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PY. ro yp seheyocniehs ONY saa’ fia er soun rm sentence foo cheats in tomas it arthunteeds Cte eoeiata ' let he pated yeas the Bonnaninaiom fae, Wale ane SONS ‘smnacs ve 2 Bees the ee rm ae SES ee eri a ST pac ona a OE z SS eee RE omer ad red scaly ining abe che DNF # re te Og vec ereeularly fe lg, wt anh : sc rina be egress bat woes workers may be : hoes seDetEDeCs. Or Truss in an oneupational epoacd franetdes during their ppliaiion n-toe Cele Tae DESCRIETIVE FOXE seperiner ankmls with 2 ‘posta othe shapes! iv wmlonld STS: Theze | ise muchanisms by-hich che SS se tenis fil for absalning MECHANISTIC TOXICOLOGI th eal wk . -tepniemas, Rea cers metanlnde eer en kd to he stag. af aeativg POE ve a ‘edoomitien fot Se devine see hema as Tasemal Ooi 2 a in cases oieolaginls tze tuna inthe. oniverl semen stv, pearctacetieal and chemical Industries Ca ee reponse ot dering, oto bass of apelin COLOGIST Ss Tay patel asl enauph sce ba mca Nigro Oe tar; ae APD) wenn he escabity f aang additives, crass, - ki seazketed * thn soe Fereasle & Ciinienl Tontealo gy. ical ees? Tumse wos sae i enbotat Bo Stipe of haraih ates of eats om naw a x a mt La she voncd co id mreslnsing she pare ef SAE Ypceienaeceratpon eamen oem, tL " Se esLOGR uisiaan area ct abiishé win Tk menial pratense ‘gisgres ars bec = wre paul pots Sead by br uniqusiy passed wilh tbe or = SESE Spain bptamasead eew floor tyre thage miowsepams.°”~ a ‘DEFINITIONS see my SHO ett Fata | DERTRUTIONS IP 7 eubecncevo.be exh, hee it Ue (9) x heme pele abst emaS i ‘esp (b) Oe a ee aie ayes with was the mp Ry Least prod 8 rong (Thee mts 8 Jeet Sedan op enuaidared eo be deltercus in he Biologie rem. : err alent as bs Adenniable in any reborced case of taxdsty of poleowing, : Tos affending agect coalt be sell io bea pols ee tein and the response could leaden jer. % eh ‘We pond therefor vate FOXICOLAGGY is de nly of ie Gaeterious offct of cbamicl or physics eyes om vine, ae Gat ile he ants! Bin oleic oat ee made foie ation oo eae pals, ypthe mubraeess| =f a 8 apc of eel apts cas hms ech iat bod eB Tapas soe ey aptly ah cho sgt wil Be hc end eee em ve a pine eto nations || : z oe aco easing oft ys nk emigre} is mFS curs roictpy pinaat rubies coe ee ea ’ ‘Tan tong pois http ef city of » Chemica the desermfsatlon nf eta? LOS) ‘Us due wae ol 50% oe fanaa ane don = seat expo LEt0: es emacs far of gsi i. et eal Uy nll ne shast ¢xposure by taal, paring ood sretis of differca?- chesrieals: Beatie ouly dais wich coe ecepolre Cea sl eoce ed sis eterenectiis afl acai = THHCAL TOMIHAPACLASSUICATION BASED ON L—eeiivines i =, pemmmmsnemsel Bu, 4 ait Ditty wah ‘a Soot a ay wa ep : ‘So rencusaltiy tren termas re % saceeae melee |: wed: rae ae 3 it : aye be ea me aa wa oe cal Ba ligt tox, rately ius) ors taseh a sium ui actie® i ntibitors, fae oe are ttecae o enc a a cn ag EES PN can peavids 4 ibe caee pes me s ; STR nie func rabenganne ees cat me Ieee a Ps ap Bue oy be ena fe Hn Pek By peony Shame ssp EEE peace aces gpd une th iy Hs cena 1a regia marcos pty pd etc wb id ery neceing fie) 1 =i RE Etpoice indian wre the reste of zm tales Be EVtee Cae eaten te gel) an ten parser ilk apes 08 rt pate se teponse wins the euresiub Tue. Saco etn ate a ee fnpoal > Sabet is etre. scuae'> Lat sdermad >a] > Topi Weds gg eee TOU spss nd scpeihot nance oa oe emperor the ech ah en ase alas Kear pets ceeen suntan ia sie ona eer tage rena Te (Ceenpariann of te lethel does eft. ‘ (pr ecal Sigediog topic Sepa heat er fe ee Sceang the i a ee SUR about ef acs tar tr icv wma il bb those 5 i oti : cea i tes tal ae a rp ila te th ve shea ue apg share py ad are gly MEE HEIs DURAITON AND FREQUENCT OF EXPO! ‘Tonle effesus may be. TOF TOSERE 1 nateat . Tairteeczclbe Roem anemia to eg . é Serene ube rm an vain a rei pe os Sa + See ld mm, a fom may heaven schncaic e peTS Ere along es Ribs tir nl et te elo sie efi af ie ape! roth eh ashen ie elineme sages rs ae EXVINGSMETAL TeCCANTS | Ct ne ee Lene Ee ear cr aoais +» Enstrousseatel tenizal * x fF a ‘aga enpats, The Um enrbente he oe og A tes pe a wii te romans a Acid stingy t2 esmeeabA eae alan fe wevcctned wei So Hmpu fs apetca of Uv = eee hie ete evircomsesral event exerting Sev CERT oe ¢ 2 ‘bevel o¢ fh arpfcantigust oe population er nn gramps 6 ipevInonpsiNTAL TOXICANTS ways GF Eye meat av mon erst Cer an i corfongimal thes. vada to Infocnuion den aa Pete sent the Gegradailty ofthe visits er Merci : is environmerital impact : peapiaras | eee i aerate casing ectinizeat hy 6 eens owe he argu" ety DEAS substance, the chemica! vt hsnaas ofthe organi {alr ealed Blosrumulaion, Abou ancuiooos of pa eozingd umdrads Ox thoopaus of sunt xs the eceeeminant pitts th OL awacct anal la fo Rice edo ibe 2S Cn ae ete pec (those mibotaces. are opin’ to lib Game Treas te quay der to barons loss hare Sosy wll lS ere DON? : nin aubndebrele amie tt ih isan ar armen OF ths, pth fo cba, WR ral bs be 10 t» £9 tas bhi ‘perne of ele entra ofan, « pease — afirosemene ROEROTARTS et Ps Ai Patan alti offered yebtaesst in alrmemptess Favurang bn drape nthe etn quiity ofits, Qpe.t may fuera af polation, pol cil bequry aside emai chooks, x fide etchant eve miata at pelluer mikes pooete sick cute beeing peer At i franz ples, aclenas, fd ie exogvamems jirwiich dae Tive. Some sir polluinat nrtara sn Barth i hig ects facia sk Zot, inf ederpde toos a beige damng exces ond dri, and wit aes al reams puta areal Jf ne i ‘Pollorion is changing Bard's ammoapbere ap thot it leg ss axore barenful rains from the Sp. ‘At the sami time, cur palisted sttscaphers is breoming a Betwer-izerabaior, leading wo u rite in global iverma temparetores, Scientists predict that ort -will afleet world food meblycaliersenSevel, rae Weather mince extreme and Increase the aad ab rupicel disease, (MAJOR POLLUTANT SOURCES ‘Autaronite Toapfte Ballerion a ‘ mae ‘hnacoabile ecbuit enotalns abumed Iydredetns, purteulates cactica Garde and oxide of trope fonirinae 1 acid rein, sieog, 4nd pola waikog. Thi one conch wh water vapor inthe alr form hei; eile Tena. ine growed as acidrem Seong, a minus of empl (particulates) end fog, indies the aye threas, dd Bologs Radlndes * denoqos fs, Phuaehendol nog ptiary bith ors af eg, eid hen se ths uniumed byproea/vons eal tre ocdes of rltropm ix unematile aust Cares Wanda, prota “Yeruing offal fala incloing guyoline, tan lending cause oF Sk Groene effet; & phenome respon Bo tsing wo terparage, : 2 te asec ys stb “Maat ae polllatsia comes from ene buman actie{ty: burning Fall Fusls—aatarg! gaa; Coal, sad oll—tn . See ee ee ee ae eateres tied ine, carbo moxokdos, ads, suf Viana, a bsy sod patielea— ioe eal fo stdiave— Fe ae ne aye opera abe a ara ie plats in wesc male rece W290 portant Wine fins we comply berber Sere merce em 0 pent seer na See coe aes [pacman enteng the lp ag caved ihr io rm Se ra ade vhensllircamrt coxysea. The ef is ms Tian onic wae er ad to eae DEES -Giiutiea 4 prodaeed ee atoteering laird i is bis arodaeet eStore one Se ara mai wll Sle ras af Erevan in bol n 4 z lg Sa iii be spun A FP ay Bet aon - : feSgeeeot Tei tuy conden ad wit igh salbgerans, Priore th dvdlopenene of vena, sot 0 eS regeat ead hector pate. m & slsp used oocereally me scent ther mate gy! Erm sul ionds fords ta coreg ay lay cog TERETE TO REAL + is : ‘okra cetcasom tc talip nis a iahoned nasi’ coughing andl sed maty Shaws olmanary disap Whea meee wish ‘ a‘ : i ma ed wc an ome yf cen, Wea mals anc dh eas PARTICULATES) |. ¥ may! o . tence via) particle aie GP a gaia “ond infra, err re anew te pu Gre eee ss Seeing Fo Yoherocy Set Ya sae oe or ce be fan arrce= p Ean ioe epslae fr ahows 10 poet ttf tna pene eh ea ‘ 3 L oe oc rmay be similarly speeled. This ie useful wren not eniy tye coger bound of Gectinh le rlevem vs a Ct aoe parle Sink aSGEE rc. ret ler sng oe aaa am can ape eS Spe eo clsbuh srve oti wns of al ake py, don and apes EALTH EFFECTS : Sa uaa dl uae ee ee sanliewraculr soe, 7 Dr ern pe sine, ale - perl will cme ta ak EE phe rose aud Ta and cnet ens probes, ut pious atin em Aran ne LE i pcea dene woos ond Rg nd ease esl pabce.Th 10 erm Narn esr sea yori aarp pr, Pl SD ston dass 5 Tarn panticulaie mater by moet recaiaary nganciot. Siz suey then nse for ins of en, ta vey sl is (= 400 syctan stpi ut};idattn biph plaque’ amy puted savtne Journiet of the American Medica! Association tote et ap past ana og wercd}er inflemmmation: ene oth cokers! — SE ee reairat Saat ceaercat tema pines aera ee eveted neerebarnt. coud sigtiticnntly consrihte to beet dises ws een ere cartes, tees Gan HOR manamtier (asnaputiies} may be sve eer ARAB a ee va sf bain deme ax Tal fo : aay Deal Pareslnte Mader, a[OPP} aro a on dee soot panies ol sary. cofeinegeale coi range 10 san mT) ig mommenly oer ar get i on o Le proper mmuurs Of te heal tazmnd. Qe partial of 1 jn disraeter Ha redlamane, BUT auch tant baseraloury as & probably * icon WU Hache a ek prelahy taijsen poles was tra Aemecuatraten! fa the ecty, rlcninston sujontccuu aun por year Soe : ares 73 som of music ve ing. nfs crate. Th wird “bag? incendie Wash cde oe ar estingathnbia. The Grasks trmal whestoa the "eitarlswineral? becavee of AE ot med plant proper; 9s Welk ny a oeransngty popular mong wae Siccares ent bullae In ye toe 10th oontury dus t i, Hatten to bent, Shemical damage, sound Aborstion and bemile samp: Wham aoeins la sed for ay seiianes on ce Ga sro fen mbeed with cement gr wren Into fibro ae ru. Aabestds ie used fs beak doe Bal gps Gy ile sleDnes, ahd in the pet was cent on eee over ated hoeplnte wiring far eluetrieal mulation at shiv putes, cc a buldings fer is Mamerdcandsce and cating reupestes, taco atvength, DEAS, vericals, retistanes ty ff etre fibeds tae eau parieif Iss, tocladi esthelinms i nce ti al : ove bie beamed inmeny cours ims i asbestosis, ince ier 196, ue Became & ets ncnteen hen igh i os : = sen hen high coneenirasions ofa jpeeene rem ieesos ate dima thats who ree ‘hers sep intal ever ~ aed bn ear pyres. Sine Manes ~ iced : ~ emir tn , tn ‘om cnice Na ipa sxonlated with asbestos, taste proce Gree OORT: aie Te) PS ame oa sty we Oy st ee ida posters ae # charsdekcrug -ata Sfdtiee and enh the 4 fae ha par ration of alti alos 2 Gaim Seas i a en rit anes ether oe aad he : i nm. The ratonele ferausing an esmali ik 4 controled clinical date ere available: eerie teats ar ean, Hany, eontel eaten se Aecthaneas cf cal oes ihe trealmett! of paianind: ‘Gatharlles generally are considers ai ges ecihaneas fhe qustralvaatinel ect, GabnSetcr ied ata nual ob smtare-coe}* 2 " re a oeatign is araoter than 1 Neut, acid fore ing By velstin MySCREREPRAS.. 5 Beaten i eS oats aman cla a0 WS UR are f ssuolly have ici) aM However, eyignesium: guifate should bo.used cautiously in patients with rena! Sees those lskl to Belo rer} defureson. i erartaining catiarion should be avoked In ser wh core mon tahini halatian 2n6 Txignal Eypeaurete Poisons. nen a peigon has Been, Inhaled, the first pricitty 4s to pameve: pra paliert fern the ues of exposure, Sinilanty, iF tne sen hae had corfiact wih @ palaan, R should bs maces Ca er ity uitiapier Gnrtarinaked cloing shou be removed. iil teatmont of ell EYP ‘of i “parieal SR ofp est ba raplactnareagh rrgation af toy wiih war fOr "S minutes should bere? es ERI HOED ELRWANION OF THE Polson a tes re aller} Grog » chernesl nab Swen absorasd, provedensh wimetinés ean, ba amployad i Se eT ascataas be tapas GY Pe. ate eomenenia of tas 6 Hee eatcy Enambge ef compaucas. Hirraeet, Induction of these axddsttve erzymes [sto iow bls ing fresemarm of acu paisoring by mest chemical sur. emesis Lio eau they. af bigkantor ned nie mbretale coemicets. Fw Inpumbiiion of, wlanredign apo Uecresee [Ne teelty of nuch drags. Far eaarmpks, oan! fs sad ta int the. ‘eenwe sion OF n3epaie! Be fy, fon eetyppeanaldeheciraper minaret corwarted by C8 ct ajsiorn 10 afvelechophiie matcoolts nak ix Gained by ulations, a oalluhar a fusbooh’> Acetupinophan coos nat cause hepatatonldly wath gutatniona le depleted whereupon the: . oli raga wsertal moeromascular cansilugeds ofthe hepshoeys, ree. itig i ieidgenaneril mae e, feaulting is eal dant ene ‘the consatpattt St atutatnione. ‘end this canbe ‘sevarnellst crue cre cotalfied by corgugation with glucurpiia ncid'Sr kutfate’yatara elimination fram the badly.-lnd!: ihy.0F Uy ate iagett ily bs shiogereus eeatraot fer contin) may Ln he ret at efrinabion, such tthe 7 Geoteion. Eruge and polgonmare svratag into the un: . ua ea sate Cnt eins tana tna ea) urpe, and arhenpemts of alert fac fitret ae siren i eee an ipsa fzen ne ibs Tumien can ba alieted Uhsolee ates BR Ne Ineo eae are ofthe dug om the urnen ta the ular eat ander 0S edd be ube ee EC Ma che Camo uae alka an ne pet lan. aepaciky im ptiota wth Tena, cardian, oc pulmonary ke Bont ‘ignizadl polar molecules! Het . hag terme rid Te ea the GH of he alas tug 3 3 of the toxicant UY TA Sioylstes are eleared rfrach rare rs ee spol picarhnats) Werasne pt ifumizal, Quoide, mieceltan, tye spmmended os firt-ine|trealitent the exteria forhemodialfsis, Ueya be considered infpatieg pin ara high wena fk Frag bean shown fe Se eeiels Bi H 96 first-line treatment mesten of phenaberbil, ‘sala geen shevi to be ae catia poker g bees rnisadirenal function or failure. Hyporal \ivng abiessium suppienen rsa raed z oan ke énhaticad by ch 3s amphetsimine theareticelly can | by acid Acide terempihas my the earns of aramanlurn enlgide er asactoie ‘eficn af gn acidic campounctize paricuieely ea veltive to changes in urinary Tis. ite Is W oF bes 7g: for hsoas, ho cane spanding tage S75 10.5." Hemodialysis orhamapefiusion vue! |, 3 fmbed vsa:in the treatment of intokibaljop win’ foa's. Maweres, uncer comtaliciroumstane: ch procasiinee can be lifessvini tility of, daly: Cepends on the amauet wf palzonih the Hood. © to the fptahbody burden, Thet/i a polgon hes a lan 2 wwitatian, as is the cane for tite tris ididapreagetite, a ntain tex 24 near lor eacdve removal ayia iy inde ef he carmeua te neo eee ne ot alysis greaty, Tha elimhatian ofa tories Sinsieg shad Ih Geauee: for come chernl Fonuan, purtariwercialyaie haigetre ier ‘uscyied fin Ung hereon ly Ye iatBnie ta trasocpornel Galpsie| ke much mera 6) (ip Serta wissen encogh 2 be gactar fant Of RGLite:mioaienrisres Faarnies ne eres mwuincing Imoettions, wach am wih frat eaten be ox inf far, i Panaegs of Wieud trrough a cuhumn dhe an Pe 2° dhomebeerieton ia’ betiiqive for dha srecurlen Gdam pend ce el Sree ea Fees bepie a abet Farmeved, The principat i r Chomies! Insetiraticn anes vith a comport yamrberrenion ef et % a S.Liste, ne dur ‘with to anti _Sihsetorls 6 anitoaion hthe sresimanl ef polar fe wale. Transraet ef hutan menasianal onivadiee eiesiag cyan spachs wn ha Table 1: $oma.spesitic antidatas for toxie arugd ane ehemle: | Mechaniam ofActien 3 hjonn-npoain I canos of palsoming with cligaxhy Thee pirieun pst Tene nea Pe Fesceiyleyetelne. Teleaare colies end Op ENTS Tsplaees Thactivafan ions Melaka raga Fa Toor rypaaticn | as Fanvarsse gieeoee desltion | Berens a | ethan a { eranal_ ga Wiacke velabolan te ve melat | Rreeterer crema lagi Fea Tae =, Far athemaplalaaenonSy Spee thus eamaving kifam acti poot | | Cesplocan anaty Raacivwies sean: Diapieces exert am hemog a TRAUuCes MmoMTmoGIOER ia hormagk Fane ae ana Forma ive porrplete | Blimulstes esenuia

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