SBAs:

Regarding the complement system, which of the following is true:

A. The lectin pathway is always first to act in the activation of complement and can be
activated by a soluble pattern recognition receptor
B. C5 doesn’t have an active thioester group and so is not able to directly link to the pathogen
surface
C. The classical C3 convertase is C4b2b
D. A deficiency in the molecule which is a positive regulator of the alternative pathway may
result in autoimmune-like conditions
E. Paroxysmal nocturnal haemoglobinuria can be caused by a deficiency in properdin and
results in complement mediated lysis of red blood cells

Regarding the adaptive immune system, which of the following is true:

A. All B-plasma cells are able to continually secrete low levels of specific antibody that may last
a lifetime for the host
B. T cells are able to recognise molecules in their natural conformation
C. MHC class II molecules are expressed on most cells
D. MHC class I molecules express the CD4 co-receptor and MHC class II molecules express the
CD8 co-receptor
E. MHC class I molecules present peptides made from inside the cell only

Regarding antibody diversity, which of the following is true:

A. Heavy chain rearrangement always occurs on both chromosomes

B. Both heavy and light chains are made up of V, D and J segments
C. Somatic hypermutation of B cells takes place in the bone marrow
D. Mature B cells can undergo class switching changing from an IgM to an IgE molecule
E. A soluble antibody molecule can be generated by having a polyadenylation site downstream
of the transmembrane domain in the DNA