BIOMARKERS IN VARIOUS DISEASES

Biomarkers in kidney disease

1. GFR 1. Cystatin-C
2. Beta trace protein
2. Tubulointerstitial injury 1. NGAL
2. KIM-1
3. NAG
4. L-FABP
3. Glomerular injury 1. Podocin
2. Nephrin
3. podocalyxin
4. Endothelial dysfunction 1. ADMA
5. Oxidative stress 1. AOPP
2. TBARS
3. Protein reduced thiols
4. TAS
6. Inflammation 1. CRP,hs-CRP
2. PTX-3
3. IL-18
4. TGF-B1
7. Fibrosis 1. TGF-B1
8. Cardiovascular dysfunction 1. ANP
2. BNP
3. NT-PRO BNP
4. CTNT
9. Metabolic disorders 1. Adiponectin
2. FGF-23

Biomarker in sepsis
1. CRP
2. Procalcitonin
3. S-TREM-1
4. SUPAR
5. Pro-ADM
6. Presepsin

Biomarkers in liver disease

1. AST
2. ALT
3. TSB
4. ALP
5. GGTP
6. 5-HT
7. Albumin
8. Ammonia
 Biomarkers in CNS disease
1. Tissue markers 1. S-100B
2. NSE
3. GFAP
4. CK-BB
5. BNP
6. MBP
2. Excitotoxicity &proteiolysis 1. Caspase-3
marker
3. Cell death marker
A. Apoptosis marker 1. TNF-1,
2. DR3,4,5,
3. Soluble Fas
B. Inflammatory markers 1. IL-1,
2. TNF-A,
3. 1L-6,
4. 1L-8
C. Oxidative stress markers 1. SOD
2. Glutathione peroxidase
D. Vascular injury 1. VWF
2. MMP
E. Cellular stress prteins 1. HSP-70,72
F. Neuroendocrine markers 2. FSH,
3. TSH,
4. ACTH,
5. LH

Biomarkers in lung disease

1. Proinflammatory 1. TNF-A
2. IL-1B
3. IL-6
4. IL-8
5. ANG-2
2. Antiinflammatory 1. IL-1ra
2. IL-10
3. IL-13
4. ANG-1
5. Growth factors
3. Injured epithelium 1. ROS
4. Endothelial dysfunction 2. ANG-2
5. Neutrophil recruitment 3. VWF
4. RAGE
5. Clara cell-1.6
6. Coagulation 1. PAI-1
2. Protein-c
7. Fibrosis 1. PCP-III
8. Endothelium 1. E-Selectin
2. ICAM-1
 3. VWF

Biomarkers in heart disease

1. Inflammation 1. CRP
2. TNF-A
3. Fas
4. IL-1,6,18
2. Oxidative stress 1. Myeloperoxidase
2. Urinary biopyrrins
3. Oxidized LDL
3. Extracellular matrix remodelling 1. MMP
2. Tissue inhibitors of
metalloproteinases
3. Collagen propeptides
4. Neurohormones 1. Norepinephrine
2. Renin
3. Angiotensin-II
4. Aldosterone
5. AVP
6. Endothelin
5. Myocyte injury 1. Troponin I &T
2. Myosin light chain kinase-1
3. H-FABP
4. CK-MB
6. Myocyte stress 1. BNP
2. PROBNP
3. ST2
4. mid regional fragment of
proadrenomedullin
7. New biomarkers 1. Chromogranin
2. Galactin-3
3. Osteoprotegerin
4. Adiponectin
5. Growth differentiation factor 15