Clinical Immunology:

Principles and Practice

FIFTH ED]TION

BOBERT R. RICH [4D

rnerirus, univ.nny .i lhbrm.r BiNnrxhanr, Bnmnrshnr, lr, LISA

THOMAS A, FLEISHEF IIID

WLLIAM I. SHEANEN MD, PhD

IIARRY W, SCflNOIOEB, JB, MD, PhD

AI'IIIONY J, FBEW MD, FRCP

::;\ EL A IIT, WEYAND I!1D, PhD

:J.
 CONTENTS

fuF,Ngoplnldbarql6,
Tl'e H!flai C0nrlefle svnem, Basic coiceprs rnd

:::- \a :. iciples ol lm uno Bcsponse 22 Phdsocrra Delichrci.r 3r g

23Ma{cIlk,Ba30[l'ik,andMaftcylosk,335
24 E0sin0[hilsind Eositrophilh,3{9

r-::_ r.:!pld Gei* G€ie Pmdnds.,'d PART THEEE HostDelenses ro lnlectiors

': !! r H noconpdihir(y Cohtlei,79

LrolT Ce lBecosiilion: Matiiq Pirl'osens

tsrii ard Cyrokirc Receptots, r?7

l-L.rb Adh.doi rnd Tdfiickinr, I71

I-C.I rdiYrioi and Idlenma th3

PABT F0UR lnmmological oeli.iencies
Ee. Necrosk and rb rmmunose iiiry. re7

in lmmuniry and lifiinndion,207 su$errd lmmuiodeicieicy,

-EDtioh 451

rTWo Hosl DBIense Mechanisns P nao Anrihody D.lichi.i.., 471

_ €nd lnflammaiion
_lllbllintumlion,,a
rFT-C.ll Soh$ts iid Co
a-dn I tnohocnB
,,-z-|ft@.cai!AEl1.6
Primafl 'I Cell lmmunodelici.icier 439
re l ol fte liiammaioq
Jr.,a6h,E'fun1,@,h49en€ii,.5s,
M;'4Ll!!dl,Exnn\ehn@qs|i}lnED@s3ast
aid NaruhlKlle, Celk,2{,
37 lnlodiom iirl'. hnonoconprenhed HGr, t3
3ahmmeDefichmi.sdli.lxtemBilAge,s3s
 CONTENTS

ss Hunan lnmrmdeficiencyvn$ lnhcrior and Acqunsd PART SEVTN 0rgaFspecilic lnfl ammaiory
|f,fl n nod.rctrq Syid rcne, 545

lnn ohen.rolrshalDhddsq3,15
10 AdoadiIody.t/tsdiacd Ptsnocopiss olPrimary

PAFT FIVE Alleqic Diseases

41 lmmuioh s ica I Mechanisms oI AiMat D h.ascs a

Unicaia, Aisio.dema, and Anapl'yhxi!, 535

Adoimmuna Ps [t,ar umpdhi6, s03

Allersic Beacri0nsh srinsinq rnd Snins

Ahlic and coird Dam irG,6rr

Eoritrophil A$ocialed G rnn in&nii iI lmmunolo! ha I l,!ns Dneases, 96?

47 All.Eic DisodeE ol rl'e Eye,641

rnnunoro9icir 0crla, Dh6a.e, 993
aB 0 s Hype6s Biriviry, 649
lmmmololical 0issasF olrl'c GarrcinGnin'l
49 occupdioml n6lndory Alklgi6,669
liiammarory heDat i iliad Disea ies, I 021

PAfiT SII Sysr€mic lmmone Diseases

Mechanhms ol AdDinnriir, 677 PAnT EICHT Inrmtrnoloqy di Nedplasia
sydrmic trDm Er}{lefldGnii 635
Afu:)Fnr,MrPwdnrblc*914s@a,fugzn,
T3LynDhoidtsn}cnias,l0{9
Ju{enils ldiopdtic Antuiis, 7?3
R A Can.Pedwffq.thrl\s htmn
saaAfusfrL4]nYlus'lfuAhvN
s.r.odemr sFrdnic scr.b.n, 743 (amil\fuah'Srrur]M|c6rcarllllEn
lnframmdDry ilGch 0is.as6, 75?
Aa:\Nbfur,LBtrdok|'he PABT NINE T6nspl.nt8rion
Con..pu,id cl'0llenq8 in 0lganrEnslla di0n
small Msdi!n.v.6t.l P maryvrscuhh,7sg
and tuFdiorlmmuiorupprc$ioi,
aashd Artu rrturi. h, aleda bnE a M
I' aa-Vo$al V. sculhides, 30€ hrtuJ wN4sfhiastu k E Ae:a. tdt Ln
lnnune R.coisriMior Then lor
SFhic Alrjirrmm.hry syndrumst 325

H3mdopoi.ric Stm C.ll Thisrlaitariotr lor Malisna

adipio$h'lirid sYndmme, 335
PMTNMfu)i,ldlD8ow14,fuelfullr]d
:::- -a'i Prevantion and Therapy of PABT ELEVEN Draqnostic lmmunoloqy
omunolosical 0iseases
r hgtotrrinris,rpY: Replacena and
93 Asesme Dr Fr nclioidt tmmum H6[ tr ns6 in

Eh rhEpy tor Prihary tmmurc oefciency

94 Assesme Ne 0!iit Fuidion, 1273
futrLry&el'DNg]a[drc
95 A.$smdorHnmrArre4icDis.as6,1233

I Pi maDadi$rrrr7, 96 M.lecularMdllodtl29T

a ha xinasE Anbqonkl! h lt.mry

-roduhriiq
J hrloqical aod hfirnmrbo
A1 Sdeftd cD M0lecules rid Th.nChircb dicr,r3rl
a oI titummrrry a2 tlho rry Bsrercmc varue., l3r7
-!iEru.iifd.
mrhr rumdtor
:fildr|NrJMdli@r
n bo6edfi ol All.lgic ohease, tzi