’ eet RAEI: if : Fi Ee ECAIN, «=o m ¢ 18-08, aoe ft Bl largo... ee ly da the aiaiokingINSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL | Nw Blanche Lene, South Mimms, Potters Ber __, vaLsioLopIcAL = 7 Hortfordshira, EN6 306 ~~ BARDS BOARD = 2 : - talegreins Nibsac Potters Bar aan eee : {elox 21011 Nibsac @ gical Standards | fax noi- 0707 46854 . talaphone Patiary Bar (A707) A783 & 64788 ° a From the Director 21 December 1990 Pax LX CONFIDENCE + PO DR REMY METERS URGENT Dear Dr Hatters ab aenale bub doce (ew) As you will know, we have Aecently curcieit out abnormal! toxicity teating in laboratory aninaia on certain batches of : B, authzaeds and portuoate véecine. When each af the two __vaceines were. casted. wlous fey were not acsoclated with saw an trusual degcee of toxtedeyA ovever, when conbined there tau evidence of severe logs of conditdon and wadght loss in aninale. J would emphaatae that these findings gee peelininary but thay do suggest that 4f used in man aa a GombLued pre; an anheaced degraé of reactagenicity could occur, The yaur: rue vaccines may wtah to take these finddnus’ (x conadderation. Youru aincerely, : Dr ceromy Matters Deparment of Heateh Richaend Wonse Whitehall LONDOM SW