ALPHA ADRENOCEPTOR BLOCKERS PROPRANOLOL

Neuroleptic drugs: Chlorpromazine, Haloperidol Prototype agent

Antidepressant: Trazodone Actions: Blocks action of Isoproterenol
NON SELECTIVE ALPHA BLOCKERS Uses: Prophylaxis of angina pectoris,
Phentolamine Reversible blocker supraventricular, ventricular dysrhythmias
Phenoxybenzamine Irreversible blocker Migraine headache
Uses: Pheochromocytoma, Erectile dysfunction, Vasospasm in Raynaud's syndrome Antihypertensive
(-) chronotropic agent in anxiety,
SELECTIVE ALPHA BLOCKERS “zosins”
hyperthyroidism
Prazosin Chronic glaucoma
Doxazosin Myocardial infarction
Alfuzosin Risk: QT prolongation ADR: Bronchoconstriction, Arrhythmias, Sexual
Tamsulosin Risk: Increase intraoperative floppy iris impairment, Disturbances metabolism,
syndrome Patients taking insulin, Elevate levels of
Benign prostatic hyperplasia triglycerides
Oral Contraindicated: Patient with diabetes
Silodosin Benign prostatic hyperplasia

IA
Mask hypoglycemic: Sweat, Nausea
Indoramin Antihypertensive
Urapidil Antihypertensive, Benign prostatic INTRINSIC SYMPATHOMIMETIC ACTIVITY
hyperplasia
Partial agonists effect: Pindolol (Visken), Acebutolol (Sectral),
Terazosin Indications for alpha 1 sympatholytics Labetalol (Trandate)

GE
Inhibition of alpha 1 adrenergic smooth Advantage: Rebound hypertension or upon
muscle withdrawal
High blood pressure, Benign prostatic
hyperplasia
MEMBRANE STABILIZING ACTIVITY
ADR: First dose phenomenon/SYNCOPE
Orthostatic hypotension Anesthetic effect: Pindolol, Acebutolol, Propranolol,
Metoprolol, Labetalol

Y
Adjusted dose: 1/3, 1/4
Administration: Bedtime Disadvantage: Ocular topical

DRUGS AFFECTING NEUROTANSMITTER STORAGE

NON SELECTIVE BETA BLOCKERS
Propranolol
aH Plant alkaloid
Carteolol Reserpine Dependent transport of biogenic amines
Nadolol (NE, EPI, Dopamine, 5-HT)
Penbutolol Blocks storage of catecholamines
Pindolol Affecting neurotransmitter storage
Sotalol
k
Timolol ADRENERGIC NEURON BLOCKER
CARDIOSELECTIVE BETA BLOCKERS Guanadrel
Bisoprolol Guanethidine
be

Acebutolol Bethanidine
Esmolol Debrisoquin
Atenolol
Metoprolol DIRECT ACTING CHOLINOMIMETICS
Celiprolol Choline esters: Acetylcholine, Carbachol chloride,
Nebivolol Betanechol, Methacholine chloride
Re

BETA BLOCKERS USED IN GLAUCOMA Alkaloids: Pilocarpine, Nicotine, Muscarine

Non-selective: Timolol, Levobunolol
Selective: Betaxolol TREATMENT OF ORGANOPHOSPHATE POISONING
Partial agonist: Carteolol Regenerator compounds Early course of organophosphate
Other: Metipranolol poisoning
Binding of Organophosphate to
@

acetylcholinesterase
Oxime derivatives: Pralidoxime
Physiologic antidote Long term administration: Atropine

NICOTINIC BLOCKERS
Ganglionic blockers Inhibit NN
Neuromuscular blockers Inhibit NM

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