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  • Sangha Et Al 2023 Smart As A Novel Artificial Intelligence Tool To Detect Severe Aortic Stenosis From

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    This document describes a study that developed an artificial intelligence tool called SMART-AS to detect severe aortic stenosis from electrocardiogram images. The tool was trained on over 475,000 ECGs paired with echocardiograms, including nearly 7,000 with severe aortic stenosis. It uses a convolutional neural network and can integrate a patient's age, sex, and ejection fraction. Internal and external validation tests achieved area under the receiver operating characteristic curves of 0.84 to 0.87, demonstrating the tool's ability to reliably detect severe aortic stenosis across different ECG lead layouts with only image data. This AI approach could enable widespread screening for severe aortic stenosis with minimal resources.

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    This document describes a study that developed an artificial intelligence tool called SMART-AS to detect severe aortic stenosis from electrocardiogram images. The tool was trained on over 475,000 ECGs paired with echocardiograms, including nearly 7,000 with severe aortic stenosis. It uses a convolutional neural network and can integrate a patient's age, sex, and ejection fraction. Internal and external validation tests achieved area under the receiver operating characteristic curves of 0.84 to 0.87, demonstrating the tool's ability to reliably detect severe aortic stenosis across different ECG lead layouts with only image data. This AI approach could enable widespread screening for severe aortic stenosis with minimal resources.

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    7 views1 page

    Sangha Et Al 2023 Smart As A Novel Artificial Intelligence Tool To Detect Severe Aortic Stenosis From

    Uploaded by

    施展
    This document describes a study that developed an artificial intelligence tool called SMART-AS to detect severe aortic stenosis from electrocardiogram images. The tool was trained on over 475,000 ECGs paired with echocardiograms, including nearly 7,000 with severe aortic stenosis. It uses a convolutional neural network and can integrate a patient's age, sex, and ejection fraction. Internal and external validation tests achieved area under the receiver operating characteristic curves of 0.84 to 0.87, demonstrating the tool's ability to reliably detect severe aortic stenosis across different ECG lead layouts with only image data. This AI approach could enable widespread screening for severe aortic stenosis with minimal resources.

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    of 1

    2409

    JACC March 7, 2023


    Volume 81, Issue 8, suppl A

    Spotlight on Special Topics


    SMART-AS: A NOVEL ARTIFICIAL INTELLIGENCE TOOL TO DETECT SEVERE AORTIC STENOSIS
    FROM ELECTROCARDIOGRAPHIC IMAGES
    Poster Contributions
    Poster Hall_Hall F
    Monday, March 6, 2023, 12:45 p.m.-1:30 p.m.

    Session Title: Spotlight on Special Topics: Spotlight on Special Topics: Innovation, Digital Health, and Technology 18
    Abstract Category: 60. Spotlight on Special Topics: Innovation, Digital Health, and Technology
    Presentation Number: 1812-033

    Authors: Veer Sangha, Evangelos K. Oikonomou, Akshay Khunte, Kartikeye Gupta, Bobak Mortazavi, Rohan Khera, Yale University, New
    Haven, CT, USA
    Background: Early detection of severe aortic stenosis (AS) is critical for timely intervention to prevent morbidity and mortality. We sought
    to develop a layout-independent artificial intelligence (AI) model that can identify severe AS directly from electrocardiographic (ECG)
    images.
    Methods: We identified 475,968 ECGs with paired echocardiographic readings within 15 days of the index ECG (age 68±10 years,
    n=213,859 women), including n=6,988 (1.5%) with severe AS to train a convolutional neural network (CNN) model predicting severe AS.
    This was subsequently combined with the patientʼs age, sex, and predicted ejection fraction (EF) from our previously validated AI-ECG
    EF model to build an ensemble model. In addition to internal validation, we validated our model on 200 ECG images from Lake Regional
    Hospital in rural Missouri (n=8, 4% with severe AS).
    Results: In the internal testing set, the model had an AUROC of 0.84 (95%CI, 0.81-0.87). For the ensemble model AUROC was 0.87
    (95%CI, 0.84-0.89). The model demonstrated consistent performance across different lead layouts. In external validation, the model
    performed comparably (AUROC 0.85 and 0.87, respectively). GradCAM analysis showed localization of discriminative signal to the anterior
    precordial leads.
    Conclusion: A novel AI-ECG model can reliably detect severe AS directly from ECG images without the need for raw signal data. This
    approach may enable point-of-care screening of severe AS across diverse settings with minimal resource utilization.

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