Det PARTMENT OF HUMAN ANATOMY, FACULTY OF BASIC MEDICAL SCIENCES, UNIVERSITY OF UY END OF FIRST SEMESTER EXAM FOR POU (Mi BBS) CLASS 2021/2022 Session ESSAY PAPER DURATION: 3 HOURS DATE: 18™ SEPTEMBER 2023, ANS\ VER ANY TWO QUESTIONS FROM EACH Course, EACH QUESTION CARRIES TEN MARKS, EST ESTION CARRIES TEN MARKS 2. Write on the 3. With a suitaby ANM 312 (NEUROANATOMY) 1. With the aid of a labelled dia, 2. With the aid of a labelled dia, 3. Discuss the Ventral group of Bram, describe the functional and phylogenie distribution of the cerebellum, ‘gram, describe the floor of the fourth ventricle, the thalamic nuclei. ANM 314 (EMBRYOLOGY OF THE HEAD AND NEC 1. Describe the development of the K AND ORGANS OF SPECIAL SENSES) 2. Discus semicircular canals, 6 the development of the face, 3. Discuss the development of the tongue ANM 315 (MEDICAL GENETICS) 1. With a suitable diagram describe the following: centromere (5 marks) fi. kinetochore (5 marks) 2. With suitable diagrams, classify chramiosomes on the basis of the location of the centromere, using the following headings: i. metacentric ii, submetacentric 3. Classify structural chromosomal abnori acrocentric iv. telocentric (2% marks each) malities and explain each type. cain eas pa sent one sry a 9. Discuss the pharyngeal pouches (10marks). ; worn 10. One of the most significant contributions of genctics to medicine is the develop e of genetic te testing, Outline the types of genetic testing and state the examples of each type of g (10marks).DEPARTMENT OF MEDICAL PHYSIOLOG FACULTY OF HASIC MEDICAL SCH COLLEGE USCIENCES Usavt ovuvo) 7 /2022 See HHLOUS Assessity IEDICAL VUYSIOLOGY (PHM StL, PLUM 312, 20. FAumination 1M 313 AND PU Course: Date: 20" mber, 2023, e Allowed: Shes ions Answer 6 aMestinns in all (Two questions fro nsession) AL SENSES) wks) result in heteronymous hemianopia, (5 Instruct SECTION A (PHM 311 PHYSIOLOGY OF SPE |. Describe the olfactory transiduetio pathway. (20 9 2. a, Briefly explain why pituitary famor will liket marks) oe b, Describe the tunetion of the middle ear. (1S marks) SECTION B (PHM 312 ENDOCRINOLOGY) 3. a. Describe the synthesis of thyroid hormone. (10 marks) b. Explain the abnormal incre 4. Describe the synthe marks) ase in thyroid hormone seer regulation, and actions of ion. (10 marks) 5a. Explain the regulation of hormonal reeeptors and give examples, (10 marks) b. Differentiate between primary and secondary adrenocort SECTION C (PHIM 313 NEUROPHYSIOLOGY) 6. a. Write on the initiation, generation, maintenance lution of sleep. (12 marks) b. Describe how the Golgi tendon protect the muscle trom damage in an event of extreme tension. (8 marks) he function of somatosensory carte a muscle spindle? (5 marks) ibe how musele spindle helps to maintain muscle length during stretch and muscle contraction. (15 marks) - (20 marks) SECTION D (PIM 314 REPRODUCTIVE PHYSIOLOGY) 9. Write short note on the following: is (5 marks) is (5 marks) s affecting spermatogenesis (5 marks) d. Male sex hormone (5 marks) 10. Describe sex determination and differentiation, Add note on Tumer's syndrome. (20 marks) . a. Spermatogenes b. Spermiogene c. Any two factoUNIVERSITY OF UYO FACULTY OF BASIC MEDICAL SCIENCES: DEPARTMENT OF MEDICAL BIOCHEMISTRY 2021/2022 END OW THIRD SEMESTER CONTINOUS ASSESSMENT IN MEDICA. BIOCHEMISTRY FOR PRE-CLINICAL IT PAPER ILE AY TY INSTRUCTION: Answer A Total of Twelve (12) Question TIME ALLOWE TALL, You MUST Answer Surs At Least Four (4) Questions in Bach Section. SECTION A ~ BCM 31: ME ‘ABOLISM OF BIOMOLECULES I 1. Using Ribose $ Phosphate as @ precursor discuss the salvage pathsyays for purine metabolism 10 marks b. List inborn ercors of nucleic acicl metabolism. 3 marks exch Discuss vsing suitable illustrations de novo pathways for the biosynthesis of a named nucleotide. 25 marks 3. Write short notes on a. Alkaptonuria 10 Marks b, Hyperphenylalanaemias 13Marks 4. Write short notes on a, Niemann-Piek disease 15 Marks hb. What are the eauses and risk factors associated with the development of fatty liver 10 Marks 5. Give a descriptive detail on absorption of amino acid and Meister eyele 25 Mark 6 Mustratively, describe the Urea eyele 25 Marks SUCTION B- BCM 312: CLINICAL BIOCHEMISTRY IL 7. What do you understand by infections diseases? Sma $ b. State Koch's postulates an infectious diseases 8 marks €. Distinguish between i). Infections dose and lethal dose 6 marks ii), Pathogenesis and virulence Guuarks 8. Write short notes on the following, aL various stages af path nesis of infectious diseases 12 4m b. Lrythtoeytic glycophorins 12% marks, Poa tw Pernsrdial necrosis 25 mark 9. List the four established biomarkers of myocerdial necrosis 25 marks XE paragraph, the role of myoglobin in ox b. State clearly in no more than ONE paragrap! uumption by respiratory enzymes in the mitochondria of active tissues such as heart consumption by respiratory enzy and skeleta! muscle 10. Regarding Liver Blood Test: complete these statements, 5 m i. In the event of liver damage, albumin levels would ii, Elevations in ALT and AST in out of proportion to ALP and Bilirubin is indicative of iii, Elevation of bilirubin with normal ALP and AST/ALT levels is regarded as iv. ALT/AST detected in the blood stream is indicative of” we An inerea ¢ in ALP and GGT is indicative of nd label a cross section of biological membrane a. Gestational Diabetes Mellitus (GDM) 9Marks b. Hypogonadism in Men 8M c. Hypogo: ism in Women 8Marks 12. Describe the Mechanism of Action of Steroid Hormones in Target Cells. 15 m. b. Explain the Role of CAMP as a Second Messeng: marks in Cellular Signaling 10 SECTION C ~ BCM 313: SPECIAL TOPICS IN BIOCHEMISTRY 13, Distinguish between the carcinomas and sarcomas as. types of cancer 10 marks -TRmarks 14, What are oncofetal antigens and why are they important? Give e. ample: Simarks b. Write briefly on tumour markers giving at least 2 example: 10 marks 15. What do you understand by “Bivtransformation ef 15 Marks b. Differentiate between detoxification and biowe! ation of xenobiotics, 10 Marks 16. List the Phase two detoxification reactions you know and state the by mechanism 18 Marks. b, ¢ biochemical What is the importance of phase two reaction 10 Marks 17. Using Wmatic iMustration only, show the relationship between dopamine, epinephrine und norepinephrine 25 marks 8. Mlustratively deseribe the peneration of phutann te through the TCA eycle using GABA 25marks