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Second Edition
International Embryological Terminology
FIPAT
The Federative International Programme for Anatomical Terminology
A programme of the International Federation of Associations of Anatomists (IFAA)
Published pending approval by the General Assembly at the next Congress of IFAA (2019).
License:
The publication of Terminologia Embryologica is under a Creative Commons Attribution-NoDerivatives 4.0
International (CC BY-ND 4.0) license
The individual terms in this terminology are within the public domain. Statements about terms being part
of this international standard terminology should use the above bibliographic reference to cite this
terminology. The unaltered PDF files of this terminology may be freely copied and distributed by
users. IFAA member societies are authorized to publish translations of this terminology. Authors of other
works that might be considered derivative should write to the Chair of FIPAT for permission to publish a
derivative work.
Preface
This, second edition of Terminologia Embryologica, was developed from the published Terminologia
Embryologica [1]. It has been expanded substantially in extent and comprehensiveness, with the inclusion
of new terms from the fields of normal development, congenital anomalies and growth variations. This is
in accordance with the FIPAT policy of enhancing clinical relevance. It incorporates new, relevant terms in
clinical areas and in anatomical science fields such as embryology, neuroscience, stem cell biology and
in vitro fertilisation.
The format is changed relative to that of the 2013 publication. The order of the early, more general
sections was changed to a more consistent sequence, and the principal location of terms relating to early
development was brought forward from the Stages section. As before, the main part consists of pure
terms, the development of the early embryo and sections covering the later development of each system.
The arrangement of terms follows the developmental sequence as closely as possible. The final part is
chronological, indicating the times of appearance and prevalence of individual features and includes the
Carnegie Stages.
The official FIPAT terms are in Latin. This enables translation into any vernacular, in the present instance
English. The document is divided into five chapters (see below). New terms were introduced in all
sections of TE, in particular: The CNS section was extended and revised in response to new molecular
data. So were terms relating to stem cells, taking into account recent developments in that field. There
was a major increase in the number of terms relating to congenital anomalies, the core clinical elements
of TE. These are becoming increasingly relevant as imaging technologies and clinical genetics identify
and classify progressively more of them. Many of these were taken from the excellent set of papers in
Elements of Morphology: Standard Terminology, produced by a group of over 30 clinical geneticists [2-9],
and a clinical text on dysmorphologies [10]. Only terms describing qualitatively unequivocal or
quantitatively determinable anomalies [11] were included. The Latin terms have been reviewed by
members of the FIPAT Latin Subcommittee.
References
1. FIPAT. 2013. Terminologia Embryologica. Stuttgart: Thieme.
2. Carey JC. 2009. Editorial comment: Editor’s foreword to a special issue ‘Elements of Morphology:
Standard terminology’. Am J Med Genet Part A 149A:1
3. Allanson JE, Biesecker LG, Carey JC, Hennekam RCM. 2009. Elements of morphology:
Introduction. Am J Med Genet Part A 149A:2-5.
4. Allanson JE, Cunniff C, Hoyme HE, McGaughran J, Muenke M, Neri G. 2009. Elements of
morphology: Standard terminology for the head and face. Am J Med Genet Part A 149A:6-28.
5. Hall BD, Graham JM Jr., Cassidy SB, Opitz JM. 2009. Elements of morphology: Standard
terminology for the periorbital region. Am J Med Genet Part A 149A:29-39.
6. Hunter A, Frias J, Gillessen-Kaesbach G, Hughes H, Jones K, Wilson L. 2009. Elements of
morphology: Standard terminology for the ear. Am J Med Genet Part A 149A:40-60.
7. Hennekam RCM, Cormier-Daire V, Hall J, Méhes K, Patton M, Stevenson R. 2009. Elements of
morphology: Standard terminology for the nose and philtrum. Am J Med Genet Part A 149A:61-76.
8. Carey JC, Cohen MM Jr., Curry CJR, Devriendt K, Holmes LB, Verloes A. 2009. Elements of
morphology: Standard terminology for the lips, mouth and oral region. Am J Med Genet Part A
147A:77-92.
9. Biesecker LG, Aase JM, Clericuzio C, Gurrieri F, Temple IK, Toriello H. 2009. Elements of
morphology: Standard terminology for the hands and feet. Am J Med Genet Part A 147A:93-127.
10. Reardon W. 2015. The Bedside Dysmorphologist, 2nd ed. Oxford University Press.
11. Gripp KW, Slavotinek AM, Hall JG, Allanson JE. 2007. Handbook of Physical Measurements. 2nd
ed. Oxford University Press.
John Fraher
Coordinator TE; Chair FIPAT
FIPAT.library.dal.ca TE2 2
Acknowledgements
Financial
FIPAT wishes to thank the Dalhousie University Libraries for covering the costs of publication, and all the
institutions, sections, departments, Societies and Associations that materially and financially supported its
members in their work.
Academic
FIPAT meetings were held in conjunction with and thus assisted by the XVIIIth Congress of the
International Federation of Associations of Anatomists [Beijing 2014], the International Symposium on
Morphology at Istanbul [2015] and the Anatomische Gesellschaft [Göttingen 2016].
FIPAT wishes to thank the following Experts/Consultants who assisted the TE Working Group during its
deliberations: Pierre Sprumont [Switzerland], Allesandro Riva [Italy], Kieran McDermott [Ireland], Hans-
Werner Denker [Germany], Colin Wendell-Smith* [Australia], Bernard Moxham [UK], Marina Kapitonova
[Russia and Malaysia], Rick Livesey [UK], Luis Puelles (Spain), David Brynmor Thomas [UK], Beate
Brand-Saberi [Germany], Marina Quartu (Italy), David Kachlik (Czech Republic) with the aid and support
of the Officers of FIPAT [Pierre Sprumont (Secretary), Paul E. Neumann (Deputy Secretary)] and the
Latin Subcommittee [John Fraher, Paul E. Neumann, Pierre Sprumont, Alessandro Riva].
* former Secretary to FCAT and subsequently FICAT, deceased
While the individuals acknowledged here gave expert advice, the final Terminology is the responsibility of
FIPAT
FIPAT.library.dal.ca TE2 3
Contents
Front-Matter
• Title
• License
• Preface
• Acknowledgements
• Contents
• User Guide
Part 1
Caput I Nomina generalia Ch. 1 General terms
Caput II Embryogenesis Ch. 2 Embryogenesis
Caput III. Ontogenesis Ch. 3 Ontogenesis
Caput IV Histogenesis generalis Ch. 4 General histogenesis
Part 2
Caput V Organogenesis Ch. 5 Organogenesis
• Systema skeletale • Skeletal system
• Systema musculare • Muscular system
• Facies • Face
• Systema digestorium • Alimentary system
Part 3
Caput V Organogenesis (continued) Ch. 5 Organogenesis (continued)
• Systema respiratorium • Respiratory system
• Systema urinarium • Urinary system
• Systemata genitalia • Genital systems
• Coeloma et septa • Coelom and septa
• Glandulae endocrinae • Endocrine glands
• Systema cardiovasculare • Cardiovascular system
• Systema lymphoideum • Lymphoid system
Part 4
Caput V Organogenesis (continued) Ch. 5 Organogenesis (continued)
• Systema nervosum • Nervous system
• Organa sensuum • Sense organs
• Integumentum commune • The integument
Caput VI Adnexa embryonica et fetalia Ch. 6 Developmental adnexa
Part 5
Caput VII Notatio temporum ontologicorum Ch. 7 Temporal stages of development
Caput VIII Nomina dysmorphica Ch. 8 Dysmorphia terms
FIPAT.library.dal.ca TE2 4
User Guide
In accordance with the decision at the Istanbul meeting of FIPAT (2015), and as with the other FIPAT
terminologies, a new, 6-column format has been adopted. The six columns comprise the official Latin
term, Latin synonym(s) where relevant, English (UK and US) terms and English synonym(s) where
relevant. The final column includes references to Endnotes and eponyms. The former are placed in a
separate section at the end of each Part.
Each term is in the singular, except where it is a heading of a list, in which case the plural is appropriate.
A proper name between the symbols § and § indicates that the name is part of an eponym associated
with the term in the same row. The acronym IVF indicates features, details of which have been
elucidated in in vitro fertilization (IVF) procedures. A note of "In part" in the final column indicates that the
contribution of an entity to the structure in question is partial. In the urogenital systems, female
derivatives are identified by ♀ and male derivatives by ♂.
The order of terms follows development naturally for each system. Indenting and styles of heading are
used to indicate the relations of terms to one another, as follows:
FIPAT.library.dal.ca TE2 5
TERMINOLOGIA EMBRYOLOGICA
Second Edition
International Embryological Terminology
FIPAT
The Federative International Programme for Anatomical Terminology
A programme of the International Federation of Associations of Anatomists (IFAA)
TE2, PART I
Contents
Published pending approval by the General Assembly at the next Congress of IFAA (2019)
The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use
the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA
member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the
Chair of FIPAT for permission to publish a derivative work.
Caput I: NOMINA GENERALIA Chapter 1: GENERAL TERMS
160 Mensurae embryonicae et Embryonic and fetal Embryonic and fetal Endnote 12
fetales measurements measurements
161 Aetas a fecundatione Fertilization age Fertilization age Endnote 13
162 Aetas ab ovulatione Ovulation age Ovulation age Endnote 14
163 Aetas ab inseminatione Insemination age Insemination age Endnote 15
164 Hebdomades post coitum Coital weeks Coital weeks Endnote 16
165 Hebdomades post menses ultimas Menstrual weeks Menstrual weeks Endnote 17
166 Longitudo corona calx Crown-heel length Crownheel length CHL; Total length; Standing height
167 Longitudo maxima Greatest length Greatest length GL Endnote 18
168 Longitudo corona nates Crown-rump length Crownrump length CRL; Sitting height
169 Longitudo cervix nates Neck-rump length Neckrump length
170 Longitudo ossis femoris ossificati Ossified femur length Ossified femur length
171 Longitudo pedis Foot length Foot length FL
172 Diameter biparietalis Biparietal diameter Biparietal diameter
173 Diameter cavitatis amnioticae Amniotic cavity diameter Amniotic cavity diameter
174 Diameter cavitatis chorionicae Chorionic cavity diameter Chorionic cavity diameter
175 Diameter vesiculae umbilicalis Diameter sacci vitellini Umbilical vesicle diameter Umbilical vesicle diameter Yolk sac diameter
176 Circumferentia abdominis Abdominal circumference Abdominal circumference
177 Circumferentia capitis Head circumference Head circumference
178 Pondus corporis Body weight Body weight
179 Pondus encephali Brain weight Brain weight
180 Pondus placentae Placental weight Placental weight
319 Folliculus ovaricus primarius Primary ovarian follicle Primary ovarian follicle
320 Folliculus ovaricus secundarius Secondary ovarian follicle Secondary ovarian follicle
337 PELLUCIDAGENESIS Zonagenesis ZONA PELLUCIDA FORMATION ZONA PELLUCIDA FORMATION Endnote 22
338 Epithelium simplex cuboideum Simple cuboidal epithelium of Simple cuboidal epithelium of
folliculi ovarici ovarian follicle ovarian follicle
339 Oocytus primarius Primary oocyte Primary oocyte Diploid (2N, 4C)
340 Zona pellucida Zona pellucida Zona pellucida
341 Processus cellulae epithelialis Process of cuboidal epithelial Process of cuboidal epithelial
follicularis cuboidalis follicular cell follicular cell
342 Processus oocyti Process of oocyte Process of oocyte
343 Proteina zonae pellucidae I - III Zona pellucida proteins 1-3 Zona pellucida proteins 1-3 ZP 1-3
717 TEMPUS EMBRYONICUM Gradus carnegienses [St.1 ad 23] EMBRYONIC PERIOD EMBRYONIC PERIOD Carnegie stages [St. 1-23] Endnote 68
718 Embryo Embryo Embryo
719 Embryo pregastrulationis Pregastrulation embryo Pregastrulation embryo Endnote 69
720 Embryo preimplantationis Pre-implantation embryo Preimplantation embryo
721 Embryo preblastocysticus Preblastocystic embryo Preblastocystic embryo
722 Gradus cellulae unicae Embryo unicellularis One-cell stage One cell stage Single cell embryo
723 Oocytus penetratus Oocytus definitivus; Embryo Penetrated oocyte Penetrated oocyte Definitive oocyte; Primordial
primordialis embryo
724 Zygotum Embryo syngamicus Zygote Zygote Syngamic embryo
725 Zona pellucida Zona pellucida Zona pellucida
726 Spatium subzonale Spatium subcapsulare Subzonal space Subzonal space Subcapsular space Endnote 70
727 Pronucleus Pronucleus Pronucleus
728 Pronucleus femininus Pronucleus maternus Female pronucleus Female pronucleus Maternal pronucleus
729 Corpus polare secundum Polocytus secundarius Second polar body Second polar body Second polocyte
730 Reactio corticalis Cortical reaction Cortical reaction
731 Reactio zonalis Reactio capsularis Zonal reaction Zonal reaction Capsular reaction Endnote 71
732 Degradatio mitochondriorum Degradation of paternal Degradation of paternal Endnote 72
paternalium mitochondria mitochondria
733 Conus fertilisationis Fertilization cone Fertilization cone IVF
734 Fusus anaphasis II Anaphase spindle II Anaphase spindle II IVF
735 Fusus telophasis II Telophase spindle II Telophase spindle II IVF
736 Intercorpus Interbody Interbody IVF
Endnote 73
737 Ootidium Ovum; Embryo pronuclearis Ootid Ootid Ovum; Pronuclear embryo
738 Pronucleus masculinus Pronucleus paternus Male pronucleus Male pronucleus Paternal pronucleus
739 Pronuclei admoti Approximated pronuclei Approximated pronuclei
740 Corpusculum precursorium Nucleolar precursor body Nucleolar precursor body
nucleolorum
741 Polus animalis Polus embryonicus presumptivus Animal pole Animal pole Presumptive embryonic pole
742 Zygotum Zygote Zygote
743 Zygotum findens Cleaving zygote Cleaving zygote Endnote 74
833 Crista previllosa mesoblasti Previllous crest of mesoblast Previllous crest of mesoblast Endnote 97
834 Reticulum extraembryonicum Magma reticulare Extra-embryonic reticulum Extraembryonic reticulum Mesenchymal reticulum Endnote 98
835 Blastocystis invadens cum Invading blastocyst with Invading blastocyst with
lacunis trophoblasticis isolated trophoblastic lacunae isolated trophoblastic lacunae
separatis
836 Lacuna trophoblastica Trophoblastic lacuna Trophoblastic lacuna
837 Aggregatio previllosa Previllous clump of cytotrophoblast Previllous clump of cytotrophoblast
cytotrophoblasti
838 Cavitas amniotica definitiva Definitive amniotic cavity Definitive amniotic cavity
839 Chorion primordiale Primordial chorion Primordial chorion
840 Endoblastus extraembryonicus Membrana exocoelomica Extra-embryonic endoblast Extraembryonic endoblast Exocoelomic membrane; Primary Endnote 99
endoderm
841 Vesicula umbilicalis primaria Saccus vitellinus primarius Primary umbilical vesicle Primary umbilical vesicle Primary yolk sac Endnote 100
842 Cavitas vesiculae umbilicalis Cavitas sacci vitellini primarii Cavity of primary umbilical vesicle Cavity of primary umbilical vesicle Cavity of primary yolk sac Endnote 100
primariae
843 Blastocystis invadens cum Invading blastocyst with Invading blastocyst with
lacunis communicantibus intercommunicating lacunae intercommunicating lacunae
844 Obturamentum fibrosus in loco Obturamentum occludens Fibrous coagulum at implantation Fibrous coagulum at implantation Closing plug
implantationis site site
845 Circulus lacunosus vascularis Lacunar vascular circle Lacunar vascular circle Endnote 101
846 Cavitas chorionica primordialis Primordial chorionic cavity Primordial chorionic cavity
992 Cellulae prestaminales Cellulae proprecursoriae; Cellulae Stem cells in early development Stem cells in early development
pluripotentes
993 Cellula externa morulae Outer cell of morula Outer cell of morula
994 Cellula staminalis trophoblastica Trophoblastic stem cell Trophoblastic stem cell TSC
995 Cellula interna morulae Inner cell of morula Inner cell of morula
996 Cellula staminalis embryonica Stipitoblastus Embryonic stem cell Embryonic stem cell ESC
997 Cellula epiblastica Epiblastic cell Epiblastic cell
998 Cellula hypoblastica Hypoblastic cell Hypoblastic cell
1002 Cellulae staminales Cellulae multipotentes et Lineage-restricted stem cells Lineage restricted stem cells Multipotent and unipotent cells Endnote 138
unipotentes
1003 Cellula staminalis somatica Somatic stem cell Somatic stem cell
1004 Cellula stromalis medullae rubrae Bone marrow stromal cell Bone marrow stromal cell
1005 Cellula staminalis medullae osseae Bone marrow stem cell Bone marrow stem cell
1006 Cellula staminalis sanguinis Cord blood stem cell Cord blood stem cell
funiculi umbilicalis
1007 Cellula staminalis umbilicalis Umbilical stem cell Umbilical stem cell
1008 Cellula staminalis conjunctivalis Conjunctival stem cell Conjunctival stem cell
1009 Cellula staminalis cornealis Corneal stem cell Corneal stem cell
1010 Cellula staminalis endothelialis Endothelial stem cell Endothelial stem cell
1011 Cellula staminalis ependymalis Ependymal stem cell Ependymal stem cell
1012 Cellula staminalis epidermalis Epidermal stem cell Epidermal stem cell
1013 Cellula staminalis gastrointestinalis Gastro-intestinal stem cell Gastrointestinal stem cell
1014 Cellula staminalis haematopoietica Haematopoietic stem cell Hematopoietic stem cell
1015 Cellula staminalis Hepatopancreatic stem cell Hepatopancreatic stem cell
hepatopancreatica
1016 Cellula staminalis hypophysialis Hypophysial stem cell Hypophysial stem cell
1017 Cellula staminalis mesechymatica Mesenchymal stem cell Mesenchymal stem cell hMSC
1018 Cellula staminalis myogenica Myogenic stem cell Myogenic stem cell
1019 Cellula staminalis nervosa Neural stem cell Neural stem cell
1020 Cellula staminalis neuronalis Neuronal stem cell Neuronal stem cell
1021 Cellula staminalis glialis Glial stem cell Glial stem cell
1022 Cellula staminalis epidermalis Epidermal neural crest cell stem Epidermal neural crest cell stem eNCSC
cristae neuralis cell cell
1023 Cellula staminalis olfactoria Olfactory stem cell Olfactory stem cell
1024 Cellula staminalis spermatogonica Spermatogonial stem cell Spermatogonial stem cell
1025 Cellula staminalis germinalis Germinal stem cell Germinal stem cell Endnote 139
1026 Cellulae progenetrices Progenitor cells Progenitor cells See relevant tissue derivatives
1070 COMPLEXUS CRISTAE OPTIC NEURAL CREST OPTIC NEURAL CREST Endnote 145
NEURALIS OPTICAE COMPLEX COMPLEX
1071 Mesenchyma oculi Optic mesenchyme Optic mesenchyme In part
1072 Basicranium anterius Anterior basicranium Anterior basicranium In part
1073 Leptomeninx Leptomeninx Leptomeninx
1074 Tunica fibrosa bulbi Fibrous layer of eyeball Fibrous layer of eyeball
1075 Cellula staminalis cornealis Corneal stem cell Corneal stem cell Endnote 146
1076 Melanocytus Melanocyte Melanocyte
1077 Tunica vasculosa bulbi Uvea Vascular layer of eyeball Vascular layer of eyeball Uvea
1078 Pigmentocytus uvealis Pigment cell of uvea Pigment cell of uvea
1079 CRISTA NEURALIS PREOTICA PRE-OTIC NEURAL CREST PREOTIC NEURAL CREST
1080 Complexus cristae neuralis Mesencephalic neural crest Mesencephalic neural crest Endnote 147
mesencephalicae complex complex
1081 Mesenchyma frontonasale Frontonasal mesenchyme Frontonasal mesenchyme
1082 Basicranium anterius Anterior basicranium Anterior basicranium In part
1083 Os frontale Frontal bone Frontal bone
1084 Pars squamosa ossis temporalis Squamous part of temporal bone Squamous part of temporal bone
1085 Viscerocranium membranaceum Membranous viscerocranium Membranous viscerocranium In part
1086 Leptomeninx Leptomeninx Leptomeninx
1087 Mesenchyma oculi Optic mesenchyme Optic mesenchyme In part
1088 Cellula staminalis cornealis Corneal stem cell Corneal stem cell
1089 Keratocytus Keratocyte Keratocyte
1090 Adipocytus Adipocyte Adipocyte
1091 Melanocytus Melanocyte Melanocyte
1092 Epithelium posterius corneae Endothelium of anterior chamber Endothelium of anterior chamber
1093 Stroma iridis Stroma of iris Stroma of iris
1094 Membrana pupillaris Pupillary membrane Pupillary membrane Iridopupillary membrane In part
1095 Ectomesenchyma dentale Dental ectomesenchyme Dental ectomesenchyme
1096 Papilla dentis Dental papilla Dental papilla
1097 Odontoblastus Odontoblast Odontoblast
1098 Crista neuralis isthmica Isthmic neural crest Isthmic neural crest Endnote 148
1099 Via migrationis dorsolateralis Dorsolateral migration pathway Dorsolateral migration pathway
1100 Mesenchyma capitis * Head mesenchyme * Head mesenchyme * In part
1101 Leptomeninx Leptomeninx Leptomeninx
1118 Complexus cristae neuralis Faciovestibulocochlear neural Faciovestibulocochlear neural Endnote 150
faciovestibulocochlearis crest complex crest complex
1119 Complexus cristae neuralis Facial neural crest complex Facial neural crest complex Endnote 151
facialis
1120 Via migrationis dorsolateralis Dorsolateral migration pathway Dorsolateral migration pathway
1121 Leptomeninx Leptomeninx Leptomeninx
1122 Mesenchyma capitis Head mesenchyme Head mesenchyme In part
1123 Dermis cervicalis Dermis of neck Dermis of neck In part
1124 Adipocytus Adipocyte Adipocyte
1125 Melanocytus Melanocyte Melanocyte
1126 Viscerocranium membranaceum Membranous viscerocranium Membranous viscerocranium In part
1127 Cartilago arcus pharyngei Second pharyngeal arch Second pharyngeal arch §Reichert§
secundi cartilage cartilage
1128 Ossiculae auditus Auditory ossicles Auditory ossicles In part
Endnote 152
1129 Os hyoideum Hyoid bone Hyoid bone In part
1130 Fasciae propriae musculorum Second pharyngeal arch Second pharyngeal arch
arcus pharyngei secundi muscle sheaths muscle sheaths
1131 Via migrationis ventrolateralis Ventrolateral migration pathway Ventrolateral migration pathway
1132 Neuron sensorium ganglii Geniculate ganglion cell Geniculate ganglion cell
geniculi
1133 Gliocytus ganglionicus Ganglionic satellite cell Ganglionic satellite cell
1134 Schwannocytus Schwann cell Schwann cell
1135 COMPLEXUS CRISTAE OTIC NEURAL CREST OTIC NEURAL CREST Endnote 153
NEURALIS OTICAE COMPLEX COMPLEX
1136 Via migrationis dorsolateralis Dorsolateral migration pathway Dorsolateral migration pathway
1137 Leptomeninx Leptomeninx Leptomeninx
1146 CRISTA NEURALIS POSTOTICA POSTOTIC NEURAL CREST POSTOTIC NEURAL CREST
1147 Complexus cristae neuralis Glossopharyngeal neural crest Glossopharyngeal neural crest Endnote 154
glossopharyngealis complex complex
1148 Via migrationis dorsolateralis Dorsolateral migration pathway Dorsolateral migration pathway
1149 Leptomeninx Leptomeninx Leptomeninx
1150 Crista neuralis cardiaca Cardiac neural crest Cardiac neural crest In part
Endnote 155
1151 Cartilago arcus pharyngei tertii Third pharyngeal arch cartilage Third pharyngeal arch cartilage
1152 Os hyoideum Hyoid bone Hyoid bone In part
1153 Fascia propria musculi Stylopharyngeus muscle sheath Stylopharyngeus muscle sheath
stylopharyngei
1154 Via migrationis ventrolateralis Ventrolateral migration pathway Ventrolateral migration pathway
1155 Neuron sensorium ganglii Glossopharyngeal ganglion cell Glossopharyngeal ganglion cell
glossopharyngei
1156 Ganglion glossopharyngeum Superior glossopharyngeal Superior glossopharyngeal
superius ganglion ganglion
1157 Ganglion glossopharyngeum Inferior glossopharyngeal Inferior glossopharyngeal
inferius ganglion ganglion
1158 Gliocytus ganglionicus Ganglionic satellite cell Ganglionic satellite cell
1159 Schwannocytus Schwann cell Schwann cell
1160 Complexus cristae neuralis Vagal neural crest complex Vagal neural crest complex Endnote 154
vagalis
1161 Via migrationis dorsolateralis Dorsolateral migration pathway Dorsolateral migration pathway
1162 Leptomeninx Leptomeninx Leptomeninx
1163 Crista neuralis cardiac Cardiac neural crest Cardiac neural crest In part
1164 Cartilago arcus pharyngei quarti Fourth pharyngeal arch cartilage Fourth pharyngeal arch cartilage
1165 Cartilagines laryngeae Laryngeal cartilages Laryngeal cartilages Endnote 156
1166 Fasciae propriae musculorum Fourth pharyngeal arch muscle Fourth pharyngeal arch muscle
arcus pharyngei quarti sheaths sheaths
1167 Via migrationis ventrolateralis Ventrolateral migration pathway Ventrolateral migration pathway
1168 Neuron sensorium ganglii vagalis Vagal ganglion cell Vagal ganglion cell
1169 Ganglion vagale superius Superior vagal ganglion Superior vagal ganglion
1170 Ganglion vagale inferius Inferior vagal ganglion Inferior vagal ganglion
1171 Gliocytus ganglionicus Ganglionic satellite cell Ganglionic satellite cell
1182 Complexus cristae neuralis Cardiac neural crest complex Cardiac neural crest complex
cardiacus
1183 Arcus pharyngei tertii, quartii et Third, fourth and sixth pharyngeal Third, fourth and sixth pharyngeal
sexti arches arches
1184 Aa. arcuum pharyngeorum Pharyngeal arch arteries Pharyngeal arch arteries Aortic arches Endnote 157
1185 Paraganglion Paraganglion Paraganglion
1186 Paragangliocytus Cellula typi I Paragangliocyte Paragangliocyte Type I cell
1187 Glandulae parathyroideae Parathyroid glands Parathyroid glands In part
1188 Stroma glandulae Parathyroid stroma Parathyroid stroma
parathyroideae
1189 Cor Heart Heart In part
1190 Basis cordis Base of heart Base of heart In part
1191 Ductus tractus communis Common outflow tract of heart Common outflow tract of heart In part
egressionis cordis
1192 Crista endocardiaca septalis Tuber endocardiacum septale Septal ridge Septal ridge Septal cushion; Parietal cushion
1193 Septum aorticopulmonale Aorticopulmonary septum Aorticopulmonary septum In part
1194 Valva aortae Aortic valve Aortic valve Aortic arterial valve In part
1195 Valva trunci pulmonalis Pulmonary valve Pulmonary valve Pulmonary arterial valve In part
1196 Tubera endocardiaca Atrioventricular endocardial Atrioventricular endocardial In part
atrioventricularia cushions cushions
1197 Cardiomyocytus atrialis Endocrine atrial cardiomyocyte Endocrine atrial cardiomyocyte Atrial myo-endocrine cell; Atrial
secretans myoendocrine cell
1198 Trachea et bronchi Trachea and bronchi Trachea and bronchi In part
1199 Neuroendocrinocytus Respiratory neuro-endocrine cell Respiratory neuro-endocrine cell
respiratorius
1200 Gemma thymica Thymic bud Thymic bud In part
1201 Stroma thymi Thymic stroma Thymic stroma
1202 Glandula thyroidea Thyroid gland Thyroid gland In part
1203 Thyrocytus C C thyrocyte C thyrocyte C cell; Parafollicular cell
1204 Crista neuralis nervi accessorii Neural crest of accessory nerve Neural crest of accessory nerve Endnote 158
1208 Crista neuralis hypoglossalis Crista neuralis occipitalis Hypoglossal neural crest Hypoglossal neural crest Occipital neural crest Endnote 159
1209 Via migrationis dorsolateralis Dorsolateral migration pathway Dorsolateral migration pathway
1210 Leptomeninx Leptomeninx Leptomeninx
1211 Adipocytus Adipocyte Adipocyte
1212 Melanocytus Melanocyte Melanocyte
1213 Chorda hypoglossalis Hypoglossal cord Hypoglossal cord In part
1214 Schwannocytus Schwann cell Schwann cell
1215 CRISTA NEURALIS SPINALIS SPINAL NEURAL CREST SPINAL NEURAL CREST Endnote 160
1216 Via migrationis dorsolateralis Dorsolateral migration pathway Dorsolateral migration pathway Endnote 161
1217 Melanocytus Melanocyte Melanocyte
1218 Via migrationis ventrolateralis Ventrolateral migration pathway Ventrolateral migration pathway Endnote 162
1219 Neuron sensorium ganglii spinalis Spinal ganglion cell Spinal ganglion cell
1220 Gliocytus ganglionicus Ganglionic satellite cell Ganglionic satellite cell
1221 Schwannocytus Schwann cell Schwann cell
1222 Via migrationis ventromedialis Ventromedial migration pathway Ventromedial migration pathway Endnote 163
1223 Linea generationis cellularum Sympathosuprarenal cell lineage Sympathosuprarenal cell lineage Sympatho-adrenal cell lineage;
sympathicosuprarenalium Sympathoadrenal cell lineage
1224 Ganglion trunci sympathici Ganglion of sympathetic trunk Ganglion of sympathetic trunk
1225 Gliocytus ganglionicus Ganglionic satellite cell Ganglionic satellite cell
1226 Medulla suprarenalis Suprarenal medulla Suprarenal medulla
1227 Endocrinocytus chromophilus Medullary chromaffin cell Medullary chromaffin cell
medullaris
1228 Ganglion preaorticum Pre-aortic ganglion Preaortic ganglion §Zuckerkandl§
1229 Gliocytus ganglionicus Ganglionic satellite cell Ganglionic satellite cell
1230 Linea generationis cellularum Parasympathetic cell lineage Parasympathetic cell lineage
parasympathicarum
1231 Ganglion parasympathicum Parasympathetic ganglion Parasympathetic ganglion
1232 Gliocytus ganglionicus Ganglionic satellite cell Ganglionic satellite cell
1233 Textus connectivi atque Connective and supporting Connective and supporting
sustinentes tissues tissues
1234 TEXTUS ADIPOSUS ADIPOSE TISSUE ADIPOSE TISSUE
1235 Mesenchyma somiticum Somitic mesenchyme Somitic mesenchyme
1236 Mesenchyma somatopleurale Somatopleuric mesenchyme Somatopleuric mesenchyme Endnote 164
1237 Mesenchyma splanchnopleurale Splanchnopleuric mesenchyme Splanchnopleuric mesenchyme Endnote 165
1238 Ectomesenchyma Mesenchyma cristae neuralis Ectomesenchyme Ectomesenchyme Neural crest mesenchyme
1239 Mesenchyma ex eminentia Mesenchyme from caudal Mesenchyme from caudal
caudale eminence eminence
1240 Cellula adipocytoprogenetrix Fat cell progenitor Fat cell progenitor Endnote 166
1275 Ossificatio membranacea Ossificatio desmalis Membranous ossification Membranous ossification Intramembranous ossification
1276 Mesenchyma blastemale Blastemal mesenchyme Blastemal mesenchyme
1277 Textus chondroideus Chondroid tissue Chondroid tissue
1278 Centrum ossificationis Ossification centre Ossification centre
1279 Motus detondens Shearing movement Shearing movement
1280 Stratum osteoblasticum Osteoblastic layer Osteoblastic layer
1281 Osteoblastus Osteoblast Osteoblast
1 Ejaculatio The reflex process of ejaculation occurs in two phases: in the first – emission – contraction of smooth muscle of glands and ducts delivers the various components of semen into the prostatic urethra;
in the second – ejaculation proper – the striated muscles of the urogenital triangle (particularly the bulbospongiosus muscles) contract spasmodically and expel semen from the urethra.
2 Embryogenesis Embryogenesis is the process of embryo formation. It entails the formation of the principal organs and systems and the acquisition of uniquely human surface features that are apparent with the
unaided eye. The process begins at fertilization and ends, somewhat arbitrarily, 56 days later.
3 Fetogenesis Fetogenesis entails the growth and differentiation, particularly functional differentiation, of the conceptus after embryogenesis is completed. It thus begins on day 57, following the Stage 23 embryo
that already has its principal organs, systems and distinctly human features, and ends at birth, when the fetus becomes a newborn infant or neonate. The time in which fetogenesis occurs may be divided into early,
intermediate and late fetal periods, which correspond to the trimesters of pregnancy in which they occur. There is, however, no agreement on precisely which weeks are encompassed by the first trimester; here it is
regarded as beginning at fertilization and as consisting of embryogenesis and the early fetal period, the 9th to the 13th post-fertilization weeks.
4 Cyclus vaginalis Cyclical changes in the stratified squamous epithelium of the vagina are not obvious in histological sections: under normal circumstances its desquamated cells remain nucleated and it does not
keratinize. However, according to Papanicolaou, there is a relative increase in acidophilic cells with small dark nuclei at the time of ovulation and thus three phases of the vaginal cycle may be recognized
(Papanicolaou GN. The sexual cycle in the human female as revealed by vaginal smears. Am J Anat 1933;52:519-637). The changes at ovulation may represent a prekeratinization process, which is completed
when the epithelium is exposed to the air, as in cases of prolapse.
5 Conceptus Conceptus refers to the entire product of conception from fertilization onwards.
6 Cyema The cyema is the embryonic or fetal part of the conceptus and thus excludes the developmental adnexa (q.v.), which are the placenta, umbilical cord and extra-embryonic membranes (O’Rahilly R, Müller,
F. Human Embryology and Teratology, 3rd ed. New York: Wiley-Liss; 2001).
7 Embryo [St.1 ad 23] Both embryonic and extra-embryonic cell lineages extend forward from the zygote and both extra-embryonic and embryonic tissues are necessary for normal development. Nevertheless, it
has been argued that to include the early stages in the use of the term embryo is misleading because a discrete and identifiable population of exclusively embryonic or cyemic cells does not exist until gastrulation is
under way and because most of the tissues formed prior to this are extra-embryonic or adnexal (Johnson MH and Selwood L. Nomenclature of early development in mammals. Reprod Fertil Dev 1996;8:759-64).
However, communication risks attend the redefining of a commonly and colloquially used term such as embryo and scientific purposes can be as well served by not redefining the term but defining the cells present
at a particular time. Embryo remains the preferred term for all 23 Carnegie Stages.
8 Adnexa developmentalia; Membranae embryonicae et fetales; Adnexa embryonica et fetalia The Latin word adnexum has been used almost exclusively in this plural form to indicate the structures (more than
one) adjacent to or subservient to a major structure. The form adnexae, although frequently used, is incorrect. The developmental adnexa are commonly referred to as the 'fetal membranes'. This is inaccurate
since they include the trophoblast, amnion, chroin, umbilical vesicle, allantoic vesicle, placenta and umbilical cord (O'Rahilly R, Muller F. Human Embryology and Teratology. 3rd ed. New York: Wiley-Liss; 2001).
9 Phasis pregastrulationis The pregastrulation and postgastrulation phases of the embryonic period and the fetal period are stages of prenatal development, each with its own distinctive characteristics, particularly
in respect of its responses to teratogens. The pregastrulation phase begins at fertilization, continues through cleavage and implantation and ends with the establishment of a definite primitive streak in Carnegie
Stage 6b at about two and a half weeks. It is a phase characterized by rapid increase in cell numbers and by regulation. As a result, response to teratogens is uncertain: induced errors of development may regulate
but, if they do not, the errors are likely to be of such magnitude that early spontaneous abortion follows.
10 Phasis preparatoria; Phasis embryogenica The characteristic of the preparative phase is that it is spent preparing extra-embryonic membranes and presumptive embryonic cells but that no cells of the
conceptus have yet been determined as substantive embryonic cells. It has therefore been called the embryogenic phase (Johnson MH and Selwood L. Nomenclature of early development in mammals. Reprod
Fertil Dev. 1996;8:759-64). The term “pre-embryonic stage”, which has been used in legal and clinical contexts, is not recommended.
11 Pregnatio cervicalis; Pregnatio ectopica; Pregnatio extrauterina Although appropriately listed with uterine pregnancy sites, a cervical pregnancy is often considered to be an ectopic pregnancy.
13 Aetas a fecundiatione Fertilization age begins at the time of fertilization with the sperm penetrating the oocyte and the formation of the zygote. It is the true age of the conceptus and the preferred measure.
14 Aetas ab ovulatione Ovulation age begins on the day of the ovulation that preceded fertilization and the formation of the zygote: it is about 0.5 day longer than fertilization age.
15 Aetas ab inseminatione Insemination age begins when the sperm and oocyte are introduced in artificial insemination or in vitro fertilization.
16 Hebdomades post coitum Coital weeks begin from the time of the coitus that resulted in the pregnancy. Normally, fertilization occurs early in the first coital week. Since the embryo does not exist for the first part
of the first coital week, the term coital age is inappropriate.
17 Hebdomades post menses ultimas Menstrual ("gestational") weeks begin from the first day of the mother's last menstrual period [LMP] before becoming pregnant and are the usual measure in obstetric practice.
Since the embryo does not usually come into being until the first two menstrual weeks have passed, the term menstrual “age” is inappropriate. The term gestational age is superfluous, ambiguous and should be
abandoned, it having been variously equated with menstrual weeks, ovulation age and fertilization age (O’Rahilly R, Müller F. Developmental Stages in Human Embryos: Revised and New Measurements. Cells
Tissues Organs 2010;192:73-84).
18 Longitudo maxima Greatest length [GL] is the preferred measure of length, being independent of fixed points, which are not always easy to determine. GL coincides with crown-rump length [CRL] at Stages 11
and 12; GL is generally more than CRL and coincides with neck-rump length from Stages 13-17; GL and CRL again coincide from Stages 18-20 onwards (O’Rahilly R, Müller F. Developmental Stages in Human
Embryos: Revised and New Measurements. Cells Tissues Organs 2010;192:73-84).
19 Gemini conjuncti See Spencer R. Conjoined twins. Baltimore: Johns Hopkins University Press; 2003. In conjoined twins, as elsewhere, convention has the suffixes –ia in Latin and –y in English indicating the
condition; the suffix –us, in either language, refers to an individual with that condition.
20 Genum a parente impressum Genomic imprinting occurs during meiosis II of gametogenesis and persists until the primary gametocyte stage in the next generation.
21 Polus animalis Being microlecithal, the human primary oocyte does not exhibit the obvious polarity characteristic of more richly yolked oocytes. It does, however, exhibit some degree of asymmetry in
distribution of cytoplasmic elements. The animal pole of the arrested secondary oocyte is identified by the position of the second meoitic spindle and the lack of microvilli on the cell membrane overlying it. After
fertilization, the animal pole of the ootid is characterized by the presence of the female and male pronuclei. There is no necessary relationship between the animal-vegetal axis and the future embryonic-
abembryonic (dorsoventral) axis. In some (but not all) mouse zygotes, the animal-vegetal axis corresponds to the long axis of the ellipsoid blastocyst and thus to the anteroposterior axis of the embryo. In these
cases the animal-vegetal axis is orthogonal to the embryonic-abembryonic axis (Selwood L, Johnson MH. Trophoblast and hypoblast in the monotreme, marsupial and eutherian mammal: evolution and origins.
BioEssays 2006;28:128-145).
22 Pellucidagenesis; Zonagenesis Although the term zonagenesis is widely used in zoology, it is not recommended as it lacks a locational adjective and could thus apply to any zone. Although the zona pellucida
cannot be seen with the light microscope before the primary ovarian follicle has developed, the heavily glycosylated proteins ZP 1-3 can be demonstrated in the oocytes and follicle cells of primordial follicles (Gook
DA, Edgar DH, Borg J and Martic M. Detection of zona pellucida proteins during human folliculogenesis. Hum Reprod 2008;23:394-402).
23 Regulatio The process by which the developmental fates or rates of development of cells of embryonic subsystems may change during embryonic development, thereby permitting normal integrated
development of the embryo as a whole and compensating for anomalies. It is the result of changes in gene expression; moreover, since the DNA sequence that comprises the genome remains unchanged during
the differentiation of systems, organs, tissues and cell-types, regulation is said to be an epigenetic process. The human zygote is said to be regulatory because in it the primordia of tissues and organs are not
24 Differentiatio cellularum in zygoto findenti Differentiation of the cells of the cleaving zygote into outer blastomeres, which are polarized, and inner blastomeres, which are not.
25 Polarisatio cellularum externarum Transformation of rounded, radially symmetrical outer blastomeres into highly asymmetric cells with the characteristics of epithelia. Longitudinal divisions of polarized cells are
conservative, resulting only in more polarized cells. Transverse divisions of polarized cells are differentiative, resulting in both embryoblastic cells and polarized cells. Cells remaining polarized give rise to
trophoblast (Johnson MH. Origin of pluriblast and trophoblast in the eutherian conceptus. Reprod Fertil Dev 1996;8:699-709).
26 Divisio differentiativa embryoblasti; Divisio differentiativa massae cellularis internae; Divisio differentiativa pluriblasti Differentiation of the cells of the embryoblast, inner cell mass or pluriblast into the dorsal cells
of the epiblast and the ventral cells of the hypoblast, with a basal lamina between them.
27 Morphogenesis The development of shape, size or other feature of a particular organ or of a part or the whole of the body. “The word ‘morphogenesis’ is often used in a broad sense to refer to many aspects of
development, but when used strictly it should mean the moulding of cells and tissues into definite shapes” (Waddington CH. Principles of Embryology. London: George Allan & Unwin; 1956). In this strict sense, it
refers particularly to the wide-ranging phenomena associated with gastrulation and organogenesis and to local phenomena like budding, branching and clefting (Hogan BLM. Morphogenesis. Cell 1999;96:225-233).
28 Blastema An identifiable mass of rapidly proliferating undifferentiated cells that gives rise to a differentiated structure/organ.
29 Primordium A term applied to a structure making its first appearance as a differentiating structure. Anlage, from the German, is a synonym. It is now appreciated that, particularly in branching morphogenesis,
an epithelial primordium may be preceded by a mesenchymal primordium, which determines the pattern of arborization (Denny PC, Ball WD, Redman RS. Salivary glands: a paradigm for diversity of gland
development. Crit Rev Biol Med 1997;8:51-75).
30 Rudimentum; Vestigium These terms are not interchangeable: a rudiment (from the Latin rudimentum – that which is unwrought) is an underdeveloped or immature part or organ; a vestige (from the Latin
vestigium – that which is tracked) is a part or organ that has become reduced in function and/or size in the course of phylogeny; some vestiges, nevertheless, play an important part in ontogeny.
31 Status presumptivus The condition of a tissue, region or organ that will, in the course of normal development, become a morphologically differentiated tissue, region or organ. A structure may be presumptive
solely by virtue of its position or it may have undergone determination or chemodifferentiation but as yet shows no visible signs of differentiation.
33 Formatio ansae See, for example: Männer J. The anatomy of cardiac looping: a step towards the understanding of the morphogenesis of several forms of congenital heart malformations (Clin Anat 2009;22:21-
35).
34 Formatio primaria corporis Primary body development involves the primary germ layers and neural plate more or less directly. It includes primary neurulation, the formation of somites 1-29, of spinal ganglia 1-
25, of the foregut, midgut and hindgut and of the corresponding part of the notochord.
35 Formatio secundaria corporis Secondary body development does not involve the germ layers: in it structures develop directly from the axial dense mesenchyme of the caudal eminence or tail bud, which is the
remnant of the primitive streak. It includes secondary neurulation, the formation of somites 30-39, of spinal ganglia 26-35, of the most caudal gut and of the corresponding part of the notochord.
36 Gastrulatio It has been said that the term gastrulation is inappropriate as it refers to the invagination of a monolayered blastula to form a bilayered gastrula containing an endoderm-lined archenteron (O'Rahilly
R and Müller F. Human embryology and teratology. 3rd ed. New York: Wylie-Liss; 2001). While this was the original meaning of gastrulation, its meaning has undergone a profound change (Collins P and Billett FS.
The terminology of early development: history, concepts, and current usage. Clin Anat 1995;8:418-25). It may now be defined as the formative process by which the three germ layers and an axial organization are
37 Inflatio The ballooning model has succeeded the segmental model of heart chamber formation (Horsthuis T, Christoffels VM, Anderson RH, Moorman AFM. Can recent insights into cardiac development
improve our understanding of congenitally malformed hearts? Clin Anat 2009;22:4-20).
38 Invectio Introduction of material into a structure from outside. An example is the process by which material from the mesocardium is added to the venous and arterial poles of the early heart tube (Horsthuis T,
Christoffels VM, Anderson RH, Moorman AFM. Can recent insights into cardiac development improve our understanding of congenitally malformed hearts? Clin Anat 2009;22:4-20).
39 Maturatio Maturation may be defined as the progressive acquisition of definitive structure and function: its prenatal aspects, particularly, are within the compass of Terminologia Embryologica.
40 Morphogenesis gemmans Budding morphogenesis and the ensuing canalization have been most widely studied in the lung, kidney, mammary gland and salivary glands and the processes detailed for it are
generally followed elsewhere (Varner VD, Nelson CM. Cellular and physical mechanisms of branching morphogenesis. Development 2014;141:2750-2759).
41 Morphogenesis ramificans Branching morphogenesis is the process of forming organized patterns of epithelial cords and then tubules in organs such as the kidney, glands and lungs. It appears to be
determined by mesenchyme and regulated by a wide range of factors (Williams MJ, Clark P. Microscopic analysis of the cellular events during scatter factor/hepatocyte growth factor-induced epithelial
tubulogenesis. J Anat 2003;203:483-503). The term tubulogenesis is not recommended in this context as the product is initially solid and only canalizes later.
42 Morphogenesis findens Clefting is the process in which a terminal bud is cleaved into multiple lobules with the ingrowth of mesenchyme and the deposition of extracellular matrix. In some organs, such as the
lung, budding, branching and clefting each occur at different stages of development, whereas in salivary glands clefting appears to predominate (Hogan BLM. Morphogenesis. Cell 1999;96:225-233).
43 Motus condensationis; Motus densationis Movement occurring in a morphogenetic field, called a densation field (Blechschmidt E, Gasser R. Biokinetics and biodynamics of human differentiation. Springfield:
Charles C Thomas; 1978). With loss of intercellular fluid, the cells come closer together. The first appearance of the skeleton is as mesenchymal condensations. The cells have rather spherical cell bodies and very
little intercellular substance present between them. They show no particular orientation which means that they are under tension stresses that are equal in all directions. A densation field is characterized by its
position.
44 Motus dilatationis Movement occurring in a morphogenetic field, called a dilation field (Blechschmidt E, Gasser R. Biokinetics and biodynamics of human differentiation. Springfield: Charles C Thomas; 1978).
The field is spatially and kinetically highly organized. Dilation occurs in mesenchymal tissue when it becomes elongated and slenderized by pull in a particular direction without transverse compression. The
primordia of skeletal, cardiac and smooth muscle fibres and fibre systems arise in dilation fields. The shape of a muscle is closely related to its position while its structure is closely related to its shape.
45 Motus expansionis longitudinalis; Motus distusionalis Movement occurring in a morphogenetic field, called a distusion field (Blechschmidt E, Gasser R. Biokinetics and biodynamics of human differentiation.
Springfield: Charles C Thomas; 1978). The spherical mesenchymal cells of a densation field become compressed by opposing forces in the longitudinal axis of the field. Initially, such zones of flattened cells are
located only in the centre of a field that has attained sufficient size. For example, cells in such a contusion field become disc-shaped and develop into cartilage cells.
46 Motio involutionis; Involutio The rolling-in of cells over a rim. In this context the term involutionary movement is preferred because of the different connotations of the term involution.
47 Motus translationis; Migratio When re-examined appropriately (Gasser RF. Evidence that some events in mammalian embryogenesis can result from differential growth, making migration unnecessary. Anat
Rec B New Anat.2006;289B:53-63), many examples of changing positional relations turn out not to be examples of true migration.Cell migration may be false or true. In false migration, structures do not move from
one site to another but their positional relationships change and they become separated as an embryo enlarges and changes shape. See, for example: Freeman B. The active migration of germ cells in the embryos
of mice and men is a myth (Reproduction 2003;125:635-643), which explains the relocation of primordial germ cells from the wall of the umbilical vesicle to that of the hindgut by growth movements and shape
changes. True migration, such as occurs in cytokinesisis in the cerebellum and the cerebral cortex, is the movement of cells, cell groups and organs from one site to another, among, around, through or over other
structures, in relation to a central reference point that moves minimally as the embryo enlarges or changes shape.
49 Neurulatio secundaria Secondary neurulation is the process entailing canalization that leads to the formation of the spinal cord beyond the limits of primary neurulation. It occurs after the closure of the caudal
neuropore in Stage 12, and thus in Stages 13-18. Axial dense mesenchyme in the caudal eminence forms a neural cord in continuity with the neural tube: the cavity in the neural tube extends into the neural cord
(Müller F, O'Rahilly R. The development of the human brain, the closure of the caudal neuropore, and the beginning of secondary neurulation at stage 12. Anat Embryol 1987;176:413-30). The term secondary
neurulation is best confined to the process rather than applied to the phase of development in which it occurs, which is best referred to as secondary body development.
50 Transitio epitheliomesenchymalis For sessile cells to become free and migrate they must undergo an epitheliomesenchymal transition, first becoming flask-shaped, with the dissolution of juxtaluminal junctions,
and then becoming frankly mesenchymal.
51 Transitio mesenchymoepithelialis Mesenchyme cells that have reached their destinations may condense and revert to sessile epithelial cells, by polarizing, developing basal laminae and specialized
juxtaluminal junctions. Some such epithelia may subsequently undergo an epitheliomesenchymal transition.
52 Ontogenesis Ontogenesis is defined here as the development of the individual, beginning at fertilization and ending at death. It thus covers the principal concerns of this terminology (embryogenesis,
fetogenesis and immediate postnatal development) but extends beyond them.
53 Tempus fetale The pregastrulation and postgastrulation phases of the embryonic period and the fetal period are stages of prenatal development, each with their own distinctive characteristics, particularly in
respect of their responses to teratogens. The fetal period is taken, somewhat arbitrarily, to begin on day 57, by which time the embryo has already acquired the distinctly human features that are apparent with the
unaided eye, and ends at birth, when the fetus becomes a newborn infant or neonate. The main events of organ formation having been completed by Carnegie Stage 23, the fetal period is mainly one of growth and
differentiation, particularly functional differentiation, in preparation for extra-uterine life. Notable in this context is the skeletal system, in which cartilaginous precursors are being replaced by bone, and the nervous
system, which is forming functional connections. Thus anomalies arising during this period entail disturbances of growth, of hard tissues and of neural connections.
54 Aetas fetalis Fetal age is usually given in weeks and is determined by the use of various starting points, of which only fertilization, insemination and ovulation are valid.
55 Tempus fetale initiale; fetus hebdomadis nonae ad hebdomadam tertiam decimam The early fetal period here corresponds to that of the 9 to 13 week fetus and ends at 90 days and about 90mm: the conclusion
of the “second sous-stade de finition histogénétique, de réglage des proportions” (Guyot R. Théorie nouvelle sur les âges de la vie. 2nd ed. Paris: Barré & Dayez; 1985) and probably the end of the first trimester.
There is, however, no agreement on precisely which weeks are encompassed by the first trimester. The attributes of fetuses have not been subjected to the same systematic, intensive investigation as have
embryos. Nevertheless, there are attributes other than size and weight that characterize progression during the early fetal period.
56 Tempus fetale intermedium; Fetus trimestris secundi The intermediate fetal period here corresponds to that of the second trimester fetus and thus begins at 90 days and about 90mm, after the conclusion of the
“second sous-stade de finition histogénétique, de réglage des proportions” (Guyot R. Théorie nouvelle sur les âges de la vie. 2nd ed. Paris: Barré & Dayez; 1985).
57 Tempus fetale serum; Fetus trimestri tertii The late fetal period corresponds to that of the third trimester fetus.
58 Tempus perinatale The perinatal period extends from immediately prior to birth, through birth and through the first 7 days of postnatal life, the early neonatal period.
59 Tempus neonatale The first 7 days after birth constitute the early neonatal period. The following 21 days of postnatal life constitute the late neonatal period, which thus ends with day 28.
61 Paedomorphosis Paedomorphosis is exhibited in features such as the human flat face, position of the foramen magnum, retarded skeletal development and continuation of fetal growth rates into infancy and
childhood.
62 Fertilisatio post penetrationem spermatozoi Some of the features included in this section are inferred because they are common to all mammalian fertilization: others, such as Zonal reaction and Fertilization
cone, have been observed in the human as a result of in vitro fertilization.
63 Ootidium; Ovum; Embryo pronuclearis [Gradus Ib] The imprecise term ovum has been variously applied, alone or qualified, to stages from the primary oocyte to the implanting blastocyst and beyond. The use of
the more precise term is recommended. In mammals, it is the secondary oocyte, arrested in the metaphase of meiosis II, which is penetrated and thus best referred to as a penetrated oocyte until meiosis II has
been completed. Penetration activates the oocyte into completing meiosis II, with the formation of the ootid and the second polar body. The mammalian ootid contains two separate haploid elements, the female and
male pronuclei. As these two elements fuse into a single diploid aggregation of chromosomes, the ootid becomes a zygote.
64 Corpus polare secundum; Polocytus secundarius A line through the centres of the zygote and the second polar body defines the polar axis and indicates the plane of the first cleavage division (Veeck L L,
Zaninovic N. An atlas of human blastocysts. New York: Parthenon Publishing Group; 2003).
65 Numerus diploideus chromosomatum nonreplicatorum; Numerus diploideus chromosomatum nonreplicatorum This relates to the condition in the penetrated (or definitive) oocyte [2N].
66 Syngamia Traditionally, syngamy has meant sexual reproduction or, more specifically, the fusion of gametes. However, in in vitro fertilization it has come to describe a stage, beginning some 21-32 hr after
insemination, in which maternal and paternal chromosomes intermingle, although this is not easily discernible by ordinary microscopy (Sathananthan H, Trounson AO, Wood C. Atlas of fine structure of human
sperm penetration, eggs and embryos cultured in vitro. New York: Praeger Publishers; 1986).
67 Activatio prima genorum zygoticorum This first transcription produces only a minor population of mRNAs whereas the second transcription (ZGA2), in the two-celled embryo, produces a major population: most
maternal mRNA is degraded at this time although maternal proteins persist into the blastocyst stage (Selwood L, Johnson MH. Trophoblast and hypoblast in the monotreme, marsupial and eutherian mammal:
evolution and origins. BioEssays 2006;28:128-145); De Paepe C, Krivega M, Cauffman G, Geens M, van de Velde H. Totipotency and lineage segregation in the human embryo. Mol Hum Reprod 2014;20:599-618).
68 Tempus embryonicum; Gradus carnegiensis [1-23] There are 23 defined stages of development during the embryonic period, which begins at fertilization and ends, somewhat arbitrarily, 56 days later, by which
time the embryo has already acquired uniquely human surface features that are apparent with the unaided eye. The stages are the internationally accepted Carnegie Stages (O'Rahilly R, Müller F. Developmental
stages in human embryos. Washington DC: Carnegie Institution of Washington; 1987). Each Carnegie Stage is an arbitrarily defined cut through the time axis of the embryo and is based upon carefully-defined
external and internal morphological criteria and not length or age. Thus, embryos of a particular length or age are not necessarily embryos of a particular stage. Carnegie Stage cannot be assigned solely on the
basis of such measurements. See Dickey RP, Gasser RF. Ulltrasound evidence for variability in the size and development of normal human embryos before the tenth postinsemination week after assisted
reproductive technologies. Hum Reprod 1993;8:331-337; Wisser J, Dirschedl P, Krone S. Estimation of gestational age by transvaginal sonographic measurement of greatest embryonic length in dated human
embryos. Ultrasound Obstet Gynecol 1994;4:457-462; Blaas HG-K, Eik-Nes SH, Kiserud T, Hellevik LR. Early development of the forebrain and midbrain: A longitudinal ultrasound study from 7 to 12 weeks of
gestation. Ultrasound Obstetr Gynecol 1994;16:25-29; Pooh RK, Kurjak A, eds Fetal Neurology. Jaypee, St.Louis; 2009; Pooh RK, Shiota K, Kurjak A. Imaging of the human embryo with magnetic resonance
imaging microscopy and high-resolution transvaginal 3-dimensional sonography: Human embryology in the 21st century. Am J Obstet Gynecol 2011;204:77.e1-77.e16.). See also O’Rahilly and Müller F, op.cit. for
further discussion of staging and for further references on ultrasound studies. Data have also been derived from MR studies on embryos from the Kyoto Collection of Embryos: Yamada S, Samtani RR, Lee ES,
Lockett E, Uwabe C, Shiota K, et al. Developmental atlas of the early first trimester human embryo. Dev Dyn 2010; 239:1585-1595.
69 Embryo pregastrulationis [St.1 ad 6a] The term pregastrulation embryo is useful because such an embryo has distinctive attributes. The foreshortened term “pre-embryo”, which has been used in legal and
clinical contexts, is not recommended.
70 Spatium subzonale; Spatium subcapsulare The commonly used term perivitelline space is inappropriate for the space surrounding the human oocyte, which is deficient in yolk (Latin - vitellus).
72 Degradatio mitochondriorum paternalium See Sutovsky P, Van Leyen K, McCauley T, Day BN, Sutovsky M. Degradation of paternal mitochondria after fertilization: implications for heteroplasmy, assisted
reproductive technologies and mtDNA inheritance. Department of Animal Science, University of Missouri-Columbia, MO, USA. SutovskyP@missouri.edu, Reprod Biomed Online. 2004 Jan;8(1):24-33.
73 Intercorpus The interbody is a prominent intracytoplasmic electron-dense contractile structure in the equatorial plane of the second meiotic spindle, extending from the penetrated oocyte into the extruding
second polar body. Fine electron-dense particles of unknown chemical nature are associated with spindle microtubules and the interbody represents the site of detachment of the second polar body and
reconstitution of the cell membranes of the embryo and second polar body.
74 Zygotum findens [Gradus II] Embryos of Carnegie Stage 2 consist of between 2 and about 32 cells but have no blastocystic cavity by light microscopy. They are generally 0.1-0.2mm in diameter and about 2-3
days old.
75 Morula Stage 2 embryos from 12 to about 32 cells and without a blastocystic cavity are called morulae (from Latin Morus, mulberry). The term is not ideal because, unlike the amphibian morula, for which the
term was coined, the human morula gives rise to extra-embryonic as well as embryonic tissues. Nevertheless, when the number of blastomeres cannot be counted, there is no other term to describe the solid mass
that precedes the formation of the blastocystic cavity.
76 Cellula externa morulae; Cellula trophoblastica presumptiva; Cellula polarisata; Polarblastus The outer cells of the morula are polarized and are asymmetrical cells with the characteristics of epithelia. Their
longitudinal divisions are conservative and result only in more polarized cells. Their transverse divisions are differentiative and result in both unpolarized embryoblastic cells and polarized cells. Cells remaining
polarized become trophoblast (Johnson MH. Origin of pluriblast and trophoblast in the eutherian conceptus. Reprod Fertil Dev 1996;8:699-709). The term polarblast appropriately describes the tissue.
77 Cellula interna morulae; Cellula embryoblastica presumptiva; Pluriblastus initialis The inner cells of the morula are unpolarized and remain rounded and radially symmetrical. Their divisions are conservative and
result only in more unpolarized cells. They will become the embryoblast or inner cell mass. The term pluriblast (Johnson MH. Origin of pluriblast and trophoblast in the eutherian conceptus. Reprod Fertil Dev
1996;8:699-709) recognizes the fact that its derivatives are both extra-embryonic or adnexal and embryonic or cyemic.
78 Blastocystis libera [Gradus III] Embryos of Carnegie Stage 3 are free blastocysts with a blastocystic cavity by light microscopy. They consist of up to 90 cells, of which about 30 are inner cell mass cells. They
are about 4-5 days old and are generally 0.1-0.2mm in diameter.
79 Embryoblastus; Massa cellularis interna; Pluriblastus serior The term embryoblast is widely used although the derivatives of this tissue are both extra-embryonic or adnexal and embryonic or cyemic. The term
inner cell mass is also used but cannot be used as a comparative term as the corresponding cells are not inner in many, if not all, marsupials (Johnson MH and Selwood L. Nomenclature of early development in
mammals. Reprod Fertil Dev 1996;8:759-64). The term pluriblast has neither of these disadvantages.
80 Epithelium primordiale The tissues of the pre-implantation embryo proper are all epithelial in that their cells are sessile, are polarized between a free surface and a basal lamina and they have specialized
juxtaluminal junctions and little intercellular substance. Daughter cells may be epithelial or, as a result of epitheliomesenchymal transition, become mesenchymal (see below).
81 Epiblastus The term epiblast is preferred for this tissue as it provides appropriate information about its site, fate and potential. Primary ectoderm is less preferred both because the term has been used to include
amnioblast and because current usage postpones the use of the suffix -derm until after gastrulation (Johnson MH and Selwood L. Nomenclature of early development in mammals. Reprod Fertil Dev 1996;8:759-
64). Alternatives that include the term ectoderm, the use of which should be limited to the cells remaining on the dorsal surface of the embryo after the early somite stage, are not recommended.
82 Hypoblastus The term hypoblast is preferred for this tissue as it provides appropriate information about its site, fate and potential. It appears to induce the formation of the primordial amniotic cavity
(Coucouvanis E, Martin GR. Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell 1995;83:279-287) and of axial patterning in the epiblast, including the forebrain
(Beddington RSP, Robertson EP. Axis development and early asymmetry in mammals. Cell 1999;96:195-209). The term primary endoderm is less preferred both because the term has been used to include the
83 Mesenchyma A tissue consisting of free cells without polarity or specialized juxtaluminal junctions. The loosely arranged, often stellate, cells are suspended in a gelatinous matrix and are amoeboid and actively
phagocytic. As they migrate their processes make temporary contact with each other, with overlying epithelial cells and with their basal laminae. The outcome of eptheliomesenchymal transition is that there are two
types of tissue, namely, epithelial and mesenchymal. These tissue types do not correspond to the primary germ layers, ectoderm, endoderm and mesoderm [q.v.].
84 Cavitas blastocystica The term blastocystic cavity is recommended, rather than blastocoel, because the cavity is not homologous with the blastocoel of amphibians and birds, the homologue of which is "the
very narrow slit confined between the epiblast and hypoblast" (Eyal-Giladi H. Establishment of the axis in chordates: facts and speculations. Development 1997;124:2285-2296).
85 Trophoblastus; Trophoectoderma The term trophoblast is preferred for this tissue, which is defined as the earliest appearing stem cell population dedicated to nourishment of future embryonic tissues. Its cells
are adhesive, migratory and, initially, multinucleate. They appear, at least in the mouse, to signal the specification of primordial germ cells and the allantois in the caudal epiblast (Lawson KA, Dunn NR, Roelen BA,
Zeinstra LM, Davies AM, Wright CV, Corving JP, Hogan BL. Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes Dev 1999;13:424-436). The term trophectoderm and its
variants are not recommended because current usage postpones the use of the suffix -derm until after gastrulation (Johnson MH and Selwood L. Nomenclature of early development in mammals. Reprod Fertil Dev
1996;8:759-64). Alternatives that include the term ectoderm, the use of which should be limited to the cells remaining on the dorsal surface of the embryo after the early somite stage, are not recommended.
86 Blastocystis unilaminaris [Gradus III] The cavity of a unilaminar blastocyst is surrounded by a single layered extra-embryonic ectodermal membrane, the trophoblast; in the bilaminar blastocyst, the trophoblast
is lined by extra-embryonic endoblast; the interposition of extra-embryonic mesoderm creates the trilaminar blastocyst.
87 Insignia miscellanea cellularum trophoblastorum nondifferentiatarum These miscellaneous features have only been observed in vitro. Similar observations on the differentiated trophoblast are not readily
available.
88 Blastocystis adhaerens [Gradus IV] An embryo of Carnegie Stage 4 is an attaching blastocyst but no such in vivo human specimen has been recorded. Previously reliance was placed on those of the macaque
(Heuser CH, Streeter GL. Development of the macaque embryo. Contrib Embryol 1941;29:15-55) but direct information about Stage 4 is now derived from in vitro experiments in which blastocysts are placed on
monolayers of cultured endometrial epithelial cells. Embryos of Stage 4 would be about 6 days old and about 0.1-0.2mm in diameter.
89 Cavitas amniotica primordialis It appears that a primordial amniotic cavity forms by cavitation within the epiblast, that the roof of the primordial amniotic cavity breaks down creating a transient tropho-epiblastic
cavity and that the definitive amniotic cavity becomes roofed by cells that arise from the margins of the epiblast. There is no primordial amniotic cavity in embryos of Stage 3 and while most embryos of Stage 5a
have a tropho-epiblastic cavity, the “earliest known human implantation stage” (Carnegie No 8020) has a primordial amniotic cavity (Luckett WP.The development of primordial and definitive amniotic cavities in early
Rhesus monkey and human embryos. Am J Anat 1975;144:149-168). It is therefore presumed that for most embryos a primordial amniotic cavity occurs in Stage 4.
90 Blastocystis implantata; Blastocystis invadens; Conceptus previllosus [St.5] Embryos of Carnegie Stage 5 are implanted but previllous blastocysts. Their trophoblast is solid in Stage 5a, contains isolated
lacunae in Stage 5b and contains intercommunicating lacunae in Stage 5c. The embryonic disc in embryos of Stage 5, which are about 7-12 days old, is generally 0.1-0.2mm in diameter.
91 Margo syncytiodecidualis The endometrium responds to the presence of syncytiotrophoblast by undergoing the predecidual reaction, characterized by oedema and then saw–toothed glands, particularly in the
stratum spongiosum. It is thenceforward called decidua.
92 Cavitas trophoepiblastica The trophoepiblastic cavity is apparently formed by the breakdown of the roof of the primordial amniotic cavity. See above.
93 Amnioblastus; Cellulae amniogenicae; Ectoderma amnioticum The term amnioblast is preferred for this tissue as it provides appropriate information about its site, fate and potential. Extra-embryonic ectoderm is
least preferred because current usage postpones the use of the suffix -derm until after gastrulation (Johnson MH and Selwood L. Nomenclature of early development in mammals. Reprod Fertil Dev 1996;8:759-64).
Alternatives that include the suffix -derm are not recommended.
95 Area caudalis mesoblastogenica An area at the future caudal margin of the epiblast, which precedes the appearance of a definite primitive streak [St.6b]. Extra-embryonic mesoblast is thought to arise from this
area rather than by delamination from the trophoblast.
96 Mesoblastus extraembryonicus The term mesoblast is preferred for this tissue because it provides appropriate information on its site, fate and potential. Lankester used the term to describe those cells, which
he thought derived from enteric cells (extra-embryonic endoblast), separated, spread out, became amoebiform and “crawled all over the inner wall of the ectodermic vesicle (blastocoele or blastocystic cavity)
(Lankester R. Notes on the embryology and classification of the animal kingdom. Q J Microscop Sci 1877;17:399-454). A term is necessary to describe the tissues found outside the extra-embryonic endoblast and
inside the trophoblast before gastrulation and the use of the suffix -blast is a corollary of current usage (Johnson MH, Selwood L. Nomenclature of early development in mammals. Reprod Fertil Dev 1996;8:759-64).
The qualifying adjective extra-embryonic is necessary because the term mesoblast has been used to describe the free cells that migrate between the epiblast and intra-embryonic endoderm (Collins P, Billett FS.
The terminology of early development: history, concepts, and current usage. Clin Anat 1995;8:418-25) and to denote a temporary, embryonic cell lineage, which will later generate either an epithelial or a free-cell
arrangement (Collins P. Embryology and development. In: Williams PL, Bannister LH, Berry MM, Collins P, Dyson M, Dussek J, Ferguson MWJ, editors. Gray’s Anatomy 38th ed. Edinburgh: Churchill Livingstone;
1995).
97 Textus angioblasticus mesoblasti / Crista previllosa mesoblasti Extra-embryonic mesoblastic tissues produced from the epiblast before gastrulation.
98 Reticulum extraembryonicum; Magma reticulare Extra-embryonic mesoblast produced, initially from the hypoblast, before gastrulation. At least in the rhesus monkey, the cells of both the hypoblast and the
initial reticulum are mitotically active (Enders AC, King BF. Formation and differentiation of extraembryonic mesoderm in the rhesus monkey. Am J Anat 1988;181:327-340) so that later reticulum may have arisen
from either source.
99 Endoblastus extraembryonicus; Membrana exocoelomica The term endoblast is preferred for this tissue as it provides appropriate information about its site, fate and potential. The term primary endoderm is
least preferred both because it applies also to the hypoblast and also because current usage postpones the use of the suffix -derm until after gastrulation (Johnson MH, Selwood L. Nomenclature of early
development in mammals. Reprod Fertil Dev 1996;8:759-64). Other alternatives that include the term endoderm are not recommended.
100 Vesicula umbilicalis primaria / Saccus vitellinus primarius; Cavitas vesiculae umbilicalis primariae / Cavitas sacci vitellini primarii; Vesicula umbilicalis secundaria / Saccus vitellinus secundarius; Cavitas
vesiculae umbilicalis secundariae / Cavitas sacci vitellini secundarii The term umbilical vesicle, which has been in use for many years, is preferred because yolk (Latin vitellus) is not present in the human vesicle
and because the term indicates location, the vesicle being a feature of the umbilical region of the embryo and becoming, at least partially, incorporated into the umbilical cord.
101 Circulus lacunosus vascularis The lacunar vascular circle is visible from the endometrial surface.
102 Lamina prechordalis precoqua “The first clear evidence of a (rostro)caudal embryonic axis appears [at Stage 5c] as a pronounced thickening of the [hypoblast] at the future cranial end of the embryonic disc to
form a prechordal plate.” (Luckett WP. Origin and differentiation of the yolk sac and extraembryonic mesoderm in presomite human and rhesus monkey embryos. Am J Anat 1979;152:59-98). However, this
thickening may not correspond to the prechordal plate but to the extra-embryonic rostral visceral endoderm or rostral marginal crescent found in other mammals (Viebahn C.The anterior margin of the mammalian
gastrula: comparative and phylogenetic aspects of its role in axis formation and head induction. Curr Top Dev Biol 1999;46:63-103). The prechordal plate proper may not appear until Stage 7.
103 Polus rostralis embryonis Although rostrum means a beak, a snout or the prow of a ship, rostral is commonly used as the opposite of caudal, particularly before the appearance of cephalic structures in Stage
8 or cranial structures in Stage 13, but also thereafter: it is also used in neuroanatomy to mean nearer the rostrum of the corpus callosum in the unfolded nervous system.
105 Latus dextrum embryonis Although the sides of the embryo can be recognized and cranial patterning occurs in Stage 5, it is not until Stage 6b, with the formation of the primitive node, that the molecular basis
for left-right asymmetry is established.
106 Conceptus villosus [Gradus VI] Embryos of Carnegie Stage 6 are villous conceptuses. There may be the suggestion of a primitive streak in embryos of Stage 6a or earlier, but one is definitely present in
embryos of Stage 6b. The embryonic discs of embryos of Stage 6 are generally about 0.2mm in diameter and they are about 17 days old.
107 Chorion frondosum The predecidual reaction around embryos of Carnegie Stage 5 becomes a full-blown decidual reaction around embryos of Carnegie Stage 6, with the transformation of stromal cells into
decidual cells: they become rounded or polyhedral and glycogen, lipids and mitochondria accumulate within their vacuolated cytoplasm.
108 Vasculogenesis Formation of a primordial capillary network from cells that differentiatie locally: they may be invading angioblasts (Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol. 1995:11;79-91)
or be endothelial progenitor cells (EPCs) which differentiate in splanchnopleuric mesenchyme or its derivatives.
109 Mesenchyma capitis Head mesenchyme is listed as present in embryos from Stage 6b onwards in the Edinburgh atlas and database of human developmental anatomy.
http://www.ana.ed.ac.uk/anatomy/database/humat/ but the primary source of the listing is not known. Its presence in embryos of Stage 7 may be inferred from Hill JP, Florian J. A young human embryo (embryo
Dobbin) with head-process and prechordal plate (Phil Trans Roy Soc London B 1931;219:443-486).
110 Linea primitive / Linea gastrulationis; Nodus primitivus / Nodus gastrulationis; Sulcus primitivus / Sulcus gastrulationis The terms primitive streak/node/groove are widely used but may be misuses of the term
primitive, which more usually refers to phylogeny rather than ontogeny. The alternative terms, gastrulation streak / node / groove, do not have this anomaly and, from a functional viewpoint, are more informative.
111 Mesoderma embryonicum; Mesoblastus These terms describe the intermediate germ layer of the trilaminar embryo, which will form bone, muscle and connective and blood-vascular tissues. Experimental
studies suggest that cells ingressing through the rimitive node and the rostral part of the primitive streak give rise to paraxial mesoderm and those through the middle part give rise to lateral plate mesoderm. The
qualifying adjective embryonic is necessary as long as terms such as primary mesoderm remain in use. The term mesoblast has been used (Collins P. Embryology and development. In: Williams PL, Bannister LH,
Berry MM, Collins P, Dyson M, Dussek J, Ferguson MWJ, editors. Gray’s Anatomy 38th ed. Edinburgh: Churchill Livingstone; 1995 and subsequent editions). However, the use of the suffix -derm for a germ layer
produced by gastrulation is preferred and has that restricted use here : the parts of the germ layer are paraxial and lateral plate mesoderms; their derivatives are either epithelial or mesenchymal and are named
accordingly.
112 Endoderma embryonicum The term describes the ventral germ layer of the trilaminar embryo, which will form the epithelium of the gut, including the prechordal plate, and many of their derivatives. These
possibly include prechordal mesenchyme but this may be of notochordal origin. Experimental studies suggest that the first cells ingressing through the primitive node give rise to notochord and embryonic endoderm,
which will form the roof of the secondary umbilical vesicle, displacing the cells of the hypoblast laterally into its walls. The qualifying adjective embryonic is necessary as long as terms such as primary endoderm
remain in use.
113 Lamina prechordalis The prechordal plate may not appear until Stage 7: certainly in Stage 8 it is “a highly developed mesendodermal mass [in which cells resemble either endoderm or mesenchyme] in
contact with the floor of the neural groove”. At stages 9 and 10, the plate is related to neuromere D1. Lateral growth at stages 9-11 gives rise to the bilateral premandibular condensations (Müller F, O'Rahilly R. The
prechordal plate, the rostral end of the notochord and nearby median features in staged human embryos. Cells Tissues Organs 2003;173:1-20). Prechordal mesenchyme does not become truly plate-like until Stage
9 and some would thus say that the prechordal plate appears in Stage 9.
114 Diverticulum allantoicum; Ductus allantoicus Several examples of “allantoic diverticula” have been reported in embryos of Stage 6. Nevertheless, “it is difficult to find a convincing example of an allanto-enteric
diverticulum at Stage 6” (O'Rahilly R, Müller F. Developmental stages in human embryos. Washington DC: Carnegie Institution of Washington; 1987).
116 Embryo postgastrulationis [St.6b ad 23] The pregastrulation and postgastrulation phases of the embryonic period and the fetal period are stages of prenatal development, each with its own distinctive
characteristics, particularly in respect of its responses to teratogens. In postgastrulation embryos the main events of organ formation occur. These entail delicate and complex tissue interactions that are particularly
susceptible to teratogens, which have dramatic effects upon morphology. Palate and lips, eyes, ears, brain, spinal cord and heart are all highly susceptible. Susceptibility diminishes as the main events of organ
formation are completed by Carnegie Stage 23.
117 Embryo cum processu notochordali [Gradus VII]; Embryo cum processu axiali Gradus VII]; Embryo cum chordomesoderma Gradus VII] Each embryo of Carnegie Stage 7 has a notochordal process
immediately rostral to its primitive node and streak. The embryos are generally about 0.4mm in diameter and about 19 days old.
118 Cardo chordoneuralis; Punctum chordoneurale cardinis Once the primitive node has started to form, gene expression centred on it becomes asymmetrical and the molecular basis for left-right asymmetry is
established. For a review of the first description by Hensen, see: Viebahn C. Hensen’s node. Genesis 2001: 29;96-103. See also: Müller F, O'Rahilly R. The primitive streak, the caudal eminence and related
structures in staged human embryos (Cells Tissues Organs; 177:2-20:2004); Charrier J, Teillet M, Lapointe F, Le Douarin N. Defining subregions of Hensen's node essential for caudalward movement, midline
development and cell survival (Development 1999; 126:4771-4783); Cambray, N, Wilson, V. Axial progenitors with extensive potency are localised to the mouse chordoneural hinge (Development 2002; 129:4855-
66).
119 Canalis neurentericus The neurenteric canal is a temporary passage between the amniotic cavity and the umbilical vesicle. It develops during Stage 8 and is constant (whether patent or not). It is most clearly
visible at Stage 9 and has almost disappeared at Stage 10 (Müller F, O’Rahilly R. The primitive streak, the caudal eminence and related structures in staged human embryos. Cells Tissues Organs 2004;177:2-20).
120 Embryo presomiticus [St.8] Embryos of Carnegie Stage 8 are late presomite embryos. They are generally 1-1.5mm in greatest length and about 23 days old. The term presomite embryo is sometimes applied
more generically to include also Stages 6-8 but this usage is not recommended. Originally, phases were not ascribed to Stage 8 (O'Rahilly R, Müller F. Developmental stages in human embryos. Washington DC:
Carnegie Institution of Washington; 1987). However, only advanced specimens show a neural groove: in the same specimens the floor of the notochordal process is breaking down and a notochordal plate is
present (O'Rahilly R, Müller F.The first appearance of the human nervous system at stage 8. Anat Embryol 1981;163:1-13). These distinct phases are recognised here by the use of the terms Presomite embryo
without neural groove [St.8a] and Presomite embryo with neural groove [St.8b].
121 Fovea primitive The term primitive pit is widely used but may be a misuse of the term primitive, which more usually refers to phylogeny rather than ontogeny. The term notochordal pit does not have this
anomaly and is more informative.
122 Ectoderma embryonicum The term describes the dorsal germ layer of the somite embryo, which will form the epithelium of the skin and nervous system and their derivatives. Experimental studies suggest
that, after obvious primitive streak activity ceases, epiblastic cells continue to ingress through the most caudal part of the primitive streak until the early somite stage. They form axial dense mesenchyme and thence
become the endoderm and mesoderm of more caudal parts in secondary body development. The cells remaining on the dorsal surface of the embryo thereafter constitute the embryonic ectoderm. The qualifying
adjective embryonic is necessary as long as terms such as primary ectoderm remain in use.
123 Somitomerum Somitomeres are paired whorls of mesenchymal cells that appear metamerically in paraxial mesoderm before the appearance of epithelial somites. Somitomeres form in strict craniocaudal
sequence beginning in the head where they subsequently contribute to head mesenchyme. Elsewhere, they condense, epithelialise and form somites. They have been found in all amniote embryos that have been
examined by stereo scanning electron microscopy (Jacobson AG. Somites and head mesoderm arise from somitomeres. In: Sanders EJ, Lash JW, Ordahl CP. Eds. The origin and fate of somites. Amsterdam: IOS
Press; 2001).
124 Zona junctionalis mesenchymalis The bar of mesenchyme where somatopleuric and splanchnopleuric mesenchymes meet and which separates the embryonic and extra-embryonic coeloms on each side of
the Stage 9 embryo. It breaks down, allowing them to communicate, in Stage 10.
126 Tuberculum caudale In Stage 20 the caudal tubercle (see above) is produced by vestiges of the nonvertebrated part of the caudal eminence or tail bud and may become cystic.
127 Mesenchyma intermedium; Mesoderma intermedium The tissue primarily responsible for the formation of the kidneys and internal genitalia and their ducts. Experimental studies suggest that intermediate
mesoderm in amniotes arises from the middle of the primitive streak distal to somite origin and proximal to lateral plate mesoderm origin. The term intermediate mesenchyme is thus more appropriate than the
commonly used intermediate mesoderm.
128 Cellulae antecedentes The term antecedent cell is used here solely in a generic sense and without any specific connotation. The term precursor is not used in a generic sense, to avoid confusion with the
specific term cellula precursoria, a synonym for the official term for stem cell, cellula staminalis.
129 Potestas totalis Totipotency is the capacity (a) to form all cell lineages, embryonic and extra-embryonic, and (b) to self-organise, i.e., to form the body axis and the basic body plan (e.g., zygote; blastomere).
130 Potestas pluralis Pluripotency is the capacity to form either all embryonic or all extra-embryonic cell lineages (e.g., cells of the inner cell mass or pluripotent stem cells).
131 Potestas multiplex Multipotency is the capacity to form multiple cell types of one cell lineage (e.g., cells of one germ layer; somatic adult stem cells).
132 Potestas una Unipotency is the capacity of adult stem cells to form only one cell type (e.g., haematopoietic stem cells; spermatogonia).
133 Formabilitas Plasticity is the ability of a specific stem cell population to transdifferentiate, i.e, to switch to a stem cell population with a different differentiation potential.
134 Cellula primordialis A primordial cell is totipotent; the zygote and its immediate progeny are primordial cells.
135 Cellula fundatoria Founder cells are capable of contributing to the establishment of one or more cell populations.
136 Cellula progenitalis; Cellula proprecursoria A prestem cell is capable of contributing to the establishment of one or more stem cell populations.
137 Cellula staminalis; Cellula precursoria A stem cell is a constituent of a population that is capable of maintaining its own size while exporting an appropriate output of progeny to one or more cell lineages. The
term Cellula staminalis was adopted by FIPATas the preferred term.
138 Cellulae multipotentes et unipotentes Cells are here usually listed according to both their derivation and their potential: an exception is the epidermal neural crest cell stem cell [eNCSC], which is derived from
epidermis but is capable of giving rise to neural crest cells.
139 Cellula staminalis germinalis An embryo of Stage 6b showed a marked concentration of glycogen in the extra-embryonic endoderm of the secondary yolk sac and some of the cells may be primordial germ
cells (Hertig AT, Adams EC, McKay DG, Rock J, Mulligan WJ, Menkin MF. A thirteen-day human ovum studied histochemically. Am J Obstet Gynecol 1958;76:1025-1043).
140 Factores crescentiae The factors listed here are only representative but all are known to be active in normal embryogenesis and specific congenital anomalies are known to be associated with disturbances of
them (TGF-α). Whether or not these criteria are appropriate and whether or not other growth factors should be included here is debatable. The number of growth factors and their families that have been identified
continues to increase as does knowledge of their activities.
142 Crista neuralis Cells of the primary neural crest separate from the neurosomatic ectodermal junction to give rise to the mesencephalic, rhombencephalic and spinal neural crest down to S1. Following
secondary neurulation, cells delaminate from the surface of the secondary neural tube and give rise to spinal neural crest beyond S1 (O'Rahilly R, Müller F. The development of the neural crest in the human. J Anat
2007;211:335-351). Neural crest is here divided according to the adjacent part of the brain. The term circumpharyngeal neural crest is not used as it describes a migration route to the pharyngeal region, the outflow
tract of the heart and great vessels and much of the gut-associated crest derivatives. Furthermore, it is said to be in the posterior rhombencephalic region but the crest for the first two pharyngeal arches is mainly
associated with rhombomeres 2 and 4.
143 Structurae cristae neuralis Neural crest tissue is dealt with under General histogenesis because of the wide range and distribution of its derivatives outside the nervous system. Groups of cells, which behave
in a similar manner but arise from some placodes and by delamination from the optic and otic vesicles are classified here as neural crest-like cells. Neural crest cells and neural crest-like cells meld seamlessly into
neural crest complexes and are no longer morphologically distinguishable (O'Rahilly R, Müller F. The development of the neural crest in the human. J Anat 2007;211:335-351). Here the term neural crest is used in
sensu stricto and the term neural crest complex recognizes the dual lineage of its component cells.
144 Complexus cristae neuralis nasalis The nasal neural crest complex develops from the epithelium of the nasal placodes in Stage 13 and migrates towards the telencephalon, reaching it in Stage 15, at which
stage complex-derived olfactory fibres enter the region of the future olfactory bulb.
145 Complexus cristae neuralis opticae The optic neural crest complex develops from the optic primordium in Stages 11 and 12 at the level of Diencephalon 1 and is the only forebrain-derived neural crest-like
tissue.
146 Cellula staminalis cornealis Corneal stem cells come from the corneoscleral junction.
147 Complexus cristae neuralis mesencephalicae The mesencephalic neural crest complex appears at Stage 9 and at Stage 11 spreads out towards the frontonasal region where it mingles with the optic neural
crest complex.
148 Crista neuralis isthmica Neural crest cells, seen in the roof of the isthmic rhombomere in Stage 13, appear to be destined more for the leptomeninges than for the mesencephalic nucleus of the trigeminal
nerve.
149 Complexus cristae neuralis trigeminalis At Stage 10 neural crest cells migrate mainly from future rhombomere 2 but with contributions from adjacent future rhombomeres and with neural crest-like cells from
the overlying ectoderm form the trigeminal neural crest complex.
150 Complexus cristae neuralis faciovestibulocochlearis At Stage 11 some cells from the otic vesicle, representing the primordial vestibular ganglion, attach to the facial neural crest. At Stage 14 afferent fibres to
the geniculate ganglion and efferent fibres from the vestibular ganglion distinguish between the two parts; at Stage 15 the smaller primordial cochlear ganglion cells appear and fibres are present at Stage 16.
151 Complexus cristae neuralis facialis At Stage 10 neural crest cells migrate mainly from rhombomere 4 but with contributions from adjacent rhombomeres and with neural crest-like cells from the overlying
ectoderm form the facial neural crest complex.
152 Ossiculae auditus (partim) Thompson et al. suggested that the mesenchyme of the auditory ossicles may also originate as a whole or in part from the neural crest. (Thompson H, Ohazama A, Sharpe PT,
Tucker AS. The origin of the stapes and relationship to the otic capsule and oval window. Dev Dyn 2012;241:1396-1404.)
154 Complexus cristae neuralis glossopharyngealis; Complexus cristae neuralis vagalis At Stage 10 neural crest cells migrate mainly from the roof of rhombomere 6 and probably from adjacent rhombomeres and
meld with neural crest-like cells from the overlying ectoderm to form part of a continuous glossopharyngeal/vagal neural crest complex. In Stage 13, the glossopharyngeal and vagal parts separate and each
develops superior and inferior ganglia, of which only the superior ganglia are believed to be derived from neural crest per se.
155 Crista neuralis cardiaca At Stage 12 some neural crest cells from rhombomeres 6 and 7, which are in continuity ventrally with the hypoglossal neural crest, proceed via pharyngeal arches towards the truncus
arteriosus; at Stage 13 they are joined by neural crest and neural crest-like cells and, continuing beyond the inferior glossopharyngeal and vagal ganglia, migrate into the 3rd and 4th pharyngeal arches; these
components are interpreted as human cardiac neural crest tissue.
156 Cartilagines laryngeae The Vagal neural crest complex does not contribute to all of the laryngeal cartilages.
157 Aa. arcuum pharyngeorum The terms pharyngeal arch artery / arteries are preferred to those of aortic arch/es to avoid confusion with the definitive aortic arch.
158 Crista neuralis nervi accessorii At Stage 12 neural crest cells from rhombomere 7 migrate and form the neural crest of the accessory nerve, which, by Stage 13, extends uninterruptedly between the vagal
neural crest and the spinal neural crest.
159 Crista neuralis hypoglossalis; Crista neuralis occipitalis In Stage 10 neural crest cells migrate from rhombomere 8 and spread between occipital somites where they mingle with myotomic cells to form the
hypoglossal cell cord; at Stage 12 the cord has reached the 1st pharyngeal arch; and by Stage 16 it has reached the lateral lingual swelling.
160 Crista neuralis spinalis The spinal leptomeninges, mesenchyme of the neck, trunk and lower limb dermis and adipocytes were formerly attributed to the spinal neural crest but are now known to be derived
from somites (Christ B, Huang R, Scaal M. Amniote somite derivatives. Dev Dyn 2007;236:2382-2396).The traditional distinction between trunk and lumbosacral spinal neural crest seems inappropriate because the
trunk lumbar and 1st sacral spinal neural crest all form in the same way, whereas the remaining sacral and coccygeal spinal neural crest, which form after the caudal neuropore closes at Stage 12, do so by direct
outgrowth from the secondary neural tube. The caudal limit of the spinal neural crest descends with each Stage, as does the formation of primordial spinal ganglia, which lie at somite 19 at Stage 13 and 33 at Stage
14.
161 Via migrationis dorsolateralis Dorsolateral migration from the spinal neural crest passes between the surface ectoderm and the dermatomyotome.
162 Via migrationis ventrolateralis Ventrolateral migration from the spinal neural crest passes between the dermatomyotome and the sclerotome.
163 Via migrationis ventromedialis Ventromedial migration from the spinal neural crest passes between the sclerotome and the neural tube.
164 Mesenchyma somatopleurale Together with ectoderm, somatopleuric mesenchyme makes up the body wall. The unqualified term somatopleure is not recommended because it is ambiguous, having been
used to mean either the whole thickness of the body wall or only its mesenchymal component
165 Mesenchyma splanchnopleurale Together with endoderm, the splanchnopleuric mesenchyme makes up the walls of the gut-related viscera. The unqualified term splanchnopleure is not recommended
because it is ambiguous, having been used to mean either the whole thickness of the visceral wall or only its mesenchymal component.
166 Cellula adipocytoprogenetrix Adipose tissue not only develops from mesenchyme from various sources but also from fat cell progenitors derived from granulocyte macrophage colony-forming units (GM-CFU).
168 Osteoclastus Osteoclasts form by the fusion of osteoclast progenitor cells (Bar-Shavit Z. The osteoclast: a multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell. J Cell Biochem
2007;102:1130–1139).
169 Canalis cartilagineus Cartilage canals first appear in the early fetus and by 28 weeks all the larger masses of cartilage are permeated by them. They contain blood vessels surrounded by loose cellular tissue
and provide the osteoblastic tissue for ossification when this later occurs (Haines RW. Cartilage canals. J Anat 1933;68:45-64).
170 Ossificatio perichondralis diaphysialis Adjectives derived from nouns such as diaphysis, epiphysis and hypophysis are, in a strict grammatical sense, probably best constructed using the suffix –alis giving
diaphysalis, epiphysalis, hypophysalis and symphysalis. However, for reasons of terminological precedence and consistency, the spellings of diaphysialis, epiphysialis, hypophysialis and symphysialis have been
here retained.
171 Anulus perichondralis This term describes the site of periosteal activity around the cartilaginous bud of a bone, and later the periosteal activity around the diaphysial cartilage.
172 Extensio gemmae osteogenicae The spread is that which takes place through an erosion canal into the cartilage model.
173 Osteonum primarium; Osteonum secundarium Primary osteons are directly deposited by the periosteum and not in a preceding resorption cavity. As a result, unlike secondary osteons, primary osteons are
not limited by resorption or reversal lines. Secondary osteons are deposited in a resorption cavity and are limited by resorption or reversal lines.
FIPAT
The Federative International Programme for Anatomical Terminology
A programme of the International Federation of Associations of Anatomists (IFAA)
TE2, PART II
Contents
Published pending approval by the General Assembly at the next Congress of IFAA (2019)
The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use
the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA
member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the
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Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS
1406 Ossificatio membranacea Ossificatio desmalis Membranous ossification Membranous ossification Intramembranous ossification See General Histogenesis
1407 Ossificatio chondralis Chondral ossification Chondral ossification Cartilaginous ossification See General Histogenesis
1408 Textus osseus reticulofibrosus Woven bone Woven bone See General Histogenesis
1609 Pars caudalis sclerotomi Pars densa sclerotomi Caudal part of sclerotome Caudal part of sclerotome Dense part of sclerotome
1610 Corpus vertebrae Vertebral body Vertebral body
1611 Pars major costae distalis Major part of distal rib Major part of distal rib
1612 Angulus caudolateralis partis Caudolateral corner of caudal Caudolateral corner of caudal
caudalis sclerotomi part of sclerotome part of sclerotome
1613 Tendines musculorum dorsi Tendons of muscles of back Tendons of muscles of back Syndetome
propriorum proper proper
1614 Vagina notochordalis Vagina cellularis notochordalis Notochordal sheath Notochordal sheath Perichordal sheath; Cellular
notochordal sheath;
Perinotochordal sheath
1615 Pars rostralis vaginae Pars laxa vaginae notochordalis Rostral part of notochordal Rostral part of notochordal Loose part of notochordal sheath
notochordalis sheath sheath
1616 Blastema centri vertebrae Blastema of centrum of Blastema of centrum of
vertebra vertebra
1617 Pars caudalis vaginae Pars densa vaginae notochordalis Caudal part of notochordal Caudal part of notochordal Dense part of notochordal sheath
notochordalis sheath sheath
1618 Discus intervertebralis Intervertebral disc Intervertebral disc Endnote 179
1619 Anulus fibrosus disci Anulus fibrosus of Anulus fibrosus of
intervertebralis intervertebral disc intervertebral disc
1666 Membra et skeleton Limbs and appendicular Limbs and appendicular See also under Muscles
appendiculare skeleton skeleton
1667 Mesoderma laminae lateralis Lateral plate mesoderm Lateral plate mesoderm
1668 Mesenchyma somatopleurale Somatopleuric mesenchyme Somatopleuric mesenchyme
1669 Ectoderma embryonicum Embryonic ectoderm Embryonic ectoderm
1670 Anulus ectodermalis primordialis Primordial ectodermal ring Primordial ectodermal ring §Wolffe§
1671 Gemmae membrorum Limb buds Limb buds
1672 Gemma membri superioris Upper limb bud Upper limb bud Rostral limb bud
1673 Gemma membri inferioris Lower limb bud Lower limb bud Caudal limb bud
1674 Axis craniocaudalis Craniocaudal axis Craniocaudal axis
1675 Margo preaxialis Pre-axial border Preaxial border
1676 Zona apoptotica anterior Anterior apoptotic zone Anterior apoptotic zone Endnote 180
1796 Hyperostosis corticalis infantilis Infantile generalized cortical Infantile generalized cortical §Caffey-Silverman§
diffusa hyperostosis hyperostosis
1797 Hyperostosis diffusa Generalized hyperostosis with Generalized hyperostosis with §Uehlinger§
pachydermatina pachydermia pachydermia
1798 Melorheostosis Melorheostosis Melorheostosis
1799 Osteopetrosis Marble bone disease Marble bone disease §Albers-Schönberg§
1800 Osteopoikilosis Osteopoikilosis Osteopoikilosis
1801 Pyknodysostosis Pyknodysostosis Pyknodysostosis
1802 Sclerosis diaphysialis hereditaria Multiple hereditary diaphysial Multiple hereditary diaphyseal §Ribbing§
multiplex sclerosis sclerosis
1803 Sclerosteosis Sclerosteosis Sclerosteosis
1804 Toxopachyostosis Toxopachyostosis Toxopachyostosis §Weismann-Netter§
1805 Hypoplasiae Hypoplasias Hypoplasias
1806 Acroosteolysis Acro-osteolysis Acroosteolysis
1807 Dysostosis cleidocranialis Cleidocranial dysostosis Cleidocranial dysostosis
1808 Dystrophia Dermochondrocorneal dystrophy Dermochondrocorneal dystrophy §François§
dermochondrocornealis
1809 Hypochondroplasia Hypochondroplasia Hypochondroplasia
1810 Osteofibrosis monoosteotica Osteofibrosis mono-osteoticus Osteofibrosis monoosteoticus §Allbright-McCune§
1811 Osteofibrosis polyosteotica Osteofibrosis polyosteoticus Osteofibrosis polyosteoticus §Jaffé-Lichenstein§
1812 Osteogenesis imperfecta Osteogenesis imperfecta Osteogenesis imperfecta §Vrolik/Lobstein§
1813 Osteoporosis idiopathica Idiopathic osteoporosis Idiopathic osteoporosis
1814 Macroplasia Macroplasia Macroplasia
1815 Microplasia Microplasia Microplasia
1816 Mucopolysaccharidoses Mucopolysaccharidoses Mucopolysaccharidoses
1817 Dysostosis multiplex typi I Type I Type I Dysostosis multiplex §von Pfaundler-Hurler§
1818 Dysostosis multiplex typi II Type II Type II Dysostosis multiplex §Hunter§
1819 Typus III Oligophrenia polydystrophica Type III Type III Polydystrophic oligophrenia §Sanfilippo§
1820 Typus IV Dysplasia spondyloepiphysialis Type IV Type IV Intermediate spondyloepiphysial §Morquio-Brailsford§
intermedia dysplasia; Intermediate
spondyloepiphyseal dysplasia
1821 Typus V Type V Type V §Ulrich-Scheie§
1822 Typus VI Nanismus polydystrophicus Type VI Type VI Polydystrophic dwarfism §Maroteaux§
1823 Typus VII Nanismus pseudopolydystrophicus Type VII Type VII Pseudopolydystrophic dwarfism §Maroteaux-Lamy§
1824 Synostosis Synostosis Synostosis
1825 Anomaliae et variationes Cranial anomalies and growth Cranial anomalies and growth Endnote 186
crescentiae cranii variations variations
1826 Dysinductio encephalica Encephalic dysinduction Encephalic dysinduction
1895 Anomaliae et variationes Maxillary and mandibular Maxillary and mandibular See also Syndromes involving face
crescentiae mandibulae et anomalies and growth variations anomalies and growth variations
maxillae of the jaws of the jaws
1896 Agnathia Agnathia Agnathia
1897 Dignathia Dignathia Dignathia
1898 Gnathoschisis Schistognathia Gnathoschisis Gnathoschisis Cleft jaw
1899 Hypognathia Hypognathia Hypognathia
1900 Macrognathia Macrognathia Macrognathia
1901 Micrognathia Micrognathia Micrognathia
1902 Prognathia Prognathia Prognathia
1903 Retrognathia Retrognathia Retrognathia
1904 Mandibula lata Broad jaw Broad jaw
1905 Mandibula angusta Narrow jaw Narrow jaw
1906 Anomaliae columnae vertebralis Vertebral column anomalies Vertebral anomalies Endnote 188
1920 Spina bifida Spina bifida Spina bifida See also Neural tube anomalies
1921 Spina bifida aperta Spina bifida aperta Spina bifida aperta
1922 Spina bifida cystica Spina bifida cystica Spina bifida cystica
1923 Meningocoelia Meningocele Meningocele
1924 Meningomyelocoela Myelomeningocoela Mingomyelocoele Meningomyelocele Myelomeningocele
1925 Myelocoelia Myelocoele Myelocele
1926 Spina bifida occulta Spina bifida occulta Spina bifida occulta
1927 Anomaliae nervosae in spina bifida Nerve anomalies in spina bifida Nerve anomalies in spina bifida
1928 Hypoplasia nervi spinalis Spinal nerve hypoplasia Spinal nerve hypoplasia
1929 Malformatio nervi spinalis Spinal nerve malformation Spinal nerve malformation
1954 Anomaliae caveae thoracicae Thoracic cage anomalies Thoracic cage anomalies
1955 Schistosternia Cleft sternum Cleft sternum
1956 Foramen sternale Sternal foramen Sternal foramen
1957 Processus xiphoideus bifidus Cleft xiphoid process Cleft xiphoid process
1958 Costa bifida Costa bifurcata Bifid rib Bifid rib Forked rib
1959 Costa supernumeraria Supernumerary rib Supernumerary rib Accessory rib
1960 Pectus excavatum Funnel chest Funnel chest
1961 Costae conjunctae Fused ribs Fused ribs
1962 Pectus carinatum Pigeon chest Pigeon chest Keel chest
1963 Anomaliae membrorum et Limb and other appendicular Limb and other appendicular
aliarum partium skeleti skeletal anomalies skeletal anomalies
appendicularis
1964 Absentiae Absences Absences
1965 Absentiae longitudinales Longitudinal absences Longitudinal absences
1966 Absentiae centrales Central absences Central absences
1967 Absentiae transversae Transverse absences Transverse absences
1968 Absentiae terminales Terminal absences Terminal absences
2016 Dyscheiriae et variationes Hand anomalies and variations Hand anomalies and variations
crescentiae manus
2017 Absentia radii manus Absent hand ray Absent hand ray
2018 Acheiria Acheiria Acheiria Absence of hand
2019 Dicheiria Dicheiria Dicheiria
2020 Deviatio radialis manus Radial deviation of hand Radial deviation of hand Radial club hand
2021 Deviatio ulnaris manus Ulnar deviation of hand Ulnar deviation of hand Ulnar club hand
2022 Macrocheiria Macrocheiria Macrocheiria Prominent hand
2023 Manus compressa in pugnum Clenched hand Clenched hand
2024 Microcheiria Acromicria; Manus parva Microcheiria Microcheiria Small hand
2025 Manus trifida Trident hand Trident hand
2026 Os metacarpi breve Short metacarpal Short metacarpal
2027 Palma brevis Short palm Short palm
2028 Palma angusta Narrow palm Narrow palm
2029 Palma lata Broad palm Broad palm Wide palm
2030 Palma longa Long palm Long palm
2031 Absentia rugae palmaris Absent palmar crease Absent palmar crease
2032 Schistocheiria Cheiroschisis; Manus fissus; Cleft hand Cleft hand Split hand; Ectrodactyly; Bifurcate
Manus bifurcatus hand; Lobster claw hand
2036 Dyspodiae et variationes Foot anomalies and variations Foot anomalies and variations
crescentiae pedis
2037 Absentia radii pedis Absent foot ray Absent foot ray
2038 Acheiropodia Acheiropodia Acheiropodia Thanatophoric dysplasia
2039 Apodia Apodia Apodia Absence of foot
2040 Apodia partialis Partial apodia Partial apodia Partial absence of foot
2041 Calx prominens Prominent heel Prominent heel
2042 Dipodia Dipodia Dipodia
2043 Macropodia Macropodia Macropodia
2044 Metatarsus adductus Metatarsus adductus Metatarsus adductus
2045 Micropodia Micropodia Micropodia
2046 Os metatarsi breve Short metatarsal Short metatarsal
2139 Musculi Systema musculare Muscles Muscles Muscular system Endnote 190
2140 NOMINA GENERALIA GENERAL TERMS GENERAL TERMS
2141 Mesenchyma Mesenchyme Mesenchyme
2142 Mesenchyma capitis Head mesenchyme Head mesenchyme
2143 Mesenchyma prechordale Prechordal mesenchyme Prechordal mesenchyme
2144 Lamina prechordalis Prechordal plate Prechordal plate
2145 Mesoderma Mesoderm Mesoderm
2146 Mesoderma segmentatum Segmented mesoderm Segmented mesoderm
2147 Mesoderma nonsegmentatum Unsegmented mesoderm Unsegmented mesoderm
2148 Mesoderma capitis Unsegmented head mesoderm Unsegmented head mesoderm
nonsegmentatum
2149 Chorda hypoglossalis Hypoglossal cord Hypoglossal cord
2150 Mesenchyma pharyngomericum Pharyngomeric mesenchyme Pharyngomeric mesenchyme
2151 Ectomesenchyma Mesenchyma cristae neuralis Ectomesenchyme Ectomesenchyme Neural crest mesenchyme
2152 Mesoderma paraxiale Paraxial mesoderm Paraxial mesoderm
2153 Placoda epipharyngea Epipharyngeal placode Epipharyngeal placode
2154 Somitomerum Somitomere Somitomere
2155 Somitus Somite Somite
2156 Dermomyotomus Dermatomyotomus Dermomyotome Dermomyotome Dermatomyotome
2157 Myotomus Myotome Myotome
2158 Mesenchyma somatopleurale Somatopleuric mesenchyme Somatopleuric mesenchyme
2159 Mesenchyma gemmarum Mesenchyme of limb buds Mesenchyme of limb buds Appendicular mesenchyme
membrorum
2160 Striomyohistogenesis noncardiaca Noncardiac striomyohistogenesis Noncardiac striomyohistogenesis See Myohistogenesis in General
histogenesis (Part 1, Chapter 4)
2161 M. epaxialis M. primaxialis Epaxial muscle Epaxial muscle Primaxial muscle
2162 M. hypaxialis M. abaxialis Hypaxial muscle Hypaxial muscle Abaxial muscle
2163 M. preaxialis Pre-axial muscle Preaxial muscle
2164 M. postaxialis Postaxial muscle Postaxial muscle
2165 M. appendicularis Appendicular muscle Appendicular muscle
2166 Mm. compartmentorum Muscles of limb compartments Muscles of limb compartments See Terminologia Anatomica
membrorum
2167 Tendinogenesis Tendinogenesis Tendinogenesis See General histogenesis
2168 Tendo Tendon Tendon
2169 Aponeurosis Aponeurosis Aponeurosis
2170 Fascia Fascia Fascia
2171 Epimysium Epimysium Epimysium
2172 Perimysium Perimysium Perimysium
2173 Endomysium Endomysium Endomysium
2186 Primordium musculare arcus Second pharyngeal arch muscle Second pharyngeal arch muscle
pharyngei secundi primordium primordium
2187 Blastemata musculorum faciei Blastemata of facial muscles Blastemata of facial muscles Endnote 193
2188 Blastema musculi stapedii Blastema of stapedius Blastema of stapedius
2189 Primordium musculare arcus Third pharyngeal arch muscle Third pharyngeal arch muscle
pharyngei tertii primordium primordium
2193 Primordium musculare arcus Sixth pharyngeal arch muscle Sixth pharyngeal arch muscle
pharyngei sexti primordium primordium
2194 Blastemata musculorum Blastemata of laryngeal muscles Blastemata of laryngeal muscles
laryngeorum
2195 Blastemata musculorum Blastemata of superior, middle and Blastemata of superior, middle and
constrictorium superioris, medii et inferior pharyngeal constrictors and inferior pharyngeal constrictors and
inferioris pharyngis atque of salpingopharyngeus of salpingopharyngeus
salpingopharyngei
2208 Partes hypaxiales myotomorum Hypaxial parts of postoccipital Hypaxial parts of postoccipital
postoccipitalium myotomes myotomes
2209 Blastemata musculorum pharyngis Blastemata of pharyngeal muscles Blastemata of pharyngeal muscles
2210 Blastemata musculorum laryngis Blastemata of laryngeal muscles Blastemata of laryngeal muscles
2211 Blastema musculi Blastema of sternocleidomastoid Blastema of sternocleidomastoid Endnote 194
sternocleidomastoidei
2212 Blastema musculi trapezii Blastema of trapezius Blastema of trapezius
2213 Blastemata musculorum Blastemata of suprahyoid muscles Blastemata of suprahyoid muscles
suprahyoideorum
2214 Blastemata musculorum Blastemata of infrahyoid muscles Blastemata of infrahyoid muscles
infrahyoideorum
2215 Blastemata musculorum Blastemata of prevertebral Blastemata of prevertebral
prevertebralium muscles muscles
2216 Blastemata musculorum Blastemata of scalene muscles Blastemata of scalene muscles
scalenorum
2217 Blastema textus muscularis striati Blastema of oesophageal striated Blastema of oesophageal striated
oesophagei muscle tissue muscle tissue
2218 Blastemata muscularia Muscular blastemata of diaphragm Muscular blastemata of diaphragm
diaphragmatis
2219 Blastemata musculorum parietis Blastemata of muscles of thoracic Blastemata of muscles of thoracic
thoracici wall wall
2220 Blastemata musculorum parietis Blastemata of muscles of anterior Blastemata of muscles of anterior
abdominalis anterioris abdominal wall abdominal wall
2221 Blastemata diaphragmatis pelvis Blastemata of pelvic diaphragm Blastemata of pelvic diaphragm
2222 Blastema musculi sphincteris ani Blastema of external anal sphincter Blastema of external anal sphincter
externi
2223 Blastemata musculorum regionis Blastemata of muscles of Blastemata of muscles of
urogenitalis urogenital triangle urogenital triangle
2236 Anomaliae parietis abdominalis Anomalies of anterior abdominal Anomalies of anterior abdominal
anterioris wall wall
2237 Occlusio noncompleta Incomplete closure Incomplete closure Defective formation
2238 Syndroma defectionis musculorum Abdominal muscle deficiency Abdominal muscle deficiency
abdominalium syndrome syndrome
2239 Aplasia musculorum abdominis Prune-belly syndrome Prune belly syndrome
2240 Eventratio Eventration Eventration
2241 Gastroschisis Gastroschisis Gastroschisis
2242 Schistocoelia Coeloschisis Schistocoele Schistocele Celoschisis
2243 Exomphalos Exomphalos Exomphalos
2244 Omphalocoelia Omphalocoele Omphalocele Umbilical eventration
2245 Myotomi membri superioris Upper limb myotomes Upper limb myotomes
2246 Primordium musculare dorsale Dorsal muscle mass Dorsal muscle mass Dorsal muscle primordium
2247 Blastemata in compartimento Blastemata in posterior Blastemata in posterior
posteriore brachii compartment of arm compartment of arm
2248 Blastemata in compartimento Blastemata in posterior Blastemata in posterior
posteriore antebrachii compartment of forearm compartment of forearm
2249 Blastemata musculorum deltoidei Blastemata of deltoid and teres Blastemata of deltoid and teres
et teretis minoris minor minor
2250 Blastema musculi latissimi dorsi Blastema of latissimus dorsi Blastema of latissimus dorsi
2251 Blastemata musculorum Blastemata of rhomboid muscles Blastemata of rhomboid muscles
rhomboideorum
2261 Myotomi membri inferioris Lower limb myotomes Lower limb myotomes
2262 Primordium musculare dorsale Dorsal muscle mass Dorsal muscle mass Dorsal muscle primordium
2263 Blastemata in compartimento Blastemata in anterior Blastemata in anterior
anteriore femoris compartment of thigh compartment of thigh
2264 Blastemata in compartimento Blastemata in anterior Blastemata in anterior
anteriore cruris compartment of leg compartment of leg
2265 Blastema musculi tensoris fasciae Blastema of tensor fasciae latae Blastema of tensor fasciae latae Blastema of tensor of fascia lata
latae
2266 Blastema capitis brevis musculi Blastema of short head of biceps Blastema of short head of biceps
bicipitis femoris femoris femoris
2267 Blastemata in compartimento Blastemata in lateral compartment Blastemata in lateral compartment
laterale cruris of leg of leg
2268 Blastema musculorum dorsalium Blastema of dorsal muscles of foot Blastema of dorsal muscles of foot
pedis
2269 Blastemata musculorum gluteorum Blastemata of gluteus maximus, Blastemata of gluteus maximus,
maximi, medii et minimi medius and minimus medius and minimus
2270 Blastema musculi piriformis Blastema of piriformis Blastema of piriformis
2271 Blastemata musculi iliopsoatis Blastemata of iliopsoas Blastemata of iliopsoas
2272 Primordium musculare ventrale Ventral muscle mass Ventral muscle mass Ventral muscle primordium
2273 Blastemata in compartimento Blastemata in medial compartment Blastemata in medial compartment Endnote 199
mediale femoris of thigh of thigh
2274 Blastemata in compartimento Blastemata in posterior Blastemata in posterior Endnote 199
posteriore femoris compartment of thigh compartment of thigh
2275 Blastemata in compartimento Blastemata in posterior Blastemata in posterior
posteriore cruris compartment of leg compartment of leg
2276 Blastemata musculorum Blastemata of plantar muscles of Blastemata of plantar muscles of
plantarium pedis foot foot
2277 Blastema musculorum obturatorii Blastema of obturator internus and Blastema of obturator internus and Endnote 200
interni et gemellorum gemelli gemelli
2278 Blastema musculi quadrati femoris Blastema of quadratus femoris Blastema of quadratus femoris
2327 Facies Face Face See also Exernal ear and Nose
2328 Ectoderma embryonicum Embryonic ectoderm Embryonic ectoderm
2329 Epidermis Epidermis Epidermis
2330 Periderma Periderm Periderm
2331 Epitrichium Epitrichium Epitrichium
2332 Mesoderma Mesoderm Mesoderm
2333 Zona ectodermatis facialis Facial ectodermal zone Facial ectodermal zone
2334 Zona ectodermatis frontonasalis Frontonasal ectodermal zone Frontonasal ectodermal zone
2335 Mesoderma paraxiale Paraxial mesoderm Paraxial mesoderm
2336 Mesoderma prechordale Prechordal mesoderm Prechordal mesoderm
2337 Mesenchyma pharyngomericum Pharyngomeric mesenchyme Pharyngomeric mesenchyme
2338 Ectomesenchyma Mesenchyma cristae neuralis Ectomesenchyme Ectomesenchyme Neural crest mesenchyme
2339 Mesoderma paraxiale Paraxial mesoderm Paraxial mesoderm
2340 Placoda epipharyngea Epipharyngeal placode Epipharyngeal placode
2341 Stomodeum Stomatodeum Stomodeum Stomodeum
2342 Membrana oropharyngea Membrana buccopharyngea Oropharyngeal membrane Oropharyngeal membrane Buccopharyngeal membrane
2343 Processus frontonasalis Prominentia frontonasalis Frontonasal process Frontonasal process Frontonasal prominence
2344 Prominentia frontalis Processus frontalis Frontal prominence Frontal prominence Frontal process
2345 Placoda nasalis Placoda olfactoria Nasal placode Nasal placode Olfactory placode Endnote 201
2346 Fovea nasalis Nasal pit Nasal pit
2347 Saccus nasalis Nasal sac Nasal sac
2348 Pinna nasalis Nasal fin Nasal fin
2349 Prominentia nasalis medialis Processus nasalis medialis Medial nasal prominence Medial nasal prominence Medial nasal process
2350 Prominentia nasalis lateralis Processus nasalis lateralis Lateral nasal prominence Lateral nasal prominence Lateral nasal process
2351 Naris Naris Naris
2352 Septum nasi Nasal septum Nasal septum
2353 Membrana oronasalis Oronasal membrane Oronasal membrane
2354 Obturamentum epitheliale nasale Nasal epithelial plug Nasal epithelial plug
2355 Arcus mandibularis Mandibular arch Mandibular arch
2356 Arcus hyoideus Hyoid arch Hyoid arch
2357 Processus maxillaris Prominentia maxillaris Maxillary process Maxillary process Maxillary prominence
2358 Processus mandibularis Prominentia mandibularis Mandibular process Mandibular process Mandibular prominence
2359 Crescentia rostralis faciei Rostral growth of face Rostral growth of face
2387 Anomaliae et variationes faciei Facial and craniofacial Facial and craniofacial
et craniofaciales anomalies and variations anomalies and variations
2388 Aprosopia Aprosopy Aprosopy
2389 Diprosopia Diprosopy Diprosopy
2390 Fissura facialis obliqua Prosoposchisis Oblique facial cleft Oblique facial cleft
2391 Fissura mediana faciei Median facial cleft Median facial cleft
2392 Fissura transversa faciei Transverse facial cleft Transverse facial cleft Lateral facial cleft
2393 Fissura mandibulae Cleft mandible Cleft mandible Gnathoschisis
2394 Facies lata Broad face Broad face
2395 Facies angusta Narrow face Narrow face
2396 Facies duplex Duplicated face Duplicated face Janus deformity
2397 Facies longa Long face Long face
2398 Facies brevis Short face Short face
2399 Glabella prominens Prominent glabella Prominent glabella
2510 Dysplasia familiaris fibrosa Cherubismus Familial fibrous dysplasia of jaw Familial fibrous dysplasia of jaw Cherubism
mandibularis
2511 Dysplasia frontonasalis Frontonasal dysplasia Frontonasal dysplasia
2512 Dysplasia craniofrontonasalis Craniofrontonasal dysplasia Craniofrontonasal dysplasia
2513 Hypertelorismus ocularis Ocular hypertelorism Ocular hypertelorism §Greig/Opitz§
2514 Hypotelorismus ocularis Ocular hypotelorism Ocular hypotelorism
2515 Paralysis congenita Congenital abducens-facial Congenital abducens facial §Möbius§
abducentofacialis paralysis paralysis
2516 Sequentia mandibulolinguopalatina Mandibulolinguopalatal sequence Mandibulolinguopalatal sequence §Pierre-Robin§
2596 CAVITAS ORIS PROPRIA ORAL CAVITY PROPER ORAL CAVITY PROPER
2597 Primordium adenohypophysis Adenohypophysial primordium Adenohypophyseal primordium
2598 Saccus adenohypophysialis Adenohypophysial pouch Adenohypophyseal pouch
2730 Fissurae labiorum et palati Cheilopalatoschises Clefts of lips and palate Clefts of lips and palate Endnote 211
2731 Cheiloschisis Schistocheilia; Fissura labialis Cleft lip Cleft lip
2732 Cheiloschisis totalis Schistocheilia totalis; Fissura Complete cleft lip Complete cleft lip
labialis completa
2733 Cheiloschisis partialis Schistocheilia partialis; Fissura Partial cleft lip Partial cleft lip
labialis partialis
2734 Fissura unilateralis labii Unilateral cleft of upper lip Unilateral cleft of upper lip
superioris
2735 Fissura bilateralis labii superioris Bilateral cleft of upper lip Bilateral cleft of upper lip
2736 Fissura mediana labii superioris Median cleft of upper lip Median cleft of upper lip
2737 Dysostosis orodigitofacialis Orodigitofacial dysostosis Orodigitofacial dysostosis §Mohr§
2738 Fissura mediana labii inferioris Median cleft of lower lip Median cleft of lower lip
2739 Palatum fissum Fissura palatina Cleft palate Cleft palate
2740 Fissura palati primarii Cleft primary palate Cleft primary palate
2741 Fissura palati secundi Cleft of secondary palate Cleft of secondary palate
2742 Fissura anterior obliqua palati Anterior oblique cleft of palate Anterior oblique cleft of palate
2743 Fissura unilateralis anterior Unilateral anterior oblique cleft Unilateral anterior oblique cleft
obliqua palati of palate of palate
2744 Fissura bilateralis anterior Bilateral anterior oblique cleft Bilateral anterior oblique cleft
obliqua palati of palate of palate
2745 Fissura posterior mediana palati Posterior median cleft of palate Posterior median cleft of palate
2746 Uvula bifida Bifid uvula Bifid uvula
2747 Fissura submucosa palati Submucosal cleft of palate Submucosal cleft of palate
2748 PARS INITIALITER VESTITA PART INITIALLY COVERED BY PART INITIALLY COVERED BY
ECTODERMATIS ET ECTODERM AND ENDODERM ECTODERM AND ENDODERM
ENDODERMATIS
2749 Lingua Tongue Tongue
2750 Primordia linguae Tongue primordia Tongue primordia
2784 PARS INITIALITER VESTITA PART INITIALLY COVERED PART INITIALLY COVERED
ENDODERMATIS SOLUM WITH ENDODERM ONLY WITH ENDODERM ONLY
2785 Glandula submandibularis Submandibular gland Submandibular gland
2786 Epithelium linguogingivale Linguogingival epithelium Linguogingival epithelium
2787 Lamina basalis linguogingivalis Linguogingival basal lamina Linguogingival basal lamina
2788 Mesenchyma glandulae Presumptive submandibular Presumptive submandibular
submandibularis presumptivae mesenchyme mesenchyme
2789 Sulcus submandibularis Submandibular groove Submandibular groove
2874 Canalis digestorius Canalis oesophagogastro- Alimentary canal Alimentary canal Endnote 218
intestinalis
2875 PARS INTERNA ENDODERMAL LINING ENDODERMAL LINING See below
ENDODERMALIS
2876 PARS EXTERNA MESENCHYMA SURROUNDING MESENCHYME SURROUNDING MESENCHYME
PERICANALE
2877 Irruptio cellularum cristae neuralis Invasion of neural crest cells Invasion of neural crest cells
2878 Cellula interstitialis stimulans Interstitial cell Interstitial cell Pacemaker cell §Cajal§
2879 Plexus nervosus myentericus Myenteric plexus Myenteric plexus §Auerbach§
2880 Plexus nervosus submucosus Outer submucous plexus Outer submucous plexus §Schabadasch§
externus
2881 Plexus nervosus submucosus Inner submucous plexus Inner submucous plexus §Meissner§
internus
2882 Papilla mesenchymalis Mesenchymal papilla Mesenchymal papilla
2883 Textus muscularis levis Smooth muscle tissue Smooth muscle tissue
2884 Stratum circulare tunicae Circular muscle layer Circular muscle layer
muscularis
2885 Stratum longitudinale tunicae Longitudinal muscle layer Longitudinal muscle layer
muscularis
2886 Lamina muscularis mucosae Muscularis mucosae Muscularis mucosae
2887 Lamina propria mucosae Lamina propria Lamina propria
2888 Tela submucosa Submucous coat Submucous coat
2889 Tunica adventitia Adventitial layer Adventitial layer Adventitial coat
2909 Tertiarium superius oesophagi Cranial third of oesophagus Cranial third of esophagus
2910 Irruptio a myoblastis somiticis Invasion by somitic myoblasts Invasion by somitic myoblasts
2911 Textus muscularis striatus Noncardiac visceral striated Noncardiac visceral striated
visceralis noncardiacus muscle tissue muscle tissue
2912 Stratum circulare tunicae Circular muscle layer Circular muscle layer
muscularis
2913 Stratum longitudinale tunicae Longitudinal muscle layer Longitudinal muscle layer
muscularis
2914 Tertiarium medium oesophagi Middle third of oesophagus Middle third of esophagus
2915 Tertiarium inferius oesophagi Caudal third of oesophagus Caudal third of esophagus
2916 Textus muscularis levis Smooth muscle tissue Smooth muscle tissue
2917 Stratum circulare tunicae Circular muscle layer Circular muscle layer
muscularis
2918 Stratum longitudinale tunicae Longitudinal muscle layer Longitudinal muscle layer
muscularis
2964 Glandula gastrica propria Gastric gland proper Gastric gland proper
2965 Foveola exoepithelialis gastrica Exo-epithelial primordial gastric pit Exoepithelial primordial gastric pit
primordialis
2966 Cellula nondifferentiata Undifferentiated cell Undifferentiated cell
2967 Exocrinocytus parietalis Primordial parietal cell Primordial parietal cell
primordialis
2968 Elongatio glandulae Elongation of gland Elongation of gland
2969 Differentiatio cellularum glandulae Gastric gland cell differentiation Gastric gland cell differentiation
gastricae
2970 Exocrinocytus cervicalis Neck cell of gastric gland Neck cell of gastric gland Mucous neck cell
2971 Exocrinocytus principalis Principal cell of gastric gland Principal cell of gastric gland Zymogenic cell
2972 Exocrinocytus parietalis Parietal cell of gastric gland Parietal cell of gastric gland Oxyntic cell
2973 Canaliculus intracellularis Intracellular canaliculus Intracellular canaliculus
2974 Endocrinocytus gastrointestinalis Entero-endocrine cell Enteroendocrine cell Gastro-enteropancreatic cell;
Gastroenteropancreatic cell;GEP
endocrine cell
3035 Crypta intestinalis Glandula intestinalis Intestinal crypt Intestinal crypt Intestinal gland §Lieberkühn§
3036 Gemma cryptae Crypt bud Crypt bud
3037 Lumen cryptae Lumen of crypt Lumen of crypt
3038 Cellula gastrointestinalis staminalis Gastro-intestinal stem cell Gastrointestinal stem cell
3039 Exocrinocytus caliciformis Goblet cell Goblet cell
3040 Cellula panethensis Exocrinocytus cum granulis Paneth cell Paneth cell §Paneth§
acidophilis
3041 Endocrinocytus gastrointestinalis Entero-endocrine cell Enteroendocrine cell Gastro-enteropancreatic cell; §Paneth§
Gastroenteropancreatic cell; GEP
endocrine cell
3060 Ansa umbilicalis intestini Midgut loop Midgut loop Umbilical intestinal loop
3061 Mesenteron Midgut Midgut
3062 Crus proximale ansae umbilicalis Proximal limb of midgut loop Proximal limb of midgut loop
intestini
3063 Apex ansae umbilicalis intestini Apex of midgut loop Apex of midgut loop
3064 Ductus omphaloentericus Ductus vitellointestinalis Omphalo-enteric duct Omphaloenteric duct Vitello-intestinal duct;
Vitellointestinal duct; Yolk stalk
duct
3065 A. mesenterica superior Superior mesenteric artery Superior mesenteric artery
3088 Anomaliae jejuni et ilei Anomalies of jejunum and ileum Anomalies of jejunum and ileum
3089 Duplicatio intestini Intestinal duplication Intestinal duplication
3090 Stenosis intestini Intestinal stenosis Intestinal stenosis
3091 Atresia intestini Intestinal atresia Intestinal atresia
3092 Malrotatio intestini Intestinal malrotation Intestinal malrotation
3093 Rotatio partialis intestini Incomplete intestinal rotation Incomplete intestinal rotation Partial intestinal rotation
3094 Caecum subhepaticum Subhepatic caecum Subhepatic cecum
3095 Hyperrotatio intestini Intestinal hyper-rotation Intestinal hyperrotation
3096 Nonrotatio intestini Intestinal nonrotation Intestinal nonrotation
3097 Inversio rotationis intestini Reverse intestinal rotation Reverse intestinal rotation
3098 Situs inversus abdominalis Abdominal situs inversus Abdominal situs inversus
3099 Heterotaxia Heterotaxy Heterotaxy Isomerism
3100 Colon retrojejunale Retrojejunal colon Retrojejunal colon
3101 Vestigium ductus omphaloenterici Vestigium ductus vitellointestinalis Omphalo-enteric duct vestige Omphaloenteric duct vestige Vitello-intestinal duct vestige;
Vitellointestinal duct vestige
3102 Diverticulum jejuni Jejunal diverticulum Jejunal diverticulum
3103 Diverticulum ilei Ileal diverticulum Ileal diverticulum §Meckel§
3171 Anomaliae coli et appendicis Anomalies of colon and Anomalies of colon and
vermiformis appendix appendix
3172 Aganglionosis coli Colonic aganglionosis Colonic aganglionosis
3173 Aganglionosis coli completa Total colonic aganglionosis Total colonic aganglionosis §Zeulzer-Wilson§
3174 Aganglionosis coli partialis Partial colonic aganglionosis Partial colonic aganglionosis
3175 Megacolon congenitum Congenital megacolon Congenital megacolon §Hirschprung§
3176 Diverticulum congenitum coli Congenital colonic diverticulum Congenital colonic diverticulum
3231 Urenteron Pars postcloacalis intestini Postcloacal gut Postcloacal gut Tailgut; Endgut Endnote 226
3232 Anomaliae recti et canalis analis Anomalies of rectum and anal Anomalies of rectum and anal
canal canal
3233 Aganglionosis recti Rectal aganglionosis Rectal aganglionosis
3234 Atresia recti Rectal atresia Rectal atresia
3235 Fistula rectalis Rectal fistula Rectal fistula
3236 Fistula rectovaginalis Rectovaginal fistula Rectovaginal fistula
3237 Fistula rectovesicalis Rectovesical fistula Rectovesical fistula
3238 Fistula rectovestibularis Rectovestibular fistula Rectovestibular fistula
3239 Fistula rectourethralis Recto-urethral fistula Rectourethral fistula
3240 Stenosis recti Rectal stenosis Rectal stenosis
3241 Anus imperforatus Imperforate anus Imperforate anus
3242 Anus tectus Covered anus Covered anus
3243 Fistula anocutanea Anocutaneous fistula Anocutaneous fistula
3244 Fistula anovestibularis Anovestibular fistula Anovestibular fistula
3245 Atresia canalis analis Atresia of anal canal Atresia of anal canal
3246 Stenosis canalis analis Stenosis of anal canal Stenosis of anal canal
3247 Anus ectopicus Ectopic anus Ectopic anus
3248 Fistula anoperinealis Anoperineal fistula Anoperineal fistula
3306 Histogenesis hepatica definitiva Final hepatic histogenesis Final hepatic histogenesis Final hepatic histogeny
3307 Lobulus hepaticus classicus Lobulus hepaticus polygonalis Classic hepatic lobule Classic hepatic lobule Polygonal hepatic lobule
3308 V. centralis Central vein Central vein
3309 Lamina hepatocytica Hepatocyte lamina Hepatocyte lamina Hepatocyte plate; Hepatic
trabecula
3310 Epithelium bistratificatum Two-layered cuboidal epithelium Twolayered cuboidal epithelium
cuboideum
3311 Hepatoblastus Hepatoblast Hepatoblast
3312 Hepatocytus Hepatocyte Hepatocyte
3313 Canaliculus bilifer Bile canaliculus Bile canaliculus
3314 Vas sinusoideum hepaticum Hepatic sinusoid Hepatic sinusoid Vascular sinus
3315 Endotheliocytus Endothelial cell Endothelial cell
3316 Cellula necatoria hepatica Pit cell Pit cell Natural killer cell; NK cell
3317 Macrophagocytus stellatus Stellate macrophage Stellate macrophage §Kupffer§
3318 Cellula perisinusoidalis; Cellula Perisinusoidal cell Perisinusoidal cell Fat storing cell §Kupffer; Ito§
accumulans adipem
3319 Spatium perisinusoideum Perisinusoidal space Perisinusoidal space §Disse§
3356 Anomaliae ductus biliaris Bile duct anomalies Bile duct anomalies
3357 Absentia ductus choledochi Absentia ductus biliaris Absence of bile duct Absence of bile duct
3358 Absentia ductus hepatici Absence of common hepatic duct Absence of common hepatic duct
communis
3359 Atresia biliaris extrahepatica Extrahepatic biliary atresia Extrahepatic biliary atresia
3360 Atresia ductus choledochi Atresia ductus biliaris Bile duct atresia Bile duct atresia
3361 Dilatatio congenita intrahepatica Congenital intrahepatic bile duct Congenital intrahepatic bile duct §Caroli§
ductus biliaris dilatation dilatation
3362 Ductus hepaticus accessorius Accessory hepatic duct Accessory hepatic duct
3363 Ductus biliaris duplicatus Duplication of bile duct Duplication of bile duct
3364 Ductus communis duplicatus Duplication of common bile duct Duplication of common bile duct
3365 Hamartoma ductus biliaris Bile duct hamartoma Bile duct hamartoma §von Meyenberg§
3366 Junctura intrahepatica ductuum Intrahepatic union/junction of Intrahepatic union/junction of
hepaticorum hepatic ducts hepatic ducts
3367 Ductus hepaticocysticus Hepatocystic duct Hepatocystic duct
3371 Vesica biliaris et ductus Gallbladder and cystic duct Gallbladder and cystic duct
cysticus
3372 Preenteron distale Distal foregut Distal foregut
3373 Epithelium endodermale Endodermal epithelium Endodermal epithelium
3374 Mesenchyma splanchnopleurale Splanchnopleuric mesenchyme Splanchnopleuric mesenchyme
3375 Irruptio cellularum cristae Invasion of neural crest cells Invasion of neural crest cells
neuralis
3376 Gemma hepatopancreatica Hepatopancreatic bud Hepatopancreatic bud
3377 Ductus hepatopancreaticus Hepatopancreatic duct Hepatopancreatic duct
3378 Diverticulum cysticum Cystic diverticulum Cystic diverticulum
3379 Vesica biliaris Vesica fellea Gallbladder Gallbladder
3380 Epithelium simplex columnare Simple columnar epithelium Simple columnar epithelium
3381 Cholecystocytus Cholecystocyte Cholecystocyte
3382 Epitheliocytus penicillatus Brush cell Brush cell Tuft cell
3383 Lamina propria mucosae Lamina propria Lamina propria
3384 Crypta mucosae Mucosal crypt Mucosal crypt Diverticulum §Rokitanski; Aschoff; Luschka§
3385 Plica mucosae Ruga Mucosal fold Mucosal fold Ruga
3386 Glandula mucosa vesicae Mucous gland of gallbladder Mucous gland of gallbladder
biliaris
3387 Tunica muscularis Muscular coat Muscular coat Muscular layer
3388 Ductus cysticus Cystic duct Cystic duct
3389 Epithelium simplex columnare Simple columnar epithelium Simple columnar epithelium
3390 Plica spiralis Spiral fold Spiral fold
3391 Tunica fibromuscularis Fibromuscular coat Fibromuscular coat
3392 Anomaliae vesicae biliaris et Anomalies of gallbladder and Anomalies of gallbladder and
ductus cystici cystic duct cystic duct
3393 Absentia vesicae biliaris Absence of gallbladder Absence of gallbladder
3394 Duplicatio vesicae biliaris Duplication of gallbladder Duplication of gallbladder
3395 Vesica biliaris bilobata Bilobed gallbladder Bilobed gallbladder
3396 Vesica biliaris rudimentaria Rudimentary gallbladder Rudimentary gallbladder
3397 Vesica biliaris ectopica Ectopic gallbladder Ectopic gallbladder
3398 Vesica biliaris intrahepatica Intrahepatic gallbladder Intrahepatic gallbladder
3399 Vesica biliaris sinistra Left-sided gallbladder Leftsided gallbladder
3400 Vesica biliaris mobilis Mobile gallbladder Mobile gallbladder
3401 Deformationes vesicae biliaris Vesica biliaris deformata Gallbladder deformities Gallbladder deformities
3402 Vesica biliaris constricta Hourglass deformity Hourglass deformity
3403 Vesica biliaris pileiformis Phrygian cap deformity Phrygian cap deformity
3404 Vesica biliaris sacciformis Gallbladder pouch Gallbladder pouch §Hartmann§
3405 Diverticulum vesicae biliaris Gallbladder diverticulum Gallbladder diverticulum
174 Nodus primitivus; Nodus gastrulationis Once the primitive node has formed, gene expression centred on it becomes asymmetrical and the molecular basis for left-right asymmetry is established.
175 Vagina acellularis notochordalis; Lamina basalis notochordalis The extracellular notochordal basal lamina is rich in glycosaminoglycans and is to be distinguished from the cellular notochordal sheath (Gotz W,
Osmers R, Herken R. Localization of extracellular matrix components in the embryonic human notochord and axial mesenchyme. J Anat 1995;186:111-121). An expansion of the notochord between the centra of
adjacent vertebrae blends with perinotochordal tissue to form the nucleus pulposus.
176 Calvaria The calvaria, which consists of the parietal bones and the squamous parts of the frontal, temporal and occipital bones, is formed as lamellar bone and replaces chondroid tissue, which persists only in
the sutural areas.
177 Cartilagines arcuum pharyngeorum sequentium Only the first four pharyngeal arches, grooves and pouches are distinct structures. As the cartilages of the larynx develop caudal to the fourth arch, their precise
origin is unknown. While the arch cartilage derivatives of the head are universally regarded as components of the viscerocranium, the arch cartilage derivatives of the neck may be regarded as postcranial axial
skeleton.
178 Mesenchyma pharyngomericum Pharyngiomeric mesenchyme is thought to be derived from paraxial mesoderm, supplemented by ectomesenchyme (neural crest) and possibly also from epipharyngeal
placodes.
179 Discus intervertebralis The whole of an anulus fibrosus, at least, is derived from a caudal dense part of the notochordal sheath.
180 Zona apoptotica anterior; Zona apoptica posterior; Zona apoptotica interdigitalis Programmed cell death in the development of the limb bud is regulated by local growth factors. After apoptotic cell death,
macrophages clear and remove cell remnants without inducing any inflammatory reaction. With the recognition that programmed cell death in the embryo is not by necrosis, a pathological process evoking
inflammation, the terms anterior, posterior and interdigital necrotic zones are not recommended
181 Zona progressus The progress zone model for proximodistal patterning postulates that cells acquire positional information according to the length of time they spend in the subectodermal apical mesenchyme.
The alternative early specification model postulates that segmental progenitors are already localized along the proximodistal axis. However, neither model fits the large amount of molecular expression data
generated in the last decade (Tabin C, Wolpert L. Rethinking the proximodistal axis of the vertebrate limb in the molecular era. Genes Dev 2007;21:1433-42).
182 Radius manus The five rays that form in the hand plate are appropriately named hand rays rather than digital rays because they give rise to the metacarpals as well as to the phalanges.
183 Radius pedis The five rays that form in the foot plate are appropriately named foot rays rather than digital rays because they give rise to the metatarsals as well as to the phalanges.
184 Amentum articulationis An articulation loop is a tissue connection between the anlagen of antagonistic muscles. Joint clefts form in a gliding zone (see next footnote) in the connection.
185 Zona defluens A gliding zone is where adjacent tissue layers undergo relative movement along their substrata, thereby giving origin to tissue discontinuities such as joint cavities and synovial bursae and
sheaths.
186 Anomaliae et variationes crescentiae cranii Only cranial defects without underlying neural tube defects are listed here. Dysraphias are dealt with substantively under Nervous System. As elsewhere,
convention has the suffixes –ia in Latin and –y in English indicating the condition; the suffix –us, in either language refers to an individual with that condition.
187 Frons latus In relation to this and a multiplicity of other anomalies, previous embryological terminologies have included a substantial list of dysmorphias. Here, however, dysmorphias have been been distributed
between the sections and systems and a representative selection has been listed at the end of each. See, for example,
188 Anomaliae columnae vertebralis Only vertebral anomalies thought to be congenital and without underlying neural tube defects are listed here: thus for example, Spondylolisthesis and Os odontoideum, no
longer considered congenital, are not listed. Dysraphias are dealt with substantively under Nervous System.
189 Talipes The term Club foot has not been listed because of its inconsistent use in describing the results of more than one of these anatomical deformities.
190 Musculi; Systema musculare This section refers only to noncardiac striated muscle. Other muscle is presented under the corresponding structures (e.g. alimentary system, cardiovascular system).
191 Primordia musculorum externorum bulbi oculi The extra-ocular muscles are derived from preotic somites which migrate to a position around the developing eyeball.
192 Blastemata musculorum masticatoriorum The primordia of the principal muscles of mastication (masseter, temporalis and pterygoids) as well as of mylohoid and the anterior belly of the digastric.
193 Blastemata musculorum faciei The primordia of the muscles of facial expression as well as of stylohyoid and the posterior belly of the digastric.
194 Blastema musculi sternocleidomastoidei; Blastema musculi trapezii The single primordium for these two muscles is located in the epicardial ridge, caudal to the fourth pharyngeal arch and the cervical sinus.
As the neck elongates the primordium divides so that the two muscles come to bound the posterior triangle.
195 Ectoderma embryonicum anuli umbilicalis Embryonic ectoderm, apart from providing surface epithelium and throughepitheliomesenchymal transformation and ingression of embryonic ectoderm of the
umbilical ring, may contribute mesenchyme to the underlying tissues.
196 Mesenchyma ex eminentia caudale Mesenchyme from the caudal eminence passes ventrally around the cloacal membrane to contribute to the musculature and connective tissue of the infra-umbilical
abdominal wall and the underlying bladder wall.
197 Blastema musculi recti abdominis Only material from the midthoracic segments has reached its destination by the end of the embryonic period so that only the cranial parts of the blastemata of rectus
abdominis have come together by then. At that time, more caudally, they are still divaricated and a triangular transparent area between them includes the umbilical ring. By the end of the first trimester, the recti have
come together throughout, except at the umbilical ring.
198 Annulus umbilicalis The term umbilical ring is used in two different but related ways. Firstly, it describes the site on the ventral aspect of an embryo where the margins of the folded embryonic disc converge;
the structures transmitted by the ring become covered by amnion and mesenchyme and form the umbilical cord; secondly, it describes the opening through which the umbilical vessels pass: in young embryos it is
199 Blastemata in compartimentis medialis et posterioris femoris These blastemata give rise to the muscles of the posterior and medial compartments of the thigh apart from the short head of biceps femoris.
These are abductors magnus, longus and brevis, gracilis, obturator externus, semitendinosus, semimembranosus and the long head of biceps femoris.
200 Blastema musculorum obturatorii interni et gemellorum In the 14mm embryo no distinction can be made between the obturator internus and the two gemelli (Bardeen CR. Development and variation of the
nerves and musculature of the inferior extremity and of the neighbouring regions of the trunk in man. Am J Anat 1907;6:259-390)
201 Placoda nasalis; Placoda olfactoria The term nasal placode is preferred as the placode gives rise to respiratory and vomeronasal as well as olfactory structures.
202 Prominentia nasalis medialis; Sulcus nasolacrimalis; Sulcus lacrimalis The term prominence is recommended for this and similar facial features because they are not processes or projections but swellings
caused by growth centres; they do not fuse as processes do but merge as mesenchyme fills the depressions and raises the epithelium between them. The nasolacrimal groove is said to appear approximately
along, but independently of, the line where the maxillary and frontonasal prominences merge and is thus not to be synonymous with the nasomaxillary groove (O'Rahilly R and Müller F. Human Embryology &
Teratology. 3rd ed. New York: Wiley-Liss; 2001).
203 Lamina lacrimalis The lacrimal lamina is a thickening of the epithelium at the bottom of the lacrimal groove: its tip bifurcates to form primordial canaliculi before it canalises and connects conjunctival and
inferior meatal epithelia (de la Cuadra-Blanco C, Peces-Peña MD, Jáñez-Escalada L, Mérida-Velasco JR. Morphogenesis of the human excretory lacrimal system. J Anat 2006;209:127-135).
204 Blastema glandulae lacrimalis Mesenchyme condenses in relation to the superior conjunctival fornix, the epithelium of which thickens before the appearance of epithelial buds (Cuadra-Blanco C, Peces-Peňa
MD, Mėrida-Velasco JR. Morphogenesis of the human lacrimal gland. J Anat 2003;203:531-536).
205 Labium fetale et neonatale The parts are as given by Miethke R-R. Zur Anatomie der Ober- und Unterlippe zwischen dem 4. intrauterinen Monat und der Geburt. (Gegenbaurs morph Jahrbuch 1977;123:424-
452).
206 Pars distalis vesiculae umbilicalis secundariae; Pars distalis sacci vitellini secundarii There are no known derivatives of the endodermal lining of this embryonic structure.
207 Fovea analis Although there is no proctodeal depression comparable to the stomodeum, there is a slight anal pit over the terminal hindgut
208 Gemma glandulae parotideae See Gasser RF. The early development of the parotid gland around the facial nerve and its branches in man (Anat Rec 1970:167; 63-78).
209 Organum juxtaorale The development, possible function and clinical importance of the juxta-oral organ have been described (Mérida-Velasco JR, Rodrígez-Vásquez JF, Cuadra-Blanco C, Salmerón JI,
Sánchez-Montesinos I, Mérida-Velasco JA. Morphogenesis of the juxtaoral organ in humans. J Anat 2005:206;155-163).
210 Processus palatinus medianus The median palatal process is located in and adjacent to the midline and is the conjoined, lower (caudal) part of the medial nasal prominences. It is sometimes referred to as
the intermaxillary segment because of its location between the maxillary processes and rostral to the presumptive incisive canal. The incisive tooth buds form in the region. Historically, the region has been called
the premaxilla but this usage is not recommended because of possible confusion with the premaxilla of the maxillary bone.
211 Fissurae labiorum et palati; Cheilopalatoschises Clefts of the gums and alveolar arches are associated with these anomalies.
212 Epithelium linguogingivale; Epithelium sublinguale Whether the epithelia of the submandibular and sublingual glands are of ectodermal or endodermal origin is uncertain because they arise in the linguogingival
sulcus, between the ectodermal epithelium of the gingiva and the endodermal epithelium of the tongue.
214 Recessus tubotympanicus As the first pharyngeal pouch is probably no longer distinguishable when the tubotympanic recess grows out from the oropharynx, there is uncertainty about the pouch of origin of
the recess.
215 Gemma thymica Most of the thymic epithelium, including its medullary cytoreticulum (epithelioreticular cells types IV to VI), is derived from the endoderm of the ventral part of the third pharyngeal pouch but its
cortical cytoreticulum (epithelioreticular cells types I to III) is derived from the ectoderm of the third pharyngeal groove.
216 Corpus ultimopharyngeum The ultimopharyngeal bodies, which are said to provide the lateral components of the thyroid and parathyroid glands (Weller JL.Development of the thyroid, parathyroid and thymus
glands in man. Carnegie Instn Wash Publ 443, Contrib Embryol 1933;24:93-139), separate from pharyngeal pouches III and IV in Carnegie Stage 12.
217 Cystis cervicalis; Fistula cervicalis The term cervical is preferred to pharyngeal for these defects since it refers to their definitive location rather than to their supposed origin. Many cervical lesions are acquired
rather than congenital and originate in the lympho-epithelial system rather than the pharyngeal arch system.
218 Canalis oesophagogastrointesinalis; Canalis digestorius Listed here are features common to the development of the entire alimentary canal, in the order in which they appear. They are not repeated
subsequently for individual organs or parts.
219 Pars mesenteronica duodeni; Pars mesenteronica coli primordialis; Pars mesenteronica coli transversi primordialis; Pars mesenteronica coli transversi. The neologism mesenteralis has been coined to refer to
the mesenteron or midgut in order to avoid confusion with mesentericus, which refers to the mesenterium or mesentery.
220 Positio intraperitonealis Although not strictly so, an organ is said to be intraperitoneal when it is almost completely surrounded by peritoneum.
221 Lumen duodeni obturatum The duodenal lumen is obliterated in places due to epithelial proliferation. Recanalization starts with the formation and expansion of intra-epithelial vacuoles (Patzelt V. Der Darm. In
von Möllendorf W. ed. Handbuch der mikroskopischen Anatomie des Menschen. Vol 5/3. Berlin: Springer Verlag; 1932:1-448).
222 Noduli lymphoidei aggregati The term aggregated lymphoid nodules is shorthand for the localized, persistent, macroscopic, subepithelial aggregations of coalescent lymphoid nodules, which not only
penetrate the submucosa but also are visible from the serosal aspect of the small intestine.
223 Rotatio ansae umbilicalis intestini Although not entirely appropriate, the commonly used word rotation is retained. The process is one of differential growth of the developing organs, of which one result is
‘rotation’.
224 Pars analis membranae cloacalis Because the urorectal septum does not reach the cloacal membrane, a separate anal membrane does not exist. After the cloacal membrane ruptures, the anorectal lumen is
temporarily closed by an epithelial plug, which might previously have been interpreted as an anal membrane.
225 Canalis analis occlusus The anus is temporarily occluded by adhesion and an epithelial plug, which may have been mistaken for an anal membrane. A separate anal membrane does not exist because the
urorectal septum does not reach the cloacal membrane.
226 Urenteron; Pars postcloacalis intestini The term postanal gut is a misnomer because the tailgut is evanescent and has disappeared before there is an established anorectum.
227 Lamina hepatocytica frontalis dorsalis Differentiation results in the formation first of two frontal plates and then of sagittally-orientated plates between them: the ventral plate also gives rise to ventrally-
projecting hepatic plates (Lipp W. Die frűhe Strukturentwicklung des Leberparenchyms beim Menschen. Z Mikrosk Anat Forsch 1952; 59:161-186).
229 Insula pancreatica initialis At twenty weeks the organization of the endocrine cells is still not definitive: β cells lie in the centre and α, δ and PP cells surround them.
230 Insula pancreatica definitiva At twenty-four weeks the organization of the endocrine cells in the islets is complete: α, δ and PP cells lie in the centre and are surrounded by β cells.
231 Differentiatio endocrinocyti Endocrinocytes β, δ, α, and PP are present in that descending order of relative volume fraction at 10 weeks (Hahn von Dorsche H. Inselorgan. 626-32 in Hinrichsen KV.
Humanembryologie. Berlin: Springer-Verlag; 1990); the relative volume fraction of other endocrinocytes is not known from this reference.
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Published pending approval by the General Assembly at the next Congress of IFAA (2019)
The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use
the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA
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Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS
3552 Formatio arboris respiratoriae Formation of respiratory tree Formation of respiratory tree Endnote 236
3553 Epithelium endodermale Endodermal epithelium Endodermal epithelium
3554 Sulcus laryngotrachealis Laryngotracheal groove Laryngotracheal groove
3555 Gemma respiratoria Respiratory bud Respiratory bud Endnote 237
3556 Mesenchyma splanchnopleurale Splanchnopleuric mesenchyme Splanchnopleuric mesenchyme
3557 Gradus initialis formationis Initial stage of formation Initial stage of formation
3558 Diverticulum laryngotracheale Diverticulum respiratorium Laryngotracheal diverticulum Laryngotracheal diverticulum Respiratory diverticulum
3559 Crista tracheooesophagea Tracheo-oesophageal fold Tracheoesophageal fold
3560 Septum tracheooesophageum Tracheo-oesophageal septum Tracheoesophageal septum
3626 Tempus sacci terminalis Tempus sacculare Terminal sac stage Terminal sac stage Saccular stage
3627 Acinus pulmonalis Pulmonary acinus Pulmonary acinus
3628 Bronchiolus respiratorius Respiratory bronchiole Respiratory bronchiole
3629 Pneumocytus typi II Type II pneumocyte Type II pneumocyte
3630 Pneumocytus typi I Type I pneumocyte Type I pneumocyte
3631 Exocrinocytus bronchiolaris Bronchiolar exocrine cell Bronchiolar exocrine cell §Clara§
3632 Ductus transitionalis Transitional duct Transitional duct
3633 Saccus terminalis Terminal sac Terminal sac
3634 Ductus alveolaris Alveolar duct Alveolar duct
3635 Alveolus primitivus Primitive alveolus Primitive alveolus
3636 Parenchyma pulmonis Parenchyma of lung Parenchyma of lung
3637 Interstitium pulmonis Interstitium of lung Interstitium of lung
3647 Anomaliae arboris respiratoriae Anomalies of respiratory tree Anomalies of respiratory tree
3648 Anomaliae laryngis Laryngeal anomalies Laryngeal anomalies
3649 Atresia laryngis Laryngeal atresia Laryngeal atresia
3650 Atresia partialis laryngis Partial laryngeal atresia Partial laryngeal atresia Laryngeal web
3651 Cystis laryngis Laryngeal cyst Laryngeal cyst
3652 Fissura Laryngotracheal-oesophageal cleft Laryngotrachealesophageal cleft
laryngotracheooesophagea
3801 Vesica urinaria et Urethra Urinary bladder and Urethra Urinary bladder and Urethra
3802 VESICA URINARIA URINARY BLADDER URINARY BLADDER
3803 Pars vesicalis canalis Vesical part of vesico-urethral Vesical part of vesicourethral canal
vesicourethralis canal
3804 Incorporatio partis terminalis Incorporation of terminal part of Incorporation of terminal part of
ductus mesonephrici mesonephric duct mesonephric duct
3805 Ostia separata ureteris et ductus Openings for ureter and Openings for ureter and
mesonephrici mesonephric duct separated mesonephric duct separated
3806 Motio cephalolateralis ostii Cephalolateral movement of Cephalolateral movement of
ureterici ureteric duct opening ureteric duct opening
3807 Motio caudomedialis ostii ductus Caudomedial movement of Caudomedial movement of
mesonephrici mesonephric duct opening mesonephric duct opening
3808 Trigonum vesicae Bladder trigone Bladder trigone §Lieutaud§
3809 Urachus Urachus Urachus
3810 Lig. umbilicale medianum Median umbilical ligament Median umbilical ligament
3811 Epithelium endodermale Endodermal epithelium Endodermal epithelium
3812 Tunica mucosa vesicae Bladder mucosa Bladder mucosa Bladder mucous membrane
3813 Urothelium Epithelium transitionale Urothelium Urothelium Transitional epithelium
3814 Urotheliocytus superficialis Superficial urothelial cell Superficial urothelial cell
3815 Area intermedia Intermediate area Intermediate area
3816 Mesenchyma intermedium Intermediate mesenchyme Intermediate mesenchyme Contributes to most of the bladder
wall
3817 Mesoderma laminae lateralis Lateral plate mesoderm Lateral plate mesoderm Contributes to the wall of the body
of the bladder
3818 Lamina propria mucosae Lamina propria Lamina propria
3819 Tunica muscularis Muscular layer Muscular layer Muscular coat
3820 Tunica adventitia Adventitial layer Adventitial layer Adventitial coat
3838 Dimidium proximale urethrae Proximal half of prostatic Proximal half of prostatic ♂
prostaticae urethra urethra
3839 Tuberculum sinuale Sinus tubercle Sinus tubercle §Müller§
3840 Colliculus seminalis Seminal colliculus Seminal colliculus
3841 Glandula collicularis Collicular gland Collicular gland
3842 Utriculus prostaticus Vagina masculina Prostatic utricle Prostatic utricle Endnote 252
3843 Ductus ejaculatorius Ejaculatory duct Ejaculatory duct
3844 Epithelium endodermale Endodermal epithelium Endodermal epithelium
3845 Tunica mucosa urethrae Urethral mucosa Urethral mucosa Urethral mucous membrane
3846 Urothelium Epithelium transitionale Urothelium Urothelium Transitional epithelium
3847 Textus mesenchymalis Mesenchymal tissue Mesenchymal tissue
3848 Tunica muscularis Muscular layer Muscular layer Muscular coat
3849 Pars pelvina sinus urogenitalis Pelvic part of definitive Pelvic part of definitive See below
definitivi urogenital sinus urogenital sinus
3850 Pars distalis minima urethrae Minor distal part of female Minor distal part of female
femininae urethra urethra
3851 Apertura urethrae femininae Common female urethral opening Common female urethral opening
communis cum vagina with vagina with vagina
3852 Crescentia perinei Growth of perineum Growth of perineum Endnote 253
3853 Apertura urethrae femininae Separate female urethral opening Separate female urethral opening
separata a vagina from vagina from vagina
3854 Epithelium endodermale Endodermal epithelium Endodermal epithelium
3855 Epithelium stratificatum Nonkeratinized stratified Nonkeratinized stratified
squamosum noncornificatum squamous epithelium squamous epithelium
3856 Gemma glandulae urethralis Urethral gland bud Urethral gland bud
3857 Glandula urethralis Urethral gland Urethral gland §Müller§
3858 Gemma glandulae paraurethralis Para-urethral gland bud Paraurethral gland bud
3859 Glandula paraurethralis Prostata feminina Para-urethral gland Paraurethral gland Female prostate §Skene; Guērin§
3860 Ductus paraurethralis Para-urethral duct Paraurethral duct §Skene; Schüller§
3861 Textus mesenchymalis Mesenchymal tissue Mesenchymal tissue
3866 Pars intermedia urethrae Pars membranacea urethrae Intermediate part of urethra Intermediate part of urethra Membranous urethra ♂
3867 Epithelium endodermale Endodermal epithelium Endodermal epithelium
3868 Tunica mucosa urethrae Urethral mucosa Urethral mucosa Urethral mucous membrane
3869 Epithelium stratificatum Stratified columnar epithelium Stratified columnar epithelium
columnare
3870 Epithelium pseudostratificatum Pseudostratified columnar Pseudostratified columnar
columnare epithelium epithelium
3871 Textus mesenchymalis Mesenchymal tissue Mesenchymal tissue
3872 Tunica muscularis Muscular layer Muscular layer Muscular coat
3873 Stratum nonstriatum Smooth muscle layer Smooth muscle layer
3874 M. sphincter urethrae externus External urethral sphincter External urethral sphincter Rhabdosphincter
3875 Pars phallica sinus urogenitalis Phallic part of definitive Phallic part of definitive ♂
definitivi urogenital sinus urogenital sinus
3876 Lamina urethralis Chorda glandis Urethral plate Urethral plate Cord of glans
3877 Sulcus urethralis primarius Primary urethral groove Primary urethral groove
3878 Plica urethralis primaria Primary urethral fold Primary urethral fold
3879 Cavitatio Cavitation Cavitation
3880 Sulcus urethralis secundarius Secondary urethral groove Secondary urethral groove
3881 Plica urethralis secundaria Secondary urethral fold Secondary urethral fold
3882 Mesenchyma ex eminentia Mesenchyme from caudal Mesenchyme from caudal
caudale eminence eminence
3883 Conjunctio Fusion Fusion
3945 Chorda folliculogenica Folliculogenous cord Folliculogenous cord Cortical cord of ovary
3946 Cellula germinalis precursoria Primordial germ cell Primordial germ cell
3947 Oogonium Oogonium Oogonium
3948 Mitosis oogonii Oogonial mitosis Oogonial mitosis
3949 Syncytium oogenicum Oogenetic syncytium Oogenetic syncytium
3950 Clonum oogenicum Oogenetic clone Oogenetic clone
3951 Pons intercellularis Oogonial intercellular Oogonial intercellular
oogonialis bridge bridge
3952 Apoptosis oogonii Oogonial apoptosis Oogonial apoptosis
3953 Oocytus primarius Primary oocyte Primary oocyte
3954 Meiosis I Meiosis I Meiosis I
3955 Oocytus primarius restans Primary oocyte Primary oocyte Arrested in diplotene stage
3956 Epithelium simplex squamosum Simple squamous follicular Simple squamous follicular
folliculi epithelium epithelium
3957 Epitheliocytus follicularis Folliculocytus primordialis Primordial follicular epithelial Primordial follicular epithelial
cell cell
3958 Folliculus ovaricus primordialis Primordial ovarian follicle Primordial ovarian follicle
3959 Apoptosis oocyti Oocytic apoptosis Oocytic apoptosis
3960 Folliculus atreticus ovarii Atretic ovarian follicle Atretic ovarian follicle
3969 Phasis pubertalis Pubertal phase Pubertal phase See Terminologia Histologica
3970 Folliculogenesis Folliculogenesis Folliculogenesis See Terminologia Histologica
3971 Luteogenesis Luteogenesis Luteogenesis See Terminologia Histologica
3972 Oogenesis Oogenesis Oogenesis
3994 Chorda sexualis primordialis Chorda testicularis Primordial sex cord of testis Primordial sex cord of testis Medullary cord of testis
testis
3995 Prospermatogonium Spermatogonium presumptivum Prospermatogonium Prospermatogonium Presumptive spermatogonium
3996 Mitosis prospermatogonialis Prospermatogonial mitosis Prospermatogonial mitosis
3997 Syncytium spermatogenicum Spermatogenic syncytium Spermatogenic syncytium
3998 Clonum spermatogenicum Spermatogenic clone Spermatogenic clone
3999 Pons intercellularis Prospermatogonial Prospermatogonial
prospermatogonialis intercellular bridge intercellular bridge
4000 Sustentocytus lucidus Light presumptive sustentacular Light presumptive sustentacular
presumptivus cell cell
4001 Inhibitio mitosis et meiosis Inhibition of mitosis and meiosis Inhibition of mitosis and meiosis
4002 Factor antiparamesonephricus Antiparamesonephric hormone Antiparamesonephric hormone AMH; MIS Endnote 260
4028 Phasis pubertalis Pubertal phase Pubertal phase See Terminologia Histologica
4029 Spermatogenesis Spermatogenesis Spermatogenesis See above
4030 Spermatogonium Spermatogonium Spermatogonium Diploid (2N, 2C)
See Terminologia Histologica
4031 Spermatogonium typi A Type A spermatogonium Type A spermatogonium
4032 Spermatogonium typi B Type B spermatogonium Type B spermatogonium
4033 Spermiogenesis Spermiogenesis Spermiogenesis
4034 Spermatozoon Spermium; Gametus masculinus Sperm Sperm Sperm cell; Male gamete Haploid (1N, 1C)
See Terminologia Histologica
4230 TUBERCULUM SINUALE FUGAX TRANSIENT SINUS TUBERCLE TRANSIENT SINUS TUBERCLE ♀
Endnote 251
§Müller§
4231 Bulbus sinuvaginalis Sinuvaginal bulb Sinuvaginal bulb ♀
4232 Lamina vaginae Vaginal plate Vaginal plate
4233 Canalisatio Canalization Canalization
4234 Vagina Vagina Vagina
4235 Hymen Hymen Hymen
4306 Plica urethralis secundaria Secondary urethral fold Secondary urethral fold
4307 Labium minus Labium minus Labium minus ♀
4308 Frenulum labiorum minorium Frenulum labiorum pudendi Frenulum of labia minora Frenulum of labia minora Fourchette ♀
4309 Vestibulum vaginae Vestibule of vagina Vestibule of vagina ♀
4310 Corpus spongiosum clitoridis Bulbus vestibularis Corpus spongiosum of clitoris Corpus spongiosum of clitoris Vestibular bulb Endnote 266
4311 Glandula vestibularis major Greater vestibular gland Greater vestibular gland ♀
§Bartholin§
4312 Exocrinocytus glandulae Secretory cell of greater Secretory cell of greater ♀
vestibularis major vestibular gland vestibular gland
4327 Tuberculum labioscrotale Labioscrotal swelling Labioscrotal swelling Labioscrotal fold; Genital swelling
4328 Mons pubis Mons pubis Mons pubis
4329 Labium majus Labium majus Labium majus ♀
4330 Commissura labiorum anterior Anterior commissure Anterior commissure ♀
4331 Commissura labiorum posterior Posterior commissure Posterior commissure ♀
4332 Sulcus phallicus lateralis Lateral phallic groove Lateral phallic groove
4333 Scrotum Scrotum Scrotum ♂
4334 Raphe scroti Raphé of scrotum Raphé of scrotum ♂
4335 Raphe perinealis Perineal raphé Perineal raphé ♂
4369 Coeloma et septa Coelom and septa Celom and septa Endnote 268
4370 COELOMA EXTRA-EMBRYONIC COELOM EXTRAEMBRYONIC CELOM
EXTRAEMBRYONICUM
4371 Mesoderma extraembryonicum Extra-embryonic mesoderm Extraembryonic mesoderm Extraembryonic mesoderm
4372 Mesoderma somaticum Extra-embryonic somatic Extraembryonic somatic Extraembryonic somatic
extraembryonicum mesoderm mesoderm mesoderm
4373 Mesoderma splanchnicum Extra-embryonic splanchnic Extraembryonic splanchnic Extraembryonic splanchnic
extraembryonicum mesoderm mesoderm mesoderm
4374 Spatium extracoelomicum Extracoelomic space Extracelomic space
4375 Cavitas chorionica Chorionic cavity Chorionic cavity
4376 Coeloma umbilicale Umbilical coelom Umbilical celom Endnote 269
4377 COELOMA INTRA-EMBRYONIC COELOM INTRAEMBRYONIC CELOM
INTRAEMBRYONICUM
4378 Cavitas coelomica Coelomic cavity Celomic cavity Coelomic space; Celomic space
4379 Epithelium coelomicum Coelomic epithelium Celomic epithelium
4380 Mesoderma laminae lateralis Lateral plate mesoderm Lateral plate mesoderm
4381 Cavitatio mesenchymatis Cavitation of mesenchyme Cavitation of mesenchyme
4382 Spatium coelomicum segregum Isolated coelomic space Isolated celomic space
4383 Spatia coelomica coalita Coalesced coelomic spaces Coalesced celomic spaces
4384 Mesenchyma cardiogenicum Cardiogenic mesenchyme Cardiogenic mesenchyme
4385 Septum transversum Septum transversum Septum transversum
4386 Pars transversa cavitatis Transverse part of coelomic Transverse part of celomic cavity
coelomaticae cavity
4387 Cavitas pericardiaca Primordial pericardial cavity Primordial pericardial cavity
primordialis
4388 Canalis pericardioperitonealis Primordial pericardioperitoneal Primordial pericardioperitoneal
primordialis canal canal
4389 Mesenchyma somatopleurale Somatopleuric mesenchyme Somatopleuric mesenchyme
4390 Mesenchyma splanchnopleurale Splanchnopleuric mesenchyme Splanchnopleuric mesenchyme
4461 Massae mesenchymales Mesenteria primordalia Mesenchymal mesenteric Mesenchymal mesenteric Primordial mesenteries
mesentericae masses masses
4462 Mesenterium dorsale primordiale Primordial dorsal mesentery Primordial dorsal mesentery
4463 Mesocardium Mesocardium Mesocardium Dorsal mesocardium
4464 Mesooesophagum dorsale Dorsal meso-oesophagus Dorsal mesooesophagus
4465 Mesogastrium dorsale Dorsal mesogastrium Dorsal mesogastrium
4466 Omentum majus Greater omentum Greater omentum
4467 Plica cystoduodenalis Cystoduodenal fold Cystoduodenal fold
4468 Plica gastrocolica Gastrocolic fold Gastrocolic fold
4469 Plica gastrophrenica Gastrophrenic fold Gastrophrenic fold
4470 Plica gastrosplenica Plica gastrolienalis Gastrosplenic fold Gastrosplenic fold Gastrolienal fold
4471 Plica pancreaticocolica Pancreaticocolic fold Pancreaticocolic fold
4472 Plica pancreaticosplenica Pancreaticosplenic fold Pancreaticosplenic fold
4473 Plica paraduodenalis Paraduodenal fold Paraduodenal fold
4474 Plica vascularis caecalis Vascular fold of caecum Vascular fold of cecum
4475 Plica phrenicocolica Phrenicocolic fold Phrenicocolic fold
4476 Plica phrenicosplenica Phrenicosplenic fold Phrenicosplenic fold
4477 Plica presplenalis Presplenal fold Presplenal fold
4478 Plica splenorenalis Plica lienorenalis Splenorenal fold Splenorenal fold Lienorenal fold
4479 Mesoduodenum dorsale Dorsal mesoduodenum Dorsal mesoduodenum
4480 Mesenterium dorsale commune Common dorsal mesentery Common dorsal mesentery
4481 Mesojejunum Mesojejunum Mesojejunum
4482 Mesoileum Meso-ileum Mesoileum
4483 Mesoappendix Meso-appendix Mesoappendix
4484 Mesocolon Mesocolon Mesocolon
4485 Mesorectum Mesorectum Mesorectum
4486 Mesenterium ventrale primordiale Primordial ventral mesentery Primordial ventral mesentery
4487 Omentum minus Lesser omentum Lesser omentum
4488 Mesooesophageum ventrale Ventral meso-oesophagus Ventral mesoesophagus
4489 Plica hepatooesophagea Hepato-oesophageal fold Hepatoesophageal fold
4490 Plica hepatophrenica Hepatophrenic fold Hepatophrenic fold
4491 Mesogastrium ventrale Ventral mesogastrium Ventral mesogastrium
4492 Plica hepatogastrica Hepatogastric fold Hepatogastric fold
4493 Mesoduodenum ventrale Ventral mesoduodenum Ventral mesoduodenum
4494 Plica hepatoduodenalis Hepatoduodenal fold Hepatoduodenal fold
4495 Mesocolon ventrale Ventral mesocolon Ventral mesocolon
4496 Plica hepatocolica Hepatocolic fold Hepatocolic fold
4497 Plica umbilicalis mediana Median umbilical fold Median umbilical fold
4498 Plica umbilicalis medialis Medial umbilical fold Medial umbilical fold
4499 Mesenterium urogenitale Urogenital mesentery Urogenital mesentery
4572 Glandula pinealis Epiphysis cerebri; Corpus pineale Pineal gland Pineal gland Pineal body
4573 Primordium glandulae pinealis Primordium of pineal gland Primordium of pineal gland
4574 Diverticulum pineale Pineal diverticulum Pineal diverticulum
4586 Anomaliae glandulae pinealis Pineal gland anomalies Pineal gland anomalies
4587 Aplasia glandulae pinealis Aplasia of pineal gland Aplasia of pineal gland
4588 Hypoplasia glandulae pinealis Hypoplasia of pineal gland Hypoplasia of pineal gland
4589 Hyperplasia glandulae pinealis Hyperplasia of pineal gland Hyperplasia of pineal gland
4590 Cystis glandulae pinealis Cyst of pineal gland Cyst of pineal gland
4591 Pinealoma Pinealoma Pinealoma
4592 Adenoma pineale Pineal adenoma Pineal adenoma
4593 Teratoma pineale Pineal teratoma Pineal teratoma
4608 Anomaliae glandulae thyroideae Thyroid gland anomalies Thyroid gland anomalies
4609 Agenesis glandulae thyroideae Thyroid agenesis Thyroid agenesis
4610 Agenesis glandulae thyroideae Partial thyroid agenesis Partial thyroid agenesis
partialis
4611 Agenesis glandulae thyroideae Complete thyroid agenesis Complete thyroid agenesis
totalis
4612 Hypoplasia glandulae thyroideae Thyroid hypoplasia Thyroid hypoplasia
4613 Cretinismus congenitus Congenital cretinism Congenital cretinism
4614 Struma congenitalis Congenital goitre Congenital goiter
4678 GLANDULA SUPRARENALIS AD SUPRARENAL GLAND AT FULL SUPRARENAL GLAND AT FULL Endnote 278
PARTUM MATURUM TERM TERM
4806 Cornu dextrum sinus venosi Right horn of sinus venosus Right horn of sinus venosus Right sinus horn
4807 Cornu dextrum sinus Incorporated right sinus horn Incorporated right sinus horn
incorporatum
4808 Auriculae dextra et sinistra Right and left auricles Right and left auricles
4809 Sinus venarum cavarum Systemic venous sinus Systemic venous sinus Smooth-walled part of right atrium;
Smooth walled part of atrium
4810 V. cava superior Superior vena cava Superior vena cava
4811 Myocardium nodale Nodal myocardium Nodal myocardium
4812 Nodus sinuatrialis Sinu-atrial node Sinuatrial node §Keith-Flack§
4813 V. cava inferior Inferior vena cava Inferior vena cava
4814 Valva sinuatrialis Sinu-atrial valve Sinuatrial valve
4815 Valva venosa dextra Right venous valve Right venous valve
4816 Crista terminalis Terminal crest Terminal crest
4817 Valvula venae cavae inferioris Valve of inferior vena cava Valve of inferior vena cava §Eustachius§
4821 Pars mediastinalis atrii Mediastinal part of atrium Mediastinal part of atrium
4822 Myocardium mediastinale Mediastinal myocardium Mediastinal myocardium
4823 Septum primum Primary interatrial septum Primary interatrial septum
4824 Foramen primum Primary interatrial foramen Primary interatrial foramen
4825 Foramen secundum Foramen secundum Foramen secundum
4826 Spina vestibuli Atrial spine Atrial spine Vestibular spine; Dorsal §His§
mesenchymal protrusion
4827 Fulcimen basale septi atrialis Basal buttress of atrial septum Basal buttress of atrial septum
4828 Solum fossae ovalis Floor of oval fossa Floor of oval fossa Floor of fossa ovalis
4829 Tendo valvulae venae cavae Tendon of valve of inferior vena Tendon of valve of inferior vena §Todaro§
inferioris cava cava
4830 Plica pulmonalis Pulmonary fold Pulmonary fold
4831 V. pulmonalis incorporata Incorporated pulmonary vein Incorporated pulmonary vein
4832 Pars levis atrii sinistri Smooth-walled part of left atrium Smooth walled part of left atrium
4833 Plica secunda interatrialis Septum secundum Secondary interatrial fold Secondary interatrial fold Endnote 286
4834 Foramen ovale Oval foramen Oval foramen §Botallo§
4835 Fossa ovalis Oval fossa Oval fossa
4836 Limbus fossae ovalis Border of oval fossa Border of oval fossa Border of fossa ovalis
4906 Formatio ulterior valvarum Further development of Further development of Endnote 289
atrioventricularium atrioventricular valves atrioventricular valves
4907 Valva atrioventricularis sinistra Valva mitralis; Foliolum Left atrioventricular valve Left atrioventricular valve Bicuspid valve; Mitral valve
bicuspidale
4908 Foliolum anterior valvae Foliolum anterior valvae mitralis Anterior leaflet of left Anterior leaflet of left Anterior leaflet of mitral valve;
atrioventricularis sinistrae atrioventricular valve atrioventricular valve Anterior cusp of mitral valve
4909 Foliolum posterior valvae Foliolum posterior valvae mitralis Posterior leaflet of left Posterior leaflet of left Posterior leaflet of mitral valve;
atrioventricularis sinistrae atrioventricular valve atrioventricular valve Posterior cusp of mitral valve
4910 Valva atrioventricularis dextra Valva tricuspidalis Right atrioventricular valve Right atrioventricular valve Tricuspid valve
4932 ANOMALIAE CORDIS CARDIAC ANOMALIES CARDIAC ANOMALIES See also Vascular anomalies
4933 Acardia Acardia Acardia
4934 Diplocardia Diplocardia Diplocardia
4935 Cor bifidum Bifid heart Bifid heart
4936 Ectopia cordis Ectocardia Ectopic heart Ectopic heart
4937 Hemicardia Hemicardia Hemicardia
4938 Heterotaxia Heterotaxy Heterotaxy Isomerism
4939 Isomerismus dexter Right isomerism Right isomerism
4940 Isomerismus sinister Left isomerism Left isomerism
4941 Dextrocardia Dextrocardia Dextrocardia
4942 Laevocardia Laevocardia Levocardia
4943 Mesocardia Mesocardia Mesocardia
4944 Cor biloculare Bilocular heart Bilocular heart
4945 Cor decussans Connexio atrioventricularis Criss-cross heart Crisscross heart Atrioventricular criss-cross
decussans connection; Atrioventricular
crisscross connection
5022 Aa. arcuum pharyngeorum Pharyngeal arch arteries Pharyngeal arch arteries Aortic arch arteries
5023 A. arcus primi pharyngei First pharyngeal arch artery First pharyngeal arch artery
5024 A. maxillaris Maxillary artery Maxillary artery
5025 A. arcus secundi pharyngei Second pharyngeal arch artery Second pharyngeal arch artery
5026 R. stapedius Stapedial branch Stapedial branch
5027 A.hyoidea Hyoid artery Hyoid artery
5028 A. arcus tertii pharyngei Third pharyngeal arch artery Third pharyngeal arch artery
5029 Radix arteriae carotidis internae Root of internal carotid artery Root of internal carotid artery
5030 Reliquum arteriae carotidis Remainder of internal carotid Remainder of internal carotid
internae artery artery
5031 A. cerebri anterior Anterior cerebral artery Anterior cerebral artery
5032 A. cerebri media Middle cerebral artery Middle cerebral artery
5033 A. cerebri posterior Posterior cerebral artery Posterior cerebral artery
5034 A. basilaris Basilar artery Basilar artery
5035 Circulus arteriosus cerebri Cerebral arterial circle Cerebral arterial circle
5036 A. lentis Lens artery Lens artery
5037 A. hyaloidea Hyaloid artery Hyaloid artery
5038 Anastomosis caroticobasilaris Caroticobasilar anastomosis Caroticobasilar anastomosis
5039 A. trigemina Trigeminal artery Trigeminal artery
5040 A. otica Otic artery Otic artery
5041 A. hypoglossea Hypoglossal artery Hypoglossal artery
5042 A. quarti arcus pharyngei sinistri Left fourth pharyngeal arch artery Left fourth pharyngeal arch artery
5043 Pars intermedia arcus aortae Intermediate part of arch of aorta Intermediate part of arch of aorta
5044 A. quarti arcus pharyngei dextri Right fourth pharyngeal arch artery Right fourth pharyngeal arch artery
5045 Pars proxima arteriae Proximal part of right subclavian Proximal part of right subclavian
subclaviae dextrae artery artery
5046 A. quinti arcus pharyngei Fifth pharyngeal arch artery Fifth pharyngeal arch artery Endnote 294
5047 Gemma ventralis a sacco aortae Ventral sprout from aortic sac Ventral sprout from aortic sac
5048 Gemma dextra dorsalis a sacco Right dorsal sprout from dorsal Right dorsal sprout from dorsal
aortae aorta aorta
5049 A. sexti arcus pharyngei Arcus pulmonalis Sixth pharyngeal arch artery; Sixth pharyngeal arch artery;
Pulmonary arch Pulmonary arch
5050 Bifurcatio trunci pulmonalis Bifurcation of pulmonary trunk Bifurcation of pulmonary trunk
5051 A. pulmonalis Pulmonary artery Pulmonary artery
5052 Ductus arteriosus Ductus arteriosus Ductus arteriosus
5053 Lig. arteriosum Ligamentum arteriosum Ligamentum arteriosum §Botallo§
5054 Gemma sinistra dorsalis a sacco Left dorsal sprout from dorsal Left dorsal sprout from dorsal
aortae aorta aorta
5055 Radices arteriarum pharyngearum Roots of pharyngeal arch arteries Roots of pharyngeal arch arteries
5056 Pars arteriae carotidis externae Part of external carotid artery Part of external carotid artery
5057 Pars arteriae carotidis communis Part of left common carotid artery Part of left common carotid artery
sinistrae
5058 Pars arteriae brachiocephalicae Part of brachiocephalic artery Part of brachiocephalic artery
5059 Pars aortae ascendentis Part of ascending aorta Part of ascending aorta
5060 Radices aortae ventralis Ventral aortic roots Ventral aortic roots
5069 Aortae dorsales nonconjunctae Unfused dorsal aortae Unfused dorsal aortae
5070 Radix sinistra aortae dorsalis Pars sinistra par aortae dorsalis Left dorsal aortic root Left dorsal aortic root Left paired part of dorsal aorta
5071 Pars distalis arcus aortae Distal part of arch of aorta Distal part of arch of aorta
5072 Pars proximalis aortae Proximal descending aorta Proximal descending aorta
descendentis
5073 Radix dextra aortae dorsalis Pars dextra par aortae dorsalis Right dorsal aortic root Right dorsal aortic root Right paired part of dorsal aorta
5074 Pars intermedia arteriae Intermediate part of right Intermediate part of right
subclaviae dextrae subclavian artery subclavian artery
5075 Aortae dorsales conjunctae Fused dorsal aortae Fused dorsal aortae
5076 Pars impar aortae dorsalis Unpaired part of dorsal aorta Unpaired part of dorsal aorta
5077 A. segmentalis ventralis Ventral segmental artery Ventral segmental artery
5078 A. omphalomesenterica A. vitellina Omphalomesenteric artery Omphalomesenteric artery Vitelline artery
5079 Truncus coeliacus Coeliac trunk Celiac trunk
5080 A. hepatica Hepatic artery Hepatic artery
5081 A. mesenterica superior Superior mesenteric artery Superior mesenteric artery
5082 A. mesenterica inferior Inferior mesenteric artery Inferior mesenteric artery
5083 Truncus umbilicalis Umbilical trunk Umbilical trunk
5084 A. iliaca communis Common iliac artery Common iliac artery
5085 A. iliaca interna Internal iliac artery Internal iliac artery
5086 A. uterina Uterine artery Uterine artery
5087 A. spiralis uteri Spiral artery of uterus Spiral artery of uterus
5088 A. umbilicalis Umbilical artery Umbilical artery Endnote 295
5089 Radix umbilicalis medialis Medial umbilical root Medial umbilical root
5090 Radix umbilicalis lateralis Lateral umbilical root Lateral umbilical root
5091 A. axialis membri inferioris Rete arteriosum axiale membri Axial artery of lower limb Axial artery of lower limb Axial arterial plexus of lower limb
inferioris
5092 A. nervi ischiadici Artery of sciatic nerve Artery of sciatic nerve
5093 A.sciatica Sciatic artery Sciatic artery
5094 Lig. umbilicale mediale Medial umbilical ligament Medial umbilical ligament
5095 A. vesicalis superioris Superior vesical artery Superior vesical artery
5096 A. segmentalis lateralis Lateral segmental artery Lateral segmental artery
5097 A. phrenica communis Common phrenic artery Common phrenic artery
5098 A. suprarenalis media Middle suprarenal artery Middle suprarenal artery
5099 A. renalis Renal artery Renal artery
5100 A. gonadalis Gonadal artery Gonadal artery
5101 A. testicularis Testicular artery Testicular artery
5281 Anomaliae et variationes Major venous variations and Major venous variations and
maiores venarum anomalies anomalies
5282 Transpositio venae Transposition of vein Transposition of vein
5283 Absentia venae Absence of vein Absence of vein
5284 Rete venosum persistens Persistent plexiform arrangement Persistent plexiform arrangement
5285 Duplicatio venae Duplication of vein Duplication of vein
5286 Duplicatio partialis venae Partial duplication Partial duplication
5287 Duplicatio completa venae Complete duplication Complete duplication
5288 V. supernumeraria Vena accessoria Supernumerary vein Supernumerary vein Accessory vein
5289 Terminatio anomala Anomalous termination Anomalous termination
5290 Terminatio proximalis Proximal termination Proximal termination Late termination
5291 Terminatio distalis Distal termination Distal termination Early termination
5292 Bifurcatio venae Bifurcation of vein Bifurcation of vein
5318 Formatio haemocytorum Blood cell production Blood cell production Endnote 298
5319 TEXTUS HAEMANGIOGENICUS HAEMANGIOGENIC TISSUE HEMANGIOGENIC TISSUE
5320 Textus haemangiogenicus Extra-embryonic Extraembryonic hemangiogenic
extraembryonicus haemangiogenic tissue tissue
5321 Chorion Chorion Chorion
5322 Pedunculus connectans Connecting stalk Connecting stalk
5323 Vesicula umbilicalis Saccus vitellinus Umbilical vesicle Umbilical vesicle Yolk sac Endnote 299
5324 Placenta Placenta Placenta
5427 Textus lymphoidei secundarii Secondary lymphoid tissues Secondary lymphoid tissues Endnote 315
5428 Textus lymphoideus diffusus Diffuse lymphoid tissue Diffuse lymphoid tissue
5429 Textus lymphoideus circumscriptus Circumscribed lymphoid tissue Circumscribed lymphoid tissue
5430 NODULUS LYMPHOIDEUS LYMPHOID NODULE LYMPHOID NODULE Endnote 316
5431 Nodulus lymphoideus fugax Transient lymphoid nodule Transient lymphoid nodule
5432 Nodulus lymphoideus permanens Persistent lymphoid nodule Persistent lymphoid nodule
5433 Nodulus lymphoideus solitarius Solitary lymphoid nodule Solitary lymphoid nodule
5434 Nodulus lymphoideus multiplex Multiple lymphoid nodule Multiple lymphoid nodule
5442 Nodulus lymphoideus primarius Primary lymphoid nodule Primary lymphoid nodule
5443 Nodulus lymphoideus Nodulus lymphoideus strenuus Secondary lymphoid nodule Secondary lymphoid nodule Active lymphoid nodule
secundarius
5444 Centrum germinativum Germinal centre Germinal center
5445 Zona pallii Mantle zone Mantle zone
5446 Zona densa Dark zone Dark zone
5447 Zona lucida basalis Basal light zone Basal light zone
5448 Zona lucida apicalis Apical light zone Apical light zone
5449 Centroblastus Lymphocytus B dividens Centroblast Centroblast Dividing B lymphocyte
5450 Centrocytus Centrocyte Centrocyte
5458 NODUS LYMPHOIDEUS Nodus lymphaticus; Lymphonodus LYMPH NODE LYMPH NODE
5459 Mesenchyma somiticum Somitic mesenchyme Somitic mesenchyme
5460 Mesenchyma somatopleurale Somatopleuric mesenchyme Somatopleuric mesenchyme
5461 Mesenchyma splanchnopleurale Splanchnopleuric mesenchyme Splanchnopleuric mesenchyme
5462 Ectomesenchyma Mesenchyma cristae neuralis Ectomesenchyme Ectomesenchyme Neural crest mesenchyme
5463 Mesenchyma ex eminentia Mesenchyme from caudal Mesenchyme from caudal
caudale eminence eminence
5464 Capsula nodi lymphatici Capsule of lymph node Capsule of lymph node
5465 Vas lymphaticum afferens Afferent lymphatic vessel Afferent lymphatic vessel
5466 Valva lymphatica Lymphatic valve Lymphatic valve
5467 Spatium subcapsulare Subcapsular space Subcapsular space Subcapsular lymphatic sinus
5541 Anomaliae tonsillae palatinae Anomalies of palatine tonsil Anomalies of palatine tonsil
5542 Aplasia tonsillae Aplasia of tonsil Aplasia of tonsil
5543 Ectopia tonsillae Ectopic tonsil Ectopic tonsil
5544 Tonsilla palatina supernumeraria Supernumerary palatine tonsil Supernumerary palatine tonsil
232 Diverticulum sinus maxillaris The maxillary sinus is large enough to be clinically important at birth. It grows significantly during the first 3 years of postnatal life and again from 7-18 years (Snow JB, Ballenger
JJ. Eds. Ballenger’s Otorhinology Head and Neck Surgery. 16th ed. Hamilton, Ontario: BC Decker Publisher; 2003).
233 Diverticulum cellulae ethmoidalis At birth there are 3 or 4 ethmoidal cells and they are large enough to be clinically important (Snow JB, Ballenger JJ. Eds. Ballenger’s Otorhinology Head and Neck Surgery.
16th ed. Hamilton, Ontario: BC Decker Publisher; 2003).
234 Anomaliae nasi For more see: Losee JE, Kirschner RE, Whitaker LA, Bartlett SP. Congenital nasal anomalies: a classification scheme. (Plast Reconstr Surg 2004;113:676-689).
235 Eminentia hypopharyngea The hypopharyngeal eminence was formerly called the hypobranchial eminence and is not to be confused with the adult hypopharynx.
236 Formatio arboris respiratoriae The term respiratory tree is used to denote the postpharyngeal airways: the larynx, the trachea, the bronchi, the bronchioles, the respiratory bronchioles, the alveolar ducts, atria
and saccules and the pulmonary alveoli.
237 Gemma respiratoria The term respiratory bud denotes the single bud from which the respiratory tree originates.
238 Septum epitheliale laryngis The epithelial septum is a primary structure responsible for the final configuration of the laryngotracheal groove (Sanudo JR, Domenech-Mateu JM. The laryngeal primordium and
epithelial lamina: a new interpretation. (J Anat1990;171:207-222).
239 Condensatio mesenchymalis epiglottidis The epiglottis begins to chondrify during the fetal period.
240 Cartilago ossis hyoidei The hyoid cartilage begins to ossify during the fetal period.
241 Cartilago laminae thyroideae The thyroid laminae fuse during the fetal period.
242 Vestibulum larynges; Ventriculus laryngis Although the subdivisions of the laryngeal cavity, the infrahyoid muscles and most of the major laryngeal muscles are established by the eighth week, some events
occur during the fetal period. In addition to those listed under previous footnotes, first the vocal and then the vestibular folds develop; the aryepiglottic, thyroepiglottic and vocalis muscles develop; the larynx
undergoes relative descent until, at birth, its lower border is at the level of C 4.
243 Mesoderma intermedium The Mesoderma intermedium is primarily responsible for the formation of the kidneys and internal genitalia and their ducts. Experimental studies suggest that it arises in amniotes
from the middle of the primitive streak distal to somite origin and proximal to lateral plate mesoderm origin.
244 Pronephros The parts of the pronephros are rudimentary and do not form tubules so that it is never a functioning structure in man.
245 Glomerulus externus Pronephric tubules which link the pronephric duct with the intraembryonic coelom via a nephrostoma are occasionally present in human embryos (Hinrichsen KV. Humanembryologie.
Berlin:Springer-Verlag, 1990).
246 Chorda nephrogenica; Chorda mesonephrica The term nephrogenic cord is preferred as the cord gives rise to both mesonephric structures and the metanephric blastema.
247 Gemma ureterica; Diverticulum metanephricum The term ureteric bud is preferred. While it is initially a hollow diverticulum, it becomes solid and then recanalises. While it is largely surrounded by a
metanephric cap, its origin is from the caudal end of the mesonephric duct.
249 Ductus interpolaris; Ductus polaris superior; Ductus polaris inferior Each of the ducts induces change in part of the overlying metanephrogenic blastema to form a transient embryonic lobule.
250 Arcuatio nephronis Early in the second trimester additional nephrons form from the points where metanephric tubules fuse with ampullae and form chains of adjacent nephrons.
251 Tuberculum sinuale fugax Sinual, mesonephric and paramesonephric epithelia meet at the sinus tubercle.
252 Utriculus prostaticus; Vagina masculina; Vagina Accounts vary but the cephalic parts of the vagina and of the utricle are probably derived from the paramesonephric ducts and their caudal parts from the mixed
epithelium of the sinus tubercle.
253 Crescentia perinei Growth of the perineum brings the urethral and vaginal orifices to the surface (Ammini AC, Pandey J, Vijyaraghavan M, Sabherwal U. Human female phenotypic development: role of fetal
ovaries. J Clin Endocrinol Metab 1994;79:604-8).
254 Gemma prostatica A series of five clusters of endodermal buds grow into the surrounding mesenchyme. The latter becomes the fibromuscular part and forms about one third of the prostate. The five fetal
lobules are obscured in postnatal life, so that there is no external sign of lobulation.
255 Translatio cellularum germinalium precursorium; Migratio cellularum germinalium precursorium The relocation of primordial germ cells from the wall of the umbilical vesicle to that of the hindgut can be
explained by growth movements and shape changes (Freeman B. The active migration of germ cells in the embryos of mice and men is a myth. Reproduction 2003;125:635-643). However, relocation from the wall
of the hindgut to the gonadal ridge is difficult to envision - even at a time when the dorsal mesentery is still extremely short or barely distinguishable at the level of the genital ridge (at Stage 12) - without true
migration, at least through the basal lamina of the hindgut, playing a part.
256 Chorda epithelii coelomici These cords were previously called primary sex cords but they represent only proliferative coelomic epithelium, presumably contributing to gonadal mesenchyme. They are not the
precursors of the cords in which primordial germ cells will develop (Satoh M. Histogenesis and organogenesis of the gonad in human embryos. J Anat 1991;177:85-107).
257 Mesenchyma gonadale The gonadal mesenchyme that forms most gonadal cells comes from the mesonephros (Campagnolo L, Russo MA, Puglianello A, Favale A, Siracusa G. Mesenchymal cell precursors
of peritubular smooth muscle cells of the mouse testis can be identified by the presence of the p75 neurotrophin receptor. Biol Reprod 2001;64:464-472). However, that which forms sustentacular (and granulosa)
cells comes from the coelomic epithelium (Karl J, Capel B. Sertoli cells of the mouse testis originate from the coelomic epithelium. Dev Biol 1998;203:323-333).
258 Chorda sexualis primordialis gonadalis Gonadal cords or primordial sex cords extend from the mesonephros into the gonadal ridge and become associated with primordial germ cells; the coelomic epithelium
flattens and the gonad protrudes into the coelomic cavity (Satoh M. Histogenesis and organogenesis of the gonad in human embryos. J Anat 1991;177:85-107).
259 Chorda sexualis primordialis ovarii In the ovary, primordial sex cords enlarge, extend peripherally, pick up primordial germ cells, leave the medulla and become the folliculogenic sex cords of the cortex (Satoh
M. Histogenesis and organogenesis of the gonad in human embryos. J Anat 1991;177:85-107). Some cords remain in the medulla but do not develop and disappear in the third trimester.
260 Factor antiparamesonephricus The antiparamesonephric factor is eponymously known as AMH (AntiMüllerian Hormone) or MIS (Müllerian Inhibiting Substance).
261 Conjunctio tubuli recti cum rete testis incipiens Although the primordium of the rete testis is present in the embryo, it is not until the second trimester that it begins to connect with straight tubules and the
process is not completed until puberty.
263 Perineum primarium Mesenchyme from the caudal eminence tracks around the anal pit and forms the primary perineum between the anal canal and the pelvic part of definitive urogenital sinus.
264 Perineum secundarium As the perineum is reinforced by mesenchyme from the urorectal septum, it becomes prominent and expands to form the perineal body.
265 Plica cloacalis The cloacal folds are commonly referred to as primary urethral folds. However, they extend beyond presumptive urethra to flank the presumptive anus and thus have both urethral and anal
derivatives, the primary urethral and anal folds.
266 Corpus spongiosum clitoridis; Bulbus vestibularis The corpus spongiosum of the clitoris extends anteriorly from the bilateral vestibular bulbs to terminate as the glans clitoridis and corresponds to the corpus
spongiosum penis (Van Turnhout AA, Hage JJ,van Diest PJ. The female corpus spongiosum revisited. Acta Obstet Gynecol Scand 1995;74:767–771). For homology with the male, this term is preferrred to the
proposed term bulbus clitoridis (O’Connell HE, Hutson JM, Anderson CR, Plenter RJ. Anatomical relationship between urethra and clitoris. J Urol 1998;159:1892–1897).
267 Endocrinocytus glandulae vestibularis majoris Endocrine cells similar to those found elsewhere in the urogenital tract (Fetissov F, Arbeille B, Bellet D, Barre I, Lansac J. Endocrine cells in human Bartholin’s
glands. Virch Arch B Cell Pathol1989;57:117-121).
268 Coeloma et septa The coelom is described as a tubular blastema. The walls of this hollow organ are built up of prospective mesothelium which delimits the lumen from the surrounding mesenchyme. The
lumen enlarges by the coalescence of small spaces in this mesenchyme. In this way organs are “liberated” from their surrounding mesenchyme and may reach an intraserosal position. This process leads to serosal
connections of the organs with the body wall, carrying vessels and nerves. The mesenterial relations in the developing embryo are quite different from those in the fetus. The “mesenteria” are relatively much more
voluminous in the younger organism. They are shaped by the aforementioned “liberation” process and much less so by real folding and rotation. Notwithstanding this difference in relations and topography, the
names of the ligaments and plicae (folds) are identical with those in Terminologia Anatomica (1998).
269 Coeloma umbilicale The coelom in the proximal part of the umbilical cord communicates with the intraembryonic coelom and is a remnant of the extraembryonic coelom, most of which is obliterated as the
amnion surrounds the connecting stalk to form the umbilical cord.
270 Primordium epicardii; Proepicardium A cluster of mesothelial cells over the septum transversum; pro-epicardial vesicles flatten and join to form the epicardium, the cells of which undergo
epitheliomesenchymal transition and invade the heart tube (Poelmann RE, Lie-Venema H, Gittenberger-de Groot AC. The role of the epicardium and the neural crest. Tex Heart Inst J 2002;29:255-261).
271 Mesocardium Athough a homologue of the dorsal mesocardium in other species, the recommended term is mesocardium because, unlike chick embryos, there is no corresponding ventral mesocardium in
normal human embryos.
272 Plica pleuropericardiaca septi transversi The pleuropericardial fold of the septum transversum contains the common cardinal vein.
273 Cavitas peritonealis minor; Bursa omentalis The anlage of the omental bursa is a thickening and invagination of coelomic epithelium on the right side of the dorsal mesogastrium (C. Viebahn, unpublished
observation on 7mm embryo).
274 Anulus umbilicalis The term umbilical ring is used in two different but related ways: Firstly, it describes the site on the ventral aspect of an embryo where the margins of the folded embryonic disc converge.
The structures transmitted by the ring become covered by amnion and mesenchyme and form the umbilical cord. Secondly, it describes the opening through which the umbilical vessels pass. In young embryos it is
relatively closer to the pubis than in the fetus, in which it becomes an umbilical hiatus in the linea alba, which normally closes in postnatal life.
275 Lig. scrotale A scrotal ligament is not usually seen on dissection of the adult scrotum.
277 Cortex suprarenalis temporarius The term provisional cortex, rather than fetal cortex, is recommended because it is present in embryos from Stage 16 onwards.
278 Glandula suprarenalis ad partum maturum The suprarenal gland is relatively large at birth but the volume of its fetal cortex decreases rapidly, as it undergoes haemorrhagic non-inflammatory necrosis, and is
negligible after two postnatal months. The definitive cortex, however, continues to differentiate and grow until early childhood while the medulla also differentiates and undergoes some postnatal growth.
279 Cor tubulare The adjective simplex has been used at this stage but the phenomenon of polarity makes its use inappropriate.
280 Myocardium primarium; Myocardium cordis camerati; Myocardium mediastinale; Myocardium nodale Four different types of myocardium can be distinguished by their properties and the level of expression of
genes and atrial natriuretic factor (Horsthuis T, Christoffels VM, Anderson RH, Moorman AFM. Can recent insights into cardiac development improve our understanding of congenitally malformed hearts? Clinical
Anatomy 2009;22:4-20).
281 Ansa cordis dextra A D-loop is the normal configuration and usually results in a heart with the apex pointing to the left. An L-loop is abnormal and usually results in a heart with the apex pointing to the right.
282 Curvatura externa With ballooning, the ventricles and atria develop in series on the outer curvature but share the inner curvature.
283 Anulus interventricularis myocardii This term denotes the myocardium surrounding the primary ventricular foramen.
284 Aa. coronariae For a recent review see: Ratajska A, Czarnowska E, Ciszek B. Embryonic development of the proepicardium and coronary vessels (Int J Dev Biol 2008;52:229-36).
285 Dens mesenchymalis in cristis tractus effluxionis Such prongs represent the precursors of the cardiac skeleton.
286 Plica secunda interatrialis; Septum secundum The term plica or fold is preferred as the structure is not a septum, sensu stricto.
287 M. papillaris superolateralis ventriculi sinistri; M. papillaris anterior ventriculi sinistri; M. papillaris inferoseptalis ventriculi sinistri; M. papillaris posterior ventriculi sinistri These muscles are well defined in the
Stage 18 heart. The terms superolateral and inferoseptal papillary muscles are appropriate for the left ventricle with the heart in the anatomical position (Anderson RH, Loukas M. The importance of attitudinally
appropriate description of cardiac anatomy. Clin Anat 2009;22:47-51).
288 Pars membranacea septi interventricularis This part develops from the muscular septum after the septal leaflet of tricuspid valve has delaminated after the twelfth week.
289 Formatio ulterior valvarum atrioventricularium While the anterosuperior leaflet of the tricuspid valve and the anterolateral papillary muscle of the right ventricle develop in embryonic life, the other four
atrioventricular leaflets and the septal papillary muscle of the right ventricle develop after the twelfth week.
290 Flexus ductus communis effluxionis This is an external landmark that separates the proximal and distal portions of the tract; at the site of the bend the pitch of the spiralling endocardial outflow tract ridges is
highest, explaining claims for separate proximal and distal (conal and truncal) ridges.
291 Septum distale The distal septum lies between intrapericardial parts of aorta and pulmonary trunk (distal to the arterial valves).
293 Angiogenesis The formation of new vessels from existing ones (Risau W. Mechanisms of angiogenesis. Nature. 1997:386;671-4). It occurs in somatopleuric mesenchyme or its derivatives. For the different
forms of angiogenesis, see Charnock-Jones DS, Kaufmann P, Mayhew TM Aspects of human fetoplacental vasculogenesis and angiogenesis. I. Molecular regulation. (Placenta 2004;25:103-13).
294 A. arcus quinti pharyngei Only the first four pharyngeal arches, grooves and pouches are distinct structures. Nevertheless, arch arteries develop caudal to the fourth arch. The pulmonary arch caudal to the
fourth arch artery is sometimes named a sixth arch artery because of its phylogeny, even when a fifth arch artery is not present (Congdon ED.Transformation of the aortic-arch system during the development of the
human embryo. Contrib Embryol Carneg Instn 1922;14:47-110).
295 A. umbilicalis The umbilical arteries develop precociously in the mesoderm of the connecting stalk in relation to the allantoic diverticulum, where they may be regarded as allantoic arteries. The vascularization
of the placenta is thus said to be chorio-allantoic.
296 V. postcardinalis In the human embryo there are no supracardinal veins and the azygos system develops from the postcardinal veins (Lamers WH., unpublished observations; Hochstetter F. Entwickelung des
Venensystems der Wirbeltiere. Ergeb Anat Entwicklungsgesch 1893;3:460-489).
297 Lymphangiogenesis The formation of lymphatics (Oliver G. Lymphatic vasculature development. Nature Rev Immunol. 2004:4;35-45).
298 Formatio haemocytorum This section on Blood cell production complements the extensive section with the same name in Terminologia Histologica 2008. Here it is restricted to the initiation of
haemangiogenesis and the most distinctive features of embryonic and fetal blood.
299 Vesicula umbilicalis; Saccus vitellinus The umbilical vesicle or yolk sac accommodates primordial erythroblasts, together with a relatively very small population of macrophages which are the only other
differentiated blood cells that it accommodates (Kelemen E, Calvo W, Fliedner TM. Atlas of Human Hemopoietic Development. Springer-Verlag, Berlin, Heidelberg, New York, 1979; Palis J, Yoder MC, Yolk-sac
hematopoiesis: The first blood cells of mouse and man. Exp Hemat 2001;29:927-936).
300 Macroblastus Macroblasts are large cells which contain pyknotic nuclei and a substantial amount of haemoglobin. These cells are similar in form to the macrocytes, which do not contain nuclei. Both
populations are numerous in the early embryo but disappear before the end of the first trimester. Macroblasts are readily distinguished from megaloblasts, the cells which characterize megaloblastic anaemias.
301 Erythroblastus Fetal blood contains erythroblasts at all stages of maturation, together with corresponding progenitor cells and stem cells (Thomas DB, Yoffey JM. Human fetal haematopoiesis I. The cellular
composition of fetal blood. Br J Haematol 1962;8:290-295; Thomas DB. The leuco-erythroblastic anaemia of the human foetus. Arch Dis Childhood 1963;38:95; Kelemen E, Calvo W, Fliedner TM. Atlas of Human
Hemopoietic Development. Springer-Verlag, Berlin, Heidelberg, New York, 1979).
302 Haemoglobinum embryonicum Changes in haemoglobin molecules during the course of development reflect changes in their two dissimilar pairs of polypeptide chains (globin chains) :
Embryonic haemoglobins invariably contain one or both of the distinctive globin chains that appear early in the first trimester (zeta and epsilon chains), which may be combined with alpha, beta or gamma chains.
During the fifth week of gestation zeta chains and epsilon chains are already being synthesized by primitive erythroblasts in the umbilical vesicle. From the sixth week onwards these same cells also synthesize
alpha, beta and gamma chains. Zeta chains and epsilon chains disappear before the end of the first trimester. During the fetal period alpha chains are combined with gamma chains in fetal haemoglobin (HbF) which
is the predominant haemoglobin until early in the neonatal period. During the second half of gestation the bone marrow is established as the main site of haematopoiesis and adult haemoglobin (HbA), in which
alpha chains are combined with beta chains, starts to replace fetal haemoglobin. Within a month or so of birth adult haemoglobin is the predominant haemoglobin but traces of fetal haemoglobin may persist for
several months. In a minor adult haemoglobin (HbA2), alpha chains are combined with delta chains.
303 Haemangiogenesis/Haemangioblast It was suggested by Sabin in 1920, that the precursors of both blood cells and endothelial cells may be the progeny of a single population of cells, which were
subsequently termed haemangioblasts by Murray in 1932. Haemangioblasts have now been characterised and isolated. Presumably haemangioblasts confer upon the endoderm-associated splanchnopleuric
mesenchyme its capacity to sustain haemangiogenesis, the ability to give rise to both blood cells and endothelial cells, which is not shared by the ectoderm-associated somatopleuric mesoderm. Endothelial
networks are established in somatopleuric mesodermal derivatives extrinsically, by ingrowth from pre-existing vessels of paraxial origin (angiogenesis q.v.). They are established in splanchnopleuric mesenchymal
derivatives intrinsically, by haemangioblasts (vasculogenesis q.v.). Paraxial derivatives are barred from vascularizing visceral organs and from integrating into the floor of the aorta but those of splanchnopleuric
origin enter the body wall, the kidney and the visceral organs. (Pardanaud L, Luton D. Prigent M, Bourcheit L-M, Catala M, Dieterlen-Lievre F. Two distinct endothelial lineages in ontogeny, one of them related to
hemopoiesis, Development 1996;122:1363-1371; Bailey AS, Fleming WH. Converging roads: Evidence for an adult hemangioblast, Exp Hematol 2003;31:987-993).
304 Textus haematopoieticus in pulpa rubra splenis In the human fetus the spleen is not a preferential site of blood cell production between the fourth and seventh months of gestation but, like any other site, the
spleen may accommodate intravascular blood cell precursors. (Thomas DB. Is the spleen a preferential site of blood cell production in the human fetus? Ital J Anat Embryol 1995;100(Supp 1):245-252).
305 Thymus Developmental phases: 1. Primordial; 2. Colonization of primordium by cells derived from the hepatic haematopoietic stem cell population of the liver; 3. Proliferation of T cell antecedents; 4.
Generation of T cells; 5.Emigration of mature T cells (to secondary lymphoid tissues).
306 Saccus pharyngeus quartus The ventral part of the fourth pharyngeal arch may contribute to the thymus in a proportion of human embryos (Van Dyke JH. On the origin of accessory thymus tissue, thymus IV:
the occurrence in man. Anat Rec 1941;79:179-209).
307 Epithelium ectodermale Histological observations have suggested a contribution from the third pharyngeal groove but recent experimental studies suggest otherwise (Gordon J, Wilson VA, Blair NF, Sheridan
J, Farley A, Wilson L, Manley NR, Blackburn CC. Functional evidence for a single endodermal origin for the thymic epithelium. Nat Immunol 2004;5:546-553).
.
308 Ectomesenchyma; Mesenchyma cristae neuralis Ectomesenchymal cells appear to be required to expand the number of thymic epithelial cells in early stages (Anderson G, Jenkinson WE, Jones T, Parnell
SM, Kinsella FA, White AJ, Pongrac’z JE, Rossi JW, Jenkinson EJ. Establishment and functioning of intrathymic microenvironments. Immunol Rev 2006;209:10-27).
310 Progenies cellularum T Thymocytic progenitor cells reaching the thymic cortex express high levels of Cluster of Differentiation molecule 34 and CD45. They become CD1 positive but they remain negative for
CD3, CD4 and CD8 (triple negative cells). In due course, prothymocytes which are CD3+, CD4-and CD8- (double negative cells) form in the cortex, move to the medulla and come to express both CD4 and CD8
(double positive cells), giving rise to both CD4+CD8- helper cells and CD4-CD8+ cytotoxic cells, which leave the thymus.
311 Prothymocytus Prothymocytes are double negative cortical cells that are morphologically recognizable antecedents of T cells.
312 Cellula T adjuvans B lymphocytes are numerous during the fifteenth week of gestation but plasma cells remain rare and serum immunoglobulins virtually absent until after birth. This may reflect functional
immaturity of T helper cells in the fetus.
313 Cellula necatoria anticorporibus non subjecta Antibody-independent natural killer cells are found in the thymus: they are the progeny of haematopoietic stem cells, derived initially from the liver and
subsequently from the bone marrow.
314 Cellula myoidea thymi Thymic myoid cells are demonstrable from the 10 week embryo onwards (Sato T, Tamaoki N. Acta Pathol Jpn 1989;39:509-519).They are more numerous in the fetus and contain
myofilaments but poorly developed sarcomeres (Lambropoulou M, Tamiolakis D, Venizelos I, Alexiadis G, Limberis V, Galzios G, Tsikouras P, Karamanidid D, Koutsougeras G, Nikolaidou S, Petrakis G,
Papadopoulos H, Papadopoulos N. A stromal myoid cell line provokes thymic T-cell immigration at the second and third gestational trimesters. Rev Med Chir Soc Med Nat Iasi 2007;11:710-716).
315 Textus lymphoidei secundarii Lymphocytes, which are ultimately derived from the haematopoietic tissues, leave the primary or central lymphoid tissues to be distributed by the blood and lymph to the
secondary or peripheral lymphoid tissues. The completion of secondary lymphoid tissue maturation coincides with the establishment of antibody production during the neonatal period.
316 Nodulus lymphoideus Lymphoid nodules are units of B lymphocyte organization in the secondary lymphoid tissues. They are unencapsulated clones of activated B lymphocytes, which may be transient or
persistent and solitary or multiple. Multiple lymphoid nodules may be separate or coalescent, free in mucosa-associated lymphoid tissues (MALT) or associated in encapsulated organs where interaction between B
and T lymphocytes is facilitated, exposure to antigens is promoted and integration may occur with lymphatic vessels (in lymph nodes) or blood vessels (in the spleen). An active lymphoid nodule may contain a
germinal centre, in which a mantle zone can be distinguished from a dark zone, a basal light zone and an apical light zone. The dark zone contains dividing B lymphocytes, termed centroblasts, which give rise to
centrocytes that migrate into the basal light zone, where they give rise to plasma cells and memory cells that enter the apical light zone.
317 Textus lymphoideus adjunctus mucosae Persistent, multiple coalescent aggregates of lymphoid nodules occur: in the palatine, pharyngeal and lingual tonsils where they form an incomplete ring at the
crossover point between the alimentary and respiratory tracts (pharyngeal lymphoid ring); in the small intestine, especially the ileum (aggregated lymphoid nodules) and in the appendix. Together with solitary
nodules, these gut-associated lymphoid tissues (GALT), bronchus-associated lymphoid tissues (BALT) and ureter-associated lymphoid tissues (UALT) constitute a group of mucosa-associated lymphoid tissues
(MALT). This serves as a common mucosal immune system in which unencapsulated lymphoid nodules, devoid of afferent lymphatic vessels, receive antigens that cross the lamina propria. The highly modified
epithelial cells that facilitate this process have been termed membrane-like cells (M cells) or, mistakenly, follicle-associated epithelial cells (FAE cells).
318 Paracortex Differentiation of the paracortex occurs about 4 weeks earlier than that of the cortex.
319 Arteriola vaginata pulpae albae The walls of vessels within peri-arteriolar lymphoid sheaths are too thin to warrant their being called arteries.
320 Tonsilla pharyngea; Tonsilla lingualis; Tonsilla tubaria The histogenesis of the pharyngeal, lingual and tubal tonsils is essentially similar to that of the palatine tonsil.
FIPAT
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A programme of the International Federation of Associations of Anatomists (IFAA)
TE2, PART IV
Contents
Published pending approval by the General Assembly at the next Congress of IFAA (2019)
The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use
the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA
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Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS (continued)
5719 Zonae longitudinales tubi Longitudinal zones of neural Longitudinal zones of neural
neuralis tube tube
5720 Lamina dorsalis Roof plate Roof plate
5721 Epithelium plexus choroidei Choroid plexus epithelium Choroid plexus epithelium
5722 Lamina alaris Alar plate Alar plate Endnote 328
5726 Derivativa tubi neuralis Derivatives of neural tube Derivatives of neural tube
5727 Vesicula prosencephalica Forebrain vesicle Forebrain vesicle
5728 Vesicula mesencephalica Mesencephalic vesicle Mesencephalic vesicle
5729 Vesicula rhombencephalica Rhombencephalic vesicle Rhombencephalic vesicle
5730 Medulla spinalis Spinal cord Spinal cord
5731 Rhombencephalon Rhombencephalon Rhombencephalon Hindbrain
5732 Truncus encephali Brain stem Brain stem
5733 Myelencephalon Medulla oblongata; Bulbus Myelencephalon Myelencephalon Medulla oblongata; Bulb
5734 Metencephalon Metencephalon Metencephalon
5735 Pons Pons Pons
5736 Cerebellum Cerebellum Cerebellum
5737 Isthmus rhombencephali Rhombencephalic isthmus Rhombencephalic isthmus
5738 Mesencephalon Mesencephalon Mesencephalon Midbrain
5739 Prosencephalon primarium Primary prosencephalon Primary prosencephalon Forebrain
5740 Prosencephalon caudale Caudal prosencephalon Caudal prosencephalon
5741 Diencephalon Diencephalon Diencephalon
5742 Prosencephalon rostrale Prosencephalon secundarium Rostral prosencephalon Rostral prosencephalon Secondary prosencephalon
5743 Hypothalamus Hypothalamus Hypothalamus
5744 Telencephalon Telencephalon Telencephalon
5745 DIFFERENTIATIO EPITHELII Differentiatio neuroectodermatis DIFFERENTIATION OF NEURAL DIFFERENTIATION OF NEURAL Endnote 330
TUBI NEURALIS TUBE EPITHELIUM TUBE EPITHELIUM
5746 Phasis zonae unae One-zone phase One zone phase
5747 Zona ventricularis Matrix germinalis Ventricular zone Ventricular zone Germinal matrix
5755 ANOMALIAE TUBI NEURALIS ANOMALIES OF NEURAL TUBE ANOMALIES OF NEURAL TUBE Neural tube defects
5756 Dysraphia Dysraphism Dysraphism
5757 Anomaliae tubi neuralis spinalis Spinal neural tube defects Spinal neural tube defects
5758 Spina bifida aperta Spina bifida cystica Spina bifida aperta Spina bifida aperta Spina bifida cystica
5759 Myeloschisis Myeloschisis Myeloschisis
5760 Myelocoelia Myelocoele Myelocele
5761 Myelomeningocoelia Myelomeningocoele Myelomeningocele
5762 Meningocoelia Meningocoele Meningocele
5776 Anomaliae tubi neuralis Cranial neural tube defects Cranial neural tube defects
cranialis
5777 Anencephalia Anencephaly Anencephaly Meroencephaly
5778 Craniorachischisis totalis Craniorachischisis totalis Craniorachischisis totalis
5779 Craniorachischisis partialis Craniorachischisis partialis Craniorachischisis partialis
5780 Iniencephalia Iniencephaly Iniencephaly
5781 Encephalomeningocoelia Encephalomeningocoele Encephalomeningocele
5782 Meningocoelia cranialis Cranial meningocoele Cranial meningocele
5783 Malformationes crescentiae Chiari malformations Chiari malformations
cerebellaris
5784 Chiari I Chiari I Chiari I
5785 Chiari II Chiari II Chiari II Arnold-Chiari malformation; Arnold Endnote 331
Chiari malformation
5786 Chiari III Chiari III Chiari III
5787 Chiari IV Chiari IV Chiari IV
5884 Zonae longitudinales nuclei Longitudinal zones of brain stem Longitudinal zones of brain
trunci encephali nuclei stem nuclei
5885 Nucleus somaticus afferens Special somatic afferent nucleus Special somatic afferent nucleus
proprius
5886 Nucleus vestibularis Vestibular nucleus Vestibular nucleus
5887 Nucleus cochlearis Cochlear nucleus Cochlear nucleus
5888 Nucleus somaticus afferens General somatic afferent nucleus General somatic afferent nucleus Somatosensory nucleus
5889 Nucleus principalis nervi Principal sensory nucleus of Principal sensory nucleus of
trigemini trigeminal nerve trigeminal nerve
5890 Nucleus spinalis nervi trigemini Spinal nucleus of trigeminal Spinal nucleus of trigeminal
nerve nerve
5891 Nucleus branchialis afferens Branchial afferent nucleus Branchial afferent nucleus Special viscerosensory nucleus
5892 Nucleus tractus solitarii Nucleus of solitary tract Nucleus of solitary tract
5893 Nucleus visceralis afferens Visceral afferent nucleus Visceral afferent nucleus General viscerosensory nucleus
5894 Nucleus tractus solitarii Nucleus of solitary tract Nucleus of solitary tract
5895 Nucleus visceralis efferens Visceral efferent nucleus Visceral efferent nucleus Visceromotor nucleus
5896 Nucleus branchialis efferens Branchial efferent nucleus Branchial efferent nucleus Branchiomotor nucleus; Special
visceral efferent nucleus
5897 Nucleus somaticus efferens Somatic efferent nucleus Somatic efferent nucleus
5922 Myelencephalon Medulla oblongata; Bulbus Myelencephalon Myelencephalon Medulla oblongata; Bulb
5928 Substantia grisea Grey substance Gray substance Grey matter; Gray matter
5929 Lamina dorsalis Roof plate Roof plate
5930 Area membranacea caudalis Caudal membranous area Caudal membranous area
5931 Lamina alaris myelencephali Myelencephalic alar plate Myelencephalic alar plate
5932 Nucleus gracilis Gracile nucleus Gracile nucleus
5933 Nucleus cuneatus Cuneate nucleus Cuneate nucleus
5934 Labium rhomboideum laminae Rhombic lip of alar plate Rhombic lip of alar plate Endnote 338
alaris
5935 Labium rhomboideum caudale Lower rhombic lip Lower rhombic lip
5936 Corpus pontobulbare Pontobulbar body Pontobulbar body
5937 Nucleus pontis Pontine nucleus Pontine nucleus
5938 Nucleus cochlearis Cochlear nucleus Cochlear nucleus
5939 Complexus olivarius inferior Inferior olivary complex Inferior olivary complex
5940 Labium rhomboideum rostrale Upper rhombic lip Upper rhombic lip
5941 Sulcus limitans Sulcus limitans Sulcus limitans §His§
5942 Lamina basalis Basal plate Basal plate
5943 Nucleus nervi hypoglossi Hypoglossal motor nucleus Hypoglossal motor nucleus
5944 Nucleus ambiguus Nucleus ambiguus Nucleus ambiguus
5945 Nucleus arcuatus Arcuate nucleus Arcuate nucleus
5946 Nucleus reticularis Reticular nucleus Reticular nucleus
5947 Formatio reticularis Reticular formation Reticular formation
5948 Lamina ventralis Floor plate Floor plate
6102 Anomaliae trunci encephali et Anomalies of brain stem and Anomalies of brain stem and
cerebelli cerebellum cerebellum
6103 Anomaliae trunci encephali Anomalies of brain stem Anomalies of brain stem Endnote 347
6104 Syringobulbia Syringobulbia Syringobulbia
6105 Disinnervationes congenitales Congenital cranial dysinnervation Congenital cranial dysinnervation CCDD Endnote 348
nervorum cranalium disorders disorders
6370 Fibrae associationis longae Long association fibres Long association fibers
6371 Fasciculus longitudinalis superior Superior longitudinal fasciculus Superior longitudinal fasciculus Endnote 376
6372 Fasciculus longitudinalis inferior Inferior longitudinal fasciculus Inferior longitudinal fasciculus
6373 Fasciculus arcuatus Arcuate fasciculus Arcuate fasciculus
6374 Capsula extrema Capsula extrema Capsula extrema
6375 Cingulum Cingulum Cingulum
6497 Anomaliae corticis cerebri Anomalies of cerebral cortex Anomalies of cerebral cortex Malformations of cortical Endnote 384
development
6498 Microcephalia Microcephaly Microcephaly
6499 Microlissencephalia Microlissencephaly Microlissencephaly
6500 Megalencephalia Megalencephaly Megalencephaly
6501 Hemimegalencephalia Hemimegalencephaly Hemimegalencephaly
6502 Heterotopia Heterotopia Heterotopia
6503 Heterotopia nodularis Periventricular nodular Periventricular nodular
periventricularis heterotopia heterotopia
6504 Heterotopia nodularis Bilateral periventricular nodular Bilateral periventricular nodular
periventricularis bilateralis heterotopia heterotopia
6505 Heterotopia leptomeningealis Leptomeningeal heterotopia Leptomeningeal heterotopia
6506 Lissencephalia Lissencephaly Lissencephaly
6507 Lissencephalia classica Classic lissencephaly Classic lissencephaly
6508 Heterotopia laminaris Subcortical band heterotopia Subcortical band heterotopia
subcorticalis
6509 Lissencephalia cum hypoplasia Lissencephaly with cerebellar Lissencephaly with cerebellar
cerebelli hypoplasia hypoplasia
6510 Agyria-pachygyria Cobblestone lissencephaly Cobblestone lissencephaly
6511 Polymicrogyria Polymicrogyria Polymicrogyria
6512 Dysplasia corticalis focalis Focal cortical dysplasia Focal cortical dysplasia
6530 Pars peripherica Systema nervosum periphericum Peripheral nervous Peripheral nervous PNS
system system
6531 Lamina neuralis Neural plate Neural plate
6532 Crista neuralis Neural crest Neural crest
6533 Cellula cristae neuralis Neural crest cell Neural crest cell
6534 Cellula neuraliscristaeformis Neural crest-like cell Neural crestlike cell Endnote 387
6535 Epithelium tubi neuralis Neurectoderma; Ectoderma Neural tube epithelium Neural tube epithelium Neurectoderm; Neural ectoderm
neuralis
6536 Tubus neuralis primarius Primary neural tube Primary neural tube
6537 Crista neuralis primaria Primary neural crest Primary neural crest
6538 Tubus neuralis secundarius Secondary neural tube Secondary neural tube
6539 Crista neuralis secundaria Secondary neural crest Secondary neural crest
6540 Vesicula optica Optic vesicle Optic vesicle
6541 Ectoderma embryonicum Embryonic ectoderm Embryonic ectoderm
6542 Placoda nasalis Placoda olfactori Nasal placode Nasal placode Nasal disc; Olfactory placode
6543 Vesicula otica Otic vesicle Otic vesicle Otocyst
6544 Placoda epipharyngea Epipharyngeal placode Epipharyngeal placode
6545 Placoda dorsolateralis Dorsolateral placode Dorsolateral placode
6546 Epithelium cristae neuralis Neural crest epithelium Neural crest epithelium
6547 Textus cristae neuralis Neural crest tissue Neural crest tissue
6548 Crista neuralis cranialis Cranial neural crest Cranial neural crest
6549 Complexus cristae neuralis nasalis Nasal neural crest complex Nasal neural crest complex
6550 Complexus cristae neuralis Olfactory neural crest complex Olfactory neural crest complex
olfactoriae
6551 Complexus cristae neuralis Terminal neural crest complex Terminal neural crest complex
terminalis
6552 Complexus cristae neuralis Vomeronasal neural crest Vomeronasal neural crest
vomeronasalis complex complex
6553 Complexus cristae neuralis opticae Optic neural crest complex Optic neural crest complex
6554 Crista neuralis preotica Preotic neural crest Preotic neural crest
6555 Complexus cristae neuralis Mesencephalic neural crest Mesencephalic neural crest
mesencephalicae complex complex
6556 Crista neuralis isthmica Isthmic neural crest Isthmic neural crest
6557 Crista neuralis Rhombencephalic neural crest Rhombencephalic neural crest
rhombencephalica
6558 Complexus cristae neuralis Trigeminal neural crest Trigeminal neural crest
trigeminalis complex complex
6559 Complexus cristae neuralis Facial neural crest complex Facial neural crest complex
facialis
6560 Complexus cristae neuralis oticae Otic neural crest complex Otic neural crest complex
6727 LOCUS TRANSITIONIS INTER CNS – PNS TRANSITIONAL CNS PNS TRANSITIONAL ZONE CNS-PNS TZ; TZ
SYSTEMA NERVOSUM ZONE
CENTRALE ET SYSTEMA
NERVOSUM PERIPHERICUM
6728 Glia limitans presumptiva Presumptive glia limitans Presumptive glia limitans Presumptive external limiting
membrane
6729 Projectus textus centralis Central tissue projection Central tissue projection
6730 Locus ingressus radicis dorsalis Locus ingressionis radicis Dorsal root entry zone Dorsal root entry zone Posterior root entry zone; DREZ
posterioris
6731 Taenia conexa radicularum Taenia conexa radicularum Dorsal rootlet attachment zone Dorsal rootlet attachment zone Posterior rootlet attachment zone
dorsalium posteriorium
6737 GLIOCYTI PERIPHERICI PERIPHERAL GLIAL CELLS PERIPHERAL GLIAL CELLS Endnote 390
6738 Linea generationis Schwann cell lineage Schwann cell lineage
schwannocytorum
6739 Schwannoblastus Schwannocytus primordialis Schwannoblast Schwannoblast Primordial Schwann cell
6740 Schwannocytus nonmaturus Immature Schwann cell Immature Schwann cell
6741 Schwannocytus perifascicularis Perifascicular epithelioid Perifascicular epithelioid Endnote 391
epithelioidalis Schwann cell Schwann cell
6742 Schwannocytus segregans Segregating Schwann cell Segregating Schwann cell Endnote 392
6743 Schwannocytus involvens Ensheathing schwann cell Ensheathing schwann cell Endnote 392
6744 Schwannocytus Mature Schwann cell Mature Schwann cell Schwannocytus maturus
Endnote 392
6745 Lamina basalis schwannocyti Lamina basalis strati endoneurialis Schwann cell basal lamina Schwann cell basal lamina Endoneurial layer basal lamina
6746 Schwannocytus Nonmyelinating Schwann cell Nonmyelinating Schwann cell Endnote 392
nonmyelinopoieticus
6747 Schwannocytus myelinopoieticus Myelinating Schwann cell Myelinating Schwann cell Endnote 392
6748 Schwannocytus premyelinatus Schwannocytus promyelinatus Premyelinating Schwann cell Premyelinating Schwann cell Promyelinating Schwann cell Endnote 392
6749 Schwannocytus isolatus Isolated Schwann cell Isolated Schwann cell Endnote 392
6750 Schwannocytus terminalis Cellula teloglialis Terminal Schwann cell Terminal Schwann cell Terminal glial cell Endnote 392
6751 Glioblastus ganglionaris spinalis Glioblastus ganglionaris radicis Dorsal root ganglion ensheathing Dorsal root ganglion ensheathing Spinal ganglion ensheathing blast
implicans dorsalis implicans blast cell blast cell cell
6861 Systema nervosum entericum Enteric nervous system Enteric nervous system
6862 Crista neuralis Neural crest Neural crest
6863 Ganglioblastus entericus Enteric ganglioblast Enteric ganglioblast
6864 Neuron immaturum entericum Immature enteric neuron Immature enteric neuron
6865 Plexus entericus ganglionaris Ganglionic enteric plexus Ganglionic enteric plexus Enteric nerve plexus
6866 Plexus nervosus myentericus Myenteric plexus Myenteric plexus §Auerbach§
6874 Textus connectivi nervi Connective tissues of peripheral Connective tissues of peripheral
peripherici nerve nerve
6875 Crista neuralis Neural crest Neural crest
6876 Ectomesenchyma Mesenchyma cristae neuralis Ectomesenchyme Ectomesenchyme Neural crest mesenchyme
6877 Mesenchyma dermatomyotomiale Dermatomyotomal mesenchyme Dermatomyotomal mesenchyme
6878 Mesenchyma somatopleurale Somatopleuric mesenchyme Somatopleuric mesenchyme
6879 Mesenchyma splanchnopleurale Splanchnopleuric mesenchyme Splanchnopleuric mesenchyme
6880 Ectoderma embryonicum anuli Embryonic ectoderm of umbilical Embryonic ectoderm of umbilical
umbilicalis ring ring
6881 Mesenchyma ex eminentia Mesenchyme from caudal Mesenchyme from caudal
caudale eminence eminence
6882 Endoneurium Endoneurium Endoneurium
6883 Epineurium Epineurium Epineurium
6884 Perineurium Perineurium Perineurium
6885 Fibroblastus Fibroblast Fibroblast
6886 Fibroblastus endoneurialis Endoneurial fibroblast Endoneurial fibroblast Endnote 396
6887 Fibroblastus epineurialis Epineurial fibroblast Epineurial fibroblast
6888 Fibroblastus perineurialis Perineurial fibroblast Perineurial fibroblast
6889 Vagina endoneurialis Endoneurial sheath Endoneurial sheath
6890 Lamina basalis vaginae Endoneurial sheath basal lamina Endoneurial sheath basal lamina
endoneurialis
6891 Perineurioblastus Perineurial blast cell Perineurial blast cell
6892 Perineuriocytus Perineurial cell Perineurial cell
6893 Macrophagocytus Macrophage Macrophage Endnote 397
6926 Anomaliae systematis nervosi Enteric nervous system Enteric nervous system
enterici anomalies anomalies
6927 Dysautonomia familiaris Familial dysautonomia Familial dysautonomia §Riley Day§
Endnote 399
6928 Dysplasia neuronalis intestinalis Intestinal neuronal dysplasia Intestinal neuronal dysplasia
6929 Neurofibroma Neurofibroma Neurofibroma
6930 Defectus systematis nervosi Deficiencies of postduodenal Deficiencies of postduodenal
enterici post duodenalis enteric nervous system enteric nervous system
6931 Aganglionosis coli Colonic aganglionosis Colonic aganglionosis §Hirschprung§
6932 Aganglionosis coli completa Total colonic aganglionosis Total colonic aganglionosis §Zuelzer-Wilson§
6933 Aganglionosis coli partialis Partial colonic aganglionosis Partial colonic aganglionosis
6934 Megacolon congenitum Congenital megacolon Congenital megacolon §Hirschprung§
7002 Oculus et structurae pertinentes Eye and related structures Eye and related structures
7003 BULBUS OCULI EYEBALL EYEBALL
7004 Campus oculi Eye field Eye field
7027 Cellula staminalis cornealis Cellula cornealis precursoria Corneal stem cell Corneal stem cell
7028 Placoda lentis Discus lentis Lens placode Lens placode Lens disc
7029 Fovea lentis Lens pit Lens pit
7030 Vesicula lentis Lens vesicle Lens vesicle
7031 Cavitas lentis Lens cavity Lens cavity
7032 Cavitas lentis figurata D D-shaped lens cavity Dshaped lens cavity
7033 Cavitas crescentiformis lentis Crescent-shaped lens cavity Crescent shaped lens cavity
7034 Cavitas lentis clausa Closed lens cavity Closed lens cavity
7035 Epithelium superficiale lentis Superficial lens epithelium Superficial lens epithelium
7036 Epithelium profundum lentis Deep lens epithelium Deep lens epithelium
7037 Fibra lentis primaria Primary lens fibre Primary lens fiber
7038 Epithelium aequatoriale lentis Equatorial lens epithelium Equatorial lens epithelium
7039 Fibra lentis secundaria Secondary lens fibre Secondary lens fiber
7040 Sutura fibrae lentis Suture of secondary lens Suture of secondary lens
secundariae fibre fiber
7041 Capsula lentis Lens capsule Lens capsule
7042 Tunica vasculosa lentis Vascular lens tunic Vascular lens tunic
7043 Arcus nucleorum Nuclear bow Nuclear bow
7087 Stratum neurorum immaturorum Stratum intermedium; Stratum pallii Inner immature neuron layer Inner immature neuron layer Mantle layer
internum
7088 Glioblastus radialis Radial glioblast Radial glioblast
7089 Gliocytus radialis Radial glial cell Radial glial cell §Müller§
7090 Processus radialis gliocyti Radial process of glial cell Radial process of glial cell
7091 Neuron immaturum retinae Proneuron Immature retinal neuron Immature retinal neuron Proneuron
7092 Neuron amacrinum Amacrine cell Amacrine cell
7093 Neuron interplexiforme Interplexiform cell Interplexiform cell
7094 Neuron bipolare Bipolar neuron Bipolar neuron
7095 Cellula immatura ganglionica Proneuron ganglionare Immature ganglion cell Immature ganglion cell Ganglion cell proneuron
7096 Translatio introrsum Apparent migration inwards Apparent migration inwards Endnote 401
7097 Stratum nucleare internum Inner nuclear layer Inner nuclear layer
7098 Stratum marginale residuale Residual marginal layer Residual marginal layer
7099 Stratum plexiforme internum Inner plexiform layer Inner plexiform layer
7100 Neuropilus Neuropil Neuropil
7101 Stratum ganglionare multipolare Ganglionic layer Ganglionic layer
7102 Neuron ganglionare Retinal ganglion cell Retinal ganglion cell
multipolare retinae
7103 Stratum neurofibrarum Nerve fibre layer Nerve fiber layer
7104 Ora serrata Ora serrata Ora serrata
7105 Stratum limitans internum Inner limiting layer Inner limiting layer
7114 Tunica fibrosa bulbi Fibrous layer of eyeball Fibrous layer of eyeball Endnote 402
7115 Sclera Sclera Sclera
7116 Cornea Cornea Cornea
7117 Tunica vasculosa bulbi Uvea Vascular layer of eyeball Vascular layer of eyeball Uvea Endnote 403
7118 Choroidea Choroid Choroid
7119 Corpus ciliare Ciliary body Ciliary body
7120 Iris nonretinalis Nonretinal iris Nonretinal iris
7147 Substantia propria corneae Substantia propria of cornea Substantia propria of cornea
7148 Epithelium posterius corneae Endothelium of anterior Endothelium of anterior Endnote 404
chamber chamber
7149 Epithelium simplex Simple cuboidal epithelium Simple cuboidal epithelium
cuboideum
7150 Epithelium simplex Simple squamous epithelium Simple squamous epithelium
squamosum
7151 Keratocytus Keratocyte Keratocyte
7152 Lamina limitans posterior Posterior limiting lamina Posterior limiting lamina §Descemet§
7153 Pars laminata striataque Banded, striated part Banded, striated part
7154 Pars nonlaminata et Nonbanded, nonstriated Nonbanded, nonstriated Endnote 405
nonstriata part part
7155 Tunica vasculosa bulbi Uvea Vascular layer of eyeball Vascular layer of eyeball Uvea
7156 Lamina vasculosa Vascular layer Vascular layer
7157 Lamina choroidocapillaris Choroidocapillary layer Choroidocapillary layer
7158 Stroma ciliare Ciliary stroma Ciliary stroma
7159 M. ciliaris Ciliary muscle Ciliary muscle
7160 Stroma iridis Stroma of iris Stroma of iris
7161 Membrana pupillaris Pupillary membrane Pupillary membrane Iridopupillary membrane Endnote 406
7370 Anomaliae auris mediae Anomalies of middle ear Anomalies of middle ear
7371 Atresia cavitatis tympanicae Atresia of tympanic cavity Atresia of tympanic cavity
7372 Dysplasia cavitatis tympanicae Dysplasia of tympanic cavity Dysplasia of tympanic cavity
7373 Cholesteatoma Cholesteatoma Cholesteatoma
7374 Hypoplasia cavitatis tympanicae Hypoplasia of tympanic cavity Hypoplasia of tympanic cavity
7375 Aplasia fenestrae cochleae Aplasia of round window Aplasia of round window
7376 Ectopia fenestrae cochleae Ectopia of round window Ectopia of round window
7377 Aplasia fenestrae vestibuli Aplasia of oval window Aplasia of oval window
7378 Ankylotia Otosclerosis Ankylotia Ankylotia Otosclerosis
7379 Aplasia ossiculorum auditus Aplasia of auditory ossicles Aplasia of auditory ossicles
7380 Dysplasia ossiculorum auditus Dysplasia of auditory ossicles Dysplasia of auditory ossicles
7381 Hyoplasia ossiculorum auditus Hypoplasia of auditory ossicles Hypoplasia of auditory ossicles
7382 Hyperplasia ossiculorum auditus Hyperplasia of auditory ossicles Hyperplasia of auditory ossicles
7383 M. tensoris tympani absens Absent tensor trympani Absent tensor trympani
7384 M. stapedius absens Absent stapedius Absent stapedius
7385 Aplasia tubae Aplasia tubae auditivae Aplasia of pharyngotympanic tube Aplasia of pharyngotympanic tube
pharyngotympanicae
7386 Stenosis tubae Stenosis tubae auditivae Stenosis of pharyngotympanic tube Stenosis of pharyngotympanic
pharyngotympanicae tube
7387 Canalis nervi facialis dehiscens Facial canal dehiscence Facial canal dehiscence
7388 A. stapedii persistens Persistent stapedial artery Persistent stapedial artery
7389 Anomaliae auris internae Anomalies of internal ear Anomalies of internal ear
7390 Aplasia labyrinthi Labyrinthine aplasia Labyrinthine aplasia
7391 Hypoplasia labyrinthi Labyrinthine hypoplasia Labyrinthine hypoplasia
7392 Heteroplasia labyrinthi Labyrinthine heteroplasia Labyrinthine heteroplasia
7393 Ectopia labyrinthi Ectopic labyrinth Ectopic labyrinth
7394 Absentia melanocytorum Melanocyte absence Melanocyte absence
7395 Melanocyti absentes Melanocyte deficiency Melanocyte deficiency
7396 Aplasia meatus acustici interni Aplasia of internal acoustic meatus Aplasia of internal acoustic meatus
7397 Ectopia meatus acustici interni Ectopia of internal acoustic meatus Ectopia of internal acoustic
meatus
7398 Hypoplasia meatus acustici interni Hypoplasia of internal acoustic Hypoplasia of internal acoustic
meatus meatus
7399 Hyperplasia meatus acustici interni Hyperplasia of internal acoustic Hyperplasia of internal acoustic
meatus meatus
7400 Aplasia fossae subarcuatae Aplasia of subarcuate fossa Aplasia of subarcuate fossa
7401 Hypoplasia fossae subarcuatae Hypoplasia of subarcuate fossa Hypoplasia of subarcuate fossa
7402 Ectopia fossae subarcuatae Ectopia of subarcuate fossa Ectopia of subarcuate fossa
Latin term Latin synonym UK English American English English synonym Other
7585 Adnexa embryonica et Membranae extraembryonicae et Developmental adnexa Developmental adnexa Extra-embryonic and fetal
fetales membranes; Extraembryonic and
fetalia
fetal membranes
7586 Nomina generalia General terms General terms
7587 Nutritio Nutrition Nutrition Endnote 414
7588 Endotrophia Endotrophe Endotroph
7589 Exotrophia Exotrophe Exotroph
7590 Embryotrophia Embryotrophe Embryotroph
7591 Haemotrophia Haemotrophe Haemotroph
7592 Histiotrophia Histiotrophe Histiotroph
7633 Saccus chorionicus immaturus Vesicula chorionica immatura Early chorionic sac Early chorionic sac Early chorionic vesicle
7634 Chorion frondosum Chorion frondosum Chorion frondosum Villous chorion
7635 Vesicula chorionica Chorionic sac Chorionic sac Chorionic vesicle
7636 Cavitas chorionica Coeloma extraembryonicum Chorionic cavity Chorionic cavity Extra-embryonic coelom;
Extraembryonic celom
7637 Mesoblastus extraembryonicus Extra-embryonic mesoblast applied Extraembryonic mesoblast applied Extraembryonic mesoblast applied
caudaliter et dorsaliter amnioblasto to amnioblast and trophoblast to amnioblast and trophoblast to amnioblast and trophoblast
et trophoblasto adjunctus caudodorsally caudodorsally caudodorsally
7638 Mesoblastus extraembryonicus Extra-embryonic mesoblast applied Extraembryonic mesoblast applied
amnioblasto toto adjunctus to whole amnioblast to whole amnioblast
7639 Amnion definitivum Definitive amnion Definitive amnion
7640 Cavitas amniotica Amniotic cavity Amniotic cavity
7641 Liquor amnioticus Amniotic fluid Amniotic fluid
7642 Discus embryonicus Embryonic disc Embryonic disc
7643 Pedunculus connectans Connecting stalk Connecting stalk
7644 Gemma alloenterica Alloenteric bud Alloenteric bud
7645 Diverticulum allantoicum Ductus allantoicus Allantoic diverticulum Allantoic diverticulum Allantoic duct
7646 Vasa primordialia pedunculi Primordial vessels of connecting Primordial vessels of connecting
Bookmark not
defined.
7650 Endoderma extraembryonicum Endoderma extraembryonicum Extra-embryonic endoderm of Extraembryonic endoderm of Extra-embryonic endoderm of yolk
vesiculae umbilicalis sacci vitellini umbilical vesicle umbilical vesicle sac; Extraembryonic endoderm of
yolk sac
7651 Mesoblastus extraembryonicus Extra-embryonic mesoblast applied Extraembryonic mesoblast applied
endodermati extraembryonico to extra-embryonic endoderm to extraembryonic endoderm
adjunctus
7652 Insula sanguinea vesiculae Insula sanguinea sacci vitellini Blood island of umbilical vesicle Blood island of umbilical vesicle Blood island of yolk sac
umbilicalis
7653 Cellula staminalis germinalis Primordial germ cell Primordial germ cell
7654 Pedunculus vesiculae umbilicalis Pedunculus sacci vitellini Umbilical stalk Umbilical stalk Stalk of yolk sac
7655 Vas omphalomesentericum Vas vitellinum Omphalomesenteric vessel Omphalomesenteric vessel Vitelline vessel
7656 Ductus omphaloentericus Ductus vitellointestinalis Omphalo-enteric duct Omphaloenteric duct Vitello-intestinal duct;
Vitellointestinal duct; Yolk stalk
7835 Varietates insertionis funiculi Varieties of umbilical cord Varieties of umbilical cord
umbilicalis insertion insertion
7836 Insertio centralis Central insertion Central insertion
7837 Insertio marginalis Marginal insertion Marginal insertion Battledore placenta
7838 Insertio velamentosa Velamentous insertion Velamentous insertion
7839 Varietates situs placentae Varieties of placental site Varieties of placental site
7840 Situs dorsalis placentae Dorsal placental site Dorsal placental site
7841 Situs lateralis placentae Lateral placental site Lateral placental site
7842 Situs ventralis placentae Ventral placental site Ventral placental site
7843 Situs fundalis placentae Fundal placental site Fundal placental site
7844 Situs cornualis placentae Cornual placental site Cornual placental site
7845 Placenta previa Placenta previa Placenta previa
7846 Placenta previa centralis Central placenta previa Central placenta previa
7847 Placenta previa lateralis Lateral placenta previa Lateral placenta previa
7848 Placenta previa marginalis Marginal placenta previa Marginal placenta previa
7849 Situs cervicalis placentae Cervical placental site Cervical placental site
7865 Anomaliae funiculi umbilicalis Umbilical cord anomalies Umbilical cord anomalies
7866 A. umbilicalis singularis Single umbilical artery Single umbilical artery
7867 Funiculus umbilicalis glomeratus Looped umbilical cord Looped umbilical cord
7868 Strangulatio Strangulation Strangulation
7869 Amputatio Amputation Amputation
7870 Nodus spurius funiculi umbilicalis False knot of umbilical cord False knot of umbilical cord
7871 Nodus verus funiculi umbilicalis True knot of umbilical cord True knot of umbilical cord
7872 Vesicula allantoica Allantoic cyst Allantoic cyst
321 Leptomeninx; Arachnoidea mater craniospinalis; Arachnoidea mater cranialis The term ‘mater' has been deleted in English.
322 Migratio cateniformis Chain migration occurs in the Olfactory bulb (see Lois C, Garcia-Verdugo JM, Alvarez-Buylla A 1996 Chain Migration of Neuronal Precursors. Science 271, 978-981).
323 Neuroepithelium columnare The cells of the early neural tube that give rise to glial and ependymal cells were formerly known as spongioblasts.
324 Neuroblastus; Neuron immaturum apolare; Neuron immaturum unipolare; Neuron immaturum bipolare; Neuron immaturum multipolare The term neuroblast is commonly used for an immature neuron of the
intermediate zone. However, because they are postmitotic and are capable of differentiation but not of further division, the term immature neuron is recommended for this and for similar stages elsewhere.
325 Microglia Microglial cells do not appear in the CNS until after it is invaded by blood vessels and mononuclear cells, and are not derived from the ventricular zone.
326 Neuroporus rostralis The term neuroporus anterior – anterior neuropore is frequently used but is not recommended for the human embryo.
327 Situs neuroporicus The importance of the location of the closure of the rostral neuropore is that it is said to be the site of origin of the lamina terminalis.
328 Lamina alaris The term Lamina dorsolateralis is confusing and has been deleted. Lamina alaris is correct. In English: only plate.
329 Lamina basalis; Lamina ventrolateralis The term Lamina ventrolateralis is also confusing and has been deleted.
330 Differentiatio epithelii tubi neuralis; Differentiatio neurectodermatis The development of the CNS is spatially and temporally three-dimensional; at the same time, there are features of the developing layers of
the CNS that are generally associated with a particular region, be it spinal cord, brainstem, cerebellar cortex or cerebral cortex. The development of the zones and the phases and regions in which they appear are
accommodated in this and succeeding sections.
331 Chiari II Chiari (Chiari H Ueber Veränderungen des Kleinhirns infolge von Hydrocephalie des Grosshirns. Dtsch Med Wochenschr 1891;17:1172-1175) defined three types of cerebellar deformity associated
with hydrocephalus, and acknowledged Cleland (Cleland J Contributions to the study of spina bifida, encephalocele and anencephalus. J Anat Physiol 1883;17:257-292) for describing the Chiari II type. In a
subsequent, extensively illustrated paper he added a fourth type (Chiari H Ueber Veränderungen des Kleinhirns, des Pons und der Medulla oblongata in Folge von congenitaler Hydrocephalie des Grosshirns.
Denkschr Kais Akad Wiss Math-naturwiss Classe 1896;63:71-116). Arnold (Arnold J Myelocyste, Transposition von Gewebskeimen und Sympodie. Ziegl Beitr Pathol Anat 1894;16:1-28) added one case. His
collaborators Schwalbe and Gredig (Schwalbe E, Gredig M Ueber Entwicklungsstörungen des Kleinhirns, Hirnstamms und Halsmarkes bei Spina bifida (Arnold'sche und Chiari'sche Miβbildung). Beitr Pathol Anat
Allg Pathol 1907;40:132-194) reported some additional cases, and suggested the term Arnold-Chiari malformation.
332 Encephalon Given the current state of knowledge, a system entailing neuromeres is a good working descriptor for use in organising the terminology of the developing CNS. Here, the prosomeric model
developed by Puelles and Rubinstein is used (see Puelles L Plan of the developing vertebrate nervous system. Relating embryology in the adult nervous system (prosomere model, overview of brain organization.
In: Rakic P and Rubinstein JLR, eds., Comprehensive Developmental Neuroscience, Vol 1. New York, Elsevier pp 187-209; 2013). The model as presented is a reasonable framework to encompass the current
state of knowledge of this fluid topic. The model is ‘merely an epistemic instrument … which deals straightforwardly with the available data’ (Puelles, ibid.), and which could in due course be modified or be replaced.
333 Rhombomerus I-XI Usually, 8 rhombomeres are distinguished (see O'Rahilly R, Müller F The Embryonic Human Brain. An atlas of developmental stages, 3rd ed., New York; Wiley-Liss; 2006). More recently,
however, 11 rhombomeres are distinguished (Rh1-Rh11), several not morphologically distinguishable as true rhombomeres ('cryptorhombomeres'; see Alonso M, Merchán P, Sandoval E, Sánchez-Arrones L,
García-Cazorla A, Artuch R, Ferrán Jl, Martínez-de-la-Torre M, Puelles L 2013; Tomas-Roca L, Corral-San-Miguel R, Aroca P, Puelles L, Marín F Crypto-rhombomeres of the mouse medulla oblongata, defined by
molecular and morphological features. Brain Struct Funct 2015;218:1239-1277). This approach, as already implemented for the mouse hindbrain (Watson C Hindbrain. In: Watson C, Paxinos G, Puelles, eds, The
Mouse Nervous System. Amsterdam, Elsevier, pp 398-423;2012), will be followed in this Section (see also Endnote 332). It should be emphasized, however, that temporarily only Rh1-6 are macroscopically visible.
334 Mesomerus I, II Contrary to previous studies, Mesomere 2 forms only a small, pre-isthmic part of the mesencephalon (see Martínez S, Puelles E, Puelles L, Echevarria D Molecular regionalization of the
developing neural tube. In: Watson C, Paxinos G, Puelles L, eds, The Mouse Nervous System. Elsevier, Amsterdam, 2012 pp 2-18; Puelles 2013, see Endnote 332 for full reference).
335 Prosomerus I-III Prosomeres 1-3 are the Caudal prosomeres, and give rise to the Diencephalon (= Pretectum, Epithalamus, Thalamus, Prethalamus, and Diencephalic tegmentum).
336 Prosomerus hypothalami et telencephali I-II The caudal and rostral secondary prosencephalon derive from the two hypothalamic and telencephalic prosomeres, and give rise to the Hypothalamus and the
Telencephalon.
337 Rhombomerus VIII-XI Molecular markers are quite specific for definitive rhombomeres at very early stages. Molecularly-defined rhombomeres can be seen earlier than the 6 macroscopic bulges which led
initially to their discovery. This is due to the fact that when a rhombomere is specified differentially, it also acquires differential regulation of its proliferating progenitors, leading secondarily to the interrhombomeric
boundaries as sites of less proliferation. The concept of the prorhombomeres A-D, going back to Vaage S (The segmentation of the primitive neural tube in chick embryos. Ergeb Anat Entwicklungsgesch 1969;41:3-
87), and advocated by O'Rahilly and Müller (The Embryonic Brain. An atlas of developmental stages, 3rd ed. Wiley-Liss, New York; 2006), is not consistent with these data, irrespective of the presence of transient
larger swellings of the hindbrain wall that have received these names. Molecular data clearly identify 11 rhombomeres (Alonso et al. 2013; Tomas-Roca et al. 2015; Allen Developing Mouse Brain Atlas; for full
references see Endnote 333).
338 Labium rhomboideum laminae alaris The Rhombic lip (the 'Rautenleiste' of His: His W Die Entwickelung des menschlichen Rautenhirns vom Ende des ersten bis zum Beginn des dritten Monats. I.
Verlängertes Mark. Abh Kön Sächs Ges Wiss Math Phys Kl 1890;29:1-74) is the dorsolateral part of the alar plate, and it forms a proliferative zone along the length of the hindbrain. Cells from its rostral part, the
Upper rhombic lip, form the External germinal or granular layer at the end of the embryonic period. The Lower rhombic lip gives rise to the Pontine nuclei, the Cochlear nuclei and the Inferior olivary complex (Bloch-
Gallego E, Causeret F, Ezan F, Backer S, Hidalgo-Sánchez M Development of precerebellar nuclei: Inductive factors and intracellular mediators in neuronal migration, survival and axonal pathfinding. Brain Res
Rev 2005;49:253-266).
339 Tegmentum pontis Although the term Pontine tegmentum is traditionally used, from an embryological point of view, a further subdivision into Prepontine (Rh0-2), Pontine (Rh3, 4) and Retropontine (Rh5, 6)
parts of the tegmentum is advocated. This approach is also applied in the revised Terminologia Anatomica. Some examples are given. For a full ontological subdivision of the mouse brain, see Allen: Developing
Mouse Brain Atlas (www.deve;opingmouse.brain-map.org).
340 Tuberculum cerebelli Hochstetter F (1929) Beiträge zur Entwicklungsgeschichte des menschlichen Gehirns, II. Teil, 3. Lieferung: Die Entwicklung des Mittel- und Rautenhirns. Deuticke, Vienna.
341 Subdivisiones cerebelli Edinger's archaic terms Archicerebellum, Paleocerebellum and Neocerebellum have been deleted.
342 Neuron golgiense magnum immaturum The use of 'stellatum' for the Golgi cells is unfortunate, given the presence of other Stellate cells in the Molecular layer. Following the CNS Section of Terminologia
Neuroanatomica, the official term is Neuron golgiense magnum immaturum, and the English official term: Immature large Golgi cell.
343 Neuron golgiense parvum immaturum Ibid., for Small stellate cell.
344 Phases histogeneticae The One- to Four-zone phases occur during the embryonic period, the Five- and Six-zone phases in the fetal period, and the Definitive phase in the newborn. The Stratum germinale
externum persists until the end of the first year (O'Rahilly R, Müller FHuman Embryology & Teratology, 3rd ed. New York, Wiley-Liss, 2001; ten Donkelaar HJ, Lammens M, Wesseling P, Thijssen HOM, Renier WO
2003 J Neurol 250:1025-1036; ten Donkelaar HJ, Lammens M, Hori A Clinical Neuroembryology. Development and developmental disorders of the human central nervous system, 2nd ed. Heidelberg, New York,
Dordrecht, London, Springer; 2014).
346 Pedunculus cerebri; Crus cerebri Traditionally, the Mesencephalon was subdivided into the Tectum (the Colliculi) and the Pedunculus (the Crus cerebri, the Substantia nigra/VTA-complex and the Tegmentum
mesencephali). Here, it is advocated to use the term Pedunculus only for what it actually is: a large bundle of fibres from the Telencephalon to the Brain stem and Spinal cord. It has been changed accordingly in the
Section CNS of the TNA.
347 Anomaliae trunci encephali For a recent developmental and genetic classification for brain stem malformations, see Barkovich AJ, Millen KJ, Dobyns WB. A developmental and genetic classification for
midbrain-hindbrain malformations. Brain 2009;132:3199-3230.
348 Disinnervationes congenitales nervorum cranalium A group of congenital neuromuscular diseases, characterized by abnormal eye, eyelid and/or facial movement, are currently termed Congenital cranial
dysinnervation disorders (Gutowski NJ, Bosley TM, Engle E Workshop Report (110th ENMC International Workshop: The congenital cranial dysinnervation disorders (CCDDs). Neuromusc Disord 2003;13:573-
578). One of these is Möbius syndrome (Paralysis congenita abducentofacialis). One of the most interesting syndromes is the HOXA1 syndrome (Bosley TM, Alorainy IA, Salih MA, Aldhalaan HM, Abu-Amero KK,
Oystreck DT, et al. The clinical spectrum of homozygous HOXA1 mutations. Am J Med Genet A 146A: 2008;1235-1240).
349 Malformatio vermis Agenesis or hypoplasia of the vermis may be found in a large number of malformations of the brain (see Barkovich AJ, Millen KJ, Dobyns WB A developmental and genetic classification for
midbrain-hindbrain malformations. Brain 2009;132:3199-3230; ten Donkelaar HJ, Lammens M, Hori A Clinical Neuroembryology. Development and developmental disorders of the human central nervous system,
2nd ed. Heidelberg, New York, Dordrecht, London; Springer, 2014) such as the Dandy-Walker, Joubert and Meckel-Gruber syndromes.
350 Divisiones prosencephali The embryonic Prosencephalon is currently subdivided into a Caudal prosencephalon, giving rise to the Caudal diencephalon (P1-P3, or Synencephalon, Caudal parencephalon and
Rostral parencephalon, respectively) and the Rostral or Secondary prosencephalon, giving rise to the Hypothalamus (the Rostral diencephalon), the Eye vesicles, the Neurohypophysis and the entire
Telencephalon. The current TE, based on O'Rahilly and Müller's subdivision (O'Rahilly R, Müller F The Embryonic Human Brain. An atlas of developmental stages, 3rd ed. New York, Wiley-Liss; 2006) into the
prosomeres D2 (roughly P1-P3), D1 and T is rather arbitrarily. They defined the rostral border of their D1 as the rostral border of the Chiasmatic plate, so as to include the Eye vesicle in D1, and their T
(Telencephalon medium) as the part rostral to D1. The description used here is based on the prosomeric model developed by Puelles and Rubinstein (see Puelles L, Harrison M, Paxinos G, Watson C A
developmental ontology for the mammalian brain based on the prosomeric model. Trends Neurosci 2013;36:570-578; see also Endnote 329).
351 Divisiones diencephali Here, the old terms based on Herrick's columnar doctrine (Herrick CJ The morphology of the forebrain in Amphibia and Reptilia. J Comp Neurol 1910;20:413-547; generalized by
Kuhlenbeck H Vorlesungen über das Zentralnervensystem der Wirbeltiere. Jena, Fischer; 1927) have been replaced by the modern subdivision of the Diencephalon into transverse zones (transverse to the
longitudinal axis of the brain). The Alar parts of the prosomeres P1-P3 form the (Caudal) Diencephalon (Pretectum, Epithalamus, Thalamus and Prethalamus). The term Thalamus replaces Dorsal thalamus and
includes the Metathalamus, whereas the term Prethalamus replaces the Ventral thalamus. The Basal parts of these prosomeres form the Tegmentum diencephali or Tegmentum prerubrale. The Hypothalamus
arises from the Hypothalamic prosomeres, but may be viewed as 'Rostral Diencephalon'.
352 Zona limitans intrathalamica; Limes medius diencephali The Zona limitans intrathalamica is a transversal ventricular ridge in the diencephalic neural tube, corresponding to a surface transverse constriction
between P2 and P3, originally described as Zona limitans intraparencephalica by Rendahl (Rendahl H Embryologische und morphologische Studien über das Zwischenhirn beim Huhn. Acta Zool (Stockh)
1924;5:214-344). Its role is crucial for the development of the entire thalamus (Kiecker C, Lumsden A The role of organizers in patterning the nervous system. Annu Rev Neurosci 2012;35:347-367; Puelles L,
Martínez-de-la-Torre M, Bardet S, Rubinstein JLR Hypothalamus. In: Watson C, Paxinos G, Puelles L, eds, The Mouse Nervous System. Amsterdam, Elsevier; 2012, pp 221-312).
354 Nucleus commissurae posterioris In Terminologia Anatomica, The Nucleus commissurae posterioris included Dorsal, Interstitial and Ventral subdivisions. The first two are alar plate derivatives. The so-called
Ventral subdivision (the Nucleus of Darkschewitsch) is a basal plate derivative, and is renamed as Nucleus ellipticus following data on Cetacea and Proboscidea (see Büttner-Ennever JA, Horn AKE, eds Olszewski
and Baxrer's Cytoarchitecture of the Human Brainstem, 3rd revised and extended edition. Basel, Karger; 2014).
355 Nuclei anteriores thalami For each of the groups of the thalamic nuclei, one or more examples are given; for a complete list see the Section CNS of Terminologia Neuroanatomica.
356 Pars diencephalica substantiae nigrae The Substantia nigra appears to arise from the prosomeres 1-3, the mesomeres 1 and 2, and the isthmic rhombomere (Puelles L, Verney C Early neuromeric distribution
of tyrosine-hydroxylase-immunoreactive neurons in human embryos. J Comp Neurol 1998;194:283-308; Verney C, Zecevic N, Puelles L Structure of longitudinal brain zones that provide the origin for the substantia
nigra and ventral tegmental area in human embryos, as revealed by cytoarchitecture and tyrosine hydroxylase, calretinin, calbindin, and GABA immunoreactions. J Comp Neurol 2001;429:22-44). The Ventral
tegmental area arises from the same neuromeres.
357 Crista neuralis anterior The Anterior neural ridge plays an important role in anteroposterior patterning of the forebrain (Shimamura K, Rubinstein JLR Inductive interactions direct early regionalization of the
mouse forebrain. Development 1997;124:2709-2718; Rubinstein JLR, Shimamura K, Martínez S, Puelles L. Regionalization of the prosencephalic neural plate. Annu Rev Neurosci 1998;21:445-477).
358 Cavitas prosencephalica In the prosomeric model, the Cavitas prosencephalica becomes divided into a Cavitas diencephalica and a Cavitas hypothalamica.
359 Pars diencephalica ventriculi tertii The Ventriculus tertius consists of a Pars diencephalica and a Pars hypothalamica. The latter communicates through the Foramen interventriculare with the Ventriculus
lateralis, and has a preoptic extension, the Recessus preopticus.
360 Crista marginalis; Crista limitans The Marginal ridge marks the position of the Zona limitans intrathalamica of Rendahl, not visible from the inside; below this ridge a Sulcus medius may be recognized. As
synonym Crista limitans; Limiting intrathalamic ridge (L Puelles, personal communication) has been added.
361 Sulcus hypothalamicus The Sulcus hypothalamicus marks the rostral boundary of the (Caudal) Diencephalon towards the Hypothalamus (the 'Rostral' Diencephalon). Hochstetter (Hochstetter F Beiträge zur
Entwicklungsgeschichte des menschlichen Gehirns. I. Teil. Vienna, Deuticke; 1919) named it the Sulcus of Monro (S.M.), later often confused with the Sulcus medius.
362 Velum transversum The Velum transversum does not limit the Diencephalon from the Telencephalon, but it appears at the apex of the Zona limitans intrathalamica and, therefore, limits the roof of the
Prethalamus from that of the Thalamus (see Puelles L, Harrison M, Paxinos G, Warson C A developmental ontology for the mammalian brain based on the prosomeric model. Trends Neurosci 2013;36:570-578).
363 Lamina affixa The caudal part of the Eminentia prethalamica forms a protrusion at the posterior side of the Interventricular foramen, whereas its rostral part is drawn into the developing hemisphere. For a long
time, these relations were explained by postulating that during ontogenesis a thin, membranous part of the telencephalic wall adheres to the dorsal surface of the thalamus, i.e. the Lamina affixa. Actually, this
structure does not exist (Nieuwenhuys R, Voogd J, van Huijzen C The Human Central Nervous System, 4th ed. Berlin-Heidelberg-New York, Springer, 2008; Puelles L, Martínez S, Martínez de la Torre M
Neuroanatomía. Buenos Aires, Madrid, Médica Panamericana; 2008). The territory in question, as already pointed out by Hochstetter (1919), represents the dorsal part of the Prethalamic territory, intercalated
between the Thalamus proper and the Cerebral hemisphere.
364 Lamina terminalis The Embryonic lamina terminalis or Lamina reuniens ('Schlussplatte' of His: His W Die Formentwickelung des menschlichen Vorderhirns vom Ende des ersten bis zum Beginn des drittem
Monats. Abh Kön Sächs Ges Wiss Math Phys Kl 1889;15:675-735) closes the Neural tube between the Chiasmatic ridge and the Septal roof. Following His, Rakic and Yakovlev (Rakic P, Yakovlev PI Development
of the corpus callosum and cavum septi in man. J Comp Neurol 1968;132:45-72) suggested that the Lamina reuniens divides into a dorsal part (the Massa commissuralis or 'Trapezplatte' of His) and a ventral part
(the Lamina terminalis sensu stricto or 'Endplatte' of His; see ten Donkelaar HJ, Lammens M, Hori A Clinical Neuroembryology: Development and developmental disorders of the human central nervous system,
365 Cavum septi pellucidi rostrale A Cavum septi pellucidi between two Medial medullary vela (term suggested by Raybaud C The corpus callosum, the other great forebrain commissures, and the septum
pellucidum: Anatomy, development, and malformations. Neuroradiology 2010;52:447-477) is present in every normal fetus up to 6 months of gestation, but it gradually narrows from the splenium towards the genu
so that the posterior part is usually obliterated by the time of birth and the rostral part by about 3 months after birth (Shaw CM, Alvord EC Jr Cava septi pellucidi et Vergae: Their normal and pathological states.
Brain 1969;92:213-224; ten Donkelaar HJ, Lammens M, Hori A Clinical Neuroembryology, 2nd ed. Heidelberg, New York, Dordrecht, London, Springer; 2014). A Cavum septi pellucidi remains in about 20% of
children; if the rostral part persists the cavity is known as Cavum septi pellucidi; if the caudal part remains open, the cavity is called Cavum Vergae.
366 Torus hemisphericus Temporarily, the Torus hemisphericus marks the border between the third and lateral ventricles. Externally, this is marked by the Sulcus diencephalicotelencephalicus (see O'Rahilly R,
Müller F The Embryonic Human Brain. An atlas of developmental stages, 3rd ed. New York, Wiley-Liss; 2006).
367 Eminentia ventricularis lateralis; Eminentia ganglionaris lateralis The term Eminentia ganglionaris lateralis is added as a Latin synonym for the commonly used English term Lateral ganglionic eminence. The
latter gives rise to the Nucleus caudatus, the Putamen and the Nucleus accumbens.
368 Eminentia ventricularis medialis; Eminentia ganglionaris medialis At the level of the Interventricular foramen, the medial surface of the Medial ventricular eminence forms part of the Third ventricle. On that
account, Kahle (Kahle W Zur Entwicklung des menschlichen Zwischenhirns. D Z Nervenheilk 1956;175:259-318), Richter (Richter E Die Entwicklung des Globus pallidus und des Corpus subthalamicum. Berlin,
Heidelberg, New York; Springer; 1965), and, more recently, O'Rahilly and Müller (The Embryonic Human Brain, 3rd ed. New York, Wiley-Liss; 2006), considered the Globus pallidus to be of diencephalic origin. The
term Eminentia ganglionaris medialis is added as a Latin synonym for the commonly used English term Medial ganglionic eminence. The latter gives rise to both parts of the Globus pallidus.
369 Eminentia ventricularis caudalis Eminentia ganglionaris caudalis The Eminentia ventricularis caudalis gives rise to most of the Amygdaloid complex.
370 Corpus gangliothalamicum Between the 16th and 34th week of gestation, cells pass from the Medial ganglionic eminence into the lateral and posterior parts of the Thalamus. Most of these neurons migrate
along a transient fetal structure, the Gangliothalamic body (Rakic P, Sidman RL Telencephalic origin of pulvinar neurons in the fetal human brain. Z Anat Entwicklungsgeschichte 1969;129:53-82; Letinić K, Kostović
I Transient fetal structure, the gangliothalamic body, connects telencephalic germinal zone with all thalamic regions in the developing human brain. J Comp Neurol 1997;384:373-395).
371 Pallium The archaic terms Neopallium, Paleopallium and Archipallium have been deleted.
372 Pallium laterale Recent studies suggest that the Lateral pallium gives rise to the Claustro-insular complex (see Puelles L Development and evolution of the claustrum. In: Smythies JR, Edelstein LR,
Ramachandran VS, eds, The Claustrum: Structural, functional and clinical neuroscience. San Diego, Academic Press, 2014, pp 119-176).
373 Sulci secundarii Secondary and Tertiary sulci are important in MRI studies and diagnosis of the fetal brain (see Garel C MRI of the Fetal Brain. Berlin, Heidelberg, New York; Springer, 2004).
374 Pedunculus hemisphericus 'Hemisphärenstiel' of Hochstetter (Hochstetter F Beiträge zur Entwicklungsgeschichte des menschlichen Gehirns. I. Teil. Deuticke, Vienn; 1919).
375 Fasciculus prosencephalicus lateralis 'Stammbündel' of His (His W Die Entwickelung des menschlichen Gehirns während der ersten Monate. Hirzel, Leipzig; 1904).
376 Fasciculus longitudinalis superior For DTI studies of long association fibres in the human fetal brain, see Huang H, Xue R, Zhang J, Ren T, Richards LJ, Yarowski P, et al. Anatomical characterization of human
fetal brain development with diffusion tensor magnetic resonance imaging (J Neurosci 2009;29:4263-4273), and Vasung L, Huang H, Jovanov-Milošević N, Pletikos M, Mori S, Kostović I. Development of axonal
pathways in the human fetal fronto=limbic brain. Histochemical characterization and diffusion tensor imaging. (J Anat 2010;217:400-407). For a complete list of Long association fibres, see Section CNS of
Terminologia Neuroanatomica.
378 Dominationes histogeneticae et derivativae The old, comparative neuroanatomical terms Neostriatum (= Caudate nucleus, Putamen and Nucleus accumbens), Paleostriatum (= Globus pallidus) and
Archistriatum (= Amygdala) have been deleted.
379 Amygdala The Amygdala has pallial (from the Ventral pallium) and subpallial (from all four Subpallial domains) origins (see Puelles L, Harrison M, Paxinos G, Watson C A developmental ontology for the
mammalian brain based on the prosomeric model. Trends Neurosci 2013;36:570-578).
380 Stratum granulare subpiale The transient Subpial granular layer of Ranke develops from the Basal periolfactory subventricular zone (Brun A The subpial granular layer of the frontal cerebral cortex in man. Its
ontogeny and significance in congenital cortical malformations. Acta Pathol Microbiol Scand 1965;179 (Suppl):1-98; Meyer G Building a human cortex: The evolutionary differentiation of Cajal-Retzius cells and the
cortical hem. J Anat 2010;217:334-343).
381 Glioblastus radialis Recently, a much more prominent role for the Radial glial cells as Neural stem cells has been shown (see Kriegstein AR, Alvarez-Buylla A The glial nature of embryonic and adult neural
stem cells. Annu Rev Neurosci 2009;35:347-367).
382 Glioblastus radialis externus These cells from the Outer subventricular zone are Intermediate progenitor cells (see Kriegstein AR, Alvarez-Buylla A The glial nature of embryonic and adult neural stem cells.
Annu Rev Neurosci 2009;35:347-367; Hansen DV, Lui J, Parker PR, Kriegstein AR Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature 2010;464:554-561). During development and
in the adult brain, many neurons and glial cells are not the direct progeny of ventricular neural stem cells but instead originate from Intermediate progenitor cells (IPCs). IPCs can generate neurons (nIPCs) or
generate glial cells, including oligodendrocytes (oIPCs) and astrocytes (aIPCs).
383 Phases histogeneticae The revised Boulder Committee Terminology (Bystron I, Blakemore C, Rakic P Development of the human cerebral cortex: Boulder Committee revisited. Nat Rev Neurosci 2008;9:110-
122) is used.
384 Anomaliae corticis cerebri The subdivision of anomalies of the cerebral cortex is based on Barkovich et al. (Barkovich AJ, Guerrini R, Kuzniecky RI, Jackson GS, Dobyns WB A developmental and genetic
classification for malformations of cortical development: Update 2012. Brain 2012;135:1348-1369). Only the major malformations are mentioned. For an overview and examples, see ten Donkelaar HJ, Lammens M,
Hori A Clinical Neuroembryology: Development and developmental disorders, 2nd ed. Heidelberg, New Yotk, Dordrecht,London; Springer 2014.
385 Fasciculus longitudinalis callosalis The Fasciculus longitudinalis callosalis is an abnormal longitudinal bundle which failed to cross in the absence of the corpus callosum ('Balkenlängsbündel' of Probst). The
term Longitudinal callosal fascicle was suggested by Lee S-K, Mori S, Kim DJ, Kim SY, Kim DI. Diffusion tensor MR images visualizes the altered hemispheric fiber connection in callosal dysgenesis. AJNR Am J
Neuroradiol 2004;25:25-28.
386 Anomaliae decussationis The various modes of decussation of the Pyramidal tract were summarized by Yakovlev and Rakic (Yakovlev PI, Rakic P Patterns of decussation of bulbar two sides of the pyramids
and distribution of pyramidal tracts on two sides of the spinal cord. Trans Am Neurol Assoc 1966;91:366-367). For examples, see ten Donkelaar HJ, Lammens M, Wesseling P, Hori A, Keyser A, Rotteveel J.
Development and malformations of the human pyramidal tract. J Neurol 2004;251:1429-1442.
387 Cellula neuraliscristaeformis Cells that behave in a similar manner to neural crest cells but arise from other sources are here referred to as neural crest-like cells. However, they meld seamlessly with neural
crest cells into complexes and are then no longer morphologically distinguishable (O'Rahilly R, Müller F. The development of the neural crest in the human. J Anat 2007;211:335-351). The term neural crest is here
restricted to temporary aggregations of cells derived from the neural folds or tube and the term neural crest complex is used when neural crest-like cell are involved.
389 Acervatio cellularum ad radiculam ventraliam; Acervatio cellularum ad radiculam motoriam; Acervatio cellularum ad radiculam anteriorem Ventral rootlet cell clusters are clusters of cells that differentiate into
Schwann cells which ensheath and eventually myelinate the axons of the ventral rootlet. Fraher J, Rossiter J. Cell clusters on developing rat ventral roots. Prenatal development. J Anat;1983:136,111-128; Fraher J,
Rossiter J. Cell clusters on rat ventral roots. II. Postnatal development. J Anat 1983;137:555-571.
390 Gliocyti peripherici The term Schwann cell is now almost universally ascribed to the PNS ensheathing cell. Terms including the stem neurolemm- are now rarely used.
391 Schwannocytus perifascicularis epithelioidalis Schwann cell precursors initially form a cellular sheath around axon bundles (perifascicular epithelioid Schwann cells). They then invade and partition the axon
bundles (segregating Schwann cells). Segregation is completed when a Schwann cell has completely surrounded the presumptively myelinated axon or the presumptively nonmyelinated axon bundle (ensheathing
Schwann cells).
392 Gliocyti peripherici; Schwannocytus segregans ; Schwannocytus involvens; Schwannocytus maturus; Schwannocytus nonmyelinopoieticus; Schwannocytus myelinopoieticus; Schwannocytus premyelinatus ;
Schwannocytus isolatus; Schwannocytus terminalis; Cellula teloglialis The term Schwann cell is now almost universally ascribed to the PNS ensheathing cell. Terms including the stem neurolemm- are now rarely
used. The term endoneurial sheath applies to the basal lamina of the Schwann cell and the collagenous sheath surrounding it. Inside that is the nerve fibre, defined as the axon(s) and the surrounding Schwann
cell(s). See above.
393: Schwannocytus uniaxonalis As a prerequisite for myelination each Schwann cell normally enfolds only one axon segment.
394 Segregatio canalium ionicorum Sodium and potassium channels are segregated into complementary membrane domains in the earliest stages of formation of nodes of Ranvier (Waxman SG, Ritchie JM.
Organisation of ion channels in the myelinated nerve fiber. Science 1985;228:1502-1507).
395 Eliminatio synapsium superfluarum In developing mammalian skeletal muscle several axons innervate a single motor end-plate. This polyneuronal innervation is lost in early postnatal life as inactive motor
neurons degenerate (Jordan C L. Ciliary neurotrophic factor may act in target musculature to regulate developmental synapse elimination. Dev Neurosci 1996;18:185-198; Favero M, Lorenzetto E, Bidoia C, Buffelli
M, Busetto G, Cangiano A. Synapse formation and elimination: role of activity studied in different models of adult muscle reinnervation.J Neurosci Res 2007;85:2610-9.
396 Fibroblastus endoneurialis/ Fibroblastus epineurialis/ Fibroblastus perineurialis Only endoneurial fibroblasts are now believed to be derived solely from neural crest cells: epineurial and perineural fibroblasts
may be of mixed lineage (Joseph NM, Mukouyama YS, Mosher JT, Jaegle M, Crone SA, Dormand EL, Lee KF, Meijer D, Anderson DJ, Morrison SJ. Neural crest cells undergo multilineage differentiation in
developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development 2004;131:5599-5612).
397 Macrophagocytus The macrophages of peripheral nerve connective tissue are not derived from the neural crest.
398 Hypomyelinisatio congenita In congenital hypomyelination there is impairment of elements of the myelination process, including segregation, ensheathment and myelin formation.
399 Dysautonomia familiaris Familial dysautonomia is characterized by dysfunction of the autonomic nervous system, sensory disturbances, neurological disorders, psychical anomalies and ophthalmological
symptoms such as dry eyes, corneal anaesthesia, keratinized conjunctiva and cornea: a smooth tongue is accompanied by absence of fungiform papillae and taste buds.
400 Spatium intraretinale; Hiatus intraretinalis Although the cavity of the optic vesicle disappears, there remains a potential cleft, the site of so-called retinal detachment, which takes place between retinal layers..
401 Translatio introrsum Ganglion cell proneurons separate as the retina increases in thickness.
403 Tunica vasculosa bulbi; Uvea The parts of the vascular layer of the eyeball are derived from both the optic cup and the surrounding ectomesenchyme: their component parts are listed either under Retina or
under Optic mesenchyme.
405 Pars nonlaminata et nonstriata The nonbanded, nonstriated part of the posterior limiting lamina is formed postnatally by the endothelium of the anterior chamber.
406 Membrana pupillaris The mesenchymal tissue developing into the sclera (Wai SM, Li WY, Chai WY, Sha O, Yew DT. The iridopupillary membrane (or pupillary membrane) in human development.
Neuroembryology 2002;1:44-46).
407 Coloboma congenita Vitreous body, lens, cornea, choroid and/or iris may be affected.
408 Sulcus nasolacrimalis; Sulcus lacrimalis The nasolacrimal groove is said to appear approximately along, but independently of, the line where the maxillary and frontonasal prominences merge and is thus not
synonymous with the nasomaxillary groove (O'Rahilly R and Müller F. Human Embryology & Teratology. 3rd ed. New York: Wiley-Liss; 2001].
409 Lamina lacrimalis The lacrimal lamina is a thickening of the epithelium at the bottom of the lacrimal groove. Its tip bifurcates to form primordial canaliculi before it canalises and connects conjunctival and
inferior meatal epithelia (de la Cuadra-Blanco C, Peces-Peña MD, Jáñez-Escalada L, Mérida-Velasco JR. Morphogenesis of the human excretory lacrimal system. J Anat 2006;209:127-135).
410 Lig. mallei anterius It is usually considered that the anterior ligament is derived from the first pharyngeal arch because of its continuity, via the sphenomandibular ligament, with the mandible. However, it has
also been suggested that the anterior ligament is derived from the second pharyngeal arch (Hanson JR, Anson BJ, Strickland EM. Branchial sources of the auditory ossicles in man. Arch Otolaryngol 1962;76:200-
215).
411 Vestibulocytus I; Vestibulocytus piriformis Type I vestibular hair cells are demonstrable in the 8 week embryo and they have synaptic vesicles at 9 weeks (Dechesne CJ, Sans A. Development of vestibular
receptor surfaces in human fetuses. Am J Otolaryngol 1985;6:378-387).
412 Cochleocytus internus; Cochleocytus externus Inner and outer hair cells of the cochlea can be found in the 10 and 11 week embryo, respectively (Pujol R, Lavigne-Rebillard M. Early stages of innervations
and sensory cell differentiation in the human organ of Corti. Acta Otolaryngol Suppl. 1985;423:43-50). Ciliogenesis starts one week later in each cell type (Lavigne-Rebillard M, Pujol R. Development of the auditory
hair cell surface in human fetuses. A scanning electron microscope study. Anat Embryol (Berl) 1986:174:369-377).
413 Mamma The prenatal and prepubertal development of the mammary glands is similar in both sexes. In the newborn, both may secrete “witch’s milk”. The definitive male gland at 20 years is similar to that of
the early pubertal female.
414 Nutritio Nutrients originating inside the conceptus as a result of specific metabolic processes such as liquefaction of its cells are described as endotrophe. Nutrients originating outside the conceptus from
maternal blood (haemotrophe) or as a result of liquefaction of maternal cells (histiotrophe) are described as exotrophe (Blechschmidt E, Gasser R. Biokinetics and biodynamics of human differentiation. Springfield:
Charles C Thomas; 1978).
415 Adnexa embryonica The terms for the development of the extra-embryonic membranes are presented here in temporal sequence, which entails some repetition and, in the earlier stages, include items
previously thought to give rise only to embryonic tissues: in particular, the embryoblast gives rise to both extra-embryonic and embryonic tissues; hence the alternative term pluriblast which recognizes this.
417 Villus mesenchymalis Until Stage 23 all villi are mesenchymal villi and are inconspicuous, “with loose connective tissue, rich in mesenchymal cells, poor in fibres; few capillaries with signs of capillary
sprouting; numerous cytotrophoblasts; and thick syncytiotrophoblastic layer, extending in trophoblastic sprouts.” In the first two trimesters mesenchymal villi develop into immature intermediate villi, which
themselves develop into stem villi. In the third trimester mesenchymal villi develop into mature intermediate villi and they and stem villi develop terminal villi (Castelluci M, Scheper M, Scheffen I, Celona A and
Kaufmann P. The development of the human placental villous tree. Anat Embryol 1990;181:117-128).
418 Trophoblastus extravillosus Extravillous trophoblast is a highly migratory, proliferative and invasive population of cells that emerges from the tips of anchoring villi (Lyall F. Mechanisms regulating
cytotrophoblast invasion in normal pregnancy and pre-eclampsia. Aust NZ J Obstet Gynaecol 2006;46:266-273). It infiltrates the maternal tissues in two phases. The first results in giant cells in the decidua basalis
around the spiral arteries, which they penetrate. In the second phase giant cells reach the inner one-third of the myometrium by extravascular and intravascular routes.
419 Cytotrophoblastus interstitialis Interstitial cytotrophoblast invades the decidual stroma and superficial myometrium, including the walls of spiral vessels (Pijnenborg R, Bland JM, Robertson WB, Dixon G,
Brosens I. The pattern of interstitial trophoblast invasion in early human pregnancy. Placenta 1981;2:303-316).
420 Cytotrophoblastus endovascularis When interstitial cytotrophoblast has penetrated the wall of a spiral vessel, it becomes endovascular cytotrophoblast. This invades the lumen and a small muscular artery is
transformed into a distended flaccid vessel (Pijnenborg R, Bland JM, Robertson WB, Dixon G, Brosens I. Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy.
Placenta 1983;4:397-414).
421 Septum placentae; Insulae cellularum placentae Placental septa and Cell islands are of mixed fetal and maternal origin, trophoblast being applied to decidual cores.
422 Zona limitans decidualis The decidual boundary zone is the part of the decidua in contact with the trophoblastic shell.
423 Substantia fibrinoidea Two types of fibrinoid are found at various sites in the placenta: fibrin-type fibrinoid is a result of blood clotting; matrix-type fibrinoid is a basal lamina-like glycoprotein secreted by
extravillous trophoblast.
424 Cotyledo maternalis When the detached placenta is examined from its decidual aspect, there are some 30 maternal cotyledons, separated by septa. However, because the septa do not reach the chorionic
plate, a maternal cotyledon may include as many as 3 fetal cotyledons.
425 Cotyledo fetalis There are some 40-60 fetal cotyledons, each based upon a main stem villus and supplied by a decidual spiral artery.
426 Villus peduncularis major; Truncus chorii The main stem villi have a dense fibrous stroma and their cytotrophoblastic cell columns anchor them to the trophoblastic shell of the basal plate.
427 Villus peduncularis Stem villi contain “fetal arteries and veins or arterioles and venules, surrounded by dense connective tissue, rich in collagen fibres” (Castelluci M, Scheper M, Scheffen I, Celona A and
Kaufmann P. The development of the human placental villous tree. Anat Embryol 1990;181:117-128).
428 Villus intermedius immaturus Immature intermediate villi are bulbous “with ample, loose connective tissue, containing few arterioles and venules and few undilated capillaries. The stroma is typified by
numerous stromal channels delineated by sail-like processes of the fixed stromal cells and numerous macrophages in the channels” (Castelluci M, Scheper M, Scheffen I, Celona A and Kaufmann P. The
development of the human placental villous tree. Anat Embryol 1990;181:117-128).
430 Nodus syncytialis Syncytial knots are localized aggregations of syncytiotrophoblastic nuclei in the lining of placental villi.
431 Gemma syncytialis Syncytial sprouts are localized aggregations of syncytiotrophoblastic nuclei on the surface of placental villi, where new terminal villi are forming. At term, however, the nuclei are largely
degenerate.
432 Substantia fibrinoidea perivillosa; Substantia fibrinoidea intravillosa Fibrin-type fibrinoid is frequently found around villi where they lack syncytiotrophoblast and may be part of a repair process. Matrix-type
fibrinoid may be found within villi.
433 Membrana placentae; Claustrum placentae The placental membrane consists of the fetal tissues separating the fetal from the maternal blood. Initially it constitutes a selectively permeable placental barrier and
consists of endothelium of fetal capillaries, connective tissue, the subepithelial basal lamina and its covering of cytotrophoblast and syncytiotrophoblast. It becomes progressively thinner until near term, when the
barrier leaks and the membrane consists only of a thin syncytiofibrinoid layer sitting on the subepithelial basal lamina, beneath which are dilated capillaries.
434 Septum placentae; Septum cotyledonarium The placental septa extend from the basal plate towards the chorionic plate but do not reach it. Like villi, where their surface is not covered by syncytiotrophoblast,
fibrinoid is exposed. Their cores contain vestiges of cytotrophoblast and connective tissue, in which are tissues of maternal origin and foci of degeneration.
435 Paraplacenta The interface between amniochorion and parietal decidua where some fetal-maternal interchanges occur.
436 Vascularisatio dispersa placentae In disperse placental vascularization the umbilical arteries undergo a succession of dichotomous divisions and rapidly diminish in calibre.
437 Vascularisatio magistralis placentae In magistral placental vascularization the umbilical arteries almost reach the placental margin before there is a marked reduction in their size.
FIPAT
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A programme of the International Federation of Associations of Anatomists (IFAA)
TE2, PART V
Contents
Published pending approval by the General Assembly at the next Congress of IFAA (2019)
The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use
the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA
member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the
Chair of FIPAT for permission to publish a derivative work.
Caput VII: NOTATIO TEMPORUM ONTOLOGICORUM Chapter 7: TEMPORAL STAGES OF DEVELOPMENT
Latin term Latin synonym UK English US English English synonym Other
7882 Notatio temporum Temporal stages of Temporal stages of
ontologicorum development development
7883 Ontogenesis prenatalis Prenatal ontogeny Prenatal ontogeny
7884 Tempus embryonicum Embryonic period Embryonic period
7885 Embryogenesis Embryogenesis Embryogenesis Embryogeny
7886 Insignia a gradibus carnegiensibus Features by Carnegie stages Features by Carnegie stages
7887 GRADUS CELLULAE UNICAE Embryo unicellularis; Embryo ONE-CELL STAGE ONE CELL STAGE Single cell embryo; Stage.1 Endnote 438
gradus I embryo
7888 Oocytus penetratus Oocytus definitivus; Embryo Penetrated oocyte Penetrated oocyte Definitive oocyte; Primordial
primordialis; Embryo gradus Ia embryo; Stage1a embryo
7889 Zona pellucida Zona pellucida Zona pellucida
7890 Spatium subzonale Spatium subcapsulare Subzonal space Subzonal space
7891 Caput spermatozoi in zona Sperm head in zona pellucida, in Sperm head in zona pellucida, in
pellucida in spatio subzonale subzonal space attaching to subzonal space attaching to
plasmalemmati adherente aut in plasmalemma or in cytoplasm of plasmalemma or in cytoplasm of
cytoplasmati oocyti oocyte oocyte
7892 Caput spermatozoi in Sperm head in cytoplasm of Sperm head in cytoplasm of
cytoplasmati oocyti sine tegumento oocyte without nuclear envelope oocyte without nuclear envelope
nucleare et cum chromatino and with decondensed chromatin and with decondensed chromatin
disperso
7893 Peractio divisionis meioticae Completion of second meiotic Completion of second meiotic
secundae division division
7894 Pronucleus femininus Pronucleus maternus Female pronucleus Female pronucleus Maternal pronucleus
7895 Corpus polare secundum Polocytus secundarius Second polar body Second polar body Second polocyte
7896 Reactio corticalis Cortical reaction Cortical reaction
7897 Dilatatio spatii subzonalis Dilatatio spatii subcapsularis Expansion of subzonal space Expansion of subzonal space Expansion of subcapsular space
7898 Reactio zonalis Reactio capsularis Zonal reaction Zonal reaction Capsular reaction IVF
7899 Degradatio mitochondriorum Degradation of paternal Degradation of paternal
paternalium mitochondria mitochondria
7900 Conus fertilisationis Fertilization cone Fertilization cone IVF
7901 Locatio partis intermediae Sperm middle piece under Sperm middle piece under IVF
spermatozoi sub cono fertilisationis fertilization cone fertilization cone
7902 Locatio partis caudae spermatozoi Intracytoplasmic sperm tail Intracytoplasmic sperm tail IVF
in cytoplasmati
7903 Fusus anaphasis II Spindle of anaphase II Spindle of anaphase II IVF
7904 Fusus telophasis II Spindle of telophase II Spindle of telophase II IVF
7905 Intercorpus Interbody Interbody IVF
7906 Ootidium Ovum; Embryo pronuclearis; Ootid Ootid Ovum; Pronuclear embryo;
Embryo gradus Ib Stage1b embryo
7907 Zona pellucida Zona pellucida Zona pellucida
7918 ZYGOTUM Embryo syngamicus; Embryo ZYGOTE ZYGOTE Syngamic embryo; Stage 1c
gradus Ic embryo
7919 Zona pellucida Zona pellucida Zona pellucida
7920 Spatium subzonale Subzonal space Subzonal space
7921 Vesiculatio et disintegratio Vesiculation and disintegration of Vesiculation and disintegration of
tegumentorum nuclearium nuclear envelopes nuclear envelopes
7922 Congrutio chromosomatum Pairing of homologous Pairing of homologous
homologorum chromosomes chromosomes
7923 Dispositio chromosomatum Arrangement of paired Arrangement of paired
homologorum conjunctorum super homologous chromosomes on homologous chromosomes on
fusum fissionis primae extra eccentric first cleavage spindle eccentric first cleavage spindle
centrum positum
7924 Deletio impressionum maternarum Erasure of maternal and paternal Erasure of maternal and paternal
et paternarum imprints imprints
7925 Zygotum findens Embryo gradus II Cleaving zygote Cleaving zygote Stage 2 embryo
7926 Zona pellucida Zona pellucida Zona pellucida
7927 Spatium subzonale Subzonal space Subzonal space
7928 Cellulae II, Cellulae III, Cellulae IV, Two-cells, three-cells, four-cells, Two cells, three cells, four cells,
et cetera etc. etc.
7929 Blastomerus Blastomere Blastomere
7930 Morula Morula Morula
7931 Compactio Compaction Compaction
7932 Nexus Macula communicans; Synapsis Gap junction Gap junction Nonvesicular synapse; Electrical
nonvesicularis; Synapsis electrica synapse
7933 Macula adhaerens Desmosoma Desmosome Desmosome Macula adhaerens; Spot
desmosome
7934 Zonula occludens Tight junction Tight junction
7935 Cellula externa morulae Cellula trophoblastica presumptiva; Outer cell of morula Outer cell of morula Presumptive trophoblastic cell;
Cellula polarisata; Polarblastus Polarized cell; Polarblast
7970 Insignia miscellanea cellularum Miscellaneous features of Miscellaneous features of Endnote 439
trophoblasticarum undifferentiated trophoblast undifferentiated trophoblast
nondifferentiatarum cells cells
7982 Blastocystis adhaerens Embryo gradus IV Attaching blastocyst Attaching blastocyst Stage 4 embryo
7983 Cavitas amniotica primordialis Primordial amniotic cavity Primordial amniotic cavity
7984 Discus embryonicus Embryonic disc Embryonic disc
7985 Cytotrophoblastus Cytotrophoblast Cytotrophoblast
7986 Adhaesio epithelio endometrii Adherence to endometrial Adherence to endometrial IVF
epithelium epithelium
7987 Complexus junctionalis apicalis Apical junctional complex Apical junctional complex IVF
7988 Desmosoma Macula adhaerens Desmosome Desmosome Macula adhaerens; Spot IVF
desmosome
7989 Invaginatio cellulae epiblasticae Cell process invaginating Cell process invaginating IVF
a processu cellulare epiblastic cell epiblastic cell
7990 Microvilli Microvilli Microvilli IVF
7991 Pori nucleares Nuclear pores Nuclear pores IVF
7992 Syncytiotrophoblastus Syncytiotrophoblast Syncytiotrophoblast
7993 Processus inter epitheliocytos Processes between endometrial Processes between endometrial IVF
endometrii cells cells
7994 Margo syncytioepithelialis Syncytio-epithelial interface Syncytioepithelial interface
7995 Blastocystis implantata Blastocystis invadens; Conceptus Implanted blastocyst Implanted blastocyst Invading blastocyst; Previllous
previllosus; Embryo gradus V conceptus; Stage 5 embryo
7996 Discus embryonicus Embryonic disc Embryonic disc
7997 Cytotrophoblastus Cytotrophoblast Cytotrophoblast
7998 Syncytiotrophoblastus Syncytiotrophoblast Syncytiotrophoblast
7999 Margo syncytiodecidualis Syncytiodecidual interface Syncytiodecidual interface
8000 Implantatio superficialis Superficial implantation Superficial implantation
8001 Adhaesio Adhesion Adhesion Attachment
8002 Incursio trophoblasti Trophoblast invasion Trophoblast invasion
8003 Testa trophoblastica Trophoblastic shell Trophoblastic shell
8015 Blastocystis invadens cum Embryo gradus Vb Invading blastocyst with Invading blastocyst with Stage 5b embryo
lacunis trophoblasticis separatis isolated trophoblastic lacunae isolated trophoblastic lacunae
8016 Pars minor abembryonica visibilis Less than abembryonic half Less than abembryonic half
in cavitate uterina exposed to uterine cavity exposed to uterine cavity
8017 Discus embryonicus parve Embryonic disc slightly longer than Embryonic disc slightly longer than
oblongus wide wide
8018 Lacunae trophoblasticae Trophoblastic lacunae Trophoblastic lacunae
8019 Aggregatio previllosa Previllous clump of cytotrophoblast Previllous clump of cytotrophoblast
cytotrophoblasti
8020 Cavitas amniotica definitiva Definitive amniotic cavity Definitive amniotic cavity
8021 Margo caudalis lineae primitivae Margo caudalis lineae Precocious caudal margin of Precocious caudal margin of Precocious caudal margin of
precoquis gastrulationis precoquis primitive streak primitive streak gastrulation streak
8022 Area caudalis mesoblastogenica Caudal mesoblastogenic area Caudal mesoblastogenic area
8023 Mesoblastus extraembryonicus Extra-embryonic mesoblast Extraembryonic mesoblast
8024 Mesoblastus extraembryonicus Extra-embryonic mesoblast Extraembryonic mesoblast
adjunctus trophoblasto applied to trophoblast applied to trophoblast
8025 Chorion primordiale Primordial chorion Primordial chorion
8026 Endoblastus extraembryonicus Membrana exocoelomica Extra-embryonic endoblast Extraembryonic endoblast Exocoelomic membrane;
Exocelomic membrane; Primary
endoderm
8027 Cavitas vesiculae umbilicalis Cavitas sacci vitellini primarii Cavity of primary umbilical vesicle Cavity of primary umbilical vesicle Cavity of primary yolk sac
primariae
8028 Endoblastus extraembryonicus Extra-embryonic endoblast applied Extraembryonic endoblast applied
trophoblasto applicatus to trophoblast to trophoblast
8029 Vesicula umbilicalis primaria Saccus vitellinus primarius Primary umbilical vesicle Primary umbilical vesicle Primary yolk sac
8045 CONCEPTUS VILLOSUS Embryo gradus VI VILLOUS CONCEPTUS VILLOUS CONCEPTUS Stage 6 embryo
8046 Conceptus villosus sine linea Conceptus villosus sine linea Villous conceptus without Villous conceptus without Villous conceptus without obvious
primitiva manifesta gastrulationis manifesta; Embryo obvious primitive streak obvious primitive streak gastrulation streak; Stage 6a
gradus VIa embryo
8047 Agnitio sexus genetici Detection of genetic sex Detection of genetic sex
8048 Chorion Chorion Chorion
8049 Trophoblastus Trophoblast Trophoblast Outer cell mass; Trophectoderm
8050 Mesenchyma chorionicum Chorionic mesenchyme Chorionic mesenchyme
8051 Mesothelium chorionicum Chorionic mesothelium Chorionic mesothelium
8052 Chorion frondosum Chorion frondosum Chorion frondosum Villous chorion
8053 Villus primarius Primary villus Primary villus
8054 Villus secundarius Secondary villus Secondary villus
8055 Villus tertiarius Tertiary villus Tertiary villus
8056 Vas primordialis villi tertiarii Primordial vessel of tertiary Primordial vessel of tertiary
villus villus
8057 Spatium intervillosum Intervillous space Intervillous space
8058 Mesoblastus extraembryonicus Extra-embryonic mesoblast applied Extraembryonic mesoblast applied
caudaliter et dorsaliter amnioblasto to amnioblast and trophoblast to amnioblast and trophoblast
et trophoblasto adjunctus caudodorsally caudodorsally
8059 Cavitas vesiculae umbilicalis Cavitas sacci vitellini secundarii Cavity of secondary umbilical Cavity of secondary umbilical
secundariae vesicle vesicle
8067 Conceptus villosus cum linea Conceptus villosus cum linea Villous conceptus with obvious Villous conceptus with obvious Villous conceptus with obvious
primitiva manifesta gastrulationis manifesta; Embryo primitive streak primitive streak gastrulation streak; Stage 6b
gradus VIb embryo
8068 Mesenchyma capitis Head mesenchyme Head mesenchyme
8069 Linea primitiva Linea gastrulationis Primitive streak Primitive streak Gastrulation streak
8070 Sulcus primitivus Sulcus gastrulationis Primitive groove Primitive groove
8071 Transformatio Epitheliomesenchymal Epitheliomesenchymal
epitheliomesenchymalis transformation transformation
8072 Mesenchyma Mesenchyme Mesenchyme
8073 Transformatio Mesenchymo-epithelial Mesenchymoepithelial
mesenchymoepithelialis transformation transformation
8074 Mesoderma embryonicum Mesoblastus Embryonic mesoderm Embryonic mesoderm
8075 Nodus primitivus Nodus gastrulationis Primitive node Primitive node Gastrulation node §Hensen§
8076 Endoderma embryonicum Embryonic endoderm Embryonic endoderm
8077 Lamina prechordalis Prechordal plate Prechordal plate
8078 Diverticulum allantoicum Ductus allantoicus Allantoic diverticulum Allantoic diverticulum Allantoic duct
8079 Testa trophoblastica Trophoblastic shell Trophoblastic shell
8080 Membrana cloacalis primordialis Primordial cloacal membrane Primordial cloacal membrane
8081 Haemangiogenesis in vesicula Haemangiogenesis in sacco Umbilical vesicle Umbilical vesicle hemangiogenesis Yolk sac haemangiogenesis; Yolk
umbilicale vitellino haemangiogenesis sac hemangiogenesis
8082 Vasculogenesis Vasculogenesis Vasculogenesis
8083 Pedunculus connectans Connecting stalk Connecting stalk
8084 Vasa primordialia pedunculi Primordial vessels of connecting Primordial vessels of connecting
connectantis stalk stalk
8085 Villus tertiarius ramosus Branching tertiary villus Branching tertiary villus
8086 Vasa villi tertiarii Vessels of tertiary villus Vessels of tertiary villus
8087 Villus ancorans Anchoring villus Anchoring villus
8088 Villus liber Floating villus Floating villus
8092 EMBRYO CUM PROCESSU Embryo cum processu axiali; EMBRYO WITH NOTOCHORDAL EMBRYO WITH NOTOCHORDAL Embryo with axial process; Stage 7
NOTOCHORDALI Embryo gradus VII; Embryo cum PROCESS PROCESS embryo ; Embryo with
chordomesoderma chordamesoderm
8093 Lamina neuralis Lamina medullaris Neural plate Neural plate Medullary plate
8094 Mesenchyma capitis Head mesenchyme Head mesenchyme
8095 Lamina prechordalis Prechordal plate Prechordal plate
8096 Processus notochordalis Processus axialis; Notochordal process Notochordal process Axial process; Chordamesoderm
Chordomesoderma
8097 Notochorda Notochord Notochord
8098 Verticula chordoneuralis Punctum chordaneurale cardinis; Chordoneural hinge Chordoneural hinge
Cardo chordoneuralis
8099 Membrana cloacalis Cloacal membrane Cloacal membrane
8100 Allantois Allantois Allantois
8101 Diverticulum allantoicum Ductus allantoicus Allantoic diverticulum Allantoic diverticulum Allantoic duct
8102 Mesenchyma allantoicum Allantoic mesenchyme Allantoic mesenchyme
8103 Vasa allantoica Allantoic vessels Allantoic vessels
8104 Cellulae sanguineae in Blood cells in allantoic Blood cells in allantoic
vasibus allantoicis vessels vessels
8105 Amnion Amnion Amnion
8106 Ectoderma extraembryonicum Extra-embryonic ectoderm Extraembryonic ectoderm
8107 Mesenchyma amnioticum Amniotic mesenchyme Amniotic mesenchyme
8108 Mesothelium amnioticum Amniotic mesothelium Amniotic mesothelium
8109 Endoderma extraembryonicum Endoderma extraembryonicum Extra-embryonic endoderm of Extraembryonic endoderm of Extra-embryonic endoderm of yolk
vesiculae umbilicalis sacci vitellini umbilical vesicle umbilical vesicle sac; Extraembryonic endoderm of
yolk sac
8110 Cellula germinalis precursoria Primordial germ cell Primordial germ cell
8111 Haemangiogenesis in vesicula Haemangiogenesis in sacco Umbilical vesicle Umbilical vesicle hemangiogenesis Yolk sac haemangiogenesis; Yolk
umbilicale vitellino haemangiogenesis sac hemangiogenesis
8112 Vasculogenesis Vasculogenesis Vasculogenesis
8113 Mesenchyma vesiculae umbilicalis Mesenchyma sacci vitellini Umbilical vesicle mesenchyme Umbilical vesicle mesenchyme Yolk sac mesenchyme
8114 Cellulae sanguineae in vasibus Cellulae sanguineae in vasibus Blood cells in vessels of umbilical Blood cells in vessels of umbilical Blood cells in vessels of yolk sac
vesiculae umbilicalis sacci vitellini vesicle vesicle
8115 Mesothelium vesiculae umbilicalis Mesothelium sacci vitellini Mesothelium of umbilical vesicle Mesothelium of umbilical vesicle Mesothelium of yolk sac
8116 EMBRYO PRESOMITICUS Embryo gradus VIII PRESOMITE EMBRYO PRESOMITE EMBRYO Stage 8 embryo
8117 Embryo presomiticus sine sulco Embryo gradus VIIIa Presomite embryo without Presomite embryo without Stage 8a embryo
neurale neural groove neural groove
8118 Embryo piriformis Pear-shaped embryo Pearshaped embryo
8119 Fovea primitiva Fovea notochordalis Primitive pit Primitive pit Notochordal pit
8120 Mesenchyma capitis Head mesenchyme Head mesenchyme
8139 EMBRYO CUM SOMITIS I ad III Embryo gradus IX 1-3 SOMITE EMBRYO 1-3 SOMITE EMBRYO Stage 9 embryo Endnote 441
8140 Embryo solearis cum lordose Slipper-sole-shaped embryo with Slipper solecshaped embryo with
lordosis lordosis
8141 Plica capitis Plica cephalica Head fold Head fold
8142 Plica caudalis primordialis Primordial tail fold Primordial tail fold Primordial caudal fold
8143 Eminentia caudalis Gemma caudalis Caudal eminence Caudal eminence Tail bud
8144 Crista ectodermalis ventralis Crista ectodermalis ventralis Ventral ectodermal ridge of Ventral ectodermal ridge of Ventral ectodermal ridge of tail
eminentiae caudalis gemmae caudalis caudal eminence caudal eminence bud; VER
8145 Mesenchyma densum axiale Axial dense mesenchyme Axial dense mesenchyme Tail cord
8146 Notochorda Notochord Notochord
8147 Cylindrus notochordalis Notochordal rod Notochordal rod
8148 Lamina notochordalis Notochordal plate Notochordal plate
8149 Corda medullaris Corda neuralis Medullary cord Medullary cord Neural cord
8150 Verticula chordoneuralis Punctum chordaneurale cardineum Chordoneural hinge Chordoneural hinge
8151 Mesoderma paraxiale Paraxial mesoderm Paraxial mesoderm
8152 Mesoderma laminae lateralis Lateral plate mesoderm Lateral plate mesoderm
8153 Somiti occipitales Somiti I ad III Occipital somites Occipital somites Somites 1 - 3
8154 Somitocoelia Somitocoeles Somitoceles
8155 Stomatodeum primordiale Primordial stomodeum Primordial stomodeum
8199 EMBRYO CUM SOMITIS IV ad XII Embryo gradus X 4-12 SOMITE EMBRYO 4-12 SOMITE EMBRYO Stage 10 embryo Endnote 442
8200 Generalia General General
8201 Ruptura zonae junctionalis Breakdown of mesenchymal Breakdown of mesenchymal
mesenchymatis inter coelomata junctional zone between embryonic junctional zone between embryonic
embryonicum et extraembryonicum and extra-embryonic coelomata and extraembryonic coelomata
8202 Plica lateralis primordialis corporis Primordial lateral body fold Primordial lateral body fold
8203 Anulus umbilicalis Umbilical ring Umbilical ring
8204 Arcus pharyngeus primus First pharyngeal arch First pharyngeal arch
8205 Densatio ectodermalis Ectodermal thickening Ectodermal thickening
8206 Prominentia maxillaris Maxillary prominence Maxillary prominence
8207 Somitus occipitalis quartus Fourth occipital somite Fourth occipital somite Somite 4
8208 Somiti cervicales Somiti V ad XII Cervical somites Cervical somites Somites 5-12
8209 Canalis pericardioperitonealis Primordial pericardioperitoneal Primordial pericardioperitoneal
primordialis canal canal
8210 Emanatio cellularum notochordae Emergence of notochordal cells Emergence of notochordal cells
ex eminentia caudale from caudal eminence from caudal eminence
8211 Anulus ectodermalis primordialis Primordial ectodermal ring Primordial ectodermal ring
8212 Alimentaria Alimentary Alimentary
8213 Stomodeum Stomatodeum Stomodeum Stomodeum
8214 Prominentia mandibularis Mandibular prominence Mandibular prominence
8215 Sulcus pharyngeus primus] First pharyngeal groove First pharyngeal groove
8216 Arcus pharyngeus secundus Second pharyngeal arch Second pharyngeal arch
8217 Densatio ectodermalis Ectodermal thickening Ectodermal thickening
8218 Placodae epipharyngeae Epipharyngeal placodes Epipharyngeal placodes
8219 Preenteron Proenteron Foregut Foregut
8220 Saccus pharyngeus secundus Second pharyngeal pouch Second pharyngeal pouch
8221 Saccus pharyngeus tertius Third pharyngeal pouch Third pharyngeal pouch
8222 Metenteron Hindgut Hindgut
8223 Urenteron Pars postcloacalis intestini Postcloacal gut Postcloacal gut Tailgut; Endgut
8224 Lamina hepatica Hepatic lamina Hepatic lamina
8225 Respiratoria Respiratory Respiratory
8272 EMBRYO CUM SOMITIS XIII ad Embryo gradus XI 13-20 SOMITE EMBRYO 13-20 SOMITE EMBRYO Stage 11 embryo Endnote 443
XX
8273 Generalia General General
8274 Placoda nasalis Placoda olfactoria Nasal placode Nasal placode Nasal disc; Olfactory placode
8275 Anulus ectodermalis imperfectus Ectodermal ring incomplete Ectodermal ring incomplete
8276 Pars rostralis anuli ectodermalis Rostral part of ectodermal ring Rostral part of ectodermal ring
8277 Gemma membri superioris Upper limb bud Upper limb bud Rostral limb bud
8278 Pars caudalis anuli ectodermalis Caudal part of ectodermal ring Caudal part of ectodermal ring
8279 Crista ectodermalis ventralis Crista ectodermalis ventralis Ventral ectodermal ridge of Ventral ectodermal ridge of Ventral ectodermal ridge of tail
eminentiae caudalis gemmae caudalis caudal eminence caudal eminence bud; VER
8280 Somiti thoracici Somiti XIII ad XX Thoracic somites Thoracic somites Somites 13-20
8281 Sclerotomi occipitales Sclerotomus IV Occipital sclerotomes Occipital sclerotomes Sclerotome 4
8282 Dermatomyotomi Dermomyotomi Dermatomyotomes Dermatomyotomes Dermomyotomes
8283 Notochorda Notochorda propria; Chorda Notochord Notochord Notochord proper
dorsalis
8284 Communicatio inter latera dextrum Communication between right and Communication between right and
et sinistrum cavitatis peritonealis left sides of peritoneal cavity left sides of peritoneal cavity
caudaliter ductui omphaloenterico caudal to omphalo-enteric duct caudal to omphaloenteric duct
8285 Alimentaria Alimentary Alimentary
8286 Abruptio membranae Rupture of oropharyngeal Rupture of oropharyngeal
oropharyngeae membrane membrane
8287 Saccus pharyngeus quartus Fourth pharyngeal pouch Fourth pharyngeal pouch
8288 Primordium oesophagei Primordium of oesophagus Primordium of esophagus
8289 Primordium gastris Primordium of stomach Primordium of stomach
8290 Primordium duodeni Primordium of duodenum Primordium of duodenum
8291 Diverticulum hepatocysticum Hepatocystic diverticulum Hepatocystic diverticulum
8292 Pars distalis diverticuli Distal part of hepatocystic Distal part of hepatocystic
hepatocystici diverticulum diverticulum
8340 EMBRYO CUM SOMITIS XXI ad Embryo gradus XII 21-29 SOMITE EMBRYO 21-29 SOMITE EMBRYO Stage 12 embryo Endnote 444
XXIX
8341 Generalia General General
8342 Somiti thoracici Somiti XXI ad XXIV Thoracic somites Thoracic somites Somites 21-24
8343 Somiti lumbales Somiti XXV ad XXIX Lumbar somites Lumbar somites Somites 25-29
8344 Lamina basalis notochordalis Vagina acellularis notochordalis Notochordal basal lamina Notochordal basal lamina Acellular notochordal sheath
8345 Sinus cervicalis Cervical sinus Cervical sinus
8346 Anulus ectodermalis completus Ectodermal ring complete Ectodermal ring complete
8347 Pars rostralis anuli ectodermalis Rostral part of ectodermal ring Rostral part of ectodermal ring
8348 Gemma membri superioris Upper limb bud Upper limb bud Rostral limb bud
8349 Pars intermembralis presumptiva Presumptive intermembral part of Presumptive intermembral part of
anuli ectodermalis ectodermal ring ectodermal ring
8350 Pars caudalis anuli ectodermalis Caudal part of ectodermal ring Caudal part of ectodermal ring
8351 Crista ectodermalis ventralis Crista ectodermalis ventralis Ventral ectodermal ridge of Ventral ectodermal ridge of Ventral ectodermal ridge of tail
eminentiae caudalis gemmae caudalis caudal eminence caudal eminence bud; VER
8352 Communicatio inter latera dextrum Communication between right and Communication between right and
et sinistrum cavitatis peritonealis left sides of peritoneal cavity left sides of peritoneal cavity
cranialiter ductui omphaloenterico cranial to omphalo-enteric duct cranial to omphaloenteric duct
8353 Alimentaria Alimentary Alimentary
8354 Copula Copula Copula
8355 Bursa omentalis Omental bursa Omental bursa Lesser sac
8356 Primordium recessus Primordium of right Primordium of right
pleuroperitonealis dexteri pleuroperitoneal recess pleuroperitoneal recess
8357 Mesenterium dorsale primordiale Primordial dorsal mesentery Primordial dorsal mesentery
8358 Gemma pancreatica dorsalis Dorsal pancreatic bud Dorsal pancreatic bud
8359 Respiratoria Respiratory Respiratory
8360 Gemma trachealis Gemma pulmonalis Tracheal bud Tracheal bud Lung bud
8361 Urogenitalia Urogenital Urogenital
8362 Ductus mesonephricus junctus Mesonephric duct joins cloaca Mesonephric duct joins cloaca
cum cloaca
8396 EMBRYO CUM SOMITIS XXX+ Embryo gradus XIII 30+ SOMITE EMBRYO 30+ SOMITE EMBRYO Stage 13 embryo Endnote 445
8397 Generalia General General
8398 Somiti sacrales Somiti XXX ad XXXIV Sacral somites Sacral somites Somites 30-34 Endnote 446
8467 EMBRYO GRADUS XIV STAGE 14 EMBRYO STAGE 14 EMBRYO Endnote 448
8468 Generalia General General
8592 EMBRYO GRADUS XVI STAGE 16 EMBRYO STAGE 16 EMBRYO Endnote 450
8593 Generalia General General Endnote 451
8594 Motus levissime perceptibiles Movements just discernible Movements just discernible Endnote 452
8595 Prominentia frontonasalis Frontonasal prominence Frontonasal prominence
8596 Sulcus nasomaxillaris Nasomaxillary groove Nasomaxillary groove
8597 Sulcus nasolacrimalis Sulcus lacrimalis Nasolacrimal groove Nasolacrimal groove Lacrimal groove
8598 Lamina lacrimalis Lacrimal lamina Lacrimal lamina
8608 Formatio curvaturae majoris Formation of greater curvature of Formation of greater curvature of
gastris stomach stomach
8609 Formatio fundi gastris Formation of fundus of stomach Formation of fundus of stomach
8610 Formatio curvaturae minoris Formation of lesser curvature of Formation of lesser curvature of
gastris stomach stomach
8611 Incisura angularis Angular incisure Angular incisure
8612 Hernia umbilicalis physiologica Primary intestinal loop projecting Primary intestinal loop projecting Physiological umbilical hernia
into umbilical cord into umbilical cord
8613 Translatio cranialiter duodeni Cranial relocation of distal Cranial relocation of distal
aboralis et flexurae duodenum and duodenojejunal duodenum and duodenojejunal
duodenojejunalis flexure flexure
8614 Stratum circulare tunicae Circular muscle layer of duodenum Circular muscle layer of duodenum
muscularis duodeni
8615 Proliferatio epithelii duodeni Proliferation of duodenal Proliferation of duodenal
epithelium epithelium
8616 Interruptio luminis duodenalis Duodenal lumen occluded Duodenal lumen occluded
8617 Canaliculi biliferi laminae hepatis Bile canaliculi of hepatic plate Bile canaliculi of hepatic plate
8618 Respiratoria Respiratory Respiratory
8619 Saccus nasalis Nasal sac Nasal sac
8620 Pinna nasalis Nasal fin Nasal fin
8621 Condensatio mesenchymalis Mesenchymal condensation of Mesenchymal condensation of
epiglottidis epiglottis epiglottis
8622 Condensatio mesenchymalis Mesenchymal condensation of Mesenchymal condensation of
cartilaginis cricoideae cricoid cartilage cricoid cartilage
8623 Urogenitalia Urogenital Urogenital
8624 Metanephros in regione lumbale Metanephros in lower lumbar Metanephros in lower lumbar
inferiore region region
8625 Incrementum metanephri Metanephros enlarging Metanephros enlarging
8626 Bifurcatio aliarum alia ampullarum Further bifurcation of ureteric Further bifurcation of ureteric
uretericarum in blastemati ampullae in metanephrogenic ampullae in metanephrogenic
metanephrogenico blastema blastema
8655 EMBRYO GRADUS XVII STAGE 17 EMBRYO STAGE 17 EMBRYO Endnote 453
8656 Generalia General General
8657 Motus tremefactionis Startle Startle Endnote 454
8658 Colliculi auriculares sex Six auricular hillocks Six auricular hillocks
8659 Radii manus Hand rays Hand rays
8729 EMBRYO GRADUS XVIII STAGE 18 EMBRYO STAGE 18 EMBRYO Endnote 458
8730 Generalia General General
8731 Motus contractionis corporalis General movements General movements Endnote 459
generalis
8732 Motus singultus Hiccup Hiccup Endnote 460
8733 Sexus gonadalis masculinus Evidence of male gonadal features Evidence of male gonadal features
8734 Initium lordosis cervicalis Beginning of cervical lordosis Beginning of cervical lordosis
8735 Initium lordosis lumbalis Beginning of lumbar lordosis Beginning of lumbar lordosis
8736 Regio cubitalis Elbow region Elbow region
8737 Lamina manus incisa Notched hand plate Notched hand plate
8738 Radii pedis Foot rays Foot rays
8739 Plicae palpebrales Palpebral folds Palpebral folds
8740 Apex nasi Apex of nose Apex of nose Tip of nose
8741 Bifurcatio apicis laminae lacrimalis Bifurcation of tip of lacrimal lamina Bifurcation of tip of lacrimal lamina
8742 Omnia centra vertebralia presentia All vertebral centra present All vertebral centra present
8743 Omnia ganglia spinalia presentia All spinal ganglia present All spinal ganglia present
8744 Initium ossificationis Beginning of intramembranous Beginning of intramembranous
membranaceae corporis claviculae ossification of shaft of clavicle ossification of shaft of clavicle
8745 Initium ossificationis Beginning of intramembranous Beginning of intramembranous
membranaceae corporis ossification of body of mandible ossification of body of mandible
mandibulae
8746 Initium ossificationis Beginning of intramembranous Beginning of intramembranous
membranaceae maxillae ossification of maxilla ossification of maxilla
8806 EMBRYO GRADUS XIX STAGE 19 EMBRYO STAGE 19 EMBRYO Endnote 461
8807 Generalia General General
8808 Motus contractionis corporalis General movements General movements
generalis
8809 Motus singultus Hiccup Hiccup
8810 Cartilagines arcuum pharyngeorum Cartilagines arcuum mandibularis, Cartilages of first, second and third Cartilages of first, second and third Cartilages of mandibular, hyoid
primi, secundi et tertii hyoidei et tertii pharyngeal arches pharyngeal arches and third arches
8811 Chorda lacrimalis et primordium Lacrimal cord and primordium of Lacrimal cord and primordium of
canaliculorum canaliculi canaliculi
8812 Lamina meatus nasalis inferioris Lamina of inferior nasal meatus Lamina of inferior nasal meatus
8813 Centrum ossificationis primarium Primary ossification centre of Primary ossification center of
femoris femur femur
8814 Ossificatio mandibulae Ossification of mandible Ossification of mandible
8815 Chondrificatio pediculi arcus Chondrification of pedicle of Chondrification of pedicle of
vertebrae vertebral arch vertebral arch
8816 Primordia articulationum coxae et Primordia of hip and knee joints Primordia of hip and knee joints
genus
8817 Septum transversum prope vel ad Septum transversum at or near Septum transversum at or near
situationem definitivam definitive level definitive level
8818 Blastema glandulae lacrimalis Blastema of lacrimal gland Blastema of lacrimal gland
8819 Alimentaria Alimentary Alimentary
8820 Chorda juxtaoralis cum lumine Juxta-oral cord with lumen Juxtaoral cord with lumen
8821 Mesenchyma appositum ad Mesenchyme applied to Mesenchyme applied to
gemmam glandulae submandibular gland bud submandibular gland bud
submandibularis
8822 Mesenteron in hernia umbilicale Midgut in umbilical hernia Midgut in umbilical hernia
8823 Exocrinocyti caliciformes intestini Goblet cells of small intestine Goblet cells of small intestine
tenuis
8824 Villi primordiales intestini tenuis Primordial villi of small intestine Primordial villi of small intestine
8825 Epithelium pseudostratificatum Pseudostratified columnar Pseudostratified columnar
columnare epithelium epithelium
8826 Colon primordiale Primordial colon Primordial colon
8827 Lamina muscularis mucosae coli Muscularis mucosae of colon Muscularis mucosae of colon
8828 Rectum primordiale Primordial rectum Primordial rectum
8829 Urogenitalia Urogenital Urogenital
8830 Bifurcatio aliarum alia perducens Further bifurcation of ureteric Further bifurcation of ureteric
ampullarum uretericarum in ampullae in metanephrogenic ampullae in metanephrogenic
blastemati metanephrogenico blastema blastema
8831 Vesiculae metanephricae Vesiculae renales Metanephric vesicles Metanephric vesicles Renal vesicles
8832 Differentiatio sexualis gonadarum Sexual differentiation of gonads Sexual differentiation of gonads
8833 Chordae medullares testis Medullary cords of testis Medullary cords of testis
8834 Endocrina Endocrine Endocrine
8897 Stratum neurorum immaturorum Stratum intermedium retinae; Inner immature neuron layer of Inner immature neuron layer of Mantle layer of retina
internum retinae Stratum pallii retinae retina retina
8898 M. tensor tympani Tensor tympani Tensor tympani
8899 Ductus cochlearis caudaliter Cochlear duct pointing caudad Cochlear duct pointing caudad
8900 EMBRYO GRADUS XXI STAGE 21 EMBRYO STAGE 21 EMBRYO Endnote 463
8901 Generalia General General
8902 Motus singularis membri Isolated limb movements Isolated limb movements Endnote 464
8903 Motus singularis extensionis capitis Isolated retroflexion of the head Isolated retroflexion of the head Endnote 465
8904 Motus singularis rotationis capitis Isolated rotation of the head Isolated rotation of the head Endnote 466
8905 Expansio plexus vasculosi Expansion of subcutaneous Expansion of subcutaneous
subcutanei capitis vascular plexus of head vascular plexus of head
8906 Alimentaria Alimentary Alimentary
8907 Rr. primarii pediculi glandulae Primary branches of Primary branches of
submandibularis submandibular stalk submandibular stalk
8908 Extensio pediculi glandulae Elongation of parotid bud Elongation of parotid bud
parotideae
8909 Papillae linguales vallatae et Vallate and foliate papillae of Vallate and foliate papillae of
foliatae tongue tongue
8910 Stratum longitudinale tunicae Longitudinal muscle layer of Longitudinal muscle layer of
muscularis oesophagi oesophagus esophagus
8911 Stratum longitudinale tunicae Longitudinal muscle layer of Longitudinal muscle layer of
muscularis gastris stomach stomach
8912 Recanalisatio luminis duodenalis Duodenal lumen recanalised Duodenal lumen recanalised
8913 Stratum circulare tunicae Circular muscle layer of rectum Circular muscle layer of rectum
muscularis recti
8914 Respiratoria Respiratory Respiratory
8915 Organum vomeronasale Vomeronasal organ Vomeronasal organ
8916 Urogenitalia Urogenital Urogenital
8917 Bifurcatio aliarum ampullarum Further bifurcation of ureteric Further bifurcation of ureteric
uretericarum in blastemati ampullae in metanephrogenic ampullae in metanephrogenic
metanephrogenico blastema blastema
8918 Capsulae glomerulares Metanephric glomerular capsules Metanephric glomerular capsules
metanephricae
8919 Lumen ureteri recanalisatum Recanalised ureteric lumen Recanalised ureteric lumen
8920 Endocrina Endocrine Endocrine
8921 Initium dissolutionis trunci sacci Beginning of fragmentation of stem Beginning of fragmentation of stem
adenohypophysialis of adenohypophysial pouch of adenohypophyseal pouch
8922 Haematolymphoidea Haematolymphoid Hematolymphoid
8923 Haemangiogenesis in vesicula Haemangiogenesis in sacco Umbilical vesicle Umbilical vesicle hemangiogenesis Yolk sac haemangiogenesis; Yolk
umbilicale vitellino haemangiogenesis sac hemangiogenesis
8924 Invasio thymi a vasis capillariis Invasion of thymus by capillaries Invasion of thymus by capillaries
8932 EMBRYO GRADUS XXII STAGE 22 EMBRYO STAGE 22 EMBRYO Endnote 467
8933 Generalia General General
8934 Motus manus adtingentis faciem Hand-face contact Hand face contact Endnote 468
8935 Expansio plexus vasculosi Expansion of subcutaneous Expansion of subcutaneous
subcutanei capitis vascular plexus of head vascular plexus of head
8936 Reflexus contractionis perioralis Peri-oral mass reflex Perioral mass reflex
totalis
8937 Reflexus contractionis facialis Facial mass reflex Facial mass reflex
totalis
8938 Responsum flexionis cervicalis Contralateral flexion response of Contralateral flexion response of
contralateralis neck neck
8939 Differentiatio partium Differentiation of canalicular, Differentiation of canalicular,
canalicularum saccularum saccular and ductular parts of saccular and ductular parts of
ductularumque chordae lacrimalis lacrimal cord lacrimal cord
8940 Tragus Tragus Tragus
8941 Antitragus Antitragus Antitragus
8942 Anulus periostealis humeri Periosteal collar of humerus Periosteal collar of humerus
8943 Alimentaria Alimentary Alimentary
8944 Rr. secundarii pediculi glandulae Secondary branches of Secondary branches of
submandibularis submandibular stalk submandibular stalk
8945 Rr. primarii pediculi glandulae Primary branches of parotid stalk Primary branches of parotid stalk
parotideae
8946 Stratum circulare tunicae Circular muscle layer of small Circular muscle layer of small
muscularis intestini tenuis intestine intestine
8947 Villi definitivi duodeni Definitive villi of duodenum Definitive villi of duodenum
8948 Epitheliocyti penicillati solitarii Enterocyti solitarii cum limbo Solitary brush cells Solitary brush cells Solitary tuft cells; Solitary
microvilloso enterocyte with microvillous
border; Solitary enterocyte with
brush border
8949 Endocrinocyti gastrointestinales Entero-endocrine cells Enteroendocrine cells Gastro-enteropancreatic cells;
gastris et intestini tenuis Gastroenteropancreatic cells; GEP
endocrine cells of stomach and
small intestine
8976 EMBRYO GRADUS XXIII STAGE 23 EMBRYO STAGE 23 EMBRYO Endnote 469
8977 Generalia General General
8978 Motus respirationis Breathing movements Breathing movements Endnote 470
8979 Motus adpertionis oris Jaw movements Jaw movements Endnote 471
8980 Motus porrectionis lentae corporis Stretching Stretching Endnote 472
9092 Fetus hebdomadis decimae Tenth week fetus Tenth week fetus Endnote 475
9093 Generalia General General
9094 Motus oscitationis Yawn Yawn Endnote 476
9095 Flexura capitis circa gradus Head flexion on trunk about 15° Head flexion on trunk about 15°
quindecim
9096 Reflexus contractionis trunci totalis Trunk mass reflex Trunk mass reflex
9097 Membrum inferius sensibile tactui Lower limb sensitive to touch Lower limb sensitive to touch
9098 Initium canalisationis chordae Beginning of canalization of Beginning of canalization of
lacrimalis et canaliculorum lacrimal cord and canaliculi lacrimal cord and canaliculi
9099 Conjunctio epithelii lacrimalis cum Fusion of lacrimal epithelium and Fusion of lacrimal epithelium and
lamina meatale inferiore inferior meatal lamina inferior meatal lamina
9100 Initium cavitationis laminae Beginning of cavitation of inferior Beginning of cavitation of inferior
meatalis inferioris meatal lamina meatal lamina
9157 Fetus hebdomadis undecimae Eleventh week fetus Eleventh week fetus Endnote 478
9158 Generalia General General
9159 Motus suctionis et glutitionis Sucking and swallowing Sucking and swallowing Endnote 479
movements movements
9198 Fetus hebdomadis duodecimae Twelfth week fetus Twelfth week fetus Endnote 481
9199 Generalia General General
9200 Motus rotationis fetus Rotational movements of fetus Rotational movements of fetus Endnote 482
9201 Flexura parva capitis Slight flexion of head on trunk Slight flexion of head on trunk
9202 Cutis paene tota sensibilis tactui Most skin sensitive to touch Most skin sensitive to touch
9203 Reflexus sardonicus Sneer reflex Sneer reflex
9204 Reflexus occlusionis labiorum Lip closure reflex Lip closure reflex
9205 Oscitatio Mouth opening Mouth opening
9206 Glutitio Swallowing Swallowing
9207 Halitus Gasping Gasping
9208 Centra ossificationis primaria Primary ossification centres for Primary ossification centers for
calcanei calcaneus calcaneus
9209 Myotubuli in omnibus musculis Myotubes in all skeletal muscles Myotubes in all skeletal muscles
9210 Completio buccarum Completion of cheeks Completion of cheeks
9211 Obliteratio coelomatis umbilicalis Obliteration of umbilical coelom Obliteration of umbilical celom
9212 Alimentaria Alimentary Alimentary
9213 Encapsulatio organi juxtaoralis Encapsulation of juxta-oral organ Encapsulation of juxtaoral organ
9214 Formatio exophytica juxtaoralis Juxta-oral exophytic formation Juxtaoral exophytic formation
9215 Completio conjunctionis Completion of fusion between Completion of fusion between
processuum palatinorum cum palatal shelves and nasal septum palatal shelves and nasal septum
septo nasi
9216 Glandulae submucosae duodenalis Duodenal submucosal glands Duodenal submucosal glands §Brunner§
9217 Ramificatio cryptarum intestini Branching of crypts of small Branching of crypts of small
tenuis intestine intestine
9218 Taeniae coli Taeniae coli Teniae coli
9219 Stratum longitudinale tunicae Longitudinal muscle coat of rectum Longitudinal muscle coat of rectum
muscularis recti
9220 Acini exocrini pancreatis Pancreatic exocrine acini Pancreatic exocrine acini
9275 Fetus hebdomadis tertiae Thirteenth week fetus Thirteenth week fetus Endnote 483
decimae
9276 Generalia General General
9277 Motus rotationis fetus Rotational movements of the fetus Rotational movements of the fetus
9278 Caput erectum Head erect Head erect
9404 Fetus hebdomadis vicesimae Twentieth week fetus Twentieth week fetus Endnote 487
9405 Generalia General General
9406 Motus rotationis fetus Rotational movements of the fetus Rotational movements of the fetus
9407 Lanugo corporis Lanugo on body Lanugo on body
9408 Initium vernicis caseosae Vernix caseosa beginning Vernix caseosa beginning
9409 Reflexus protrusionis labiorum Lip protrusion reflex Lip protrusion reflex
9410 Reflexus sufflationis labiorum Lip pursing reflex Lip pursing reflex
9411 Parvae contractiones thoracis Weak chest contractions Weak chest contractions
9412 Reflexus abdominalis Abdominal reflex Abdominal reflex
9413 Centrum ossificationis primarium Primary ossification centre for Primary ossification center for
pubis pubis pubis
9414 Myofibrae in omnibus musculis Myofibres in all muscles Myofibers in all muscles
9415 Alimentaria Alimentary Alimentary
9416 Epithelium squamosum Nonkeratinized stratified squamous Nonkeratinized stratified squamous
stratificatum noncornificatum epithelium in oesophagus epithelium in esophagus
oesophagi
9417 Insulae epithelii ciliati oesophagi Islands of ciliated epithelium in Islands of ciliated epithelium in
oesophagus esophagus
9418 Ramificatio glandularum Branching of gastric glands proper Branching of gastric glands proper
gastricarum propriarum
9419 Glandulae cardiales Cardial glands Cardial glands
9420 Endocrinocyti G in gastre Gastrin-producing cells in stomach Gastrinproducing cells in stomach
9421 Lamina muscularis mucosae Muscularis mucosae of small Muscularis mucosae of small
intestini tenuis intestine intestine
9464 Fetus hebdomadis vicesimae Twenty-fourth week fetus Twenty-fourth week fetus Endnote 489
quartae
9465 Generalia General General
9466 Motus rotationis fetus Rotational movements of the fetus Rotational movements of the fetus
9467 Vernix caseosa Vernix caseosa Vernix caseosa
9468 Deminutio lanuginis Lanugo decreasing Lanugo decreasing
9469 Centra ossificationis primaria tali et Primary ossification centres for Primary ossification centers for
phalangium mediarum talus and middle phalanges talus and middle phalanges
9470 Respiratoria Respiratory Respiratory
9471 Sulci sinus maxillaris, cellularum Sulci of maxillary sinus, ethmoidal Sulci of maxillary sinus, ethmoidal
ethmoidalium et sinuum cells and sphenoidal and frontal cells and sphenoidal and frontal
sphenoidalis frontalisque sinuses sinuses
9472 Continuatio temporis canalicularis Canalicular period of lung Canalicular period of lung
pulmonis continues continues
9473 Pneumocytus typi II Type II pneumocyte Type II pneumocyte
9474 Pneumocytus typi I Type I pneumocyte Type I pneumocyte
9475 Initium temporis saccularis Saccular period of lung beginning Saccular period of lung beginning
pulmonis
9476 Initium secretionis surfactantis Secretion of pumonary surfactant Secretion of pumonary surfactant
pulmonis beginning beginning
9477 Urogenitalia Urogenital Urogenital
9537 Fetus hebdomadis trigesimae Thirty-second week fetus Thirty second week fetus Endnote 491
secundae
9538 Generalia General General
9539 Motus rotationis fetus Rotational movements of the fetus Rotational movements of the fetus
9540 Vernix caseosa Vernix caseosa Vernix caseosa
9541 Deminutio lanuginis Lanugo decreasing Lanugo decreasing
9542 Reflexus pupillaris luci Pupillary light reflex Pupillary light reflex
9543 Alimentaria Alimentary Alimentary
9544 Canaliculi intracellulares Intracellular canaliculi of parietal Intracellular canaliculi of parietal
exocrinocytorum parietales cells of gastric glands cells of gastric glands
glandularum gastricum
9545 Respiratoria Respiratory Respiratory
9546 Sulci sinus maxillaris, cellularum Sulci of maxillary sinus, ethmoidal Sulci of maxillary sinus, ethmoidal
ethmoidalium et sinuum cells and sphenoidal and frontal cells and sphenoidal and frontal
sphenoidalis frontalisque sinuses sinuses
9547 Continuatio temporis saccularis Saccular period of lung continues Saccular period of lung continues
pulmonis
9548 Initium temporis alveolaris Alveolar period of lung begins Alveolar period of lung begins
pulmonis
9549 Secretio surfactantis pulmonis Secretion of pulmonary surfactant Secretion of pulmonary surfactant
9550 Urogenitalia Urogenital Urogenital
9551 Bifurcatio aliarum ampullarum Further bifurcation of ureteric Further bifurcation of ureteric
uretericarum in blastemati ampullae in metanephrogenic ampullae in metanephrogenic
metanephrogenico blastema blastema
9552 Conjunctio tubulorum Fusion of metanephric tubules with Fusion of metanephric tubules with
metanephricorum cum tubulis collecting tubules collecting tubules
colligentibus
9553 Ovarium juxta aperturam Ovary near pelvic brim Ovary near pelvic brim
superiorem pelvis
9554 Testis juxta anulum inguinalem Testis at superficial inguinal ring Testis at superficial inguinal ring
superficialem
9555 Haematolymphoidea Haematolymphoid Hematolymphoid
9556 Haematopoiesis in hepate minima Hepatic haematopoiesis minimal Hepatic hematopoiesis minimal
9557 Erythroblasti hepatici in Hepatic erythroblasts in small Hepatic erythroblasts in small
acervationibus residuis clusters clusters
9606 Insignia neonati maturi Features of mature neonate Features of mature neonate Endnote 495
9607 Generalia General General
9608 Vernix caseosa Vernix caseosa Vernix caseosa
9609 Lanugo parca Scanty lanugo Scanty lanugo Scanty primary hair
9610 Initium formationis pilorum Formation of secondary hair Formation of secondary hair
definitivorum beginning beginning
9611 Reflexus cervicalis tonicus Tonic neck reflex Tonic neck reflex
9612 Reflexus prehensionis Grasp reflex Grasp reflex
9613 Reflexus indagationis Search reflex Search reflex Rooting reflex
9614 Reflexus labii Lip reflex Lip reflex
9615 Reflexus glutitionis Swallowing reflex Swallowing reflex
9616 Reflexus suctionis Sucking reflex Sucking reflex
438 Gradus cellulae unicae; Embryo unicellularis [Gradus I] The feature of Carnegie Stage 1 is unicellularity. In penetrated oocytes of Stage 1a, pronuclei have not yet formed. In ootids of Stage 1b, the haploid
pronuclei remain separate. In zygotes of Stage 1c, syngamy has resulted in a single diploid aggregation of chromosomes, without the formation of a nuclear membrane. Embryos of Stage 1 are generally 0.1-
0.15mm in diameter and about 1 postovulatory day old.
439 Insignia miscellanea cellularum trophoblasticarum nondifferentiatarum These miscellaneous features have only been observed in vitro. Similar observations on the differentiated trophoblast are not readily
available.
440 Cellulae germinales precursoriae An embryo of Stage 6b showed a marked concentration of glycogen in the extra-embryonic endoderm of the secondary yolk sac and some of the cells may be primordial
germ cells (Hertig AT, Adams EC, McKay DG, Rock J, Mulligan WJ, Menkin MF. A thirteen-day human ovum studied histochemically. Am J Obstet Gynecol 1958;76:1025-1043). Experimental studies suggest that
cells originating in a caudal part of the epiblast ingress through a caudal part of the primitive streak and migrate into the extra-embryonic endoderm of the secondary yolk sac.
441 Embryo cum somitis I ad III [Gradus IX] Embryos of Carnegie Stage 9 have 1-3 pairs of somites. They are generally 1.5-2.5mm in length and about 25 days old.
442 Embryo cum somitis IV ad XII [Gradus X] Embryos of Carnegie Stage 10 have 4-12 pairs of somites. They are generally 2-3.5mm in length and about 28 days old.
443 Embryo cum somitis XIII ad XX [Gradus XI] Embryos of Carnegie Stage 11 have 13-20 pairs of somites. They are generally 2.5-4.5mm in length and about 29 days old.
444 Embryo cum somitis XXI ad XXIX [Gradus XII] Embryos of Carnegie Stage 12 have 21-29 pairs of somites. They are generally 3-5mm in length and about 30 days old.
445 Embryo cum somitis XXX+ [Gradus XIII] Embryos of Carnegie Stage 13 have 30+ pairs of somites. They are generally 4-6mm in length and about 32 days old.
446 Somiti sacrales [XXX ad XXXIV] The sacral and coccygeal somites are derived from secondary paraxial mesoderm, which comes from the axial dense mesenchyme of the caudal eminence or tail bud.
447 Somiti coccygeae [XXXV ad XXXVIII/XXXIX] The sacral and coccygeal somites are derived from secondary paraxial mesoderm, which comes from the axial dense mesenchyme of the caudal eminence or tail
bud.
448 Embryo gradus XIV [Gradus XIV] Embryos of Carnegie Stage 14, which exhibit these features, are generally 5-7mm in length and about 33 days old.
449 Embryo gradus XV [Gradus XV] Embryos of Carnegie Stage 15, which exhibit these features, are generally 7-9mm in length and about 36 days old.
450 Embryo gradus XVI [Gradus XVI] Embryos of Carnegie Stage 16, which exhibit these features, are generally 8-11mm in length and about 38 days old.
451 Generalia From Stage 16 onwards the list of General features begins with movements: either spontaneous movements (motus) observed using real-time ultrasound or responses (reflexus) elicited from
aborted embryos / fetuses. The Stages at which these items first appear are derived from the menstrual ages of the original data. Movements appear in an orderly sequence and the last appearing movements are
repeated in the Stages until the next movement in the sequence appears.
452 Motus levissime perceptibiles “A slow and small shifting of the [embryonic] contours is seen lasting from half a second to two seconds, which usually occurs as a single event” (de Vries JIP, Visser GHA,
Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322). The state of the Stage 16 embryo and animal evidence (Harris JE. Early embryonic movements.
J Obstet Gynaecol Br Emp 1962;69:818-821) suggest that these early movements may be myogenic and that conduction of contractions is along the myotomes themselves. This type of movement disappears after
a period of less than 2 weeks, whereas subsequent types persist, some until full term.
454 Motus tremefactionis “A startle is a quick generalized movement, always initiated in the limbs and sometimes spreading to neck and trunk…. lasts about one second.” (de Vries JIP, Visser GHA, Prechtl HFR,
The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
455 Regressio partis nonvertebratae eminentiae caudalis; Regressio partis nonvertebratae gemmae caudalis Only the proximal part of the caudal eminence or tail bud contains paraxial mesoderm or somitic
material. The distal part thus has no vertebral elements and some say that to call it a tail is inappropriate.
457 Nn. craniales [0 ad XII] All cranial nerves, including the nervus terminalis [0], are represented in Stage 17 as fibres from the olfactory epithelium reach the presumptive olfactory bulb. The most proximal parts
of the other cranial nerves have developed earlier and their more peripheral parts will develop subsequently.
458 Embryo gradus XVIII [Gradus XVIII] Embryos of Carnegie Stage 18, which exhibit these features, are generally 13-17mm in length and about 44 days old.
459 Motus contractionis corporalis generalis In General movements “the whole body is moved but no distinctive patterning or sequencing of the body parts can be recognized. Initially slow and of limited amplitude,
after 2 or 3 weeks they become forceful (de Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
460 Motus singultus A hiccup consists of a jerky contraction of the diaphragm (de Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development
1982;7:301-322).
461 Embryo gradus XIX [Gradus XIX] Embryos of Carnegie Stage 19, which exhibit these features, are generally 16-18mm in length and about 46 days old. Correct assignment to particular Stages in the range
19-22 gets progressively more difficult. Comparisons with Streeter’s photographs and Greatest Length are important. Also important are “point scores” based upon the state of development of the cornea, optic
nerve, cochlear duct, adenohypophysis, vomeronasal organ, submandibular gland, metanephros and humerus. Embryos of Carnegie Stage 19 score totals of 10-16.5 developmental points. These embryos have
completed the “premier sous-stade de 45j allant jusqu’à la 1ère ébauche typiquement humaine” (Guyot R. Théorie nouvelle sur les âges de la vie. 2nd ed. Paris: Barré & Dayez; 1985).
462 Embryo gradus XX [Gradus XX] Embryos of Carnegie Stage 20, which exhibit these features, are generally 18-22mm in length and about 49 days old. Embryos of Carnegie Stage 20 have scored totals of 19-
29.5 developmental points.
463 Embryo gradus XXI [Gradus XXI] Embryos of Carnegie Stage 21, which exhibit these features, are generally 22-24mm in length and about 51 days old. Embryos of Carnegie Stage 21 have scored totals of
30-39 developmental points.
464 Motus singularis membri Isolated arm or leg movements “may be rapid or slow and may involve extension, flexion, [lateral] and [medial] rotation or abduction or adduction of an extremity, without movements
in other body parts. The amplitude can vary from small to very large.” (de Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-
322).
465 Motus singularis extensionis capitis Isolated retroflexion of the head is “usually carried out slowly but can also be fast and jerky. The displacement of the head can be small or large“ (de Vries JIP, Visser GHA,
Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
466 Motus singularis rotationis capitis Isolated rotation of the head "is carried out at a slow velocity and only exceptionally at a higher speed. The head may turn from a midline position to one side and back“ (de
Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
468 Motus manus adtingentis faciem Hand-face-contact is achieved when “the hand slowly touches the face, the fingers frequently extend and flex” but rarely enter the mouth (de Vries JIP, Visser GHA, Prechtl
HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
469 Embryo gradus XXIII [Gradus XXIII] Embryos of Carnegie Stage 23, which exhibit these features, are generally 27-31mm in length and about 56 days old. Embryos of Carnegie Stage 23 have scored totals of
48-60.5 developmental points.
470 Motus respirationis Breathing movements ”consist of movement of the diaphragm (caudal direction), leading to movements of the thorax (inwards) and abdomen (outwards) “ (de Vries JIP, Visser GHA,
Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
471 Motus adpertionis oris Jaw movements ”may be either slow or quick. The extent of jaw opening is variable“ (de Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects.
Early Human Development 1982;7:301-322).
472 Motus porrectionis lentae corporis Stretching ”is a complex motor pattern, which is always carried out at a slow speed and consists of the following components: forceful extension of the back, retroflexion of
the head, and [lateral] rotation and elevation of the arms“ (de Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
473 Motus singularis flexionis capitis Isolated anteflexion of the head ”is only carried out at a slow velocity. The displacement of the head is small” (de Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal
behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
474 Fetus hebdomadis nonae The ninth week fetus is between 8 and 9 weeks old, is about 35mm long [GL], weighs about 10 g and exhibits the features listed.
475 Fetus hebdomadis decimae The tenth week fetus is between 9 and 10 weeks old, is about 45mm long [GL], weighs about 20 g and exhibits the features listed.
476 Motus oscitationis The yawn ”is similar to the yawn observed after birth: prolonged opening of the jaws followed by quick closure often with retroflexion of the head and sometimes elevation of the arms” (de
Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human Development 1982;7:301-322).
477 Endocrinocyti β, α, δ et PP solitarii partis endocrini pancreatis The first endocrine cells of the pancreas develop before the pancreatic islets, form Pro-insulin and the C-peptide required for its cleavage. Thus
the release of insulin can be demonstrated at this stage.
478 Fetus hebdomadis undecimae The eleventh week fetus is between 10 and 11 weeks old, is about 60mm long [GL], weighs about 30 g and exhibits the features listed.
479 Motus suctionis et glutitionis In Sucking and swallowing movements,”rhythmical bursts of jaw opening and closing at a rate of about one per second may be followed by swallowing, indicating that the fetus is
drinking amniotic fluid. Swallowing consists of displacements of the tongue and/or larynx” (de Vries JIP, Visser GHA, Prechtl HFR, The emergence of fetal behaviour. I. Quantitative aspects. Early Human
Development 1982;7:301-322).
480 Urogenitalia In the eleventh week fetus substantial amounts of urine are passed into the amniotic cavity.
481 Fetus hebdomadis duodecimae The twelfth week fetus is between 11 and 12 weeks old, is about 75mm long [GL], weighs about 50 g and exhibits the features listed.
483 Fetus hebdomadis tertiae decimae The thirteenth week fetus is between 12 and 13 weeks old, is about 90mm long [GL], weighs about 75 g and exhibits the features listed.
484 Phasis zonarum sex differentiationis corticis cerebri The cytoarchitecture of the neopallium does not have the adult pattern until 32 weeks.
485 Fetus hebdomadis sextae decimae The sixteenth week fetus is between 15 and 16 weeks old, is about 135mm long [GL], weighs about 200 g and exhibits the features listed.
486 Phasis secunda zonarum sex stratificati cerebelli The second variety of six-layered phases of histogenesis of the cerebellum (q.v.) persists until near the end of the second postnatal year, when the external
germinal layer disappears.
487 Fetus hebdomadis vicesimae The twentieth week fetus is between 19 and 20 weeks old, is about 185mm long [GL], weighs about 450g and exhibits the features listed.
488 Lymphocyti numerosi in sanguine The number of lymphocytes in unit volume of blood increases to reach a plateau value by mid-gestation. By contrast, the number of neutrophils remains low until late
gestation, when a dramatic increase in the number and proportion of mature neutrophils coincides with the selective trans-placental transfer of maternal antibodies. In due course the passive immunity conferred by
maternal antibodies is replaced by active immunity conferred by antibodies synthesized by the infant. A relatively vulnerable period may intervene between the loss of passive immunity and the acquisition of active
immunity.This may be mitigated by the transfer of maternal antibodies via breast milk.
489 Fetus hebdomadis vicesimae quartae The twenty-fourth week fetus is between 23 and 24 weeks old, is about 220mm long [GL], weighs about 900g and exhibits the features listed.
490 Fetus hebdomadis duodetrigesimae The twenty-eighth week fetus is between 27 and 28 weeks old, is lean, red and wrinkled, its movements are infrequent and sluggish and its cries feeble. It is about 270mm
long [GL], weighs about 1500g and exhibits the features listed.
491 Fetus hebdomadis trigesimae secundae The thirty-second week fetus is between 31 and 32 weeks old, is paler and smoother, is about 300mm long [GL], weighs about 2100g and exhibits the features listed.
492 Differentiatio retinae noncompleta The retina is not fully differentiated until some 5 to 13 months after birth.
493 Fetus hebdomadis trigesimae sextae The thirty-sixth week fetus is between 35 and 36 weeks old, is about 325mm long [GL], weighs about 3000g and exhibits the features listed.
494 Haematolymphoidea In the thirty sixth week fetus maternal antibodies transfer across the placenta.
495 Insigna neonati maturi The movements of the mature neonate are active and sustained and its cries are lusty. It is about 335mm long [GL] or 50cm long [CH], weighs about 3350g and exhibits the features
listed. Such an infant has an age of about 38 weeks post fertilization or 40 menstrual weeks.
496 Nomina dysmorphica [See Preface and Chapter 2] Previous embryological terminologies have included a substantial list of dysmorphias. Here, however, dysmorphias have been been distributed between the
sections and systems and a representative selection has been listed at the end of each. See, for example: [1] The special issue on Elements of morphology: standard terminology Am J Med Genet Part A 149A:1-
127). The treatment is based on description of the anomaly or growth variation. For details see the individual papers: Carey JC. Editorial comment: Am J Med Genet Part A 2009;149A:1; Allanson JE, Biesecker LG,
Carey JC, Hennekam RCM. Elements of morphology: introduction. Am J Med Genet Part A 2009;149A:2–5; Allanson JE, Cunniff C, Hoyme HE, McGaughran J, Muenke M, Neri G. Elements of morphology:
standard terminology for the head and face.Am J Med Genet Part A 2009;149A:6–28; Hall BD, Graham JM Jr., Cassidy SB, OpitzJM. Elements of morphology: standard terminology for the periorbital region.Am J
Med Genet Part A 2009;149A:29–39; Hunter A, Frias J, Gillessen-Kaesbach G, HughesH, Jones K, Wilson L. Elements of morphology: standard terminology for the ear. Am J Med Genet Part A 2009;149A:40–60;