BENGALURU CENTRAL UNIVERSITY SYLLABUS FOR M.Sc CHEMISTRY CHOICE BASED CREDIT SYSTEM (SEMESTER SCHEME) 2019-2020 onwards‘A meeting of the Board of Studies in Chemistey (PG) in the Department Library to approve the proposed onwards, was held on Thursday the 10" Jan, 2019 at 10.30 am M.S¢., CBCS syllabus with effective from 2019-2020 The BOS, Chairman welcomed the members and ag Was placed before the members. The members a Chemistry syllabus: with modifications wherever ne discussed and the corrections have been incorporated Ber the agenda the M. Sc:, CBCS Chemistry syllabus ftes careful serutiy approved the M.Sc, (CBCS) vessary. The following papers have been thoroughly SEMESTER ‘Code No, Title =| * | ebay Inorganic Chemistry |___— h-102 | Organic: Chemistry T Che1035 Physical Chemistry [ Chios Analytical Chemistr i Ch=105 Mathematies for Chemists (Soli Core) Ch-106 | Practical-] —Tnor Z ; Galo? Practical nor Gen Phy —_Che08 | Practical- ii Thorg/Org/Phy cl | “Practical-IV_thor, Practical-IV InongiCrg/ Phy: SS 1 SEMESTER | inorganic Ch [Organic Chemistry 11 saa ,_Physical Chemistry 11 | Spectroscopy = | ‘Green Syiihesis/Photo Chemistry (Soft Core) —] Fractigal-I InorgGra/Phy Proetical-T_InowwOrg/Phy Practical-IIT InorgiOrs/Ph; Finally the Chairman thanked all the membersMEMBERS PRESENT Prof, B. Narayana Prof. Boja Poojary Prof. V. Gayathri Prof. 8. Hariprasad Prof. P:R. Chetana Prof. K. Shivashankar Dr. G. Krishnamurthy: Prof. M, Panelurangapy - External member Enteral member fe Sh = beastie Gpemsgosisoiela Theil meinbee Ggoakee? pel = Iaternat rember FL) AL) = Thiernal member —— - ~ Internal member pa CHAIRMAN, WH. a bor yeh dw ogfai|>919 A M. Tien Genital Goniege Compus ‘br, Armpedieor Yee. 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Duration of the Course Two Years (FOUR SEMESTERS, CBCS) 3 Eligibility A candidate must have secured 40% marks in the aggregate and studied Chemistry (cognate subject) securing. $0 % marks in this subject at the B Se., level and studied Mathematics at 10 + 2 or Pre-university level. 40 + Supernumerary seats + Payment seats= 60 (Total) As per University regulations Scheme of Study and Examination M. Sc., CHEMISTRY. L Semester Code Title Theory? | Total Duration | Max, | Continuous | Total] Credits No Practical Naot — or Marks | Evaluation | Marks Heal Exam. — | (Exam) Semester_| Hows Thorganie Chel | Chemistry 1 4 2 4 80 at | too | 4 Organic 80 4 Ch-162 | Chemistry 1 4 3 20 oo Physical q Ch-103 | Chemistry 1 4 52 3 30 20 100 Analytical Chemistry 80 4 20 100 4 2 3 Mathematies for Ch-105 | Chemists 3 36 a 20 100 | 2 (Soft Core) 80 Ch-106 | Proctical-1 InorgiOrg/Phy 4 60 4 38 15 50. CB-107 | Practieal-tt InorwiOrgiPhy 4 6a 4 35 15 30 Ch-108 | Practieal-tIl 2 Inorg/Org’Phy 4 60 4 35. 1s 30 Th-109 | Praetical-1V z Inceg/Org/Phy 4 60 4 35 15 30 Tora 700 | 26 marks/creclitsI Semester Code Theory] Toil Duration Max. | Continuous | Torl | Credia No. Pructicall No.of — | of Marks | Evaluation | Marks (Hrs! Exam, | (Exam) Week) | Semester | Hours | —Trewae ——| ane Ch-201 | Chersistey-I1 4 3 80 0 wo 4 ‘Organic T Ch-202_| Chemistry-I 4 2 3 80 20 too Physical 80 20 Ch-203_| Chemistey-II 4 52 3 Lod 4 Ch-205" | Spectroscopy-t 4 ae 3 3 2 10] 4 Ch-208- | Green Synth 3 36 3 loo] 2 Photo Chemistry (Soft Core) 80 20 Practical Inorg/Org/Phy 4 % 2 Practical-tI is { Inorg/OrgPhy ‘ c z h-208 | Practical-I1 lnony/OrgPhy 4 0 4 35 15 x 2 CH-209 | Practical-IV lnorwiOnyPhy 4 60 i 15 50 2 Total a marksleredits Practical: 30 marks for experiment + 5 marks for Viva-Voce IA Marks based on Test + Assignment + Seminar + Records Scheme for continuous evaluation ‘Theory (each paper) Tests: 20-marks Tort; 20 Marks * Two tests will be conducted and the average marks of the two teat will Be taken for Continuous assessment. * There should be minimum marks of $19 be seored out of20 for getting eligibility to attead the final University examination, Practieals: (each practical) Test (1 Test) 1Smarks Total 15 marksQUESTION PAPER PATTERN Semester I: Sub: Chemisiry Time: 3 Hrs Max. Marks: 80 Note: Answer question Number one and any SIX io the remaining. 1, Answer any TEN sub div ions trom the following (10x2=20) 2409 (6x10=60) b) {5#5) ar (6F4}0r(3+3+d)SEMESTER -1 Ch-10L [INORGANIC CHEMISTRY: I UNIT-1 ish Chemical Bonding- VSEPR model, shapes of rwolecules-ClFy, ICL. TeFs, Ii, TeCl, XeF, SbCl" WF Rek;, XeFs?, TaFs"; Bent rules and energeti¢s of hybridization; electronegativity-Pauling, Allred-Rechow and Mulliken, electronegativity and partial ionic character; Bonds- Multicenter, Synergic and Agostic bonding, Lattice energy: Born-Lande equation, Kapustinskit equation; Fajan's rules polarizability and partial covalent character, radius-ratio rules-limiting radius ratios of trigonal, tetrahedral, octahedral and cubie, Structures af” solidsNaCl, CsCl, ZnStaine’ blende and wurtzite}, rutile( TiO2), perveskite(CaTIO;), Auorive and anti Muce Zinil ions, Molecular orbital theory: formation of sigma, pi and detta'bonds, LCAO and MO diagrams of heteronuclear distomic (CO, NO, HF and IC!) and triatomic molecules (COs and NO: UNIT 13h ‘Chemistry of main group elements. Boranes- nomenclature, synthesis, structure and bonding in boranes, styx code, carboranes- classification, structures of ortha, meta, para-C2BjHis, Wades rules, Metallocarboranes- synthesis and structure of [Fe(n?-C:8sHi 2s]. Fetn -CaBell )oy'-CsHs}, [Mo(CO)sth 2BoH))}". synthesis, structure and bonding in borazine, phospharenese synthesis, structure and bonding in (PNCI:), Ne compounds: Sis. S3Nz and polythizyl cates: Principles of silicates structures. classification with examples-ortho, pyro, cyclo, ino. phylto and tecte silicates, isomorphous replacement; ceolites- sedalite ‘and penuasil units, synthesis and steuctures of ZSM-5, zeolite A, faujasite and their uses. UNET-HL 13h HSAR concept: Basis of HSAB concept, acid-base strength, hantness and softness, symbiosis, applications and limitations of HSAB eoncept; Acid= base concept in non-aqueous media, reastions in Brf. N04, anhydrous H28Os, CHiCOsH. Isopoly and teteropoly acids of Wand Mo, preparations, properties, structure and applications: ‘Stereoisomerism- Chirality, optical activity- CD. ORD, Cotton effect, absolute configuration of ‘metal complexes, magnetic circular dichroism and its uses. UNETIV 13h Metal elusters- factors favouring M-M bond, classification, synthesis, structure and bonding in [Rez]. Metal carbonyl clusters: LNCC’s: and HNCC’s. Electron counting in carbonyl clusters, Wades-Mingos and Lauber rules, Nuclear Chemistry-The atomic nucteus-clememary particles, quarks, classification of nuclides based on 2 and N values, nuclear siability, nuclear potential, binding energy, Nuclear Models: Shell mode!-salient features. formsof the nuclear potential, filling of orbitals, nuclear configuration, Liquid drop model. Radiowctivity. rudioastive decay kineties, Parent-daughter deeay.growth relationship-seculae and transient equilibria, theories of @, P' f° anc! y-decay, intemal conversion, Auger effect,SUGGESTED BOOKS: 1. Basic Inorganic Chemisty F. A. Cotton, G. Wilkinson and P. L. Gaus; John Wiley and sons, Inc, 3 editian (2004). 2, Advanced Inonganic Chemistry, F, A, Cottorand G, Wilkinson, 6 edition (1999), 3. Inorganic Chemistry, J. E. Huheey, E, A, Keiterand R, L. Keiter, LY edition ‘Audis; Wesley (1993). 4. Inorganic Chemistry. D. F, Shriver, P. W. Atkins and C. H. Lanaford, ¥ edition ELBS; Qsford University Press, (2010) Chemistry of elements; N,N. Greenwood and A, E, Earnshaw, Butterworth, 1 edition Heinemann (1997) 6, Concise Inorganic Chemist 7. Essentials of nuclear chem Chapters |, 3 and 4, 8. Nuclear and Radio chemistry; G.Friedlander, 3.W.Kennedy, ES Macias and JM Milter, 1981, Chapters Sand 9. 9. Inorganic Chemistry, Gary. L. Miessler and Donald. A. Tarr 3" Edition: (2014), 10, Inorganic Chemistry CE House crofl and A G Sharpe 4" edition, pearson (2012). 14. D, Lee. W edition; (1996). 4. HJ, Amiker, 4nedition; NAIL publishers (201 1) Ch-102; ORGANIC CHEMISTRY- I UNIT 52 Hours, in ecules 13h d chemical homing: Conjugation, cross conjugation, resonance, Hyperconjugation Tautomerism. Aromatictty: Huckel’s MO theory. HMO diagram for benzene. Huckel's rules of aromaticity. “Aromatic systems with electron numbers othe: than six (including azulene, tropone, tropolone and ‘annulenes), Antisaromaticity, Aromaticity in benzenvids. Homo-aromaticity. Altermant and non- “shertant hydrocarbons. Energy levels in add and éven-attemant hydrocarbons, enerey levels for the benwy| cation, benzyl free-radical and benzyl carbanion. Mesoionic compounds. Heteroannulenes. Fullerenes: C-60. Swirhctic Moleeular Receptars: Definition and signifieance. Structure and fimetion of receptors With molecular clefts, molecular tweezers, receptors with multiple hydrogen bonding sites. Crown thers, cryptates, cyclodextrins, cyclophanes, eatenanes and rotoxanes, calixarenes, ionophores, and micelles. Reaction Mechanisms: Structure and Reactivity 13h Reactive Intermediates: Generation, structure, stability and reactivity of carbocations, carbanions, ‘carbon free radicals, carbenes, “Non-classical cabocstions, Nitrenes. Classiffeation of reactions and mechanisms. Thermodynamic and kinetic requirements, kinetic and thermodynamic control, Hammond postulate, Curtin-Hammett principle, Povential energy diagrams, transition stares and intermediates. bMethods of determining mechanisms: Based ‘on the siructare of petdusts, determination of the provenee of intermediates, jsnopie labeling, istope effects, fm stereuchamies! “Siereachemistry ata Glance J Eames, JM Peach, Blackwell, Crxford, (2003), | Heterocyclic Chemistry at a Glance, IT edition, 14 Joule and K Mills, Wiley, New York, (2012), }4 Organic Chemisiry, Valume |, LL Finar, V1 edition, Pearson, 42018). 1S. Organic Chemistry. Volume I, 1 L Finar, Vledition, Pearson. (2018 ©b-103 PHYSICAL CHEMISTRY- I UNIT ‘Quantura Mechanics+1 13h Introduction te quantum mechanics. Schrodinger wave équation, Timesindependent und tims dependent Schrodinger wave equations and the relation between their solutions, Eigen functions and Eigenvalues, Physical Jateepretation of wave fumction. Concepts of Operators: Laplacias, Hamiltonian, Linear and Hermitian operators, Angular Momentum opemtors and their properties. Commutation of eperaton Nomnaiization, trthogonality and orthonormality of wave fianetioss, Average (expectation) values. Postulaies of quantum mechanics. Solutions OF Schaddinger wave equation fora free particle, particle in ring, particle in @ three dimensional box- Quantum mechanical degeneracy. wnineling, (to derivation). Application ‘of Schrodinger equation to harmonic oscillator, gid rotator, Eigen fiinetions and eigenvalues of angular momemum. Ladder operator method tor angular mamentum. UNIT-L Quantum Mechanies-I 13h Saheodinger equation to. hydrogen atom in spherical polar co-ordinates. Solution of 1. 1. equation and aaeenente of solution of & equation. Total wave functions of hydrogen atom. Quantum numbers and their Saerreeiies Lit af wave functions Tor few initial states of hydrogen like atoms, Diagrams of radial ant angular wave functions. Radial and angutar distibution funtion and their significance, Glectron spin 4(Stem-Cerlach experiment), spinosbilal, anti symmeuy and Paull excision principle, Slater determinants. Coupling of Angular rramenia, RussellSaunders and JJ-cowpling. Atomic Term symbols. Spin-ortital Tenctgn and explanation of erm multiplicities (Na-D doublet), Zeernan effect. Approximate mthods: Need for approximate methods, Perturbation metho’ Rayleigh Schwinger perturbation They for time-indeperident non-degenerate system. Application 10 efectrog i & Has under the influence af an ee eld, application to He atom. Warltion theery-statement and proof, Application of variation method to particle in a one-dimenstonal box and He atom. UNTT-IL Chemical Dynamies-t 13h Macroscopic and microscopic kinetics, Review of theories of reaction rate-Collision theory and Transition state theory, Comparison of callision theory with transition state theory, Arrhenius equation- characteristics, Signficanee of energy of activation, Temperature coefficient and its eee uation, Thermodynamical formulation of reaction rates (Wyre-jones and Eting tweaiment), Reaction between 1ons In solutions ~ Influence of tonic stcength on reastion rates (primary ang secondary salt effects) Concept of Steady state kinetics. Chain reactions ~ chain length and ‘chain inhibition, comparison of photochemical and thermal reactions, Mechanisms of thermal and ‘photochemical reactions egwsen hydragen-bromine and hydragen-chlorine, Comparative study of therm hd photochemical hydrogen-halogen reastions. Pyrolysis of acctaldehye, Decomposition of ethane, Kineties of fist reactions Imroduction, Study of reactions by relaxation method (Teerperstie ud presaarejurmp), flow method (Plug low meynod and Stopped flow method), Fash photolysis and Shock tube method UNET-IV, Chemical Dynamies-U 13h Kinetics of homogeneous catilysis: kineties of auto catalytic reactions, Kinetics of ncid-base catalysed fractions. Comparison of eazyme catalysed and chemical cutalysed reactions, Mechan/sm (Lock and Key theory). Kineties of enzyme catalyzed reactions — Henri-MichaelisMenten mechanism, Significance of MichaelissMenten constant, Lineweaver-Burk plot Effects of enzyme concentration, pH, Temperature, Activators and Inhibitors on enzyme setivity Unimoleuclar reactiogs: Perrin theory. Lindemann theory, and Hinshelwood theory. Surtace-chemistry: Types of adsorption isotherms, Effect of emperatare on adsomption, Mechanical adsorption, Estimation of surface arca using BET equation, Gibbs adsorption isothenn ave afghifieance, Surface tension and sucfue energy, Pressure difference across curved surface {Laplace equation), Vapour pressure of droplets (Kelvin equation), Surface film an tiguids felectro-kinetic phenomena), Catalytic activity of surfaces. SGGESTED BOOKS Physieol Chemistry: P. Atkins and J, D, Paula, 9th Edn... Oxford University Press (2010). iy A Molecular Approach.D. A.MeQuarie and Simon, Viva. New Delhi, (2003), 5) tamodyetion #0 Quantum Chemistry. A. &. Chandra, 3"Edn. Tate MeGraw Hill, (1991) 5 14, Quantum Chemistey, Int, N. Levine, Prentice Holl, New Jersey, (1991), 5. Quantum Chemistry, R. K, Prasad, ‘New Age Intemational, 4" Edn., (2010). 6. Quantum Mechanics by G R Chatwal and § Anand, Himalaya Publications, 8"Edn, 2012. 7. Chemical Kinetics- K. J, Laidler, McGraw Hill, Ins. New York (1988). 8. Principles of Chemical Kinetics ~ House J. E, Wm C Brown Publisher, Boston, (1997) 9. Kinetics and Mechanism af Chemical Transformations-J. Rajaraman and 4. Kuriakose, Me Millan India Ltd. (2061). 10. Biochemistry, - Geoffrey Zubay, 2nd ‘Eda, Macmillan Publishing Co. New York (1988), JL Physical Chemisty of Surfaces- A. W. Adamson, Wiley-Interscience Publisher Ine. New York (1997): Id. tmtaduetion wo surtice chemisty and Catalysis by Gabor A. Sombqjaiand Yimin Ui, dohn 2°Edn Wiley and Sons Ltd. Hoboken, United States. 2010. Ch-104 Analytical Chemistry UNIT Basie comcepts wh Practicing safety measures in chemical biboratories, Fire hazards, toxic chemicals: Acdsthases/solveats funding, storage, dilution, disposal of chemicals, acd/ solvent bores ete. tonie chemicals sarnpling and handling hazards. safety data sheets, miniaturization of analytical instruments, theirs chemical analysis. Preparation of dilute acids from concentrated fuming acids ike H:80s, handling liquid bromine, elemental mercury. solvent ether, liquorammonia and other chemicals, Errors in chemical analysis: absolute, relative error, candor error distribution, Gaussian curve, Limitations of analytical methods, determinate and indeterminate errors, minimization of errors. Accuracy and precision, distribution of random ernars, he normal error curve. Statistical treatment of finite samples ~ measures of central tendency and variabitie median, range, standard deviation, variance, confidence limits fleance in modern ‘mean, ‘Comparison of an experimettal mean and a true mean, Fetest. rejection of result - Q-test, Student's test, numerieal problems, UNIT-IL Quantitative Analysis-Classical methods 13h Classification of analytical methods, types of instrumental analysis, factors influencing choice of analytical inethod, quafitative and quactitative analysis, Units used in chemical analysis,theix eanversion, ppm. ppb. PPL ate. ‘Titrimetry “Acid-Base: Theory of indicators, Ex: Pheitol-phthalien, Methyl red. Titration curves for mono funetionel acid ‘and base, pH calculations, fractions of phosphoric acid species as a function of pH. Titration eurves for HPO. Complexometry: Theaty of metal ion indicators, EDTA titrations, suitability of polydentate ligands a5 titrant, expressions for the differen farms of EDTA in solution as.a funetion of pH, conditional stability constants, effect of pH nd nature of titration curve. Masking and demasking, type of EDTA titrations, titrations involving monodentate bidentate und poly dentate ligands Redox: Mechanism oFindicator action, ¢riteria for the selection of indicators. Feasibility of redox titration. Titration of multicomponet system, Nemst equation. Applications: Oxidamts such as Ce(IV), bramate, todates, 6Precipitation: Solubility product, Theoretical principles of precipitation: Titration curve, end poim detection, Mohr, Vathard and adsorption indicators, Applicmions: Estimation of F.K’. COs", C0," aeetylenes and mixture of halides. Gravimetry Quantitative precipitation, Precipitation from Homageneous Sofutton (FHS). Formation and treatment of precipitates, co-precipitation, post precipitation. Conditions for precipitation, washing. drying. and igniting the precipitates. Important precipitating agents Such as DMG, oxine, thiocyanate and their significance: in inorganic analysis, errors in gravimetric anal ysis, Unite[1 - Quantitative Analysis ~ Instrumental methods(Spectrasco py) 3h Fleciromagnetic radiation, interaction with matter, absorption, Beer-Lambert's law, dccivation, molar absomtivity, Sandell sensitivity, Ringhom plot, deviations, limitations, Calibration with standards, standard ‘addition, internal standart addition, Yimit of detection, limit of quantification, Instrumentation, radiation sources, ‘wavelength selection devices, optical slits, single beam and double beam instruments. photo electric colorimeter, seanning devices, merits and limitatiens, numerical problems on- application of Beer's aw. Unit LV- Separation Methods 3h Solvent Extraction — Types batch, continuous, efficiency, selectivity. Distribution coefficient, Nemst distribution law. derivation, factors affecting the partition, applications. Chromatography ~ Types, Terminology, Principles of paper, thin layer, column, gas chromavography, column efficiency, plate theory, factors affecting, the column efficiency, bind broadening, Rr factor, VareDecmter equation. medium performance liquid chromatography. high performance liguld chromatography, reserved phase liquid chromatography. super critical fluid chromatography, characteristics of super critical fluids, 2D-thin layer chromatography, electrophoresis, principles, appticutions ete, numerical projslems on solvent extraction, Rf feetor and van Demeter equation Suggested books: 1, Fundamental of Analytical Chemistry, D.A. Skoog, D.M. West, Holler and Crouch. 8° edition, Saunders College Publishing. New York, 2005 2. Analytical Chemistry. jan, 6” edition, John Wiley & Sons, Inc, India, 2004, 3 Quantitative Analysis, R.A. Day and A.L, Underwood, 6" edition, Prentice Hall, Inc. New Delhi, 1993 4. Vogel's Texthook of Quantitative Chemical Analysis, 1. Mendtum, 8.C, Denney, 4.0. Barnes and MJ.K Thomas, 6"edition, Third Indian Reprint, Pearson Education Pvt. Lad., New Dethi, 2003. 5, Analytical Chemistry Principles, John H. Kennedy, 2" edition, Saunders College Publishing, California, 1990. 6. Principles and Practice of Analytical Chemistry, FW. Fiffeld and Kealey, 3" edition, Blackwell Sci. Lid. Malden, USA, 2000, 7. Moder Analytical Chomistry, David Harvey, McGraw Hill, New Del &. Practical Volumetric Analysis, Peter A © McPherson, RSC, Cambridge, UK, 2015. 9 f Analytical Chemistry for Technicians, John Kenkel, 4" edn. CRC Press, London, 2014, 0. Undergraduaie Instrunental Analysis. J,\¥, Robinson, E.M. Skelly Frame, G.M. Frame tl, 6° edn. Marcel Dekker, New York, 2009,Ch-105 MATHEMATICS FOR CHEMISTS: UNIT-I 12h Vectors: vectors, dot and eras products; scalarand vector triple products and their applications. Tenors and their applications. Matrix Algebra: Review of different types of matrices (ineluding Hermetian and skew Hermetian): matrix addition and mouliplicasions.detenninant of n square matrix, transpose, adjoitt and inverse of @ square matrix, Solution to system of linear equation (a) by matrix method and (b) by Cramer's Rule. Characteristic equation of square matrix, eigenvalues and eigenvectors. UNIT-H Dh Calculus: Rule for differentiation; Chain mule (for fXJ@U", sin u, log u_ ete). Implicit differemtiation und paramictric differentiation and successive differentiation of order 2 lor explicit functions only), Applications of differentiation: Derivative as-a slope of the langent, derivalive ds 4 rate measure-velocity and aceeleration, Increasing. and decreasing functions-Maxima and minima-second derivative test-point of inflectionseproblems restricted 19 polynomial, UNITE 12h Integrations: Basic rules-simple substitution-Method of partial fractions-Integration by parts. Define integral and application to areas of plane curves. Punetions of several variables: partial derivatives; co-ordinate transformation from gartesian co-ordinates 10 spherical and cylindrical coordinates and Vise-versa Elementary differential equation: Variable separable, exact first order equations, linear and homogeneous equation, Second order homogeneous differential equation with constant coefficients f(D), y~8. Solution ‘of differential equation by pawer series method. Fourier series: Simple problems. Probability: Review of permutations and combinations. Probability and addition theorem for mutually exclusive events and rmultiplication theorem for independent events. Curve fitting-Method of least squares. SUGGESTED BOOKS 1. Mathematical Preparation for physical ehomistry, F. Daniels, M.Graw Hill Ine. US, 1959, 2. Mathematics for chemists, D. M. Hirst, Chemieal Publishing Company: Incorporated, New York, 1979. 3, Mathematies for chemists, #..G, Francis, Springer, 2011 4) Basie Mathematics for cheinists, P, ebutt, Wiley-Blackwell, 1994 5. Calculus and analytic geomerry, 9" edition, G. B. Thomas, R.L. Finney, Addison-Wesley Publishing: Company, Inc. 1995, 6, Short Course in differential cquations, Rainvilies and Bedient, [BH publishers, 1968. 7. Mathematics for chemistry, G. Doggett and 8. T. Sutelitie Longmann Publishers. 1% 8Ch-IN6! PRACTICAL -1 INORG ANIC/ORGANICIPHY SICAL INORGANIC CHEMISTRY PRACTICALS, (4 days a week, 4 hours a day) C-406 Inorganic Chemistry Practical! ms and one Semi micro qualitative analysis of mixtures comaining two anions. two comman cal less familiar elements: W. Mo Ce, Zt, V and Li C-107 Tnorganie chemistry practieal-I Preparation af inorganic complexes: L. Cis- potassium dioxalatodiaquachromium( IIT) complex. 2, Hexamminecobalt( {11} chloride. 3, Mercury tetrathiecyanatocebaltate. 4 Pentamminechlorocobalt( ll} chloride. 5. Potassium tris(oxalatoyferrate trihydrate. 6. Potassium tris(oxalatoyaluminate trihydrate C-108 Inorganic Chemistry Practical HIT Gravimetric analysis 1, Determisation of Fe in iron ore as FeO Detetin ination of Nias nicheldimetlyylglyoximate in Cu and Ni solution. Determination of Ca as CAC04, 4, Determination of Al as aluminiumoxinste. 5. Determination of Cu as CuSCN in Cu and Fe solution ‘6. Determitiation of Zn as ZnNHsPO. €-109 Inorganic Chemistry Prastical-1¥' ‘Volumetric analysis 1. Determination of Ca and Mg in Dolomite solution using EDTA. 3 Determination of Cu in Cu and Ni Solution iodomettically. Determination of Fe in Cu and Fe solution (using K:Cr0)), 4, Determination of Cr and Fe in a mixtere using cericammoniumsulphate, 5, Determination of Fe and Al in mixture using EDTA, 6. Determination of percentage of Fe and oxalate in K,Fe(CO,))3H20 Suggested Books: 1. Vogel's Text book of Qualitative Chemical Analysis, J. Bassett, G. H, Jeffery and J, ‘Mendham, 7° edition, ELBS (2013), 2. Vogel’ stext book of Quantitative Chemical Analysis, 6" Edition, J, Bassett, G. H, Jeffery and J, Mendham, and R, C, Denny, JD Bames, M.Thomas Prentice Hall (2000) 3. Inorganic Seimimicro Qualitative Analysis. V. V, Ramanujam; The National Pub. Co (1990), 4, Practical Inorganic Chemistry, G, Marr and B, W, Rockett, Von Nostrand Reinhold Co, London (1972) §, An Advanee course in practical chemistry, A Ghoshal. B Mahapatra and A K Nad; New central book azency Pvt.Ltd, 3" eidition 2007 f, Advanced inorganic analysis, § K Agarwal and Keemuilal: Pragati prakashan, 12° edition 2014, gqORGANIC CHEMISTRY PRACTICALS (4 days.a week, 4 hours x day) Ch-106 Organic Chemistry Practical-1 Preparation (one stage} ‘Oxidation of cyclohexanol. Preparation of S-ben7ylisothiurosiumehtoride Synthesis of picric avid. ‘Synthesis af glicose pemtaacetate, Synthesis of 3,4,6-tibromoaniline & —-Cannizarto reaction; benaaldehyde to henzy! alcahol and benzoic acid. 7. Dehydration of eyelohesanol to cyclohexene 8. Claisen-Schiidt reaction: beizaldehyde and acetone to dibenzalacetone, 9, Sandmeyer reaction: 4-ehloraoluene from4-toluidine. 10. Pechmann reaction: resorcinol and ethylacetoacetstc to 7-hydroxy-+-methyleoumarin 11... Synthesis of 24-diehlorophenoxyacetic acid, 12. Synthesis of resacetophenone from resorcinol, weber (Ch-107 Organic Chemistry Practical-ll ‘Qualitative analysis Systematic analysis and identification of bifunctional organic compounds Ch-108 Organic Chemistry Practical IIL Preparation (Two and three stages) 4 ‘aniline from acetanilide 4-Bromonniline fromacetanitide B-Nitrobenzoic acid from benzoic acidimethy! benzoate, 2,4-Diniteophenylhydrazine from chlorobenzene. N-Methylanthranili acid from phthalic acid. Benzanilide from benzophenone. Benzilic acid liom benzoin. Synthesis of acridene, Sgnthesis of hydantcin. a Anthracene to anthrone 40, Succinic acid to N-bromosuecinimide LL. Maleic aeid co dimethylacety lenedicarboxylate, Senge Ch-109 Organic Chemistry PracticaltV Quantitative analysis ‘Titrimetric estimation of mone-, dicarboxy Estimation of carboxylic acid in presence of an emidefester 3. Suponification value of oil 4. Estimation af glucose by Fehling’s method’ Berttand’s method §, Estimation of keto-group. 6 1 loxyacetie acids Estimation of phenols, |. Hodine value of oil (Chori ‘nex? method) Acid and ester, avid and amide in the mixture of two, 10ry SUGGESTED BOOKS 1, Vogel's Text Book of Practical Organic Chemistry — V edition, B.S. Furniss, A. J, Hannaford, P, W. G. Smith and A, R. Tatchell - Pearson, (2003), 2, Laboratory manual of Organie Chemistry- B. B, Dey, M. V. Sitaraman and T-R. Govindachari, Allied Publishers, New Delhi, (1996). 5, Practical Organi¢ Chemistry, [V edition, — F.G. Mann and B.C. Saunders, ~ Pearson, 2009). 4 Text Book of Practical Organic Chemistry including qualitative analysis ~ IY Edition, A.A. Vogel and A. R. Tatchell, Longman, London, (1996). 5, Test Book of Quantitative Organi Analysise A. 1 Vogel. (1996). 6. A Handbook of Organic Analysis ~ Qualitative and Quantitative ~ IV Edition, HT, Clarks, Hedder and Staughton, New Dethi (2017), 7. Comprehensive practical organic chemistry: Preparation and quantitative Analysis, 8. V,K, Ahluwalia, R. Aggarwal, Universities Press (India), 2000. 5. Comprehensive practical organic chemistry: Qualitative analysis, V. S. Dhingra, Universities Press (India), 2000, 10, An advanced course in practical chemistry, A. Ghoshal, B. Mahapatra and A.Kr, Nad, New central book agency, Caleutts, 2000 11 Advanced pesctical organic chemistry. 1. Mohan, ol. [and Il, Himataya Publishing House, 1992. 12, Practical organie chemistry (Quantitative analysis). 8. B. Dey, M, WY. Sitareman and T.R. Govindachari, Allied Publishers, New Dethi, 1992. 13, Advanced Practical Organic Chemistry, Ill Edition, J. Leonard, B, Lygoand G. Procter, CRC Press, Routledge, (2013) 14, Qualitative Orgonie Analysis — Spectrochemiea) Techniques W. Kemp, I-edition, Me-Graw Hill, London, (1986). . Ahluwalia, HVSICAL CHEMISTRY PRACTICALS (4 days week, 4 hours a day) (C-106 Physical Chemistry Practical -1 |. Study of Acid catalysed hydrolysis of methyl acetate ut tab temperature and reporting the calculated ‘and graphical rate constants 2. Determination of Velocity constant for the suponification of Ethyl acetate at lab temperature and ‘eomparing it with graphical value 3. Verification of Beet’s Law: Colorimetris svefficient 4, Determination of heat of solution of a sparinaly soluble salt. §. Colorimetric estimation of Fe" ions ina given solution by titrating FAS versus KMnQ, solution. 6. Study of kinetics of the reaction between Kl ad Kas: Ossolution, 7 Construction of phase diagram of two component systems and determination of Ee. ET and the ‘Compasition of given unknown. 8 Determination af partial molar volume of salute ~ water system by apparent motar volume method. 9, Analysis-af a binary mixture by viscosity measurement method. 10, Verifieation of Freundlich and Langmuir isothetm for adsorption of oxalic/acetic acid on activated charcoal ic estimation of Cur" ions and reporting the Molar extinction MW€-107 Physical Chemistry Practical -I ‘Conductometric Experiments |. Preciptaton titration of lithium sulphate versus BaClzond reporting the concentration of L180. > Determination of concentration of a weak acid by titrating against a weak tase, Determination of a dissociation constant of weak acid (CHICOOH). 4, Determination of Equivalent conductance of a given strong electrolyte. 5, Determination of the concentration of a strong acid and a salt in a given a mixture of by titrating against a strong hase Potentiometric Experiments fen unknown 6, Determination af single electrode potential of Cu /Cu and estimate the g ‘eongentration. 7, Determination of single electrode potential of Zn”"/Zn and estimate the given unkown concentration. §, Titration of AgNOs versus KCI and estimation of the concentration of AgNO: 9. Determination of pKa and Ka values of the weak seid by titrating azainst a strong base using quinhydrone elcetrade. 10 Determination and comparison of pH values of buffer solutions by using quinhydrone electrode and glass electrode. C-108 Physical Chemistry Practical “HL 1, Study of acid hydroly relotive strenpth, 2, Study the hydeolysis of methyl acetate in the presence of HCL at two. different temperatures and reporting the energy of activation. 3, Determination of dissociation constant of a given indicator by colorimetric method. 41. Study of kinetics of autocatalytie reaction between KMnQ. versus oxalic acid, §, Determination of degree of hydrolysis of anifine hydrochloride at room temperature and calculation of dissociation constant of the base by pH metry. 6, Study of variation of viscosity af a liquid with temperature and determination of the constants A and B, 7. Analysis of binary mixture of two miseibe liquids by surface tension method §. Construction of phase diagram of Urea - KCI-H3O system. 9, Determination of heat of neutralization of wo acids and their relative strength. 10. Evaluation of Arrhenius parameter for the reaction beeween KyS20, versus KI (first order) is of methy/ azetate for two different concentrations af HC] and reporting the -109 Physical Chemistry Practical -IV Conductometry {Determination of concentration of misture of strong acid and weak acid versus strony base. 2 Determination of concentration of Weak acid with salt versus strong base 3 Determination of strength of a strong acid, weak actd and a salt versus stromg base —pHimetry S Determination of the ac pH metry. fic and basic dissociation constant and isoelecteic point of an amino acid by6, Determination of pKa valueor Dissociation constant of phosphoric acid. 7. Determination of pH of acetic acid with sadium acetate buffer. (on of concentration and amount of KCrs0, by titrating against FAS and ealculation of redox potential 6, Determination of concentration of mixture of acids by titrating against NEOH solution 10.Determination of concentration of K MnOby titrating against FAS and calculation of redox potenti SUGGETED BOOKS 1, Advanced Practical Physical Chemistry by J. B. Yadiv, GoeiPublications, Meerut (2012) Senior Practical Physical Chemistry by B.C, Kosla, Simla Printers, New Delhi (987). Experimental Physical Chemistey hy Daniel et al,, MeGraw Hill, New York (1962) Practical Physical Chemistry by A.M James and P. E. Pritchard, Longman's Group Ltd (1968). Experimental Physical Chemistry by Wilson, Newcombed others, Pergamon Press, New York (1962). 6. Experimental Physical Chemistry by R. C. Behra and B Behra, Tata MeGraw, New Dethi (1983), 7, Experimental Physical Chemistry hy V. D, Atavale and Paru!Mathur, New Age International, New York (2001) ‘8, Practical’s in physical chemistry A. Modem Approach by P.S Dethi (2006). indisu, Mac. Milian Publishers IL SEMESTER ORG ANIC CHEMISTRY- IT 13h Metal-Ligand equilibria in solution Step-wise and overall formation constant and their relationship, trends instep-nise constant, kinetieaukd thermodynamic stability ¢F metal complexes, factors affecting the stability of metal complexes with reference to the nature of the metal ion and ligand, chelate effect, macrocyclic effect and their thetitedynamic origin. Derermination of binary formation constant by pH metry, spectrophoiomerry, palarography and ion exchange methods. Structure and bonding- hydride, dihydrogen, dioxygen, isocyanide, N2 and tertiary phosphine complexes of transition metals. metal carbonyls-terminal and bridge carhonyls, detection, metal nitrosyls« terminal (linear and bert) and bridge, UNIT-IL 13h Metal- ligand bonding- Coordination numbers 3 10 8. Crystal field theory. salient features, speetrochersical series, splitting of d-orbitals in tetrahedral, square planar, trigonal bipyramidal, square-pyramidal and octahedral geometry, applications of CFT- colors of transition metal complexes, magnetic properties of octahedral complex, Jahn Teller distortion, CFSE and their uses, factors affecting CFSE. limitations of CFT. experimental evidences for metat-ligand covalent bonding in complexes, nephelauneti¢ effect, Ligand Field Theory, MO theory: tevahedral and octahedral complexes (including a-bonding), angular overtop model. Sterochemical nod-rigidity and its detection, 1SUNYT-ALL 13h Electronic spectra of coordination campounds- Spectroscopic ground states, selection rules, teem symbols for ions, Recah parameters. Orgel, Correlation and Tanaube-Sugaro diagrams, spectra of 34 metal-aqual Complenes of trivalent V, Crs divalent Nin, Co and Ni, CaCl, calculation of Dq, B and f) parameters, CT ‘spectra, Spectral properties of Lanthanide and Actinide metal complexes UNITY, 13h Magactic properties of coordination compounds- Types of magnetism, temperature effect, magnetic susceatibility and its determinaticn- Gouy, Faraday, VSM method. Diemagnetie correction, orbital contribution, spin-orbital coupling. ferro~ and antiferromagnetic coupling, spinetossover, Magnetic properties of Lanthanide and Actinide metal complexes, Photochemical reactions of transition metal complexes: Basic photochemical processes, Kasha's rule, quantum yield, Jabolnskii diagrams, photo substitution reactions, photo-redox reactions, ligand photoreactions. SUGGESTED BOOKS A. Cotton, G. Wilkinson and PL, Gaus: Joha Wiley 1. Advanced Inorganic Chemist and sons. Inc, Gri edition (1999), 2. Chemistry of elements- N,N. Greenwond and A. E. Eamshaw, 2" edition, Butterworth Heinemann (1997). 3, Inorganic Chemistry J. E. Huheey, E. A. Keiter and R, L. Keiter, 4!" edition; Addison; Wesley (1993). B. F. Shriver, P. W. Atkins.and C. H.Langford. 5" edition, ELBS: Oxford 10 4. tnorganie Chemist University Press edition, Elsevier. (1984), 5. Inarganic Electronic spectroscopy, A. BP. Lever, 6, Magnetochemisiry, R.L. Carlin, Springer Verlag (1 986). 7. Blectronié Absorption Spectroscopy and related Techniques, D. N. Sathyanarayana, University Press (2001). §. Inorganic Chettistry A Unified Approach by W. W. Porterfield, Elsevier 2008 edition. 9, Inorganic chemistry GL Miessler, PJ Fisher and DA Tarr'S" edition (2008), ICh-202 ORGANIC CHEMISTRY ~ UNIT-1 Reaction Mechanisms: Aromatic Substitution Reactions ih Electrophilic Sulystit wion Reactions: The arenium jon mechanism. Orignation and enttvity, Energy profile diagrams. The orthaipara ratio, jpso attack, orientation in other fing systems-Quantiative treatment of reactivity in substrates and elgctrophiles. ETfect of [eiving group, Amination, sulfenylaton reactions; Diszoniam coupling, Vilsmeler-Haack reaction, Galterman reaction, Gatterman-Koeh reaction and Hoesch reaction, Nucleophilig_ substitution revetions; The SsAr, Sxl, benzyne and Sasl_ mechanisms Reactivity: effect af substrate structure, leaving group and attacking nacleophile, Goldberg: reaction, Bucherer reaction, Schiemann reaction, von Richier reaction, Sommelet-Hauser ind Smiles rearrangements UNIT-IT Reaction Mechanisms: Addition Reactions 13h ‘Adiition 10 carbon-carhon multiple bonds: mechanistic and sterenchemical aspects of saadtion reactions involving clectrophiles, nucleophiles and tree radicals, Repio-, stereo- ind chemo- selectivities, Orientation and reactivity, Addition co. cyclopropane ring. Hiydrogenatton of doable and triple bortds, hydrogenation of aromatic rings. Addition of alkenes and/or alkynes to alkenes and/or alkynes. Ene synthesis. Michael reaction. ‘Addition 10 eqrbon-heternatom multiple bonds: Meeltanism af metal thydride reduetion (NaH, LH LiAIH,, NaBH.) of saturated and unsatumied carbonyl compounds, acids, caers and nitriles, Addition of Grignard reagents and organolithium reagents to carbons! compounds and unsaturated earbonyl compounds. Conversion of aldehydes to nitriles. Hydrolysis of nitriles and addition of amines: to isocyanates, Formation of xanthates. Wintig, Mannich and Stobbe reactions. UNIT 13h Reaction Mechupisms: Elimination Reactions Fhe EZ, El and ElcB mechanisms and their spectrum E2C and E2H mechanisms, Orientation of the double bond.Reactivity-efféets af substrate structure, attacking base, the leaving group and the medium. Mechanism and oricniation in pyrolytie efiminasion reactions (including Chugae reaction). Rearrangements and Name Reactions: Carbon-curbon: Wagner-Meerwein, PinacolPinacolone, Fries, Reazil-benzitie acld rearrangements, Wolff rearrangement. and Amdt-Eistert resetion,Tiffeneau- Dernjanoy faction, Fritsch-Buttenberg-Wiechell rearrangerient. Favorskil rexrrangement, Dienone- phenol reamangement, Baker-Verkataraman rearrangement. Cocbomniiroger: Beckmann-, Hofinanrr, Curtivs-, Lessen= and Schmidt rearrangements, Stevens, Nebet- rearrangement. Bencidine rearrangement, Corbon-oxvuen: Wittig rearrangement, Bacyer-Villiger oxidation '§UNIT-V 13h Chemistry of biotogical molecules I Amino acids and Peptides Sonthesis and reactions af aminoacids. Classification and comenclature of peptides. Sanger and Edman methods of sequencing. Cleavage of peptide bond by chemical and eneymatic methods. Peptide synthesis Protection af amino group (Boc-. Z- and Fmoc-) and carboxy! group as alkyl and ary! esters. Use of DCC, EEDQ, HOBt and active esters, acid halides, anhydrides 1m peptide band formation reactions. Deprowetion and racemization in peptide symhesis. Solution and solid phase techniques, Synthesis of oxytocin, gramicidin, enkephalins, LH-RH. Vitamins Introduction, Biological importance and synthesis of Vitamins A, Vitamin By (thiamine), Viuunin By (pyridoxine), falic acid, pantothenic acid. riboflavin, Vitamin C, Vitamin E (e-tocepheral), Vitamin H (biotin), Vitamins Ky and Kz SUGGESTED BOOKS 1. Advanced Organic Chemistry — Reactions, Mechanism and Structure, Jerry March, John Wiley (2008), 2. Advanced Organic Chemistry, F A Carey and RJ Sundberg Plenum, (2000), 3, A Guide Book to Mechanism in Organic Chemistry, P Sykes, VI edition, Pearson, (2003), 4. Structure and Mechanism of Organic Chemistry, C, K, Ingold, !! Edition, CBS, (2016). 5, Organic Chemistry, R T Morrison, RN Boyd and S K Bhattacharjee, Vil edition, Pearson, (2018), & Principles of Organic Synitiesis, II edition), RO C Noman and J M Coxon, Blackie Academie and Professtonat (Indian Reprint). (2012) 7, Natural Peaduets: their chemistry and biological significance, } Mann, Longman, (2000) 8, Organic Chemistry, Volume I, 1 L Finar, V1 edition, Pearson, (2018), 9, Organic Chemistry, Volume Il, 1 L Finar, VI edition, Pearson, (2018). 10. Organic Chemistry. J Clayden, N Greeves and § Warren, IV edition, Oxford University Press, 2014) 11, Name Reactions — A collection of detailed reaction mechanisms, J 1 Li Springer, (2012) 12. Moder Methods of Organic Synthesis: W Carruthers and | Coldham, IV edition, Cambridge University Press, (2015, 13, Peptides Chemisty: A practical text book, M. Bodansky, Springer Verlag NY, (1988). 14, Solid-phase peptide synthesis: A practical Approach-E. Artherton & RC. Sheppard. | RL Oxford Univ. Press, (1989). 15. Peptides: Chemisiry and Biology, N Selwad and H.«D. Jakubke, Wiley-VCH, (2002), [6