INDONESIA EDISI VI 2020 KEMENTERIAN KESEHATAN REPUBLIK INDONESIAJ a ina bmi ol sd rang pes da 0.05 my, oy Tnhang ak harane i 20 ap eS semua kapsal dan compar, bersihkan ote gare ssn, ng tot ‘ae sca Sh oe ee hh mee Se {SSbantn mami te dln A ah 8 “me's man an Ko fr 15 gene fan Pot a ang peta Beri sonar aoe rid 2 am dan or se i tava ree? Bete omsognl thai arn treiSintooseorm on teresa ee Pose tl Kwa Fr etnepnsa are rian santana re ce aia nears Wastes erin woman cm Norns iSirssine bee Suitan sen, tisihsejiah dra en aa 30) Lr os et Tey te dies. tora Ro nat ogre pea a Hg “dilim_img_Kloediazepoksida higroklovida, ono tal ane dan i sei) a apart SEs i ae sot, daakn 1 umiah Klorduazepoksida hidroklorida, mt i teoyingunay ils waa ‘ct Tare pemen ces CSiadnedanedn So pena > Tan a a cman pn ston pans dnp iment ge soe ye Kromatografi 31> ed fet Te aradan ia 20 ean samen die : sce tagra Kromanpa Sh apni tate et {Stayer in eg eS ae 1s Tab ees Ae tr an der Beant ae or 20 aan 2 oan ‘Sirsa pentona dem sake mac taker ‘can Somovn n oe oma Per seat ml iach reskin esha dale naoa Ro Ste 2 ta ae ‘ean oe on sh ie eet pes el Sa em sean am mle amin es veoctape tac Tints eel ns tt tt te ae kan es itl al a" tanananenee aola 0 i Peete an 11-107 Anaad 5.2 ‘Syarat lain Memenuhi persyaratan. seperti tertera pada ioe Fenetapan lar Lakukansepet yang teen pada Pencepan Kar Garam Ba Nanogen Oreo an bok Tinos salsa lebih kung 25 mg Malet BUF, artkan dala 20 masa abet dan 350) dan perakukansepet ade Larstan yj, jan kan spe yang exer pda Garo ‘asa Nien OrgonkeSi Peder Ula sigan Lenton bot den, Lorian it/pada pan glombangscrpan mais ein ‘ang 264m Hang juni dalam ne ee Disolusi<1231> Media dso: let ie 230 Cubic serapanalkol yang dengan Media dsl Jarutan baku Aloe yang sama padawe http://arveja.awardspace:com.spur mitt ian ae dali tha bight pote antihistamines eat rene than pny: eam) and peti dae ofan ‘ouomrvouaune usa yeep tote ot& 2p Chires2dtaintyen ye mle) inant Gua aay ans Dreparton 0 code 2p 2a bee stim nth dae epee tae Te et ne i a ie pet of a mo ‘tomate maa shot enter TC ame resin a ‘etescta and anteater graben ingen iin epee mc Tern ond sempom el wm Urey mtr thc is od wa anemia aa fee Inlet pn meta He) ‘at waar s9n ognl aaa 06 Bat Tene te ele rina he Ing Tse 2 ras as, Propane 65,15 97 US Pat 57 seeghlarepn ene Doerner ay. Comment Se gene ate ‘arava roRoC ROE unin dpb ane Mont: Bouin Peon rT 2Dipbumloaon¥. | Naimelyhtylenie bneede heseactiawostd aaa Preparion bs Veinetipeiirennane, Sty lone daemons ene Art {Ut eps necmeet bd ‘i ie oven thie cts oir any eens 0 sae et ns oe piel s,m a Sobiiy—1git nL vlr 2a a cine Lact lh eta ubecnerer der Ganments et cain thane at psoas Sgt ieee tte ent sl ‘Weel itis loa be we a pres am lee "ts sr iti bres emp edb ‘hat ble mpl rg mea ‘Tatar nd mpi srs ad ero ape ce of pti oda ink in mn with teary ong nthe gt ad ce dopa trea of tise tb ea tee levtn rp band touh mort tl of ah thet alem spiny cor ml el i ca it alg mie dd er tne are etal dnd ir egg urate rer ert "beh cel decal herwosi p i bate at a nacre le he Mak pn mena nied ta plana pt an natin hale ane tbr ic hdr he we smu sie i ders fs, iene vie Tarn cen, iy moto ct, ween hee ha sy ae ha, iw, pet sl ated ag nth teat mas ee oe tie Foot aban wid wera tat ‘thee fy a apn rope ares macho nob hu Tenens eae 3 MTA HYOROHLORDS ‘wpe 1etmanre Wace oreo rere pov 10 inyesnoygaetini mene alcatel ase, Preperation) rong rice wi elie? in anon propria ni peed ted hd Tv plod ot Sea ehh erp Wits i oe cnt ee ay ten iad pre’ vm ied roe ‘erin nee yw ca, ‘Baia agree td 23° PB Sober bate ld an- fm cay nat ate aa "Gannett i anit mc pel pin onl ths mr pa rain wn fei peed el wel thee ni roomie sin Age aro ed shat en sd de. ‘sm pte wh ire skeen ay oa a ot Peeper fr sumac eats dino ‘rehearsal sear act anss ‘itor rein od ond aes ad tig aca wth fea ips fea er hy ant oe (Soe oherauigns treated of ftp pa son bel lle sn bls rel ot eet el re thet pf pte a eal are tol pepe rate to eto dr teMartindale‘equ sin een, ies ih ‘amin ach Tie a meh teh tomate tse aie of Seca ae send =e eave and ine wth some Soa we ‘do bev ed rte 565, of 10mg ce i203 yous Nomis 2 oe ah ie daly those ‘tofpeteai speach: sapaicas wih Saat mabwbercced Shey esc oa Buclzne Hycrochoride/Chorphenamine Malete S71 etree ior cesar eee Prewerutore BE CEES SE TREE neem Pept cps) ele eee a Ses hoor lr tS SEIS SSSR SSL Chloroppramine Hydrochloride 0 20s ESep oni omincceraset Seats rateeci ee mon eecmarnnnamevnemaier SEEGER Gee encs machen Se ionon retest Coaun sm Eee An tases SS Seas ho terece ‘Exe Ging Care Gora cpemier ctctrae | ATC et — QOOUAOR: QROGACOR Eat = to : t ' Easton nat er Sa Oy & fest re eens caso cg rec anes pale Becpecreceeereg ac Sees Gli bettie ata dae eS e a ee toee mmceneigee kmncamimigia thutengrnaly toe rea ee ei Eee cremiteme pee Preparations Prepay Preprint cee) i nncneremnisce ed See err ene RSE ons ComnONLE IO, = 3908 Mc fosaéoe CAs 132929 (eptenamin): 12928 (ie cv OWNED ‘mani nace OO iia (einem) t (chepenamie) ‘rarmacopdian nf ee Sacra ina PRamacpei chp pS a Scepalie pode Pedy sccm cred ood ‘ecu mabe natn Asoc a Bowe Pmertoc ig ‘necueiipst Hanten renay ae ‘Sucre fnperan ex re Eo cits conmes ow ner ‘Guetta be ass Sopcaerantay samen pS) ‘er te medPres sin een, Testy wih Sain sch Tie a meh enti! Srnonsbcng iyate une teh tomate tse aie of Seca ae send =e Buclzne Hycrochoride/Chorphenamine Malete S71 AE Sar pec ins Aor Cannes tee Preparations Spaeeecemerres mers Reema see Mmehommra ter Skee SE eoerpyramin Hyder ss ESep oni omincceraset pete eeees cer Tomek cneannniemnn tot SER Aeerhetie ieee womereenrevern ee TEES iano 6170029 fee Sec Renecgirc tara scra hace Sear Frome Pyhinde) Sacer Teer Serato cette ATC vr Qooemer, QUSACOR Beficmamcetcereesiee Sei: Mite manne nana ene Serie eeceas fomma shir semios tse Sr a ae eee eeeel = a amo 5 ac ae CChioreyciine Hydrochloride wos ses) Chlorphenamine Maleate iene Naan Osean, auaryaie BAB AUS Glamor auetrirs Clorarern GOO Charen ane Clore micas Ob 9 ee (oleiene Mc fosaéoe cv OWNED . oa (ecrsoon) (ermgoenamee) ‘rarmacopdian nf ee Preracepcin Ch fr eh, 1 Pretoe eRonecsra Sens) A wha artnet ve een sts Pe Fa ae SO Pk Eu 6 (losers Muh A wht ofan Bowe Pmertoc igAMES Drug Information 2008 by Gerald K. McEvoy (Eaton Publisher: Amer Soc of Heath System; (December 2003) By OkDokKeYfolowing oral administration. Chlorpheniramine undergoes N-eakylation to form ‘monodesmattylchlorpheniramine and didesmethylchlorpheniramine, buts principally ‘metabolized to other (at last 2} unidentinted metaboltes. Chiowphoniramine and ts metabolites are apparenty excreted almost completly in urine. Urinary excretion of CHlorpheriramine and its N-dealkylated metabolites varis with urinary pH and urine flow, decreasing substantially as urinary PH increases and urine tow decreases, Following a single orl or IV dose of chlorphenramine maleate in healthy individuals with normal renal and hepatc function in one study, about 20% of the dose was. excreted in urine within 24 hours and 35% within 48 hours, and less than 1% was ‘excreted in feces within 48 hours; about 3-7% ofthe dose was excreted in urine 2s Unchanged crug within 48 hours, 2-4% as monodesmethychlorphenramine, 12% as idesmethyichorphenramine, andthe remainder as unidentified metabolites. In other ‘Studies in heathy inivduals with normal renal and hepatic function, about 20% of @ Single orl dose was excreted in urine as unchanged crug, 20% as ‘monedesmethyichlorphoniramine, and 5% as didesmethyichiorpheniramine, Chemistry and Stability -chenisy rs OF 8 me en e cntrtonte mbes Socata an seri reer a mi CChlorpheniramine fers from brompheriramine inthe substitution of a chiorne atom for the bromine atom ofthe latter comoound. Dexchiorpheniramine, the dextro isomer, i ‘approximately twice a2 activa ae racam chlorpheniramine oh a weight Basie. CChorpheniramine maleate and dexchiorpheriramine maleate occur as while, odoress, cxstaline powders, Chiorhenramine maleate has solubilies of approximately 250 ‘mgiml in water and 100 mg'ml in alcohol st 25°C. Dexehiorpheriramine maleate has Solubilties of approximately 0.9 g/ml in water and 0.5 giml. in alcohol at 25°C. CChiorpheniramine tannate occurs as a ight tan to buf or yelowishtan, amorphous, ne powder having not more than a slight characteristic odor the tannate is sighty souble + Stability CChlorpheniramine maleate and dexchiorpheniramine maleate preparations generally shouldbe stored at a temperature less than 40°C, preferably at 15-30°C. CChlorpheniramine maleate cral soliton and dexchlorphenirarine maleate oral solutionola 0 i Peete an 11-107 Anaad 5.2 ‘Syarat lain Memenuhi persyaratan. seperti tertera pada ioe Fenetapan lar Lakukansepet yang teen pada Pencepan Kar Garam Ba Nanogen Oreo an bok Tinos salsa lebih kung 25 mg Malet BUF, artkan dala 20 masa abet dan 350) dan perakukansepet ade Larstan yj, Zarda ban spe yang ere pada Gorm ‘asa Nien OrgonkeSi Peder Ula sigan Lenton bot den, Lorian it/pada pan glombangscrpan mais ein ‘ang 264m Hang juni dalam ne ee Disolust<1231> Media dso: et pe 80 ep ChllsCIN; CHO, serapanalkol yang dengan Media dsl Jarutan baku Klay yang soma padadbo on iia tri sd rang pes da 0.05 my, So amosthon eh Kuang 25 “tama Seni dan Kooth ver ‘eet Encrian dengan Para moma ca Ken a Mer? fm ano Sn cng tse ae kee 3 tsk iomatogra indy arn ss Sst wares meee adn tvauohe ers ang oe ° Mie Suitan seas teisih sums doen eh hoe 9p) Laren bos Term ke damn. srmanun’ Ram reopens panes wo it “an mp ernest da sal ane css ee) ae Kontcepoide Hideo pea Larson hab nda betart-tart Roursaauy Nat Ae MALEAT inven ea coaioleetnroue aaa ‘enzen ee Adentifikasi Spekirwn a 7 ae recat ae ‘Susut pengerngan Tia. a, Se ee sen pian oT “Camara argent aka Ponca SN oe Kromet gas spe yang ern ph Krome af P31 ut “Tena arian ei kran 20 ata ml melon era P ‘Saten dromatcgry, Krenatura os st engin shor nas nla om ac 5 {2 myn er babar emg fie Sa Cpa porch perangua SIA. Peubakan Tekan dee Deut ph 5 eng 10290 dan 25°. Cua ei cogs gos pena, dehgm_ meta Sep eke nea tama era. weak ree ae ‘rtm mnt ia bi a 145 ae Somikanesinsrang 18 Larn alan womataya. Reka oan SOE" Kora nt 2 Sal rtenain ale don Mecano ne a a oS pela dan sam ala Ttola 0 i Peete an 11-107 Anaad 5.2 ‘Syarat lain Memenuhi persyaratan. seperti tertera pada ioe Fenetapan lar Lakukansepet yang teen pada Pencepan Kar Garam Ba Nanogen Oreo an bok Tinos salsa lebih kung 25 mg Malet BUF, artkan dala 20 masa abet dan 350) dan perakukansepet ade Larstan yj, Zarda ban spe yang ere pada Gorm ‘asa Nien OrgonkeSi Peder Ula sigan Lenton bot den, Lorian it/pada pan glombangscrpan mais ein ‘ang 264m Hang juni dalam ne ee Disolust<1231> Media dso: et pe 80 ep ChllsCIN; CHO, serapanalkol yang dengan Media dsl Jarutan baku Klay yang soma padaAMES Drug Information 2008 by Gerald K. McEvoy (Eaton Publisher: Amer Soc of Heath System; (December 2003) By OkDokKeYChlorpheniramine Maleate, Dexchlorpheniramine Maleate Chlorpheniramine is an alkylamine (propylamine)-dervatve, fist generation pthistamine. Dosage and Administration + Administration Chlorpheniramine maleate, chiofbheniramine tannate, and dexthiofpheniramine maleate are administered orally Ghilotbheniramine maleate 16-ma extended-release core tablets containing the drug in ‘an immediate-release outer shell and in an extended-release matrix core should be ‘swallowed whole; the extended-release core tablets should not be divided, crushed, chewed, or dissolved. The extended-release core tablais should be taken wit Mui. Patients should be advised that the matrix core of the tablets does not completely dissolve and may be passed in the stool + Dosage Dosage of chlorheriramine and dexchlotpheniramine shouldbe inavidalzes according tothe pation’sresporse and lerance, Dosage of dexclorphenramine taleato' approximately 0% thet of chlorgnenramne maleate, ‘Chiorbheniramine Maleate For sal-medication in aduts and ciren 12 years of age and older, the usual oral dosage f chlorpheniramine maleate alone oF hn fxed-combinaion preparations 's 4 mq very 48 hours, not fo exceed 24 mgin 24 hours. Aternatvely, for selfmedication, Adults and children 12 years of age and older may recawve an extended-release formulation containing 8 or 12 mq ofthe drug twice daily inthe moming and evening, not to exceed 24 mg in 24 hours. The usual oral dosage of ehlorpheniramine maloata fione orn fxed-combination preparation for self medication in chidren 6 to younger than 12 years of ae is 2 mg every 4-6 hours, not to exceed 12.mg in 24 hours. Und the direction ofa crician, cron 2fo younger than 6 years of age may receive 1 ma every 4-6 hours, not to exceed 6 ma in 24 hours. Under the directon of a ciniien, shilren 6 to younger than 12 years of age may be given an extended-release formulation containing &'mg of tho drug once daly at bedtime or during the day, a3 indicated. For fxed-combination preparations, lower maximum dally ehlophentamine maleate dosages may be necessary because of oer inaredents (2. acetaminophen, Pseudoephedrine hydrochloride) included inthe formulations. The usual dosage of chilofoheniramine maleate as the 16-ma extended-release core tablets containing the drug in an immediate-reloase outer shell (4 mg) and in an ‘extonded-release matrix core (12.mg) for adults and children 12 years of age and older Is 1 tablet (16 ma total once dally at 24-hour intervals. The manufacturer recommends that this dosage not be exceeded. The extended-release core tablets should not be& CLINICAL PHARMACOLOGY 14th Edition “LANGEats he endl tof hh, The gt ‘iad ably or naw pom wg fom ron fh we of cae aa ‘ho ft arf he ean) Ime cas ne age ‘Sov fom he US mtr et re hg seed (eh dni wen net SH gris omen frig i eam deseranin.| ‘Orwell ofthe orale de dom ‘Srl ximalaen td alls. In ace meee eee eee ee Cras ‘mt esi abit LSD by mi of eel dae Thaw uno eds te ok tt of emia spams Mtoe pgs. Hews, at cn “ree hea eh do gael fer cae dings ast Fegan Pome | Scenes | cactermominaa | Sepencuy | fantaenannntonmacse Sima" | onesies | tye | Une rgann Sprmane | een | weanedTriprolidine ‘Dexbrompheni ramine Maleate Theophylline “Rminophyiine Terbatas ‘bat Bebas Terbatas ‘Obat Bebas ‘bat Bebas Terbatas Kemasan tidak lebih dari 10 tablet ‘Sirup $75 me/S ml kemasan tidak lebih dari 30 ml, Hanya untuk dewasa dan ‘anak lebih dart 12 tahun Kombinasi rT dengan pseudoephedrine, dengan kadar per takaran ‘Tablet « 2 me kemasan tidak lebih dari 20 tablet. ‘Sirup + 2.mg/5 ml, ‘kemasan tidak lebih dari 60 ml Penggunaan tidak lebih ‘maksimum 2 kali sehari Kadar < 150 mg pertablet, emasan tidak lebih dari 4 tablet. Penggunaan Wak lebih dari 1 tablet per kal, ‘maksimum 2 kali schati. Kadar ¢ 150 mg pertablet, ‘kemasan tidak lebih dari 4 tablet. Hin comes goldBING British National Formulary March 2011194 3.4.1 Antinistamines BNF 61 BNE for Chien, 2-5 yours 251mg3- tes dy, Breateedng se ates shove 5-2 years Sag 34 tines daly Sideeflects sere above Prenton CD 2-7 your upto 250/g -2 bese ows befor pean 1 mg ie diy raed up tm yf [Aimemazine on prpetn) rece. WA under tye ot recomend “alts tnemaze arate 10mg. net price 28th CLD 13 er 250-00 microg ce day, 3-6 sack = 2428 Label 2 ‘yas 500 mcrae tice daly 12 yas 05 Sup semaine tate 7m /Simi net pice RE wie ay S58 Jomg/Se om avi pati oun a) "lets scored, demain (shogun mart) img Net pice 6b pack = £235. Lab 2 ‘CYPROHEPTADINE HYDROCHLORIDE ctlns sync reel faery such 2 bay ever cara tern wetme of napa recom ecton 3.43) ‘a reesende Cb 6 urs mg 3 times (iy mc 2g ay 14 yas mg 23 mes sy moe eg ny Peiactia® sso) Fe eet oe ae "BIE scored. cypoheptdne boclede tmp «+ Bylowamescatinetn ory arenas ition ‘ver mint, 10mg repeated regued up oma (pane (max 231; 6 mon yeas 230. 12 yas Sg thse des maybe opened oq upto mar doses a2 Boe "snc ag ng CIR ann st ts ote a os nap ye MEmpnimet ce ay eyo a sem ‘soon, erin mete g/t, ‘er pice 150 = 2ST Label 7 teagan a ct bebe seipet npr crear (reasteding intone advises avis aso Sealpetne ts ee ute gy nee coe Seated Side-fets se ntes shove Injection. RRREne mate 1075/"L. Daye rata Pronusntaly 25mg ape nceased necessary rote oot apy whee nnineetonsfor 25g tne aly CLD T° Yas aly 5 aw seere {Sing ata cena ncaa tg aly Pritan® 65 conser eth) 3-4 died doses 6-12 yar italy 15-236 a “abet yelow scored aban malete igh neni ones to 3-100 edly 3-4 dime me pice 20= E162 Label 2 ‘ed ass Cs ude ers BAF fr Cu Sup. beanie mahate2mp/SmL et pice en ome ibe 2 sco Tilt bone draenei 1 (Mi cuewastine (rage npc bs ack 18 25mg eh Indications symone aleey sch shay Rb p= ELT Lab 2 ever uc eerax® ce pms) Canon sent shove Thblets 1 soe, ronpeinehtocherie Canraindications se ots sve Bmp net pce 2b pace E122 Label 2 Mepac impale see 2 Bove ‘yun, mjronaie eroetirde 10mg/Sma net Prognancy see rots above pce 208m pack = 78 Lape 2AMES Drug Information 2008 by Gerald K. McEvoy (Eaton Publisher: Amer Soc of Heath System; (December 2003) By OkDokKeYChiorpheniramine Maleate, Dexchiorpheniramine Maleate Introduction Dosage and Administration + Administration CChiorphenicamine maleate, chlorpheniramine tannate, and dexchlorpheniramine ‘maleate aro adminstered orally, CChiorphenicamine maleate 16-mo extended-release core tables containing the drug in ‘an mmmediate-release outer shel and in an extended-release matix core shou be ‘swallowed whole the extended-lease core tablets should not be dred, crushed. fssolve and may be passed inthe sical Dosage Dosage of chiorpheniramine and dexchlorsheniramine should be indvidualzed ecording tothe pallens response and tolerance. Dosage of dexchlorpheniramine fate 1s approximately 50% that of chlorsheniamine maleate. ‘every 48 hours, not to exceed 24 ma in 24 houts. Atematively, or self-medication, ‘aduls and chidien 12 years of age and older may receive an extended-elease formulation containing & or 12 ma ofthe crua twice daly inthe morning and evening, ‘oto exceed 24 mq in 24 hours. The usual oral dosage of chiorpheniramine maleate ‘alone orn xad-combinaton preparations for seffmedicatonin children 6 to younger {han 12 years of age is. 2 ma every 4-6 hours, not to exceed 12 mq in 24 hours. Under the drecion of a cincian,chidren 210 younger than 6 years of age may receive 11m ‘every 4-6 hours, not to exceed 6 mg in 24 hours, Under the irecion ofa cinicsan, tikdren 6 to younger than 12 years of age may be given an extended-release formulation containing 8 mg ofthe crug once day at bedtme or during the day, as Indicated, Fo ired-combination preparations, lower maximum dally chlorpheniramine ‘maleate dosages may be necessary because of other ingredients (e.9.. acetaminophen, ‘Pseudoephedrine hydrochloride) included in the formulations. “The usual dosage ofchlorpheniramine maleate as the 16-na extended-release core {abiets containing tho drug in an immediate-eleaso outer sho (4 ma) and in an ‘oxlondod-olease matic core (12 mq) fr adults and children 12 years of age and older {ist tablet (16 ma iota once dally at 24-hour intrvals. The manuiacturerrocommends ‘hat his dosage not be exceeded. The extended-release core tablets should nor beInjectable Drugs Guide Alistair Gray, Jane Wright, Vincent Goodey and Lynn Bruce146 | CHloromphericol | Chiorphenamine moleate References 1, Ashley, Curie A, es, The Renal Dra Handboo, Seen, Oxford: Radchife Medical Press, 200 2 Kasten Mf. Clindamycin, mevonidazle, and chloramphenicol. Mayo Clin Proc 1999; 748 825-833 Bibliography ‘SPC Kemicetine succinate injection (accessed 3 March 2009) Chlorphenamine maleate (chlorpheniramine maleate) 10mg/mL solution in Ll ampoules + Chlorphenamine maleate is a sedating antihistamine that causes 3 moderate degree of sedation; stalo has antimuscatnic activity. + 4s indicated for acute urticaria, conto of allergic reactions wo insect bites and sings, anglo- ‘slema, drag and serum reactions, desesitistion reactions, hay fever, vasomotor shins, severe pruritus of nonspecific igi. + tmay be given IV a an adjunct in the emergency treatinent of anaphylactic shock. Pre-treatment checks + vod in patients taking monoamine oxida inhibitor up to of extrapyramidal side-effects. + Use with caution in asthma, bronchitis or bronchiectasis sit may thicken secretions. + Use with cae in narrow-angle glaucoma, prostatic hyperttophy, usinary retention and pyloro- days previously Because of sk Ue wih eae in epilepay ait my Jeonvalaive threshold. + Chlorphenamine is thought to be stein acute porphyria. Biochemical and other tests ‘Standard dose: 10m by SC, IM or 1V nection repeated up to fous times in 24 hours freq (maximum 40mg in 24 hours. Dose in hepatic impairment: avoid in severe liver disease; may cause Seaton, Preparation and alinistration 1, Withdaw the required dose. May be diited to 10mL with NaCI 0.9% to facilitate slow administration, 2. Giveby slow IV injection over 1 minute 3. Flush with Sm NaCl 0.9%,eae aaron ene ome ges 78 si Lae Kortcoplide Seep aaron hab, dan beta ica Lars da Lartan bak ‘dlam m Kiinin trom pan kad thea nathan 0 ‘Ratkn 2 es itl ts pola ALN& CLINICAL PHARMACOLOGY 12th EditionTABLE 16-2 Some, anhitaminic drugs nial use. : ae — ani Ca sam we Stee tomodnat wan rete oaeniani Smy oo Naked sedon weraenseie ty eerranne cen somes anesseane we natenseanessenty Pree denaten erent ‘s10mg Ned aon ‘tre Mowe om Stott etn sere 4 Mec oie 250m Store sea antin ee 29) panies onphenne Dirt fam Stone saten hephenanee Oertineonse tm Soe sear conmoncamecnnt tC ‘roneeusee Peet asm ateeon wen aac erecta Pena no % ase seer one tn ) Feta oat ee Baton snus conan Sima snes, sob eyproheptadine. This gi prmened sn anni gt td deco wis at deg gop Niserickns be treteee soca dt of the phuntee snus al icisa pnt Hck age 2, Local anestheseSevr es-reration Hy egins tt pat ol sede. They ck mum cana vk Si enbees sc ns sono prs nd ors Diphetylemine and promedane at scaly more poten than pcine moe ano, Ty ae casera ed 0 prs canes in pris epi to oma lc Thc dag Asal numberof de ope se ck pen tiem chal hs ni daced lw (ne Tei | Otheractions—Cerin sno esis init Iman. Thracon nr dae Hy recor cade a may tee an Hy maar fect Ge do). The mecha not Fay weno Br cl play ol ste bei ices of thse drag in he amen: fan sch a hin, A Foe 1H nagoni (tetas) ane en hows 80 ink the Poggi tampon ound ace el he iil oft pr and de opin of he im The spi eects dit roe CLINICAL PHARMACOLOGY OF H,RECEPTOR ANTAGONISTS Clinical Uses Finn Hcp vk aman sh mo cn rotated nd wed ewes coute gy The pec rg ‘odin ad hema ay of i gc hey tor Th fry de ce lon coe ten > sala decaane se sceuimtaeec chime. Allergic Reactions Phe Hy anionic get ae fen the fl dre wed rotor tet te opepion of cape recone org ini hay eee H, anagem ine dea er280 SECTION IY. Drage th inpertnt Acton South Mane acacia al pen Iai which SEE Ee panes mel de Hy eri oe ce drags of cea ar fien gt ee gen Bev oo ture Home roca hh cen ta he yagi gyno ‘agiedoms may be preped by hace lene bt aggro he nine by ppc nie dha ot ced Uy nua agents Fr sop demain, sian Ag adh dpkenideine e we monly fr iar ‘ict wich ocr soem of iching The H, atime wed Gr trating gic conn suchas hay rarely sled wih he oof acm, Seine ots inthe USA the dry im wide te we he Sune ale ecmbgecsies aeceduny age, Hower the edie elec and the ape i fa neni ry ries nee ain te ‘ectnens foe gowp may dias with conus, Shing aoe rp ay eo dg cen fr meine “These gent Hy angina el iy er ihe tame of age das onl re tres Sree cl ‘id comparisons wi ogee, cpr can sete egal rape icc Howrey sat and at S0% of subj king fw graion antitamic ‘eed in cal ou 79 of edges king conn “ge Thc ase dus are mach ore expe, 8 seas gene bamdato 2, Motion Sickness and Vertibulr Disturbances Seopalaine (xe Chip 8) ad cen fetgeneon Hy Spero i et cctrsgee ala Eat pe Swf ton sk, The namin da with ce ow (2 kctnen inthe appended ‘romehuate Dinesh whch prac ala exlo iat beeen of meio ances a a ef pte ‘ie and hr ana ice. The piper eine a tcc sh eign ayn prove ion ‘ands sing than Spondon se pain Deng de sew tht renee for ell dodo (Cae 16-2, Rech caplanine md the snaps a ene ete In peeing main siknas when comand th ‘pene o prin Tre fre clmed seaman ps ie in tropes of eto ste we ef Men ‘eb ay deer pplaion wc enabled (G, Nausea and Vomiting of Pregnancy Sal Haagen drug eben sadder publ wea tring "amin nen" Tepper der we wit {Een tom ach we when ar demons te hy fare tegen efecs i okn- Dosiine an ethane Sogn. ws poowe fr thn apleton m3 cept oF encinspespn medion arn coed le wate ccs of dine were wily pice he ay pc ae 197 ta tn oa ow cn ep of a oo hat ove ser crop of Bedi sel lag specie sues ang oe 60000 ances of whch more than 3000 ied. mater le pcm roams es ofthe H, ani cri dad tee Seo se anon i an he be al hapa: opin counter tes at Chper Newnan th m0 "stoma doug by eration wth nme ee (Dea Inmminad) Te dagen mer ered ne USA, Drug Interactions Lil etc api ecard in erly tig, (Shr of the ety snd grertan ages esate cr re ce i conbinon ib komma core se ae ole uc nach eu, Te arama, Inked of any gs by CYPSAS ad case Slee cones ed stots of te nti “The mechanm fc ey aves dee he HERG (i) geen coe inthe theme an ofthe eo porn Ge Caper 1 Thee pon ‘lon and «dane in shape of the sian peal a hoe ‘huge oath Sethe an tem mo ‘iawn om be US mare ecg af se res ‘Wheres wie rena ond eine hd cr snd be connie in psn ling ena Coole or mcrbdes and in pss with Her deme (Gopeti cr ao ie CVPIRA ad hs fen shawn Ince ld Kee of erate nici orth Haagen ta a pica eatin, coe ‘cua ue af drat cut Sone a ‘Ereninn predic adie fy and contrite we evmgr oping mae, Sande eric lng fic of elle sth ewe wi of etm ‘Grn od eroding dng. H,-RECEPTOR ANTAGONISTS “Th dealer sign to se increta ana had notet on histamine ince‘AHES Drug Information 2004 by Gerald K. McEvoy (Elton Publisher: Amer Soc of Heath System; (December 2003) By OkDoKeYben established in children younger than 6 years of age or in those younger than 12, years of age, respectively + Mutagenicity and Carcinogenicity “The mutagenic and carcinogenic potentials of dexchlorpheriramine have not been Sreaeny at own Agtatonsppete decreed lod ‘duodenal secretion ctayncese isemodic anaemia hypotension rele twsching-ncle weaken: nghmare-plpeatons Allergic conditions 283 phorosentvtyreacton shin ections- ns 1 lode Agocdema chyna cet phe + ht aetar ee Cental esos system stilton ‘leona pychons in ads) epepaa hepa SHOE erecrs, FURTHER MFORMATION Chien ae ely patens aremoesscepabiet sees ‘spneonancy Most manacres of ntistamies a ai), prado tab and wen ‘ret mit invryng amount though ot nen be ‘sHEPaTCtuPuinth Aved neve er dese ‘nth Soda choede 0.9% us eles Chien ete gaan mate alee ‘et neu nccresetoeoe eeane Dring ant eed rowsies rye Dental practises Fermoy "Indice estan doe nat apy satin for nection “erpbenme nh opr {Bersaortarneane ur Sone 2. tee nest ug | beicemeasteriAMES Drug Information 2008 by Gerald K. McEvoy (Eaton Publisher: Amer Soc of Heath System; (December 2003) By OkDokKeYused in children younger than 12 years of age. Dexchlorpheniramine Maleate For seltynedication In adults and children 12 years of age and older, te usual oral dosage of dexchorpheniramine maleate is mg every 4-6 hours, not to exceed 12.mq In. 24 hours. The usual oral dosago ofthe drug for self‘mediation n chikren 6 to. Younger than 12 years of age is 1 mg every 4-8 hours, not to exceed 6 ma in 24 hours. Under the direction of @cinician,chiéren 2 to younger than 6 years of age may receve (0.5 mg every 4-6 hours, not to axcood 3 mg in 24 hours. ‘The usual dosage of dexchlorpheniramine maleate as extended-release tablets i 4 or 6 img at bedtime or every 8-10 hours while awake in CChlorpheniramine and dexchiorpheniramine share the toxic potentials of other anthistamines, and the usual precautions of anthistamine therapy should be observed. (See Cautions in the Anthistamines General Statement 4:00.) a ry 2} and other individuals who must retict ther intake of phorylalanine should be warned that Tiaminic® Cold & Allergy Softchews® chewable tablets and Tyleno® Cold Mult-Symptom Children's chewable tablets contain aspartame (NutraSwoet®) ‘whieh is molabolzod in the Gl tract to phonvlaianine following ral administration. Rynatuss® Pediatric and Ry-Tuss® Pediatric oral suspensions contain the dye tartrazine (FDBC velow No.5), which may cause allergic reactions including bronchial asthma in susceptble indivduas. Although the incidence of tartrazine sersitvty is lw, ‘requentiy occurs in patents who are sensitive to aspirin. ‘The possibilty that chiorpheniramine maleate extended-release core tablets rarely can cause Gl obstruction, particularly in patients with severe narrowing ofthe esophagus, Stomach, or intestine, should be considered, Patients with Gl obstuction or narrowing Should not use the extended-release core tables without consuting a elcian. I lbdominal pain or vomiting develops during therapy with these tablets, acinician Should be contacted. sdiatric Precautions. Like other antihistamines, chlorpheniramine and dexchiorpheniramine should not be used in premature or fulrierm necnates. (See Caulions: CNS Effects and Pediatic Precautons,n he Antihistamines General Statement £00.) Conventional chlorpheniramine preparations and exlended-elease preparations ofthe drug should be Used in children younger than 6 years of age and in those younger than 12 years of age, respectively, only under the rection and supervision of a physician. Safely and efleacy Of chlorpherivamine maleate extended-release core tables In children younger than 12 Years of age have not been estabished. Safety and efficacy of dexchiorpheniramine in Children younger than 2 years of age have not been established. Safety and efficacy of fexlended relaace tablets containing 4 or 6 mg of dexchlorphentramine malate ave not