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    Rabies virus in medical microbiology

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    17 views11 pages

    Rabies Virus (Medical Microbiology)

    Uploaded by

    ayushi693shinde
    Rabies virus in medical microbiology

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    of 11
    IS enc tn hp, he set wilco: | toe lat bore rhbdovnans «Dabs he denn od by adore RHABDOVIRUSES ‘ake shaped enveloped viruses witha single-stranded TRa pote are cased ae ehabdovros (om ‘Sit, meaning rod). The family Rhabdovrdne tating vires that infect rammals, reptiles, bids ‘le ects and plants. Some members multiply in ‘etdrts and arthropods, Rhabdovirass infesting ‘unmalrtelong. to. «vo. genera, Vesicle (ating vesicular tomate virus and related ‘ese, and Lysavirus containing abies views and ‘tl vses: The name Fssairs i drives fom ‘a, meaning age synonym fr rabies Rats Vinus Monolgy: The rabies virus is bullet, sores "8 73min sa, wth one end rounded CONS ‘te iher planar or, cone. ‘aries knabike spies in, Spikes do not cover “von Spikes may be rensed fom Tempore ol in plana end of Ve eweon= by reste wt id soe detergents, Beneath {he melee the membrane oF mae (MD protela Sper whch may be imaginted atthe planar 0d ‘The membrane may projet outwards from the planar {Tal osome vison, forming 3 Heb, The core ofthe ‘fon coms of ly arranged ibonckeopotein (i. SE. The genome unsegmentd, Boer Riise sense BNA Also presen in he mileeapid mee dependent RNA transcriptase and some Strata pris Resistance: The vu i sesve 10 tana, aie estates query emmoni compounds. ep. Freund pd sets oh as es clr detent irate by peel. formalin, beta ant ce, ule sradaien at suiht Pr ina cers in one hour a 50°C and Therma ort 60, es a oo temperature but fe mor werk when stab By 50% ghee SC for weks can Be preserved at ~ in dye, the fi isation, For storage eh haere inactivated on ‘ras has 0 Be sealed im ils a8 1 exposure 10 CO}, posed [Antigenic properties: The surface spikes are compo SighcopetnG. which portant in pathogens ‘fence and immunity mediates the Binding of the choline receptosinneuratsics, induces virstoacene Femaggltination ining (HI) and neutaling (protesting) antibodies and stimulates eytatoxi T ell ‘mma tisaserorype-specife antigen. The pried {hvopraein may therefore provide a safe and elective bunt vaccine Rabies virus postesses hemagglutinating activi, optimally seen with goose erythrocytes at 0-4 “C and aryl of 62. Hemaggltination is» property of the fBscoprotein spikes, es inactnaed by heat (56°C for 530-60 minutes, ther, trypsin, pronase, deoxschlae fr Tocen-80. but not” by. beta propilactone. Hi antibodies “develop fllowing infection or immunisation and poralel neural antibodies. HI tests would therefore provide a useful method of sssaping immunity to rabies bt the low sensiviy of the test and the presence of nonspecie inhibitors in al sera limi ts value” Nonspecific iahtors can be Sesroyed by treatment with acetone or kalin. The hemagghtinin antigen is species specie and disinet from the antigens on rabies related viruses, “The nucleocapsid protein induces complement faxing. abodes Thewe are not protsthe, This antigen is group specifi and cross-reactions are seen ‘with some’ rabies elated viruses. Antiserum prepared inst the nucleocapsid antigen is wed in diaghostie Immunaluresence tests. Other antigens identified include two membrane protein, glycolipid and RNA dependent RNA polymerase ‘Host Range and Growth Characteristics Animal: A mammals re susceptible 10 rabies ifcon, toh ieee in soe Berween specie Cat, cats ad foxes ae gy suscepibls shores snks, oposums “and Ey tiny ant Haas od do ecu an Intermediate poston. Pus are more usepe fan dul dogs. Experimental incon can be meage inny ory anima bt mee ae alight i yay re et invacerebal incl, thy decoy eee Sein Shay, Pee tnd “The rabies vis old from natural hun or animal infection is termed the wee an Following inoculation by any route "tan Oo a ences borin ain ae (tema pe of at a etn tale Neg ee In ontrated inthe bran of ann tvs infetion, After several serial nsec et bt, the i nee Se ea care enetone, ow Meal esorteee neo dae al enepaiis ae, int cakaton prod of 1 dye Negi ay ot demonta in hein oan erat tiod vas feon. Te eden frase production Centro The abies vis canbe roma Caine The wal med of necator sa pension n chickenbone kat SCclgmett ol tnt vaccine sire ay Sorc Shins add Yo dark ee chp Ans fies hn oe ed fore pepe Mane cine Tse ete Te abies vis cn 0 nse Pin aed comincoe of arte ak Trl freind pore or mse eo Stora ctacs reno apparent and ei iow The das si dad ow an dip est ickembyo and ences aod forth dan of tn Rasies abies as been recognised since amie Si a disease transmit fo hurans and ain # bite of ad dogs. The name becomes fo Latin word rabid, meaning tad. deed 08. Sarl roo rat, Yor fay. Ree xcs in, cain ta of Eso (2 Sou aes the appearance of the Dog Star Sirs a he OF 2 ‘of summer when dogs were contdeted 1 {0 spelpof “madness. The dase in hush SE i caleddrphebia because the pats fear of water, being incapable of eke 2 So tcl, abe in on * Desa fetes = suse BO OO ears Causatve agent of rabies had oF ts Seen asocitd with he sal of bi 0g aly 1804 that Zink dace pou {he dca to normal dogs bythe mocap om rabid gn Tn HST” Mazen #2 oo ke jag Es rl nescence nmenety Mt acl hw hl of Sh Geseecioltetewteiatidcie Pen nt i sin ne rcpaed by ing. for various entry Paar oh ak or cone spot eet of sil cord fom mths Iced haya fame nee arta smcsexclboy, severely btlen by a rabid dogandin, or sbonte niece ee parent alia tae waite) areas esr Faetcseesorien ares Gehan ale REE inci ot J bin ton mans ect re anes ce Mo rong — ruston | Cwawmnrenao") "apn atm ar) sre a. ss chck | Crarirons) cesses mem cy Seman ime Cd 7 “ne Exams ne abun GE) Sane eee eee) secs re Sms oe se00150 SONS en 4 a Nemoto selon "982 yrange of abs (BADE sboc vaccination suggests that cae Nene eal “The movement of the scar ee aed a3 see me cas cag fo 88 Speyer oP a el a nop enone unk os prt of See nt te a, ne poneee SSRENK Sh SES ae Sena eines SRitstacinotnare Teer son eae eer SSS See esa Siete sae ba rec er nd Soe ear tenon aac e nee Soares eee es Termes Seon ‘The coune othe diese in humans canbe csifed ofr saes—roome. scence enw tnd death The ort» marl pa (Byfleet fcr fetches maa ‘morc At ah pom cae "9p of pnw are fae Me for eu. Aprehen ah the iru, "nenoeane mann ea, ‘turasce the penal The sue neloe wh nperacy ‘sermitent wih boy Stianon ork sue hn i. Pn Ret ye a in ving o sch pln spasm pe sr mnt producing. chong or Phy fatents develop a dread of even the ptt ene eri Cowl shah ony ocr oe ie to respiratory artest during convulsions," ® ‘tte ret ge ipa) a (fs domi omthe Seg Sy SS hr commen ae ey ‘se ovo o rpc rt harem ponte Pen whose be oe ase et one cet A Son the Dea er op es coe Same peron exposed 10 rel riage sk rice derions phen Sidr fi ake Sed haat or fydephobepib. Pes rae wih ancy, kab eo, cpent Biter Thy ae aes ‘arene eer al tae in dogs the nabton prod wai 5+ els tt it may range from 10 days ital sn rans, trouble a na positon wih resins naping eh {Seeking or going tse ete 25 ds of hs peo stage. the ene SP ith fis nb eben ‘ahs heh mach more cm 84 Sk ing wou procaine Trekwer jw dropsand saa draft ‘acon nd Seah ewe ‘ys dn rats, te par frit ™ anil es had, unable to ee. The Stet atemps fed ae dangers, ‘em nets she one, Seto deh the wins ‘sual dein 3 dae “Therehave been epost persons eee ses ing ten ape sth oo ‘nso he nde str goa “taba nyt ne he Sates hing henner 8S Soe bcc nd polenta inde ht ees manera conan a {at hiner recon, Tero hn nt 3 rahe he Poser wean they ha ‘emyetination Inthe spinal severe vol femmon. The ange 9 oan eller evelons jaro atl mouth econ ich the vaya sone rant source of human infect st where rabies in domes 1 eed onsuleegcuees ce rae, ei hardy ever bite humans or eter soca ra mn aed ce eee eps oer wi on ica ed eat ‘Eppa eta ne ‘Eig nd the fatal outcome Vacuar ores soir netomat cor en ih ton det a hea na ice tte chee men ae MEd cod he pone fone SS nh ube Some dog of poets sev The et atte of he eee ic goem hele pry of te trees wearin he deren penne td eTnwel sy ree sel Te x oc nando eso ‘tppocempus. Negri bodies are composed of finely eran res pr Lateatry Diagnosis sie sh Labor ago fan ai ‘Tse sof le pacts porns dea sso ine and 9 une Nests eer tah eo ‘Seed fe var comieed 0 Be {SSR nw sel need Senna ean 4 mS i i bw ie mabe borer dito 18S andor forms fences paren ™ rote ue ugh Teed mat comely wed Sn ‘eu and skin on {hs cmon, and brain Ps Mtetofluorecence is done using ant Re sores moran, TM seamed oF Depess Iny be made ton of Neg ses “Sb absent in about 20 pr C8 rakes eaten anes a soation ofthe srs in mice by intracerebral inoculation Sing omer hire Gris ‘antibodies appear and the virus can then be taolated ioe — Ue é awry Si ‘mab eat nthe rand NETS etait SBOE Te Peon Taewnse cae inate rete cham he aera ro, ne SO ANE] carly and eer ae et lee 10 a pees, The pr, SEA aun he. The lowing a eatin FE ae nel epbenge a ea ue mao SENS oe ra, Euro TRE S rundrecee wtl SESS el an seg oes ay a i {alae mars laboratories Impression smears of the SENNEE Sted Sai Ea ta 6 Mane’ method —— sae 1 fin Net Bes Jot nat ‘isolate mn of te abies vrs (ioogieiy, i ob above for human ais done deseribed so opty: Specie prophase ronineiectionInaimal, ths rs cenpsore immunisation vara ame gh ik such 0 etary wae ecause eal Vaccines Cary son va compbestions, The ineduston ccc. ee ie fom wins case eRe pre-exposure immunisation in hae 15 ane Spee prophylaxis ener eg Ser exposure to infection and Is thet kt Arabi weatment. Tis consis of el Po, ‘furl acins end hypermane seam, Tcl amet ial ites epost te es ib sands rompt cautraton ofthe wounds tee fabs to destoy the vws. The wound dod ‘Sbbed wel meitly with Sap ard weet es Sn vey important sep in the preven ce ‘oop decoy te ve fcc Ae mit the samp avay complet, the wound rad utr ammonism compounds uch ce Ahrue cr aqueous solution of iol, dl {40-70 percent In severe wounds, met say be aplel topealyand initrd se ‘ound, tr adviabeopopene suing Bev iene messes and ani 1 ee = nay be wed ap ncetay Anite acts: Antirbicvccns sain categories” neural and n-ne TH fe assed. with serous kof USA mpliations and have been reas B= Neral vaccine: These ae suspens {isu of animal infected with he Hie ET The caren was Per cord sie Fe ying overcast potash, for saying Pe inetd abi spinal ord. THs WS inetd brain vaccines, of which Bese ‘evra reports Scns rie Me vas deed SSD (191) atthe Cental Reeth I, nia, een he mst widely se Seca nes poe see nected ih ied vir an inated 37°C lenge eda ew Sa pitas BP are Tat Af he Semple vaccine, in which Be re the inca age! 1 ee Neural vaccines rey are poor im Trlcocapsdantig reopratein G. wh ‘They may contain i imoctvated during ‘They ae encepha tren abandoned in reason for thei con eveloping countre Non-neural Vac eg racine) ‘ct as ada iactvecd win be Scomied een ‘ied mre ens supa Sea ta ween Two the Poy strain the So cer pee ie High Egg Pass orca ad sue culture sacc poe haan rows, Wi Sen-butyl phos : hs Cast ae, sy ones wh sae loved called sin the erefore ld be cr. This rabies washing ed with talon). ‘leah “omieed aden The Z oor ant Peabo Ind Sa sae in cites: The encepatogei ao in ier a bse prtcn sown wane “AScranen tenement td ae nails Sovaccin: wee sidopces stor rabbit bran, Occasional cae seed eatons Have Cocered flowing a ee ao. nant ran ese ened sate very rp quanies eget esses ar nttsfcor lor many ten ston mnogo ay fecal angen, ih ony small ques of ‘etn G, which the sok protec angen fer cnn fotos speis nich omy abe tise during vaccine preperstion and org. So ae crcpfaltogen Neural mains he ‘Sakowone inte developed cones, The oy Sterns cominued poducton ad weno ‘pa countes ht hey ae che Norueural Vaccines fa ain (a) Duck eg Yecne rea om ‘rated for growth duck eth ad ‘hat ih ts prostlone Was et a ‘mined because ofa poor somunaeni ‘rh mor pen dckepgacsne was de, scraped y te cre secs 8 re atatihen (Lateral cet "ings: Two types of vaccines were de wit fet rain he Low Egg Passage (LEP) "ais 0g pge evel or murano 6, oe se ligh Egg Passage (HEP) vaceine at 180 pas rand ens Ths oP Eg cre cine: The fst ce a ‘Richoman po all HDC) MS nd Se fo Pak 188 “ssa prepaato ofc rabies a Ses pee an Bo IRC) an inactive with set moi ee ot phosphate. It is highly ge is its fm dis we st de ts 8 Nig He nomial he quay eine and Se pais Ste ne deetped: Tse OES Fmt daw Thick nb re iirc row NL a el dng Ean contin om he seen eet ine ee ders of vervet monkey oF A tpg on monkey In India the oon wl fling eal eure vacins are {yall human did el (HDC) vce pri {imi cl (CEC) vain nd pried ve ce (PVC racine A he te aa le Suburb vaccine: The gyoprasn subunit on the ‘rs surface whichis the protectin antigen, has en lone and recombinant vacies produced. Tey ae stint experimental stage Vaccination Schedules Abia hole initrd when peron fonts ke an nina ich Su or eanot be pce When the BME trim can be Sel hal ot ested Seth be lop or nas The osran Pe end commended ese tee ee nn ean ot dy ete eset in nde animal yes wi 9-8 arg eee ie ia frsing te sisted hs oi fea se fay sar muy be dco orale do mk mt aco eae ea fice sc dos eee vce tad with ce sity Sat init action an aerate Sit swap The sear Sel or arene dese To a aa become or eee pend Nema ans: The dosage ftbevasin denon Newt a Dh tnt eaten eld ol ane ein in wan he eh is sit 1b Si Taste a tg det cnc wth tna on ks, a cas abn i peyote bs Bok fer uct mous meray oct. 1 kno i ch ve raed een Ben on pr Do) Se i ec or Sie io tie om coma anita capt Ren ot neat be set Soe ese inte ied 10 be more antigenic, s a 4 se ienic, so that smaller 4 Licks on deftly remenkered fresh cits oF ein ont ge Aso hes on he es AL han i acon teed es ea rohes on al rs fe Boy Net SE el ar hh Bo i Babar Sting Ber whch ve fe Be crmere ormebichaesbe bean rcured wih ae 10 retong an Persons in whan the rik estimated 1 be sre These ade 2 Licks on defintely remembered fresh UIs oF trasions on hea, ea eck All bes or scratches onthe hed face or neck. AI Biter or strathes onthe iogrs hich ore Taerated mre than fl amine hong or ave penevaed he ve sin 4. AT Bes peneraing the tr skin and drawing Sood when here are fe ce more teeth marks, Allies on any art ofthe body causing extensive Aloo and wf ies 1: Any Clas patient who hasnt esd eatment tah 14 dap cl expo “The recommended schedale of vsination for the Alert class flows Cas 2mixTdaye 2m T dae E Smix dips Sx 10 dys The abo sete for he recommended bythe Pasteur Intute Genet Resch hate, eh oe doe ‘mance’ ho ‘came nbn in 2 ami, loving iin wi myer lets acc ey a TERS pinahioe stench coe, HE wet ts dorslumbar ype, the Lan type of ascending wee ha 3 Le eo ean a contain tobe imme response 10 the ince eg 0 or ager pel Inet Sianeli Sancaons usually cer within com tient of vaccination Th eae € SShpeatons sais wih diferent yea Shad to Tin 12.000. Wher such comp! * tc during. the course of vac? {SStuom shoud be withheld andthe ay coniosterois I fre vachaion emt Syorae,non-neurlvacenes shouldbe mon and the tse of aohl daring ave been ss fo Increase the ro nang) Cal eae vss AD hs cl cae seis IDG, FOE a NO hos he ltrs sede, noch oe as nl hen inccxmae rnin rie te on snclate sed on dyn 6, at 08 ae Mme de 8 commended a a ain ye en Tovxposr ron Title 58) ei ors om aye 0, 37.14, 3Dand op? Th cnc exe oe pont thee ng chy yo tm red ono erreur ren depending on the degree of risk. After five yan. stato eof fe elon oe Shneon The azn i to be gen IM or SC ron orm chldren one amas te laa ncn eb es ns ele mance hs resto dof i indersiy ha eft 2 05-10 85 ‘SC or IM and that immurisation may tis ‘or sano Howe 2° tonne acig a iar ‘cay i na oe igen une aba ening immuniaion: ani Crue equine ata eum 542 4's liable to induce anapryactic e203 San simu ain CERIO) Se Shur ot compare fo Hk HS nmin sbi Ri eo {etiisation but should be ensured fe ats van RIG ach ee __ contain fr posexposn prophsas(IO posse) or feding of aia; Bes iat kin h Nae i ry ale \Nibbling of uncovered skin; ninor scratches or reine er ced, Satan A ese ‘penser bites oF sratches—cotamiation of ‘recous membrane with salva Rabies immune pve munition an, para acjunet patents, Tero, tere 90 dager oT ri pould be invariably employed or nursing hyena pT provided suitable feet | shoul dee of hgh isk, The pcatonareake. Anam roe ransmission rien of corneal ber the XPOS ‘ee nea HRIG 6 20 rhe who nan one see ntated a he Seo tye donor ha did unset 0 and ante in he owas ansmited rough He cnn ‘Bem belore or simulancousy “The Rabies ius 6 es ‘eresriat animals etl and Anat ition should De er if purts ofthe world vee aon ection ofthe vaccine, Bul ot ea ertan. Two epsemiolonicl vate si png tne serum anda, SF and tae lene eure vaccine on day 90 may We ST ecar mas ra, ase BY domes

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