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International Journal of Gynecology & Obstetrics 71 Ž2000.

159᎐169

Special article

Decision-directed hysterectomy: a possible approach to


improve medical and economic outcomes

S.R. KovacU
Department of Gynecology and Obstetrics, Emory Uni¨ ersity School of Medicine, Atlanta, GA, USA

Received 15 January 2000; received in revised form 7 June 2000; accepted 19 June 2000

Abstract

Objecti¨ e: This study was undertaken to determine if the use of formal guidelines in selecting the route of
hysterectomy would improve medical and economic outcomes. Method: Data from 4595 hysterectomies performed at
a single center in women whose primary diagnosis were unrelated to invasive cancer or pregnancy were analyzed in
terms of mean, uterine weight, costs, length of stay, and complications. Results: When formal guidelines were used to
determine the route of hysterectomy, vaginal hysterectomy was performed in 90% of the patients treated and in
100% of the patients in whom the pathology was confined to the uterus. In comparison, when formal guidelines were
not incorporated in the decision-making process, vaginal hysterectomy was performed in 42% of the patients treated
and in 64% of the patients in whom the pathology was confined to the uterus. Conclusions: Using these or similar
guidelines to assist in clinical decision making would have resulted in a potential savings of US$1 184 000 for every
1000 hysterectomies performed at the institution where this study was undertaken and would have freed up 1020
patient-bed days and reduced complications by approximately 20%. 䊚 2000 International Federation of Gynecology
and Obstetrics All rights reserved.

Keywords: Abdominal hysterectomy, AH; Decision making; Economics; Hysterectomy; Laparoscopically assisted vaginal hysterec-
tomy; LAVH; Vaginal hysterectomy, VH

U Department of Gynecology and Obstetrics, Emory University School of Medicine, 69 Butler Street S.E., Atlanta, GA 30303,
USA. Tel.: q1-404-616-3540; fax: q1-404-521-3589.
E-mail address: pelvicsurg@aol.com ŽS.R. Kovac..

0020-7292r00r$20.00 䊚 2000 International Federation of Gynecology and Obstetrics All rights reserved.
PII: S 0 0 2 0 - 7 2 9 2 Ž 0 0 . 0 0 3 1 6 - 7
160 S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169

1. Introduction guidelines, they were successful in reducing the


number of abdominal hysterectomies performed
The delivery of health services for hysterec- w3x. Further development of these guidelines into
tomy varies markedly from community-to-com- a decision tree provides an opportunity to test the
munity and physician-to-physician. For the past validity of this decision-making process.
19 years, abdominal hysterectomy has been the The objective of this study was to determine
preferred method of hysterectomy for gynecologic the medical and economic outcomes of applying
surgeons. During this time 7 557 285 abdominal formal practice guidelines that confirm, in-
hysterectomies were performed compared with traoperatively if necessary, the severity of the
2 934 252 vaginal hysterectomies at a rate of 2.06:1 patient’s pathologic condition ŽFig. 1.. Thus,
w1x. Does this variation represent a consensus that rather than presuming that particular route of
abdominal hysterectomy offers the greatest bene- hysterectomy is contraindicated, the surgeon is
fits to the patient group in which it was per- required to document the accuracy of the diag-
formed or does it reflect a difference in physician noses with each step of the decision tree in order
practice styles? to prevent a diagnosisrtreatment discrepancy and
An abundance of well-documented articles select the most appropriate surgical route.
show that the abdominal approach is associated
with a higher incidence of complications w2᎐4x,
more adverse post-operative quality-of-life out- 2. Materials and methods
comes w5x, longer length of stay and convalescence
w3,4x and higher hospital charges as compared Data were collected for every consecutive hys-
with the vaginal approach w3,4x. Despite the over- terectomy at St. John’s Mercy Medical Center in
whelming evidence in favor of vaginal hysterec- St. Louis between 1988 and 1993. The medical
tomy, no formal guidelines have been adopted to records department at the hospital transcribed
assist physicians in selecting the most clinically the following information from the medical charts:
appropriate route of hysterectomy. In the absence
of such practice guidelines to help identify the 䢇 patient’s diagnosis and pelvic pathology;
appropriateness of a particular route of hysterec- 䢇 route of hysterectomy;
tomy, gynecologic surgeons continue to perform 䢇 uterine weight Žfrom the pathology record, if
abdominal and vaginal hysterectomy for similar the uterine weight was not recorded, the case
indications. was excluded from analysis .;
Although some gynecologists, professional soci- 䢇 complications Žfrom the face sheet of the med-
eties, government agencies, and managed care ical record.;
organizations acknowledge that abdominal hys- 䢇 hospital charges;
terectomy is the preferred route for more serious 䢇 length of stay;
pathologic conditions, it has been shown that 䢇 age;
physicians do not always select the abdominal 䢇 parity;
route based on the severity of the patient’s condi- 䢇 race; and
tion w6x. In order to study the surgical outcomes 䢇 type of insurance Ždefined as private, managed
of the routes of hysterectomy for each indication, care, Medicare, Medicaid, or self-pay..
we must first be able to assess the severity of
pathologic conditions. Length of stay was the number of days from
Specific guidelines incorporating uterine size, admission to discharge. Charges were the actual
risk factors, and uterine and adnexal mobility and amounts the hospital charged the patient or in-
accessibility have been shown to be useful in surer. Pelvic pathology and surgical procedures
helping physicians select the operative route of were coded using ICD-9 codes and CPT-4 surgi-
hysterectomy based on the severity of the patho- cal codes, respectively. The laparoscopically as-
logic condition. When physicians used these sisted vaginal hysterectomy category included any
S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169 161

Fig. 1. Selecting the route of hysterectomy.

procedure involving laparoscopy, including total cians in the study and coded by medical record
laparoscopic hysterectomy. personnel according to ICD-9 codes. Complica-
Complications were identified on the face sheet tions were then grouped into the following seven
of the medical record by each of the 126 physi- categories using ICD-9 codes:
162 S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169

䢇 hemorrhage; 100 000 times; in each cycle, either Fisher’s exact


䢇 acute myocardial infarction; test or the Cochran-Armitage test for trends was
䢇 post-operative fever or infection; computed and compared with the value obtained
䢇 intestinal obstruction; from the original data set w8,9x. The results were
䢇 urinary complications; then confirmed by repeating the process with
䢇 injury to bladder or ureter; and another random number seed. Test statistics were
䢇 accidental perforation of a blood vessel, nerve, declared statistically significant if the resulting P
or organ. value was less than 0.05.
The intent of the analyses was to compare
The study group was composed of women who outcomes for DDH patients with identical groups
underwent a decision-directed hysterectomy of non-DDH patients. The rationale was that if
ŽDDH physician group, n s 2., in which the route differences occurred between like groups, they
of hysterectomy was determined according to the must have been caused by differences in the
guidelines shown in Fig. 1. The comparison group surgical decision-making process. Because all hys-
Žnon-DDH physician group, n s 124. was com- terectomies were performed at one institution,
posed of women whose gynecologic surgeons did policies regarding charges and LOS affected all
not use the guidelines in Fig. 1, but instead used a patients equally. Thus, differences in outcomes
personal, informal, decision-making process to between a group of DDH cases and the corre-
determine the hysterectomy route for their sponding group of non-DDH cases must be at-
patients. tributed to differences in the decision process
leading up to the selection of the route of hys-
terectomy.
3. Statistical methods and analysis plan

Cases were classified by uterine weight Ž- 280


4. Results
or G 280 g., diagnostic type ŽI or II., decision
process ŽDDH or non-DDH., and surgical proce-
dure wabdominal hysterectomy ŽAH., laparoscopi- After excluding patients whose primary diag-
cally assisted vaginal hysterectomy ŽLAVH., or noses were related to invasive cancer or preg-
vaginal hysterectomy ŽVH.x. Diagnostic Type I nancy, patients with ambiguous ICD-9 procedure
includes patients with pathology confined to the codes, patients with unrecorded uterine weight,
uterus. Type II patients included those with and patients in whom pelvic pathology was not an
pathology suspected to extend beyond the con- indication, 4595 cases remained.
fines of the uterus. Type I patients Ž n s 3177. displayed conditions
Analysis of variance ŽANOVA. was applied to confined to the uterus, including leiomyomata,
uterine weight, charges, and length of stay ŽLOS. adenomyosis, bleeding, prolapse, carcinoma in situ
using the SAS䊛 ŽSAS Statistical Software, SAS of the cervix, or cervical intraepithelial neoplasia.
Institute Inc., SAS Campus, Campus Drive, Cary, Type II patients Ž n s 1418. had at least one
NC 27513, USA. procedure GLM w7x Complica- pathological condition that was thought to extend
tions were identified and grouped into seven cate- beyond the confines of the uterus, including con-
gories. An additional eighth complication cate- ditions such as endometriosis, pelvic adhesive dis-
gory was created to indicate for each case whether ease, adnexal pathology, chronic pelvic pain, and
any of the seven categories were present. The chronic pelvic inflammatory disease and, in most
SAS䊛 procedure MULTTEST was used to form cases, at least one Type I indication. Those with
simultaneous comparisons of the eight complica- low uterine weights Ž8᎐279 g. Ž n s 4086. repre-
tion rates. The bootstrap option was used to sented 89% of all cases; the remaining 509
control the experiment-wise error. Using the patients displayed uterine weights of 280 g or
bootstrap technique, the database was resampled more.
S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169
Fig. 2. Ža. Diagnostic profile when uterus - 280 g. Cases with diagnosis Ž%.. Žb. Diagnostic profile when uterus G 280 g. Cases with diagnosis Ž%..

163
164 S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169

Fig. 2. Ž Continued..
S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169 165

Fig. 2a,b represent detailed diagnostic profiles Among the low-uterine-weight Type II patients,
of the study population. Overall diagnostic pro- the mean charge was lower for the DDH patients
files between the DDH patients and non-DDH compared with the others, resulting in a statisti-
patients were similar. Prolapse, bleeding, fibroids, cally significant Ž P- 0.001. per-case savings of
and adenomyosis were the most prevalent diag- US$1455. Among the high-uterine-weight cases,
noses. the difference in charges for Type I patients was
To assess the medical and economic benefits of also statistically significant Ž Ps 0.001. ŽTable 1..
applying guidelines to determine the surgical ap- The application of formal practice guidelines
proach, the outcomes of the 675 hysterectomies resulted in reduced length of stay. For Type I
in the DDH group were compared with the out- cases in both weight groups, DDH patients re-
comes of the remaining 3920 hysterectomies in quired 0.92᎐1.43 fewer days Ž P- 0.003, Bonferr-
the non-DDH group. Table 1 shows mean uterine oni bound..
weights, mean charges, and mean length of stay Table 2 compares the mean charges and mean
ŽLOS.. Compared with the non-DDH group, the LOS stay for the three types of hysterectomy.
DDH group had a significantly higher percentage Regardless of uterine weight, none of the sur-
of Type I patients in both weight groups. In the geons in either group chose VH as the primary
low-uterine-weight group, the mean uterine surgical decision before laparotomy or laparo-
weight of the DDH group was 13.3 g less than the scopy when they suspected the patient’s condition
weight of the non-DDH patients. Although this extended beyond the confines of the uterus. In
was a statistically significant difference Ž Ps 0.003, the DDH group, all 609 Type I patients under-
ANOVA, Type III F-test., it was not surgically went VH without laparoscopy, regardless of uter-
significant. In the high-uterine-weight group, the ine weight. In comparison, among Type I patients
mean uterine weight of the DDH patients was in the non-DDH group, 1647 Ž64%. women un-
slightly larger than non-DDH cases, although the derwent vaginal hysterectomies, 833 Ž32%. under-
difference was not statistically significant. went abdominal hysterectomies and 88 Ž3%. un-
The charge comparison reveals that the mean derwent LAVH. Among Type II, low-uterine-
charges of the DDH group were significantly less weight patients in the DDH group, 61 Ž96%.
than the mean charges of non-DDH cases, re- underwent laparoscopy to determine the severity
gardless of patient type or uterine weight. Among of their condition before uterine removal, result-
low-uterine-weight Type I patients, the mean ing in reduced charges and LOS when compared
charge was lower for DDH patients compared with the non-DDH group. In addition, in 4% of
with the others, resulting in a statistically signifi- the Type II DDH patients in the low-uterine-
cant Ž P- 0.001. per-case savings of US$1219. weight group, the laparoscope was not indicated

Table 1
Number of cases, mean uterus weight, mean charges, and mean LOS

Uterus Type DDH group Non-DDH group


size N Uterus weight Charges LOS N Uterus weight Charges LOS
Žg. ŽUS$. Ždays. Žg. ŽUS$. Ždays.

Uterus Ia 559 114.82 4343 2.53 2270 122.42 5562 3.44


- 280 g IIb 65 107.74 4990 2.83 1192 126.39 6445 3.90

Uterus Ia 50 488.72 4719 2.26 298 470.95 6068 3.69


G 280 g IIb 1 636.00 5372 4.00 160 490.21 6459 3.90
a
Type I patients displayed pathology confined to the uterus.
b
Type II patients displayed pathology extending beyond the confines of the uterus and, in most cases, Type I conditions. Normal
weight of the uterus is 70᎐125 g.
166 S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169

Table 2
Number of cases, mean charges, and mean LOS for each procedurea

Uterus Type AH LAVH VH


size N Charges LOS N Charges LOS N Charges LOS
ŽUS$. Ždays. ŽUS$. Ždays. ŽUS$. Ždays.

DDH group
Uterus Ib 0 ᎐ ᎐ 0 ᎐ ᎐ 559 4343 2.53
- 280 g IIc 4 6098 3.75 61 4917 2.77 0 ᎐ ᎐
Uterus Ib 0 ᎐ ᎐ 0 ᎐ ᎐ 50 4719 2.26
G 280 g IIc 1 5372 4.00 0 ᎐ ᎐ 0 ᎐ ᎐

Non-DDH group
Uterus Ib 609 6230 4.10 78 7500 2.63 1583 5209 3.23
- 280 g IIc 964 6390 4.13 228 6679 2.92 0 ᎐ ᎐
Uterus Ib 224 6052 3.94 10 8774 2.70 64 5701 2.98
G 280 g IIc 157 6422 3.92 3 8394 3.00 0 ᎐ ᎐
a
Abbre¨ iations: AH, abdominal hysterectomy; LAVH, laparoscopically assisted vaginal hysterectomy; VH, vaginal hysterectomy.
b
Type I patients displayed pathology confined to the uterus.
c
Type II patients displayed pathology extending beyond the confines of the uterus and, in most cases, Type I conditions.

because the patients exhibited vaginal inaccessi- As shown in Table 3, among the 61 LAVH
bility, which dictated an abdominal hysterectomy. Type II cases in the low-uterine-weight DDH
In comparison, among Type II, low-uterine-weight group, 57 Ž93%. procedures were completed via
patients in the non-DDH group, 228 Ž19%. women the vaginal route following diagnostic laparo-
underwent laparoscopy before uterine removal. scopy. In comparison, among Type II patients in
Among Type I, low-uterine weight patients in the the low-uterine-weight, non-DDH group, 81 Ž36%.
non-DDH group, 78 Ž3%. diagnostic laparo- of 228 LAVH procedures were completed through
scopies were performed at a mean charge of the abdominal route and 147 Ž64%. were com-
US$7500. pleted vaginally.

Table 3
Number of cases, mean charges, and mean LOS when laparoscopy was used a

Uterus Type Surgery DDH group Non-DDH group


size N Charges LOS N Charges LOS
ŽUS$. Ždays. ŽUS$. Ždays.

Uterus Ib LªA 0 ᎐ ᎐ 8 6841 3.75


- 280 g LªV 0 ᎐ ᎐ 70 7575 2.50
IIc LªA 4 9655 5.50 81 6465 3.94
LªV 57 4585 2.58 147 6798 2.36
Uterus Ib LªA 0 ᎐ ᎐ 0 ᎐ ᎐
G 280 g LªV 0 ᎐ ᎐ 10 8774 2.70
IIc LªA 0 ᎐ ᎐ 1 6448 3.00
LªV 0 ᎐ ᎐ 2 9367 3.00
a
Abbre¨ iations: L ª A represents a hysterectomy that includes laparoscopy to confirm the diagnosis and, consequently, the need
to complete the surgery via the abdominal route. L ª V represents a hysterectomy that includes laparoscopy to confirm the
diagnosis and, consequently, the ability to complete the surgery via the vaginal route.
b
Type I patients displayed pathology confined to the uterus.
c
Type II patients displayed pathology extending beyond the confines of the uterus and, in most cases, Type I conditions.
S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169 167

Table 4
Complications Ž% of cases. a

Complication DDH group Non-DDH group


AH LªA LªV VH AH LªA LªV VH
Ns5 Ns4 N s 57 N s 609 N s 1954 N s 90 N s 229 N s 1647

Hemorrhage 0 0 3.5 2.8 4.6 5.6 3.9 3.3


Acute myocardial 0 0 0 0.5 0.4 1.1 0 0.7
infarction
Post-operative fever 0 0 1.8 2.5 0.36 5.6 0.4 1.3
or infection
Intestinal obstruction 0 25.0 0 0 0.5 1.1 0 0.1
Urinary complications 0 0 0 0.3 0.3 0 0 1.3
Injury to bladder 0 25.0 0 0.3 0.1 0 0 0.1
or ureter
Accidental perforation: 0 50.0 1.8 2.3 1.4 0 2.2 1.2
blood vessel, nerve or organ
Any complication 0 50.0 7.0 7.9 10.1 13.3 5.7 7.3
a
Abre¨ iations: L ª A represents a hysterectomy that includes laparoscopy to confirm the diagnosis and, consequently, the need
to complete the surgery via the abdominal route. L ª V represents a hysterectomy that includes laparoscopy to confirm the
diagnosis and, consequently, the ability to complete the surgery via the vaginal route. AH, abdominal hysterectomy; VH, vaginal
hysterectomy.

Because of small sample sizes, it was not possi- 0.003., urinary complications Ž P- 0.003. and the
ble to compare the complication rates reported overall complication rates Ž P- 0.002. ŽTable 4..
for DDH and non-DDH patients. In order to Table 5 converts the findings into potential
compare the complication rate for AH and VH, savings per 1000 hysterectomies among patients
the rates for the DDH and non-DDH groups with uterine weights less than 280 g. The savings
were combined. Significant differences in favor of were most dramatic. Incorporating the guidelines
VH were detected for post-operative fever or and performing vaginal hysterectomy for all
infection Ž P- 0.005., intestinal obstruction Ž P- Type I patients with vaginal accessibility would

Table 5
Impact of applying the decision rule a

Diagnostic type Outcomes associated with Savings per case Savings per
and outcome Current Recommended Mean Ž%. 1000 cases
surgery surgery

Type Ib AH VH
Charges ŽUS$. 6182 4998 1184 19.2% 1 184 000
LOS Ždays. 4.05 3.03 1.02 25.2% 1020 days
Complications 9.1% 7.4% 1.7% 18.9% 17 cases wro complications

Type IIc AH LªV


Charges ŽUS$. 6393 6208 185 2.9% 185 000
LOS Ždays. 4.10 2.43 1.67 40.8% 1670 days
Complications 10.7% 7.3% 3.4% 31.8% 34 cases wro complications
a
Abbre¨ iations: AH, abdominal hysterectomy; VH, vaginal hysterectomy.
b
Type I patients displayed pathology confined to the uterus.
c
Type II patients displayed pathology extending beyond the confines of the uterus and, in most cases, Type I conditions.
168 S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169

have resulted in savings of US$1 184 000 for every to extend outside of the uterus. In the DDH
1000 procedures performed at the study hospital. group, the laparoscope was employed in 96% of
Applying the guidelines would free 1020 patient- such cases and, after documenting the absence of
bed days and result in approximately a 20% re- pathologic contraindications, 93% of those diag-
duction in complications. nostic laparoscopy cases were completed vagi-
nally. In comparison, in the non-DDH group,
physicians performed diagnostic laparoscopy in
5. Discussion only 3% of Type II patients and completed 36%
of these diagnostic laparoscopy cases abdomi-
Two outcome-based studies have shown that by nally. The limited use of the laparoscope by
using a formal decision process, such as the one physicians in the non-DDH group may reflect
presented here, physicians can perform VH in they were confident enough in their diagnostic
approximately 77᎐89% of their patients w3,10x. skills that they did not require laparoscopic evi-
The results of the current study support these dence to confirm the severity of the disease or
findings and also show that economic outcomes they were convinced that AH is required when-
ᎏ hospital charges and length of stay ᎏ and ever the pathologic condition is suspected to ex-
medical outcomes, specifically complication rates, tend beyond the uterus. However, since both the
are significantly improved when the surgeon uses
DDH and non-DDH groups were similar, one can
formal guidelines to select the appropriate hys-
assume that had the severity of the disease been
terectomy route.
confirmed laparoscopically, more women would
The economic benefits of using a formal deci-
have undergone VH.
sion process were especially apparent among
Traditionally, the history, physical examination,
women whose conditions were confined to the
and imaging techniques, such as ultrasound and
uterus. The guidelines recommend VH when the
X-ray studies, have been used to determine
disease is confined to the uterus, as in the case of
whether pathology extended beyond the uterus.
prolapse, small symptomatic leiomyomata, ade-
nomyosis, recurrent or severe dysfunctional uter- However, several investigators have proven that
ine bleeding, or carcinoma in situ of the cervix. these techniques are not sufficiently accurate to
Thus, in the DDH group, VH was performed in adequately document the severity of conditions
all 609 women with disease confined to the uterus such as endometriosis, adnexal pathology, chronic
ŽType I patients. at a mean charge of US$4343 or pelvic pain, and pelvic inflammatory disease
US$4719, depending on uterine weight. Contrast w3,11,12x. As this analysis shows, judicious use of
this with the non-DDH group, where both AH the laparoscope to precisely document the sever-
and LAVH were performed at mean charges of ity of the disease process when indicated yields
US$6230 and US$7500, respectively, in some significantly improved medical and economic out-
low-uterine-weight Type I patients. Had physi- comes.
cians used a formal decision process to direct The data on complications reported in this
these women to the clinically appropriate VH study for AH and VH were statistically different
route a mean savings per case of US$1184 would and support the results of previous studies
have been realized, and the complications and showing that the vaginal route is associated with
higher hospital charges associated AH and LAVH fewer complications. Overall complication rates
could have been avoided. for the surgeons in this study, however, were
For patients with disease suspected to extend similar regardless of whether the surgeon used
beyond the confines of the uterus ŽType II., the formal guidelines presented here or another, less
benefits of the guidelines were reflected in the formal process to determine the route of hys-
frequency of diagnostic laparoscopy and the con- terectomy. This was to be expected because gyne-
version to VH. The guidelines recommend la- cologic surgeons choose procedures in which they
paroscopic examination when pathology appears are experienced and have surgical competence.
S.R. Ko¨ ac r International Journal of Gynecology & Obstetrics 71 (2000) 159᎐169 169

At the teaching hospital where this study was is cost-effective and meets the standard of quality
conducted, the ratio of AH to VH was approxi- care.
mately 1.2:1, much lower than the national ratio
of 2.06:1, which demonstrated that the surgeons
in this study were highly skilled in VH techniques. Acknowledgments
However, with the application of the formal
guidelines presented here, the VH rate increased
Statistical analysis was supported in part by an
even more.
unrestricted educational grant from Ethicon
This study is not without its weaknesses. The
Endo-Surgery, Cincinnati, Ohio.
effect of confounding variables, such as age dif-
ferences, preexisting medical conditions, and con-
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