seo ee pe x Department of Anatomy First MBBS (Bateh 2022 ~23) Preliminary Examination Paper: 1 Subject: Anatomy ee Teel Mee phan ‘Time: 3 hours (09:30am to 12:30 pm) “A” MCQ (20 marks) Section “BY (80 marks) Instructions: 1. Use biue /Black ball point pen only, 2. Do not write anything on the blank portion ofthe question paper: if written anything, such ‘ope of act will be considered as an attempt to resort to unfair means. 3. All questions are compulsory +. The mumber on the right indicates full marks." 5. Draw diagrams wherever necessary ©. Distribution of syllabus in the question paper is only meant to cover the entire syllabus ‘within the stipulated period. The question paper is @ mere guideline. Questions can be «isked from any papers’ syllabus in any question paper. Students cannot claim that the ‘question is out of syllabus. As iti only for the placement, the distribution has been done 7. Use a common answer book for all sections Section “B” Q2. Brief answer questions (Any TEN out of Eleven). (10 x2=20) a, Name two nerves which an fibers from all the roots of the Brachial Plexus. b. Which two movements are affected if suprascapular nerve is injured? c, Name two structures passing through the parotid gland. d, Name the structures forming the bed of the Palatine tonsil —~ e. Enumerate the muscles of mastication. £, Name two nerves emerging from the posterolateral sulcus of the medulla. g. Name any two nuclei of cerebellum. ~ hh, What is meant by capacitation of sperm? i, Name any two structures derived from the 2" pharyngeal arch. j, Enumerate the layers of the comea. k, Give an example each of autosomal dominant and autosomal recessive disorders. Q3. Short answer questions (Any EIGHT out of Nine). @x a, A 16 yrs old boy fell of his bicycle and cut his scalp. The wound was less than Jong and within a few movements he was sitting ina pool of blood, Why does (profusely from a small wound? Why does a deep wound of the scalp always, Enumerate other clinical conditions associated with the scalp. _b. Draw a neat labelled diagram of ‘Floor of 4! Ventricle’Solve any 8 Out of 9) (Solve any Z Out of 3) ©. Cloft ip and cleft patate 4. Lateral wall of nose ©. A 52 ys old ist consults her physician, complaining of tingling and stight pain in her right hand. The symptoms are localized to her thumb, index, middle and lateral side of her ring fingers ‘The sensations are more intense at night or if she overworks. On examination, there is loss of power on certain movements of the thumb. She has impaired sensations over the thumb, index 4nd lateral side of ring finger but sensation on her palm is not affected. Tapping or pressure over the Flexor Retinaculum causes tingling. After a complete examination she is diagnosed with Caxpal Tunnel Syndrome” i, What is carpal tunnel, where is it sitated? ii, How do you explain major thumb movements are not affected. iii, How do you explain sensory deficit in the lateral Hefei sa ae r i ‘ oi £ Draty and label microscope structure of cerebellum pe Primitive streale —— _J}Tumer’s Syndrome 1 _yieCadayer— Our first teacher | — Qi. Long answer questions (Any TWO out of Three). @x10=20) ‘a. Deseribe the sulci, gyri and'functional areas of the frontal lobe of the brain, y b. A.35 year old woman hed a partial thyroidectomy for treatment of Thyrotoxicosis, During the fion the ligature slipped off the right superior thyroid artery. In order to stop the haemorrhage, the surgeon blindly grabbed the artery with the artery forceps. The operation was completed smoothly. The next moming the patient was speaking with a husky voice. ‘State what is the likely damage to haye occurred and the position of the right vocal fold...(2) Describe the Thyroid gland under the following headings: Relations. (4) ii) Development (2) iii) Microanatomy (2) A 58-year-old woman fell own the stairs and dislocated her left shoulder joint. Several days ifier the dislocation had béen reduced, it was noted that the patient has signs and symptoms Indicative of radial nerve ddmage in the Axilla. scribe the Radial nerve in the arm. 7) ‘the muscles that would be paralysed and the area of the skin that would show sensory following damage to the nerve in the axilla...) eribe the deformity of the upper limb in a person with longstanding radial nerve palsy ) , ‘p 2 ee ehean RRR RT EE* 4 gé 4, Name any 4 contents of Superior mediastinum e > 2 , Ea meeeh oo 2 2 ~ K.J, Somaiya Medical College MBBS (Batch 2022 = 23) Subject: Anatomy Total Marks: 100 Date: 16, 09, 2023 Time: 3 hours (09:30am to: 12:30 pm) ‘Section “A” MCQ (20 marks) (80 marks) Section “B” Instructions: 1, Use blue / black bal point pen only 2, Do not write anything on the blank portion ofthe question papers ifwritten anything, such ‘ppe of act will be considered as an attempt to resort to unfair means. 45. All questions are compulsory 4. The number on the right indicates ‘ull marks.” 5. Draw diagrams wherever necessary. 6 Disiribuion of syllabus inthe question paper is only meant fo cover the entire syllabus within the stipulated period. The question paper is a mere guideline. Questions can be asked from amy papers” syllabus in any question paper. Students cannot claim that the question is out of syllabus. As ies only forthe placement, the distribution has been done 7. Use a common answer book for all sections i Section “B” 2. Brief answer questions (Any TEN out of Eleven). (10x2=20) a. Name two branches of tibial nerve in the popliteal fossa. . Name two muscles responsible for inversion of the foot? ¢. Name two terminal branches of lft coronary artery. 4. Name the structures lying in the posterior interventricular suleus of heart. ¢. Name any 2 sites of portosystemic anastomosis and their communicating veins. f, What is McBurney’s point? Give its clinical significance... g, Enumerate any four branches of anterior division of internal iliae artery. h, Entimerate two types of epiphysis with examples. i, Enumerate layers of epidermis in thick skin, j, Draw and label microanatomy of vas deferens, , Enumerate four derivatives of Mesonephric duct. Q3. Short answer questions (Any EIGHT out of Nine). (8x5=40) 4A l-year-old man stated tht forthe past four years he has been frequently passing blood / stained stools, The blood was bright red in colour but small in amount, Regently, he noticed’ ‘bowel’ protruding from his anus after defection giving him discomfort, He also started to have intense perianal itritatio’, On physical examination, the perianal skin was red, moist, and excoriated, On digital examination of the anal canal, no tumour was palpated. On & 1‘ve an nity actu tine solv Proctoseopic examination, the mucous membrane at the level of the anal valves was found to bulge downward when the patient strained. The mucous membrane over the swellings was Pink but large, congested veins could be seen beneath the surface, With the patient in the 'thotomy position, the swellings were arranged at 3, 7 and 11 o'clock. This case is Giagnosed as primary haemorthoids. 4. Explain the internal features of anal canal fi, What are internal and external haemorthoitis? b. Lateral rotators of hip ©. Right atrium d, Pennate muscles ‘ ¢. A 65-year-old women has an excessive accumulation of fluid within the peritoneal cavity (scites) due to a malignant tumour of the tight ovary. Her physician decided to make her comfortable by draining off some of the fluid. i, Where would you insert the trocar and cannula? fi, Name the anatomical structures that would be traversed by the cannula? £ Draw and label microscopic structure of Cardiac muscle g. Draw and label microscopic structure of testis 4h, Rotation of gut . i. Relations of Adrenal Gland ' Q4. Long answer questions (Any TWO out of Three). (2x 10=20) 4. Describe the gross anatomy of Mediastinum. Add a note on Applied Anatomy b, A 19-year-old student was hit on the posterolateral side of his right knee by an ‘opponent player while playing a football match. At the time of impact the student”s right foot was firmly planted (weight-bearing). ‘The leg was severely abducted by the blow, and the knee buckled, and the student collapsed to the ground in severe pain, Severe pain ‘was localised to the medial side of the right knee and drawer test was positive. The student underwent surgery: Based on the information given, i, Which ligaments were probably injured? fi, What is the drawer test?. iii, Why does a blow on the lateral side of the knee usually produce a more serious injury than a blow to the medial side?.. iv, Desoribe the intraarticular structures of the knee joint. ¢, Describe the Panereas under the following headings: i, Parts & Relations... ii, Microscopic Structure.....(2) a Develppment. iv. Applied Anatomy, es HEROIN KKMax. Marks: 100 \ Time: 3 hrs Paper 22) BAG) Writeany10 outoran St (10x 2=20) a) Deffie turhor marker. Name the t i fame the tumor marker most appropriate for Colorectal carcinoma i) Ovurian Cancer b) Explain the role of p53 as a tumor suppressor gene. ©) State one function of each of the following lip one fang g lipid molecules. i. PUFA, ii, Cholesterol @) Explain the biochemical basis of alcoholic futy liver disease. @) State the biochemical changes obseryed in Kwashiarkor 1) Explain the role of proteins in the diet of pregnant women, 2) Enumerate four examples of analytical uses of enzymes h) Define glycosaminoglycans. State ‘wo examples of glycosaminoglycans i) Give an account of energetics of anaerobic glycolysis j) Enumerate the constituents and inhibitors of complex 1 of mitochondrial ETC. i { k) Define Detoxification and enumerate thé phase I reaction. Q3) SAQ~ Attempt any eight out of nine (8x5=40) a) A fifteen year old male patient was diagnosed with Marfan syndrome i) Name the various molecules of the extracellular mattix. 2) _ i) Name the protein affected in Marfan syndrome and its function. (1) ii) Mention the clinical features of Marfan Syndrome (2) ) Enumerate the various factors affecting enzyme activity. Explain the effet of any one, (+2) ¢) Banlist five homopolysaccharids of glucose and mention their biomedical importance, (8) 4d) Define and classify carcinogens with examples (5) i ‘ous lipoproteins with ©) Draw a diagram of the general structure of lipoprotein, Enumerate the various lipoproteit their functions (144) 2~ 9 _Explain the chemiosmotic theory of oxidative phosphorylation, Desetibe the mechanism of ‘hermogenesis in neonates and hibernating animals, (342) 2) rate any two enzymatic and vitamin antioxidants each, Explain the role of enzymatic antioxidants (243) { bh) A forty year old male patient presented to the medicine OPD with complaints of chrotic couupation. Dietary history revealed that he had a high intake of junk food. He was advised to have a high fiber diet, #) Define Dietary fiber and Enumetate the various molecules acting as dictaty fiber (2), ii) Describe the health benefits of dietary fiber (3) Y 1 i) Explain the various barriers to doctor-patient communication. (5) Q4.) LAQ- Attempt any two out of three (2x10=20) a)Define enzymes. Enumefate the different classes of enzymes giving suitable examples . ~Explain Competitive inhibition of enzymes and its application in methanol poisoning. Explain the diagnostic use of enzymes and isoenzymes in Myocardial infarction. (I+3+3+3) b) Enumerate any four fates of Acetyl CoA. Describe the pathways of ketone body metabolism. Write a note on Ketosis (2+5+3) ©) Define Gluconeogenesis. Enumerate the substrates for gluconeogenesis. Explain how irreversible reactions of glycolysis are bypassed in gluconeogenesis. Explain the hormonal regulation of gluconeogenesis (1+2+5+2) } JER OES HE brn }KJ. SOMAIYA MEDICAL COLLEGE, Mi =DIGAL COLLEGE, MUMBAI 7 DEPARTMENT OF BIOCHEMISTRY. PRELIM EXAMINATION - ist M.B.B.8, (2022-23 BATCH) 1e:20/09/202: Date:20/09/2023 Max Marks: 100 ime: 3 he Paper att ir ection- B Q.2) BAQ_ Write any 10 out of 14 (10 x 2=20) a) Why is carbon monoxide poisoning considered as lethal? b) Name the synthetic nucleotide analog most commonly used as i) immunosuppressive agent il) anticancer agent ©) State the role of Prostaglandin PGE2 arid Aldosterone in water electrolyte balance. 4) Enumerate the biochemical changes in primary dehydration. ) State the difference between genomic DNA and cDNA #) Give Example of point and frame-shift mutation g) Explain the role of cAMP in lac-operon regulation h) Why is Vitamin K called as antihemorthagic factor i)Explain in brief how carbon atoms from glucose can be used to synthesize cholesterol }) Deficiency of phenylalanine hydroxylase causes? Name the test to confirm the diagnosis k) State the functions of selenium and Fluorine Q.3) SAQ~ Attempt any eight out of nine (8x5=40) a) Explain the tertiary structure of proteins with egs. and why do these proteins coagulate on heating. ( 3+2) b) State the metabolic changes which are observed during prolonged starvation. c) A50 year old male complained of severe excruciating pain in his right toe after consuming alcohol His blood reports indicated the following S, Uric Acid - 10 mg/dl a) What is the probable diagnosis (0.5) b) What is the cause of this condition (3) c) Name the drugs for treatment (1.5) d) Define Acidosis, State the types & cause of this condition and enumerate it's compensatory mechanisms (1+3+1) e) Explain the homeostasis of Blood calcium (5)% De a m “Oy, 2 we s 8 yy, Or Se wr 6 ing lt is eS % a Me eg ek tht ap bay 0 Min, | Pos 1) Explain the significance of the following liver tests a) Blood ammonia and S.bilirubin test b) Plasma total Proteins, albumin (2) ©) Prothrombin test a) g) A 55 year old male came to the OPD complaining of pruritus and itching. He was oedematous. On examination it was found that he was hypertensive and diabetic. His blood report was as follows:- Fasting Plasma Glucose -160 mg/dl S. Creatinine -8 mg/dl S. Urea ~ 75 mg/dl Hb - 7 gid S.Ca- 7.5 mg/dl a) What is the probable diagnosis ? (0.5) b) What is the cause of pruritus and itching ? (1) c) Explain the cause of low Hb and Calcium levels (2) q) d) State the normal levels of S. creatinine and S. Urea h) Explain eukaryotic transcription with a diagram. i) Explain the applications of recombinant DNA technology. Q.4) LAQ — Attempt any two out of three (2x10=20) a) Explain the fate of Ammonia. State the different disorders related to defect in Urea cycle and the cause of orotic aciduria (6+3) b) State the RDA, sources and deficiency manifestation of Folic Acid and Pyridoxine.Give reasons for i] deficiency of folic acid in Folate trap ii] deficiency of folic acid due to anticonvulsant drugs. iii] pyridoxine deficiency in alcoholics (141434243) c) Explain the catabolic pathway of Haemoglobin and its final excretion, State the cause of sticky patches and sickling in HbS, (6 + 4)