Gastro-retentive Drug Delivery System By, Mrs. Mali Vidhya Vij Assistant Pre kumar SSOF, R. P. College of Pharmacy Osmanabad. i High density system Swellabe system 2 Floating Systomsnts Introduction. Anatomy of stomach Advantages of GRDDS. Disadvantages of GRDDS. Factors controlling gastro-retentive dosage forms, Approaches for GRDDS. Floating drug delivery system. Bioadhesive or mucoadhesive drug delivery system, Expandable, unfoldable and swellable system. High density system Applications of gastroadhesive system.duction » Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently, >» It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. » Different innovative approaches like magnetic field assisted gastro- retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. Definition: “Gastroretentive_drug delivery system is defined_as, one_of the site specific drug delivery system at the stomach it is obtained by retaining dosage form into stomach and drug is being released _at sustained manner to a specific site either in stomach or intestine.”GRDDS form can be ined in st ch mi ration that can be called as Gastroretentive drug delivery system. a. Conventional systems v/s b. Gastro-retentive drug delivery systems Dosage form GRDDS Absorption ===" window olved drug is released continuously and absorbed through absorption window mip “sorption window Negligible absorption of drug released in region preceding the windowOo natomy of Stomach is a muscular organ located on the left side of the upper abdomen. Stomach is a J shaped enlargement of the GI tract, connects the oesophagus to the duodenum. Stomach receives food from oesophagus . Stomach is the first part of small intestine. Stomach secrets acid and enzymes that digest food.of stomach Stomach is devided into four sections. QO Cardia: where the contents of the oesophagus empty into the stomach. QO) Fundus: is formed in the upper curved part of stomach. QO Body: is the main and central region of the stomach, OQ) Pylorus: is the lower section of the stomach that empties content to the duodenum. Esophagus Pyloric antrum