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External-internal rhythms
Temperature dependency of
circadian rhythms
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Light effects
• circadian period (T) of diurnal and
nocturnal animals change in opposite
direction in constant light (LL) :
– Aschoff’s rule:
diurnal animal: T decreases with light intensity
nocturnal animal: T increases with light
intensity
– circadian rule:
diurnal animal: wake/sleep ratio increases with
light intensity
nocturnal animal: wake/sleep ratio decreases
with light intensity
• the strong physiological effect of light is
also shown by persistent oestrus
• short light impulses can change the phase
of circadian rhythms
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Jan. Febr. March April May June July Aug. Sept. Oct. Nov. Dec.
Location ofonthe
Publications theSCN
SCN
300
250
200
150
100
50
0
1965 1970 1975 1980 1985 1990 1995 2000 2005 2010
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Bmal1
B
Clk Clock
B C
P Per1-3
Cry Cry1-2
P Cry
degradation
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light
Szentágothai, Medicina, 1971, Fig.8-60 Berne and Levy, Mosby Year Book Inc, 1993, Fig. 9-6
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1 mm
Berne and Levy, Mosby Year Book Inc, 1993, Fig. 9-16
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shell NPY
Glut
PACAP
RHT
retina IGL
24/3
clock
SCN
HT
Meijer
Meijer, J.H., Watanabe, K., Schaap, J., Albus, H., Détári, L.., J. Neurosci. 18(1998):9078
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CT 6
CT 3 CT 9
CT 0 CT 12
CT 21 CT 15
CT 18
Meijer, J.H., Watanabe, K., Schaap, J., Albus, H., Détári, L.., J. Neurosci. 18(1998):9078
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blinded sparrow, in LD
3 – removal of regrown
feathers
4 – subcutaneous Chinese
ink injection
PVN
medial HT
MPOA
PVN, sPVN
DMH, VMH IGL
endocrine neurons
CRF, TRH, GnRH
vegetative neurons
other
sympathetic,
parasympathetic SCN targets
integrating neurons
shell
core
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Desynchronization in humans