae mec comin pc de sine, jr pt citar mh Clnfzoe font de seca dane puta 6134) oo agi emp eg sine inlet pce amie ek “ent Rin J os nh oe emma ue ieee ple min hepa de ma are 250m) soup, eset Maser “ete vsenit F291 Inde en priv ees. Plt in expe eet de ni wile, prin ace iad fetch soul le efeniet pe Semel oe ae pea TRA som pamlacion cu mec alee nee RA crs mse ete ai icc pi ‘acleg cpuananpenare ie emo s¥C