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  • MCB 252 Notes

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    Kinase receptors on the cell surface activate intracellular signaling pathways in response to extracellular ligands. Binding of ligands like FGF or PDGF to tyrosine kinase receptors activates the Ras protein, which then activates the Raf protein. Raf activates a kinase cascade that leads to changes in gene expression in the cell nucleus.

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    Mcb 252 Notes

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    Kinase receptors on the cell surface activate intracellular signaling pathways in response to extracellular ligands. Binding of ligands like FGF or PDGF to tyrosine kinase receptors activates the Ras protein, which then activates the Raf protein. Raf activates a kinase cascade that leads to changes in gene expression in the cell nucleus.

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    6 views1 page

    MCB 252 Notes

    Uploaded by

    robomunkey12345
    Kinase receptors on the cell surface activate intracellular signaling pathways in response to extracellular ligands. Binding of ligands like FGF or PDGF to tyrosine kinase receptors activates the Ras protein, which then activates the Raf protein. Raf activates a kinase cascade that leads to changes in gene expression in the cell nucleus.

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    of 1

    kinase

    - tyrosine
    &
    Example of a general RTK signaling event that induces a
    change in gene expression
    ligand (example, FGF or PDGF)
    ligand Extra-cellular
    ↓

    P Ras
    GTP
    GDP
    OFF ON
    GEF

    si
    Raf
    d
    Cytoplasm SOS bactivates 14-3-3
    Ras

    Nucleus
    Copyright University of Illinois Board of
    Trustees

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