PHARM. AhANA Amti-hupenensive cognts Caries Porno Priysiaro: of hypertension M:0-% oF Santi -hypertesivs | Perse eget of a | Hapertession TNS iS aro KNOWN OS. Silent Kier leanose it Can '9e Onnoticed for years and..can lead. +o Senoos Neatn-comprication. Ay pertasin/hign boieod | Peessore iS a conddion characten3ed low @rS vored PresSore iN tho aerties MiSs accome - Med. oy diSecSES ike ttert lS, Strore € ecdingy deroge- Franaging At. «nvave Ss LifeStyle | Changes / drugs Of A Camboination o€ both (nro ee 4 Reduced the rise af assaciated | Compricar on, Regurar Mento rin 4 eon | Intervention ate essential. 1 It'S mon MENS | t | \ | \ t t A+ HO Physio : | e Q ef "4 of hypertens ron, | Tncreased Phetiphe rat MUS eoiar Nes i Stance. { K/S One Of 4ne Mos} Common muses of } hyPertension Which is, L \n Creose CARD. Th; Characte nget by an (Me preripberal VaScuian PESIStAN CE _ S accuSias a ceso OF Narrovin oO € arteries pig ereveated resistonce alyr Ane healt TO Pomp breed caer fo ik ho eusten. Anton Cirea1roy 2 Cardiac- ovspot 5 her factor iS GardBc DOrmpor WICH Keo, anor pomps wood = More than < When veart | useak Thee Can resart_fOM NANOS facta, Boch aS SieSS, obesity .oc Kecnay Aiseage t 3) Renin- Antpotensin Aidesiero! System aah) ' fays iar mr1e_in to ) Aidesre Plays croci “ty “RY CE hupedenSion, This ocor bu _renin Ceease : __ Plays a caSades Ves OF Aven + “4 dd. wonich Heges the @rease of angictes | Sing Cthis 1s 9 potent VaS@-conswicter.). This | €20Ses Wood vessas 40° consinet F Cavses | *Ne reease o¢ aldesterai,wnich leads +0 Nat dwater ceremion which teads 40 increve | blood woiome and pressor, { 4, Sympathesic Newous eer Chronic activate! | oF Symeatnet?< Merce LEwcessive aosivarionl bcom ead +0 incre reasins ORAS RES cate PAH bood pressore then Sota a nyper™5i Endo +neniat NCrion Aysfonerion Of Endothetiom Cioner ia 1 Ot owd . | Nessels) The dystonction of the Encoineriom | Can IMpair their Wonity to PIEaxrd diate: healings tO increased ‘Be. netic 4 Life sty ie : fw Facto S can Pre aseose an sesiaidiee | tO bh ASNS ON. hifesryyte FaGorsS. \\we high _ Sesiom sdiet Vike of Prgsion| Ocsiary and | Obes 44 AIS0 prays Significant cores in iS | cleveioPmente 4 { { ; } j | Kidney forction . [The Kidney equate wod pressere le | Reqqreting, ockyesiing 101K. 4 qtectrorte barre | kidney diseases or clonormarity can d8SR P+ | thes eet haan, to. NigP NS}10N j t é 8 Hormonal. Wmbatane | Condition. doch 2S C¥Shida5 Ha Pernrei disen can \ead toh Sy parame or ormonar orangcan ead to hOFrMoNal (mbaiance Whig CONtMoote +0 Increased loiecd Pre Fur, Aetiot : Lameegy.| couses of hypertension , Hypertension / his food Pessere antows NariowS cavse botin mney Cases IWS » Grace tniviegy TS nor clear. Common fectorS inejode - @ GeneticS > fami “history can Pay o | Signitiena Pole. TE PorentS or Meio VSS ha, } Hypertension yoor ot nign nse CI Life Styie factor: unhealthy tte choices Hie corm Soth as dies hign ip Savi # lov in Petessiom Fick Foods . lacie OF Physica! aetioitics, smokin 7 SNcWBSSive Alkohol__conSomPrion , chronic-Swess can Contnoete 40. h Pertersion 3) Obesity + being owese or Ovenceignt [increas © tne risic o¢ hyvertens ion excess } fOr ti88ve_ TeReire LAT oe bwod Sopey | Porting ‘Siren On the Semana syste? 4 j '4 age: Brood Pressore then +0. FiS@ With age dve 10 aa Of ArteTies andthe , agin Proce g chronic Conditions ithe diabetes, | Kidney diseases, Sleep aPNer.can FiSe biedd ere fa ‘ s | preps re: medication? Some medis@tion \nguding Cerial p 6 ote deg and prescribrion medication Con cause tenSion aS Side emact F _Mormonal_-factod: hormonal inbaince Soc \ 1aS those. Telated +40 Angroich diserder or Lhormenal bsirtn control can ingwence loiced | Pressore : e 2 2 8 Secondery Ny pertensior.\n a Smart Precentage | jos casesy hignn food pressure is aresuit O¢ LOn ondenine medical Badrtion Sock o8 Kane i diSease or hacmonat AiSoMder this iS KANON ;os Secondary hy eectensien LL Bie1. High dodiom diet. car (ead to we reased vid etemion a iger booed Pressure | Environmentar facrot !consiStOf¢ S@nvironmenh 7 i . nc toxens ¢ expasore do BG reneeso Stressors } i | ie ia icare Aao0seé wy Can contribute +o inynepseotinct in Same | \ndty idoais. Oueiew of anti-hyrertersio 4 optwreticS They are divided into 4 2 Thiagiade divreticS* hytocntnicaibce, Cri | Chior thar done, ane F Moa “ithe Inhitoit) Naty, Kt pagbeSorbTiOn fn | dispar convoiuted tobuie of the «idne Inver! nA the action orto e oganis 1 WO BraAkree ] eM channel tr diStal Convowted tvbouie Mereasin wetter Sodiom Secretion Resoting m decrease lgpod wowwme § decrease (edd Presgore. | Indication “THia3 iade doretia S the 4, rypertension : first ine IM treatment oF | | | | hy eertersion | . manag e 2 Edema 2 They cn we vsed to teat fiviid | | fetention associated with heart falues | { Kicne y AyStontion Ahiver diseases, || erect wmyre imigfance VY) POFALE rj qbiow wt] Adverse eect Hy Per Kalam loy Wefonatermia Cr0W Sediom) , Huy pertad acemia ey ai GTS 7 eS) By nyaerion won Sy MS. Uke dry mouth 8 j | { | 1 } { | = thirst, Weakness, Kian Wsfonction, @ Hy perwrecomia C LNerease in Uric acid wave | . 1. TSSo ita oa in gout arthrti S | hoop divreticS Example _forasiam se, | BMY! +Han ide, Et hacranic acicl Mk works Primary a eo | by inhibitiog nNa*, KY COALMNSperter In the | thitle AScending loop of Henle in tnd 1 Nephron of the Kidney. This 1ead +0 redoct ity in. reabsorption O¢ SBuiem- cuedse tons nas IN inerease Qeaarten’ Nq, Cl 5 Water in orine. Pracoring Nine Predect'Y Cdivresis.) INdroatian Ldama aasaciated with CHF Cconga tive Dears calkure >, SLSES Sor rena Siseese HyPerension wren cher dei que inet eees ___ ammmmaaaaaaaaaaaaasasaaaaammmssa@ ! | huperkaremia Swen vsed in Combined}o, UNE Other Medication #O ProMEse Perassiy,, lost. Acote Pormnonany edema Lireduce £1Vid_Ceten};, in the tongs nuns thea Ryhyarertion 2 YOU BP, aut ornemeiy arog 8 Uke {oraSidenide Con corse rQverSilo\2e hearing woS+ or ri ngyin (nthe ear Cri andes) Wan adminstered at hi q? dese . L te ed e Porassion SPari ng divreticS Tt reSermes Potassiom e- SPseronoiact- Ore Spiere HONS) AMI Ode Teiametriomtte FONS . They Ser fo Sxtectering ort? Gocchange Of Sodiom and POTE3Si0 mM ONS (the ENA’ Abow OF tne Kidney the | inhibit tne reabsorrion OF Nat while Pedvciing ane |rcreaat SA oy Kt and thes reading to Mvcina! Bre eretton wrt? | — Stgpificant Klos. ¢ | i" |indrcarion Ci) HIN= They may be vsed QuwwNe oF ty COMbINATION Loith Other H Pertensivg agent to Lower Dod Pressora Q); Edema They can be Vsed Edemoatus Senditions Soch oe ei Faivore, Wve serners. 4 Negprotic SypAreny, @) ry Po KOLEMIA 2 This sirvqS_Are also vSed +0 Prevent potassiom dle Pietro that an accor | With other dtoreticg f Adverse ertect Os Pais i Cy RiSic oF @revated lorood Pressure-ieve } : nl S \S Ane Main concern § can Leo ag | dardiac acter} a ‘ Q) ganecomastios -qwseS. lomost anoream aca A Potent a | NOS -conSin'stion +nis \eads +0 boioad vesse) | diodton. 4 decrease (n_@P. Additions 1, ACET cain redoce tne _predection [Secreieny-| Lo ¢ Aidesterone which &meies \n Sodiom | @ Looiter Tete nSion, 3 BncdiGrion Lower loipod Er eSSuré s Gare common lac ere wero idl redoca v's of mgasesien io byes ki } Ve parient A heart fanwore: tm prove Sym codoce nospitiigzorien ' infarction. Uns ~) eourt Cat teee ED sit al oh proms # 31 post mya cardia oo deserived atten a nearr attack ; in gabot i j 1 | } { Prevent forthe - | < Al diabetic Nee 10 PAA *1 [OA BO 8 Solan) EI Lecanpe ji | i { ASEE can loe vSed 46 Bow Progr. | NON OL Kidney diseas ¢ | Parient | | S chronic elena AiSease: thay are Some roms VSed 40 mana d Parient With | i ——s diseqse AdverSe e¢tec | 4, Covgh + Persistent dry comps (3 Qcommos ' } Side" ect of Meer. FANS “octorS a health core provider win Suoiteh tw anorthey lorand Ot ane | A ace — WD Brody Kinin =% soiosance P 4. aires |. 9itean.9 jensin Loomer Sonsitigariod Of ovr “4 > leading 40 © Increase wn dr me LQ ooo veel Recrease /ecsated (evel of “ 7. S An goede s adcoimatrion Of blood under dhe Skin @- BO, dans ues n 4} Angiotensin hte lolocKerS B-g 10SQtan, oumesarAhig santan,g ®esantan gf Tarmisartan. See¢ biocics touting Of ASNIT on AQ. receptor _ Speaficany they’ tarcet AG@n recepters— P er i. et 14'S peeling © Sopsagwoon t NGSO -Cons: Tndicorioas A hs PSASNSI0N_? IS4 ine OF arternariVe treaimen} (® Kobe snes by biosking action of AGNIL rictors, + for ee Qiweart fanore tne a a +0 sngnage heart Aare bor ere In combinaticn woth other 4 dwgs 5 Bpreroerie Nee AR g id dal ‘ Siow. REY ESOS Ot be NS. of ) i disease in Reoele Win “ATseac@_Biabet ss V 4; Posi.- ~~ MFATAHIAN « Some Aros are j vsed Y £6 improve potce me 4 redoce | pp WS Of £vtor€ AFA O-NAS Car Avent Odter a meart attacic Sh Nmigyraing PrefiaxiSs cande Sartan hag been YSed 4o migmine ROH 1axiS common side 1 Ottect o4 ProfiaxS ingwde dig3 e8S_ fatigue i Measkehe 4 INereased CiSk Of Urban raspi aren i fragrainsecsion Sther Seriovs bot Not Commay INclUads WYPOTENS 109, PYPENKA jon, 5 | G kimey YW Stonctia wail& ARB are better +0\e rote d thary Acers ] @ Aleneg~ rece pror bblocice AS Escampie N6 2ra JOS In, PraZosi N, tera 30s) 5 TAMSvIeS N= baoNgS FO A racaprorg + Which 13 used fer Benign Pro Stor 1c | HYRErPRSIA Acordey C&pHaD i Mechanism of action Ot OXF recepror | “They are POS PanSilo) o for mecdiarieg action | SE draenarine 9 nor- ~arclenaine. t4 recepter | ‘MWN0CicerS lo lode thIS Sco ptorSs Which (Cad 40 1219 40 bieed smoomn musics io bieod vesseaig . Pesoning to wasedirat ion. | 4 reload bieed press | Thdlicor ion 1b BE 4p reavee byrertensio” | Rene Senian Prostatic hyperPieshs. + TAMSMMeES\y Tero seiner Symprams cs. USSociated tn Bent roStati ¢ yp ereiasi gy cn Of ynemars AS 6 osed OF \abewed to peat pest ety GOITER Artacic | Chere cattace’y {PP } !4) PoSt-ArOoMaIe Stress Asoder, shoe 46 Aha 2 re Labiity 10 redoce Mans -mara 3 Side-ectect Soden 4 AD1O-Staric bh POVENSION : Sxsre roe in bp wmie Stand) 2 | Drowsiness or LOM Ove? cause a4 bioci Als Kren Tha, act on AAAS +o ower SP MOA; inhibiting the ensyme Renin wich reg Awe rove iN the re aver on 9, Renin, Wy prodelttion of AGAL & Qrecerser io LA GNAT which 1B A Potent VASOCONSTH y, { Lonicn in tore (eadS 40 VAS dil terri on | -¢-~v Be | Ap aiconen | ia pertEns 109 Adverse E€fec t up ericatemse C Symptoms \4Uupoetensi oo urdne Loncrie D RasheS or Skin reaction.E k Congestive Keart aukure FUE"S ComperX Ardoriascoiar disease or bheo Uonich 1S Charactensad_ bo _hean'S inalointy t2. Peme bicod AK Cthe ‘bod gpa sendin to fivid lovud ve ip lthe Teo ‘ g CAher Bec 4i3S0eS.. | AvoK yy Cocuses ) 4 coronary Artery dease : thé mMOSt commen - +s jcaose (4 AALODiNG Of artery o¢ biecuingy OF | petals WMCH AGAS AN fedtsOO ef bicod how 40 bra. el | at RyPectersion : Seolang mig biood presSore HAN \eard AC leet Neniricoiar nypertcop ~ tl 1Ond eentva congediwe neart faiiore: 5) Na Wrar Neart diseaSe ~ conditions tii € Aortic AtenosiS gr mitra eS ppauniein il Meee tne hain 7 — | i al Aorarhis LPAISeCasSe condition that tices MENG Lonctioy Soc ag diated, ns POY er eStrictioe @rdiomayo pain | Akard ial Angection damage 6¢ hert PUSSIES og reso4 of (nSv¢eicent. 61000 [Pigg | %* Abnermarity Present at birt D 2. ingection t uirar or bacteria) AN Feet OH Gn weacen B. Texins 5 dev Nsaid D Not = Steniadal ant)-In{iamnoty, N droge can ae ~he Wear 4 ( ( Forro-pnipioogy o ¢ O11 F ay Reduced Deke Heart {loo | The Weart pomPing abntyiS | com promised ea 40 des eid « f+ o1ood Sores t a | Nevronay HOrMONES . The body compensa’ | by eee Symporretic HerverS | asinine: AS; which increase hear 1 t€ F bleed Pressure bot worsen héard €onctionS in ane a ' ‘ é Congeniar nears Gegeer 2 Sarocaem) | r ane heart (v¢) Buch aS alcoho! ana ' & QB) fioid retemion? fed Cardiac ortpe! La retain Nod 25 Kidney 10 HZO leading do edeme Z Awie beiid BP ane wha vf movmeljeading ro —- edema Phen phe gy (edema C “4 4 amodeting Of tne Neat * The heart ee Saroctorayt Anant snciudipe, hypeticer x) i@ duratiom™ in an-attemps +0 adopt +o A work load. This mca @Nn be dedrimenia! \N 4ne son Oo. Symproms of Ron genicn neart faiiore , Rariend heals ex perience SYMptOMs «| | WHE Snort pss of loremn fat Ave, a peaies \N_ Aho te sannies 4 radoce dy _ @oc cersise 40lesance. wr CompiicationS Of (ale k aewranr HProtnog en can leod 10 al » Accb th oe Thrombb@boiism F orher eT, 3] _t0outi= Organ aKfencticn | Management ‘ 4 The Areatd men? Aim 10 reduce Si PtOMS Improve cardia «_ Sympiem 3 OSA EBI NG) tre Unde rine causes: creaghs MeIeds baa eS LN i a ae 7 a) s AG Medication yjxe AivrexncS, besa © RSE eCS ACE \nnivitors 2 hifesryie moditication 3 Seorgicd: intercenton & salle perabitati on } Crassitication of CHF i T's classi¢ied pase On BELEM) Cite riggs | becavse HS Compicate d | “98S base on etic | \Schemic heart gisease Ceerona_| CF AS reNoivting 4-omr~y B-Soppry +o Ahe rd MmvscisS We 40 Coronas Garter Aisease J d Al Wuperiensive Heart disease LOCUF Linked 1 40 long 4erm Be leading 146 heard | MULSCIES Thremenin Doeonenng, ~ Naweviar heart diseage”s coronas ariey doe +0 Keart RPrOOEM Aine Stenosis [Cnarrovoin oy) OF reap rgitationL equ | el 4 Faia, shel el geeue of 8. fhe | Weart meScre \NModi a) Sates, ny pert4g LEANEMOE Cardio meh eae gS censinemat Uridiseatc Brcvctvere\. heard ckfees | to yet b é | joxe ¢ arog (duced Mf 7 Heart foiyre Leavsed aa 40 40xins €-9 arcohel | arege or EfAQIN paecaai ou. Qs - cia | £onction. SHA\nated Lom Present ar M edlicaren i) Ko che me i€i.CATICD ‘4 Veet Vemricaiar 4.1 SySroui c WA Loiwore > rt faire _witn cedocecd | Q\edion {raction Charmcteri ged by woerkenin Gooe | lett yeniricieS Ineo ty +o. POMP pose O€£ec ALV Shy, Leaciin oy £0 pedvced eyecrion | fraction Useauy tess tna0 4o7% 2 Masirciic near t faiier ed neat foier & | witn ereserved Gero? gracrich occor UNEP | ano Lect Nemiricie be ome Stitt giBonad | Pera progerty-eadin +e am posites RaQ | @o@n, 4nev Ane cyection fractie® remain, normal Cosva\l 4 >sB%t BA14 1 MH aass tase on ciinic! ) Ya — New rm heart attacic BD nro -\inivation oF phypicn! Baw no Syprems | [A Shaye fimitetion of Physica! ACHOrYy | eA fortaie at rest bot — atl Tesoit 1M Syumproms- 3. greneonced rmitation in physic] AcHVItY, Comfortabe at © bot tes$ tnan ora nary activwties ti agers 2 Symptoms | oname +O Corryoot an HYysica| Actot 4) Wwithoor lies aaa yen N ' Ss PAPLOMs Present at sest | C\ASHikication of BrvgS vsed in {rear men: 1 OF CUE. CS 1S ne | vSing Combinotion 64 dheSrent dro . thar Serve dttrerent Purpose & 4 BIVENS ~ Bot tha 3a de oop_aivet { | sean Hira ad Lopp-divretic - furanziamiade tHia Re - Haare hdorotnigziade NOK ¢ | ret hep the a SumMinate excess Ffwiea # Tedoce tne voi OMea.v6 ‘Stood. PES | dre heart nas tO Pomp Ncdigtion 1, €dema Qene 3 HIN FOOTE OF Odmingirorion Oral. form 4 inyectabie s Adverse e¢eect 1 Eiectroy team batance 2 tuporension 4 lrisomeclensa 4 ay bycira ton S kisnety dystanotion 3. ACEL + \neserne Capiop : | i Mon typi Conversen CK AGNI > AC o iI | end) VASO di ation 4 yedoced bios d \ nq Aa caaion a ore ssure Ore doc: na adies (004d: tne PreSux Ane heart mst Over 2 dems Foote . Om 1 form &$ pacianny ta biers | | PAV Eeect: PresineD} - oan hye hyurekaien— bi iphone lyon clon $ ect mist Imor F, eo: |3 Agam receprer Pioceers simicar so ncers 83 es tne action c. | AGNB which aise PedeceS loiced Pressure fF Gases heart werk load r leading +o vaeseditation. f ‘ TrAdicotion [ A: ong management gspaially tor | ot thar can’t towmte ACET’S 2) ee ema ! coor | oral, ee es Kane | cigStencsian, +) BP | @) B-bwiocKer | MOA reaxe near work \cad Ane |exfect Of adrenaine NY HRS t | BP | sodi sanion t funcrion greduxe d Syn! weart Larore . WOIOTKI OF} a impreve peard mn cenep Sefoote - oral Adu. ec 1 Brad Giri Afarique 3 Worsening eens Som a@seS _ Aisesierone. Anraggnisi Sochss -- — Lone. which” eed. to st in Aad and Bao i Fetention. — ndkterion he Ac LSed__ in advance | {wid cver-load. 2 IMProve ear function: a } OM aso availabic in ora er | AN. E€¢ect. 3 H ype rteatemia 2. Hicnay dy stonerie? ace (Mbaiance 4 Hypatensio> C.F to redece 3 + 4) \NabradiNe ¢ woes oy inhipiting 19 ¢ fono Current, in ~he heart pace Maker Coens by doing So tt rocbaes tne near? {Cate LOHNOot ateeningy COMA | TMS Arvgs Tock” ne ef¢eci_o¢ ardester~ > weSnaieartion a CAF: anose having tedeced @yection 44S oSed in combination With Ding, CHF me dications. Roore of AdMINiStraton orn axeniqeiea vn tablet -form TY 3 IMportam +0 tae it With meal to WM prove absorption. Ad . Ste + 1} Braduooraio ANIS ca). AiSyorbanoe SVevatted Serom pot assiom \eve |, @ Sacvlaitni 2 18 a combination MEDCo ON eomoine d Lolth Naisertan LA resre] | MoA 4 iphtot Me Priysiny Lan Baume | CESPOMSIBIE for brearing Aousn loenef{iGal auostanc K€ brady io) 3 MirivrensS pe@psides- Sacoprten! INCPEASE Ane Lever oy this supsi009 |Lohich can Keip aate broos feng creck ng Hwict cere ntion 5 CMPTOLES Newr fone. oNtiSon Indicaricon 44S -Primar indicated +4@r mana: cas | tor Bympicm Of CUT ve itn redos Qyectien fmctrien in advit patiens 2) at can be prescrived Cr parent Who i [nave OOO been 60 ACETEr / ] rece pier LAGNbowcKeers to torner Mace ine } | 4 ciSk Of cardiovasmiar event & hospitiiz— Aros Rov té 2 orar form, shai is iabict S Adv. Eccec4 1 Hueotens ion. Q elevated Serom peratano 7, B | Hue rane mia 4 Cov h | “eacvubitri, (Nasaian Snoid act be vsed | Kombirant wit ACETs Or Within 96 hoes Of tne last dese Of ACETS due +0 ma increased fist ot ANGIC edem‘ ' t | Y | | No bthamin t MoA casei CHedr.cna OD. ore ardenc G4 receptor in the d oe irs heures ss cardiac comrace yr “| force of heart essere comract 6nd, | \Gadling 460 symnprove a Cardia’ Corpo. lt arse cavses MUD NASOiletian LONI Ch can redvce cardiae Aker oad. LE resisaaqnee tne heart MUST OLEr Com to pomp fowod | Mdicodion x Sed Ww Shes} ern ment Of aAovte Aecompasial FAVILFE OF COPEQrive Near Fawe (47st mana Qeart Ercce 7 bar) on i+ iS @{ten reserved for Patient wt) Severe reduced gardiac favre A i Bop who doesn’ respond WEN to other 4TEQt ment Qvuariawie WW NIN{esicon+—Adverse Select 9 increase HR Carack (ial mw \Ncreage @- e ¢” on PAPitatian A} artrhuanm)o S| Headache im Nevuseq | j Care. Mlirinone } MOoA Tt!S o . 3 PhoSehO-Aiesterase { ey (Meresing the leve, ¢ SMeoin_ Myscie @1), | leads t6 Reomeracsiriy lucoS@ \+ Works | OF Crean Cardia ¢ Lievate CAmp jeve/ SLANE ag rt Muscie ¢ | Lpostive -inotrapic Se KL Vas0di tation * TEDOEA Oreigga Patter lead on dng Neart Tndications Q) Acute BecompaSte d hoart faire (2); Severe cy F When ered have @) NOt pre vided Sot€icient Mweiic t ings Sed a6 aghort ter Sowt!a Sohies AM Prove cardiae goncrion j foutesiy Avanos 1 care Setting Gg HOS PHA\