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Pioneering Discoveries in DNA

Composition(June 25 1945)
Revisiting the Vault, These findings,
77 years ago this known as DNA Base
article was published Ratios, have
in The Scientific deepened our
American. understanding of
genetic composition.
Renowned scientist
Erwin Chargaff has Chargaff's Rules,
made remarkable obtained from his
strides in DNA detailed research,
research. In the past have become
ten years, he has important in the field.
conducted These rules state that
groundbreaking within a species, the
experiments focusing ratio of adenine to
on DNA "base ratios." thymine (A:T) and
Building upon earlier guanine to cytosine
work by Albrecht (G:C) always remains
Kossel, who identified 1:1, while other
the four bases of DNA, ratios, like adenine to
Chargaff discovered guanine (A:G), differ
that the proportions of from species to
these bases vary species. These
across species. insights shed light on
the intricate structure
and function of DNA.

To arrive at these conclusions, Chargaff
employed advanced techniques like paper
chromatography and UV spectrophotometry.
Through these methods, he accurately measured
the amounts of adenine, thymine,
cytosine, and guanine in DNA samples. His
experiments will help lay the foundation for future
advancements in genetics and molecular biology.

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