Title: Mastering the Challenge: Crafting a Comprehensive Neonatal Sepsis Literature Review

Crafting a literature review on neonatal sepsis presents a formidable challenge for many researchers
and academics. It demands a meticulous examination of existing scholarly works, a deep
understanding of the subject matter, and the ability to synthesize complex information into a
coherent narrative. This task requires not only extensive research skills but also critical analysis and
proficient academic writing abilities.

One of the primary difficulties in writing a literature review on neonatal sepsis lies in navigating
through the vast array of literature available. The field of neonatal medicine is constantly evolving,
with new studies and findings emerging regularly. As such, staying updated with the latest research
while also delving into foundational studies is crucial but can be overwhelming.

Furthermore, synthesizing diverse perspectives and conflicting findings into a unified discussion
poses another challenge. Neonatal sepsis is a multifaceted condition influenced by various factors
such as gestational age, birth weight, maternal health, and healthcare practices. Integrating these
different aspects into a cohesive narrative requires careful analysis and interpretation of the literature.

Moreover, ensuring the accuracy and reliability of sources is paramount in producing a high-quality
literature review. Researchers must critically evaluate the credibility of each study, considering
factors such as sample size, methodology, and potential biases. This rigorous scrutiny adds another
layer of complexity to the writing process.

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Source: superatuenfermedad.com The ability to promptly and accurately diagnose neonatal sepsis
based on clinical. Among these 560 neonates 80 near term and term neonates with weight
appropriate for gestational age had at least one episode of positive blood culture. The cascade of
sepsis and its influencing factors are shown. Consider sending a C-reactive protein from the serum,
as this is sometimes used to prognosticate in cases of probable but unproven sepsis. Neonatal sepsis
is an infection in the blood that spreads throughout the body and occurs in a neonate. The cascade of
sepsis and its influencing factors are shown. Source: image.slidesharecdn.com Neonatal sepsis
remains a serious complication, especially among very low birth weight infants (vlbw, Source:
image.slidesharecdn.com Refer infants in whom sepsis is. Your midwife will look for these signs and
check other risks during labour and wil l assess your baby after birth. Neonatal sepsis can present
with subtle signs but can rapidly progress to multisystem organ failure and meningitis, which carry
high mortality and morbidity rates. Among the seven prospective studies, two demonstrated that ET
significantly reduced mortality. Newer and more selective markers have surfaced recently, such as
presepsin and endocan, but they are currently only in the experimental research stages. However,
many times this historical information is not available or none of these risk factors are present. Next
Article in Journal Addressing Consumer Misconceptions on Antibiotic Use and Resistance in the
Context of Sore Throat: Learnings from Social Media Listening. Note that from the first issue of
2016, this journal uses article numbers instead of page numbers. Editor’s Choice articles are based on
recommendations by the scientific editors of MDPI journals from around the world. Source:
image.slidesharecdn.com Risk factors for neonatal sepsis. Source: image.slidesharecdn.com Neonatal
sepsis is the cause of substantial morbidity and mortality. Materials and Methods: This is a
retrospective observational study. For more information on the journal statistics, click here. Elevated
levels of sCD13 (macrophage cell surface glycoprotein receptor), are significantly associated with
neonatal infection before the antibiotic use. The signs of neonatal sepsis are extremely subtle in the
newborn. Diagnosing sepsis can be difficult and there is no single test that can identify it. Feature
papers represent the most advanced research with significant potential for high impact in the field. A
Feature. Journal of Pharmaceutical and BioTech Industry (JPBI). Neonatal sepsis is associated with
increased serum sICAM-1 concentrations, which are correlated with severity of disease. In this
literature review, the first related article found was from the mid-1970s. Sepsis can be the clinical
manifestation of infections acquired both in the community setting or in health care facilities. Journal
of Otorhinolaryngology, Hearing and Balance Medicine (JOHBM). We decided not to include
susceptibility studies as they did not provide data directly related to antimicrobials administration in
clinical settings. ET removes bacterial toxins and inflammatory cytokines from the blood by
replacing it with fresh and immunologically abundant blood, thereby leading to improvement in
tissue perfusion and oxygenation.
Different antimicrobials are approved in adults for the treatment of infections caused by organisms
with unfavorable susceptibility profiles. Exchange transfusion (ET) is one such treatment method; it
can rapidly remove circulating bacterial endotoxins and inflammatory cytokines. Let us know your
thoughts on how we can improve our website, don't be shy. Detection and currently available
validity of an EOS clinical diagnosis is still unsatisfactory and there is room for further improvement
of clinical criteria for EOS using modern biomarkers. Further study in larger augmentation may be
required to confirm the findings. Journal of Functional Morphology and Kinesiology (JFMK). Based
on the extremely recent introduction of novel antimicrobials in newborns and pediatric age in
general, we decided to consider all studies on patients younger than 18 years, to collect all available
data for the developmental age. Methods: We carried out a prospective analytic study in the
Pediatric Hospital in New Delhi over 1 year period from December 2009 to November 2010. New
Antimicrobials for the Treatment of Neonatal Sepsis Caused by Multi-Drug-Resistant Bacteria: A
Systematic Review. Source: image.slidesharecdn.com Neonatal sepsis is the cause of substantial
morbidity and mortality. Neonatal sepsis is an invasive neonatal infection that can affect your baby.
Therefore, cytokine elimination therapy may improve the condition of neonates with sepsis. Sepsis is
a significant cause of maternal, neonatal and child mortality. First, the main limitation is the narrative
design, which is a source of bias inherent to such studies. In the ET group, statistically significant
improvements in base deficit, IgG, IgM, IgA, and C3 levels were observed. Therefore, these drugs
might be regarded as useful treatments in newborns and infants with infections caused by MDR
organisms with limited treatment options. What needs to be done i f my baby is at risk or show s
signs of an infection. Feature papers represent the most advanced research with significant potential
for high impact in the field. A Feature. Neonatal sepsis can present with subtle signs but can rapidly
progress to multisystem organ failure and meningitis, which carry high mortality and morbidity rates.
Titles and abstracts of all retrieved articles were screened to identify potentially eligible studies, and
all selected articles were analyzed in full text for conclusive evaluation. Visit our dedicated
information section to learn more about MDPI. The aim of the study was to assess the clinical
presentation, and bacteriological profile of neonatal infections. However, ET, which requires the use
of fresh whole blood to improve neutrophil function cannot be expected to advance in the future, as
the emergent availability of fresh whole blood has until recently been limited in most centers. It can
stem from a bacterial, viral, or fungal infection. In the adult patients the reaction times for each of
these proteins has been well characterized and it seems that they present similar patterns in neonates.
Data from small study groups suggests a better correlation with severity and mortality from sepsis
compared to CRP. The quality of neonatal intensive care and the blood products, devices, and
methods used for ET have changed during the last quarter century; evaluations of efficacy and safety
made in previous studies may not be acceptable today. Cefiderocol is also recommended for the
treatment of carbapenem-resistant A. Sepsis continues to be among the leading cause of neonatal
deaths contributing to 33% of neonatal deaths in india1, despite the fact that the field of neonatology
has grown by leaps and sepsis. Moreover, ET with fresh whole blood increases neutrophil count and
immunoglobulin levels as well as enhancing neutrophil function.
However, using PE in neonates is considered a challenge due to the relatively large extracorporeal
blood volume in relation to the apheresis machines, which are developed for adults. The paediatrician
will carefully review the history of your pregnancy and labour with your midwife and will examine
your baby looking for signs of infection. Journal of Functional Morphology and Kinesiology
(JFMK). The confirmation of diagnosis and management of neonatal sepsis is challenging and time
consuming.Objective: The aim of this study was to find incidence of blood culture proven sepsis in
suspected early onset neonatal sepsis, find out sensitivity pattern of isolated organism and to find
association of risk factors and clinical signs and symptoms with blood culture proven
sepsis.Methodology: Prospective study was conducted in Nobel Medical College, Biratnagar from
November 2016 to November 2017. Conclusion: Early identification and interventions like careful
selection of antibiotics based on the clinical and etiological pattern of organisms in neonatal sepsis is
essential to prevent mortality and morbidity. In this literature review, the first related article found
was from the mid-1970s. Visit our dedicated information section to learn more about MDPI. In order
to establish a suggestive cut-off value for EOS, further studies are needed. However, the author
believes that the search was comprehensive with respect to the current state of neonatal sepsis and
its therapeutic considerations. Note that from the first issue of 2016, this journal uses article numbers
instead of page numbers. However, ET, which requires the use of fresh whole blood to improve
neutrophil function cannot be expected to advance in the future, as the emergent availability of fresh
whole blood has until recently been limited in most centers. Adverse events associated with
exchange transfusion in neonates and their incidence rates, as reported in studies conducted in the
2000s. Source: image.slidesharecdn.com Risk factors for neonatal sepsis. In their study regarding
adverse events related to ET for hyperbilirubinemia Patra et al. Feature papers are submitted upon
individual invitation or recommendation by the scientific editors and must receive. Its levels are
increased in systemic sclerosis, allergic rhinitis, and septic shock in adults. It may be acquired from
the mother, during intrauterine life, transmitted to the fetus mainly in the last trimester, or acquired
from the health care staff later, after birth. However, due to the delayed response, the sensitivity of
CRP increase at the time of evaluation for a clinical suspicion of EOS is low. You can also add CSF
HSV testing if the mother has this history or if the baby looks particularly ill. RELATED TOPICS
Medicine Sepsis Neonatal Sepsis See Full PDF Download PDF About Press Blog People Papers
Topics Job Board We're Hiring. The incidence of neonatal sepsis is inversely associated with
gestational age and birth weight. ET, exchange transfusion; R, retrospective study; P, prospective
study; F, fresh whole blood; ST, standard therapy; S, stored whole blood; RC, reconstituted blood
(packed red blood cells and fresh frozen plasma); ScT, standard care therapy; OR, odds ratio; CI,
confidence interval. A non experimental prospective cross sectional study was conducted for a period
of 6 months in Neonatal Intensive Care Unit and Sick Newborn Care Unit of tertiary care teaching
hospital located in Guntur. The number of articles published in the 1980s increased, that in the 1990s
decreased, and only a few articles were published in the 2000s ( Figure 2 ). Source:
image.slidesharecdn.com Bacterial sepsis is a major problem in. This review did not focus on drawing
conclusions as to whether ET is effective for sepsis; instead, the focus has been to comprehensively
map the various research results and adverse effects reported to date in order to provide clinicians
with information on the respective advantages and disadvantages of this treatment. Journal of Low
Power Electronics and Applications (JLPEA). Further studies are needed to address their
effectiveness and safety in newborns. Institutional Review Board Statement Not applicable. The
spectrum of organisms that cause neonatal sepsis changes over time and varies from region to another.
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers.
Sepsis is a significant cause of maternal, neonatal and child mortality. Neonatal sepsis is a blood
infection that occurs in an infant younger than 90 days old. New Antimicrobials for the Treatment of
Neonatal Sepsis Caused by Multi-Drug-Resistant Bacteria: A Systematic Review. Paper should be a
substantial original Article that involves several techniques or approaches, provides an outlook for.
Second, included studies presented variable study designs, not allowing direct comparison of the
results. Sepsis can be the clinical manifestation of infections acquired both in the community setting
or in health care facilities. Multiple requests from the same IP address are counted as one view. Just
remember that any neonate under 28 days old, no matter the birth history or maternal history, is
considered at risk for sepsis if they present to the ED with complaints of fever, poor feeding,
lethargy, or other systemic symptoms. Presentations for neonatal sepsis can be vague, varied, and
odd. Neonatal sepsis occurs when pathogenic organisms invade the bloodstream of neonates causing
generalized septicemia or localized manifestations like. We use cookies on our website to ensure you
get the best experience. Please let us know what you think of our products and services. While ET
using reconstituted blood (packed red blood cells and fresh frozen plasma) is expected to achieve
elimination of bacterial toxins and inflammatory cytokines, ET using fresh whole blood is expected
to improve neutrophil function. A non experimental prospective cross sectional study was conducted
for a period of 6 months in Neonatal Intensive Care Unit and Sick Newborn Care Unit of tertiary
care teaching hospital located in Guntur. Although advancements in prenatal screening and
intrapartum antibiotic prophylaxis over the past two decades have led to a significant reduction in
risk and severity, sepsis remains a major cause of morbidity and mortality in neonates. Testing
modalities for the detection and diagnosis of EOS continue to be developed, with novel laboratory
methods still being tested. International Journal of Translational Medicine (IJTM). Seven of the ten
patients showed immediate improvement and ultimately survived. Sustained vigilance will be crucial
in the diagnosis and neonatal sepsis management. However, ET, which requires the use of fresh
whole blood to improve neutrophil function cannot be expected to advance in the future, as the
emergent availability of fresh whole blood has until recently been limited in most centers. Despite
the abundance of research in the field of neonatal infection in the last decades, a marker or test used
in diagnosis of every case has not yet been developed. In situations when antenatal care is not
appropriate or available, identifying risk factors is not possible and EOS may occur as an unexpected
neonatal emergency. Treatment of Gram positives, such as methicillin-resistant S. New
Antimicrobials for the Treatment of Neonatal Sepsis Caused by Multi-Drug-Resistant Bacteria: A
Systematic Review. Source: desilusion.com Neonatal sepsis remains a serious complication,
especially among very low birth weight infants (vlbw, Source: image.slidesharecdn.com Signs and
symptoms of neonatal sepsis include Source: image.slidesharecdn.com Reviewed by clinical practice
committee. The incidence of neonatal sepsis is inversely associated with gestational age and birth
weight. Journal of Theoretical and Applied Electronic Commerce Research (JTAER). ET, exchange
transfusion; R, retrospective study; P, prospective study; F, fresh whole blood; ST, standard therapy;
S, stored whole blood; RC, reconstituted blood (packed red blood cells and fresh frozen plasma);
ScT, standard care therapy; OR, odds ratio; CI, confidence interval. Neonatal sepsis remains a
significant cause of morbidity and mortality especially in the preterm infant population. Source:
3.bp.blogspot.com Neonatal sepsis remains a significant cause of morbidity and mortality especially
in the preterm infant population. Sepsis is a rare but serious complication of an infection.
Seven of the ten patients showed immediate improvement and ultimately survived. New
Antimicrobials for the Treatment of Neonatal Sepsis Caused by Multi-Drug-Resistant Bacteria: A
Systematic Review. Low birth weight (56.3%) was the predominant risk factor for neonatal sepsis
and incidence rate was 20.6%. Klebsiella pneumonia (43.9%) was most isolated microorganism.
Neonatal sepsis (neonatal septicemia or sepsis neonatorum) is an infection in the blood that spreads
throughout the body and occurs in a neonate. Different antimicrobials are approved in adults for the
treatment of infections caused by organisms with unfavorable susceptibility profiles. Journal of
Experimental and Theoretical Analyses (JETA). Next Article in Journal Current Concepts in the
Etiology and Pathogenesis of Pectus Excavatum in Humans—A Systematic Review. This does not
necessarily mean your baby is more unwell. Neonatal sepsis onset at 7 to 30 days of life some studies
define late onset as everything after the first 72 hours sepsis neonatal, septicemia of newborn,
neonatal septicaemia, septicaemia of newborn. Results: A total of 207 neonates were included in the
study of which 88 neonates had culture positivity.34 neonates were early onset sepsis and 54 were
late onset sepsis. Paper should be a substantial original Article that involves several techniques or
approaches, provides an outlook for. All studies showed favorable efficacy and safety profile in
newborns and across different age cohorts. Finally, most data on the use of novel antimicrobials in
newborns were obtained from studies performed in HICs. Among these 560 neonates 80 near term
and term neonates with weight appropriate for gestational age had at least one episode of positive
blood culture. Titles and abstracts of all retrieved articles were screened to identify potentially
eligible studies, and all selected articles were analyzed in full text for conclusive evaluation. Sixty-
two percent babies were preterm and 80% were low birth weight. Exchange Transfusion in Neonatal
Sepsis: A Narrative Literature Review of Pros and Cons. New Antimicrobials for the Treatment of
Neonatal Sepsis Caused by Multi-Drug-Resistant Bacteria: A Systematic Review. Journal of
Cardiovascular Development and Disease (JCDD). Newer and more selective markers have surfaced
recently, such as presepsin and endocan, but they are currently only in the experimental research
stages. We use cookies on our website to ensure you get the best experience. Neonatal sepsis is an
invasive neonatal infection that can affect your baby. Journal of Functional Morphology and
Kinesiology (JFMK). Sepsis continues to be among the leading cause of neonatal deaths contributing
to 33% of neonatal deaths in india1, despite the fact that the field of neonatology has grown by leaps
and. Journal of Cardiovascular Development and Disease (JCDD). Signs and symptoms of neonatal
sepsis include Risk factors for neonatal sepsis. Neonatal sepsis remains a significant cause of
morbidity and mortality especially in the preterm infant population. In the ET group, statistically
significant improvements in base deficit, IgG, IgM, IgA, and C3 levels were observed. Multiple
requests from the same IP address are counted as one view. In order to be human-readable, please
install an RSS reader.
In this context, the value of CRP as a diagnostic marker for neonatal EOS is quite low. A total of 112
clinically suspected sepsis cases admitted during January 2017 to June 2018, 60 were found blood
culture positive. We use cookies on our website to ensure you get the best experience. These
combinations cover for Group B strep, E.coli, and other common gram negative pathogens.
(Ceftriaxone is generally NOT used in babies under 6-8 weeks, because it is thought to interfere with
protein binding with bilirubin, potentially causing iatrogenic hyperbilirubinemia). The majority of
studies have inadequate sample sizes and follow-up durations, varying inclusion and exclusion
criteria, and different or vague septic shock definitions and criteria for ET. Neonatal sepsis occurs
when pathogenic organisms invade the bloodstream of neonates causing generalized septicemia or
localized manifestations like. Sepsis can be the clinical manifestation of infections acquired both in
the community setting or in health care facilities. However, data on the use of these antimicrobials
are still limited for children and newborns; therefore, properly designed RCTs in these populations
are warranted, including newborns and preterm newborns, to specifically assess efficacy and safety
in these age groups. Sepsis is a rare but serious complication of an infection. The literature search was
limited to the English language. Just remember that any neonate under 28 days old, no matter the
birth history or maternal history, is considered at risk for sepsis if they present to the ED with
complaints of fever, poor feeding, lethargy, or other systemic symptoms. Presentations for neonatal
sepsis can be vague, varied, and odd. Please note that many of the page functionalities won't work as
expected without javascript enabled. Previous studies evaluating the efficacy of ET for neonatal
sepsis. Note that from the first issue of 2016, this journal uses article numbers instead of page
numbers. Precise estimates of neonatal sepsis burden vary by setting. Source:
image.slidesharecdn.com Differing estimates of disease burden have been reported from. If you
suspect HSV infection (i.e. if you're sent an HSV PCR) then you should also add IV Acyclovir to
the treatment regimen. Source: 1q3nfm4evj5z1sgm624e93ka-wpengine.netdna-ssl.com Neonatal
sepsis is a clinical syndrome consisting of nonspecific symptoms and signs of infection, accompanied
by a bacteraemia in the first 28 days of life. Upload Read for free FAQ and support Language (EN)
Sign in Skip carousel Carousel Previous Carousel Next What is Scribd. ET, exchange transfusion; R,
retrospective study; P, prospective study; F, fresh whole blood; ST, standard therapy; S, stored whole
blood; RC, reconstituted blood (packed red blood cells and fresh frozen plasma); ScT, standard care
therapy; OR, odds ratio; CI, confidence interval. Neonatal sepsis onset at 7 to 30 days of life some
studies define late onset as everything after the first 72 hours sepsis neonatal, septicemia of
newborn, neonatal septicaemia, septicaemia of newborn. Please let us know what you think of our
products and services. ET removes bacterial toxins and inflammatory cytokines from the blood by
replacing it with fresh and immunologically abundant blood, thereby leading to improvement in
tissue perfusion and oxygenation. Visit our dedicated information section to learn more about MDPI.
The confirmation of diagnosis and management of neonatal sepsis is challenging and time
consuming.Objective: The aim of this study was to find incidence of blood culture proven sepsis in
suspected early onset neonatal sepsis, find out sensitivity pattern of isolated organism and to find
association of risk factors and clinical signs and symptoms with blood culture proven
sepsis.Methodology: Prospective study was conducted in Nobel Medical College, Biratnagar from
November 2016 to November 2017. Neonatal sepsis is associated with increased serum sICAM-1
concentrations, which are correlated with severity of disease. International Journal of Environmental
Research and Public Health (IJERPH). Among the seven prospective studies, two demonstrated that
ET significantly reduced mortality. However, serum endocan could prove useful in combination with
inflammatory markers as a part of a diagnostic tool for EOS, or if used at a low threshold, for ruling
out sepsis, but more studies are necessary to establish the clinical utility of this molecule as a marker
for diagnosis of EOS. Moreover, the proposed cut-off values vary significantly between studies and
the accuracy as a diagnostic marker is questionable.
However, data on the use of these antimicrobials are still limited for children and newborns;
therefore, properly designed RCTs in these populations are warranted, including newborns and
preterm newborns, to specifically assess efficacy and safety in these age groups. Moreover, the
imbalance between proinflammatory and anti-inflammatory cytokines appears to be associated with
the severity of sepsis in neonates. A greater understanding of the pathophysiology of sepsis has led
to multiple potential therapeutic targets for interventions to improve outcomes. Cefiderocol is also
recommended for the treatment of carbapenem-resistant A. While ET using reconstituted blood
(packed red blood cells and fresh frozen plasma) is expected to achieve elimination of bacterial
toxins and inflammatory cytokines, ET using fresh whole blood is expected to improve neutrophil
function. Sepsis is a serious infection that causes your immune system to attack your body. In such a
scenario, clinicians often attempt drastic but unproven and more invasive treatment methods to save
rapidly deteriorating neonates with severe sepsis. However, in the case of neonatal population there
are multiple other pathological situations, aside from infections (bacterial or viral), associated with
an increase of CRP, such as rupture of membranes (which induces an increase in CRP levels by 0.4%
per hour), active labor (14.5% per hour), maternal administration of steroids (40%) or intrapartum
antibiotics (28%) or chorioamnionitis without invasive fetal or neonatal disease. It potentially results
in significant morbidity and mortality for the affected infant, particularly if treatment is delayed.
Sepsis continues to be among the leading cause of neonatal deaths contributing to 33% of neonatal
deaths in india1, despite the fact that the field of neonatology has grown by leaps and. In neonates
with risk factors and clinical suspicion of EOS, currently used biomarkers have insufficient
predictive performance and confirmation of diagnosis by positive cultures is not always possible in a
timely manner. Neonatal sepsis onset at 7 to 30 days of life some studies define late onset as
everything after the first 72 hours sepsis neonatal, septicemia of newborn, neonatal septicaemia,
septicaemia of newborn. It is used to remove antibody-coated erythrocytes and products of
hemolysis such as bilirubin in various immune or non-immune hemolytic diseases. Signs and
symptoms of neonatal sepsis include Sepsis neonatal from image.slidesharecdn.com This
bloodstream infection can cause fatal diseases like pneumonia, gastroenteritis, meningitis, or
pyelonephritis. A total of 112 clinically suspected sepsis cases admitted during January 2017 to June
2018, 60 were found blood culture positive. It potentially results in significant morbidity and
mortality for the affected infant, particularly if treatment is delayed. Sepsis continues to be among
the leading cause of neonatal deaths contributing to 33% of neonatal deaths in india1, despite the
fact that the field of neonatology has grown by leaps and. Neonatal Sepsis, Brain Damage, and
Medical Malpractice from 1q3nfm4evj5z1sgm624e93ka-wpengine.netdna-ssl.com Sepsis is a
significant cause of maternal, neonatal and child mortality. Exchange Transfusion in Neonatal Sepsis:
A Narrative Literature Review of Pros and Cons. J. Clin. Med. 2022, 11, 1240. Papers were excluded
if their content was not relevant to the topics of neonatal sepsis, ET, or plasma exchange (PE).
Although most studies have shown clinical benefits, other authors have reported different results.
The literature research was conducted using the well-established PubMed, Cochran Library, Google
Scholar, and ResearchGate databases. Based on the extremely recent introduction of novel
antimicrobials in newborns and pediatric age in general, we decided to consider all studies on patients
younger than 18 years, to collect all available data for the developmental age. Neonatal sepsis is an
invasive neonatal infection that can affect your baby. Journal of Theoretical and Applied Electronic
Commerce Research (JTAER). Just remember that any neonate under 28 days old, no matter the birth
history or maternal history, is considered at risk for sepsis if they present to the ED with complaints
of fever, poor feeding, lethargy, or other systemic symptoms. Presentations for neonatal sepsis can be
vague, varied, and odd. Moreover, study selection was determined by only one researcher.
International Journal of Environmental Research and Public Health (IJERPH). Exchange Transfusion
in Neonatal Sepsis: A Narrative Literature Review of Pros and Cons. Sepsis can be the clinical
manifestation of infections acquired both in the community setting or in health care facilities.