Question 7 of 46 

Regarding the metabolism of sodium

nitroprusside:

5 out of 5

True
Reaction in the red blood cell
causes release of CN – and
methaemoglobin
False

True
CN – combines with vitamin
B 12 to yield toxic thiocyanate
False

True
Rhodanase enzyme is found
only in the liver
False

True
Red blood cells can liberate
CN – from thiocyanate via the
enzyme thiocyanate oxidase
False

True
Thiocyanate and CN – are
equally toxic to cytochrome
oxidase
False

Explanation
Sodium nitroprusside enters red blood cells and
combines with oxyhaemoglobin to form five CN –
ions and methaemoglobin. CN – and
methaemoglobin form cyanomethaemoglobin
(non-toxic). CN – ions react with sulphydryl groups
in liver and renal tissue secondary to the enzyme
action of rhodanase. Thiocyanate is produced,
which is 100 times less toxic than CN –.
Thiocyanate is excreted renally with an elimination
half-life of two days. It can also be converted to
CN – by thiocyanate oxidase found in red blood
cells.
28777

Rate this question:

Next Question

Previous Question Tag Question

Feedback End Session

Difficulty: Average

Session Progress

Responses Correct: 12

Responses Incorrect: 7

Responses Total: 19

Responses - % Correct: 63%

Blog About Pastest Contact Us Help

© Pastest 2022