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VASCULAR/INTERVENTIONAL RADIOLOGY
593

Endovascular Repair of Abdominal


Aortic Aneurysms: Vascular Anatomy,
Device Selection, Procedure, and
Procedure-specific Complications1
Yolanda Bryce, MD
Philip Rogoff, MD Abdominal aortic aneurysm (AAA) is abnormal dilatation of the
Donald Romanelli, MD aorta, carrying a substantial risk of rupture and thereby marked risk
Ralph Reichle, MD of death. Open repair of AAA involves lengthy surgery time, anes-
thesia, and substantial recovery time. Endovascular aneurysm repair
Abbreviations: AAA = abdominal aortic an- (EVAR) provides a safer option for patients with advanced age and
eurysm, EVAR = endovascular aneurysm repair pulmonary, cardiac, and renal dysfunction. Successful endovascular
RadioGraphics 2015; 35:593–615 repair of AAA depends on correct selection of patients (on the basis
Published online 10.1148/rg.352140045
of their vascular anatomy), choice of the correct endoprosthesis,
and familiarity with the technique and procedure-specific complica-
Content Codes:
tions. The type of aneurysm is defined by its location with respect
1
From the Department of Radiology, Mount to the renal arteries, whether it is a true or false aneurysm, and
Auburn Hospital, 330 Mount Auburn St, Cam-
bridge, MA 02138. Presented as an education whether the common iliac arteries are involved. Vascular anatomy
exhibit at the 2013 RSNA Annual Meeting. Re- can be divided more technically into aortic neck, aortic aneurysm,
ceived April 29, 2014; revision requested July 18
and received August 4; accepted August 8. For
pelvic perfusion, and iliac morphology, with grades of difficulty with
this journal-based SA-CME activity, the authors, respect to EVAR, aortic neck morphology being the most common
editor, and reviewers have disclosed no relevant factor to affect EVAR appropriateness. When choosing among the
relationships. Address correspondence to Y.B.
(e-mail: ycdbryce@gmail.com). devices available on the market, one must consider the patient’s
vascular anatomy and choose between devices that provide suprare-
SA-CME LEARNING OBJECTIVES nal fixation versus those that provide infrarenal fixation. A success-
ful technique can be divided into preprocedural imaging, ancillary
After completing this journal-based SA-CME
activity, participants will be able to: procedures before AAA stent-graft placement, the procedure itself,
■■Discuss important elements of vascular
postprocedural medical therapy, and postprocedural imaging sur-
anatomy pertinent to endovascular aneu- veillance. Imaging surveillance is important in assessing complica-
rysm repair and device selection. tions such as limb thrombosis, endoleaks, graft migration, enlarge-
■■Describe the basic technique involved ment of the aneurysm sac, and rupture. Last, one must consider the
in endovascular aneurysm repair. issue of radiation safety with regard to EVAR.
■■List
complications of endovascular
©
aneurysm repair. RSNA, 2015 • radiographics.rsna.org
See www.rsna.org/education/search/RG.

Introduction
Abdominal aortic aneurysm (AAA) is abnormal dilatation of the
abdominal aorta greater than 50% of the normal proximal segment,
or dilatation greater than 3 cm (1). It carries a considerable risk of
rupture and thereby a substantial risk of death. The risk of rupture in-
creases with increasing diameter: It has been reported as 1%–3% per
year when aneurysm diameter is 4–5 cm, 6%–11% per year when an-
eurysm diameter is 5–7 cm, and about 20% per year when aneurysm
diameter is greater than 7 cm (2). The factors associated with devel-
opment of AAA include advanced age, coronary artery disease, high
594 March-April 2015 radiographics.rsna.org

disease is lower after EVAR than after open re-


TEACHING POINTS pair (7). Perioperative outcome in patients with
■■ Aortic neck morphology greatly influences device delivery, chronic obstructive pulmonary disease has also
deployment, aneurysm exclusion, and long-term device func-
tion, since it is the proximal fixation site for the stent-graft and
been shown to be more favorable with EVAR (8).
the most important factor in determining a successful EVAR. Moreover, endovascular repair is associated with
Unfavorable aortic neck anatomy is the most common reason fewer cardiac events in the perioperative period
influencing contraindication to EVAR. than is open repair (9).
■■ Proximal aortic neck length is measured from the lowest renal EVAR is defined as image-guided treatment of
artery to the top of the aortic aneurysm, and its measurement an AAA by using a stent-graft device, also known
is important in determining suprarenal or infrarenal fixation.
as an endoprosthesis. The device is placed within
■■ The morphology of the common femoral and iliac arteries is the native abdominal aorta and is secured proxi-
important for vascular access and device introduction, as well
as adequate fixation at the distal attachment site and mainte-
mally and distally to the diseased aneurysmal
nance of limb patency. portion of the aorta, creating a new conduit for
■■ The radiologist interpreting the postoperative CT scan should blood flow and eliminating the AAA sac pres-
analyze the stent-graft components with multiplanar imag- surization (4). Indications for EVAR are the same
ing to assess for subtle migration. Linked side-by-side unen- as those for an open surgical approach; however,
hanced, arterial phase, and delayed contrast-enhanced im- contraindications are derived largely on the basis
ages should be carefully studied for the presence of subtle en-
of the patient’s vascular anatomy. The success of
doleak and to exclude calcification within the sac mimicking
an endoleak. Measurement of sac volume is the optimal way the procedure is dependent on the correct selec-
to monitor aneurysm sac size, instead of maximal sac diam- tion of the patient on the basis of his or her vas-
eter on a single axial image. It can be difficult to distinguish cular anatomy, most important neck morphology,
type 2 from type 1 or type 3 endoleak on CT images, and as well as selection of the correct endoprosthesis
any increase in sac size with a demonstrated endoleak should
and familiarity with the technique and proce-
prompt arteriographic imaging with an eye toward concur-
rent treatment. dure-specific complications (10). Postoperative
■■ Type 2 endoleak is the most common type of endoleak,
imaging surveillance is standard to confirm that
occurring in about 20%–30% of patients and persisting in the device remains appropriately positioned and
10%–15% of patients after 6 months. These endoleaks occur that the aneurysm sac stabilizes or decreases in
when there is retrograde flow of blood into the aneurysm sac size and to exclude endoleaks. It should be noted,
through branch vessels such as lumbar arteries or a patent however, that operator experience is one of the
inferior mesenteric artery. These close spontaneously in about
half of patients.
most important predictors of success (11).

Vascular Anatomy
An AAA is preliminarily defined by its location
cholesterol level, hypertension, and smoking (3). relative to the renal arteries. A suprarenal AAA
The standard for aortic aneurysm repair has tradi- involves the renal arteries and extends superiorly
tionally been an open surgical approach. Surgery so that the superior mesenteric artery and celiac
is indicated in an aneurysm with a diameter of 5.5 arteries arise from the aneurysmal aorta (Fig 1). A
cm or greater, an aneurysm size that is 2.5 times juxtarenal aneurysm extends to the renal arteries,
the normal aortic diameter, an aneurysm exceed- with a normal-sized aorta superiorly (Fig 2). An
ing a growth rate of 1 cm per year, a rupture, and infrarenal AAA arises at least 10 mm below the
a symptomatic aneurysm, such as one with accom- renal arteries (Fig 3). Endovascular repair is best
panying back pain, a potential warning sign of suited for infrarenal AAAs because the renal arter-
impending rupture (4). The open surgical ap- ies and superior mesenteric arteries are not in-
proach involves lengthy surgery time, anesthesia, volved; with recent advances, however, EVAR may
and substantial recovery time. Endovascular an- also be used for juxtarenal aneurysms. Aneurysms
eurysm repair (EVAR) provides a safer option for are also classified as a true aneurysms, usually fu-
patients of advanced age and with pulmonary, siform, involving all three arterial layers (Fig 4a),
cardiac, and renal dysfunction. A study conducted and pseudoaneurysms, usually saccular, involving
by Schermerhorn et al (4) involving 22,830 fewer than three walls (Fig 4b). Endovascular re-
patients showed a lower perioperative mortal- pair can be used to address both true aneurysms,
ity rate among patients who underwent EVAR usually resulting from atherosclerotic disease, and
compared with those who underwent open repair, pseudoaneurysms, usually caused by infection or
with the reduction of mortality rate being more trauma. The vast majority of cases addressed with
pronounced with increasing patient age (5). The EVAR are true aneusysms. In addition, aneurysms
EVAR Trial 1 demonstrated a 30-day mortality may (Fig 5a) or may not (Fig 5b) involve the iliac
rate of 1.8% in EVAR patients and 4.3% in open arteries. Iliac artery involvement makes endovas-
repair patients (6). Mortality and morbidity in cular repair more complex. Size is also important
patients with moderate or severe chronic renal to note, as the larger the aneurysm, the less favor-
RG • Volume 35 Number 2 Bryce et al 595

Figure 1. Suprarenal aortic aneurysm. Schematic diagram (left), aortogram (middle), and computed tomographic (CT) angiogram
(right) in two patients demonstrate the aortic aneurysm extending above the renal arteries (arrow). SMA = superior mesenteric artery.

Figure 2. Juxtarenal aortic aneurysm. Schematic diagram (left), CT angiogram (middle), and three-dimensional rendition (right) of
an AAA in the same patient demonstrate the aneurysm extending just to the level of the renal arteries (arrows).

Figure 3. Infrarenal aortic aneurysm. Schematic diagram (left), CT angiogram (middle), and three-dimensional rendition (right) of
an AAA in the same patient demonstrate the aortic aneurysm extending 1 cm below the level of the renal arteries. Arrows = renal
arteries.

able the anatomy and the more complicated the aortic neck morphology, aneurysm morphol-
repair (12). However, anatomic aneurysm analysis ogy, pelvic perfusion, and common iliac artery
goes beyond these few factors. morphology, which are fully described in Table 1.
A grading scale to analyze AAA anatomy was These factors can be graded to provide a severity
developed by the Ad Hoc Committee for Stan- score (14,15). Each factor is graded from 0 to 3,
dardized Reporting Practices in Vascular Surgery with 3 being the most severe (Table 1).
of the Society for Vascular Surgery/American As- Scoring is an aid in determining potential
sociation for Vascular Surgery in 2002 (12). The clinical outcomes. Ahanchi et al (15) assigned
grading scale factors taken into account include the number 14 to distinguish between low-score
596 March-April 2015 radiographics.rsna.org

Figure 4. True aneurysm and pseudoaneurysm. (a) Schematic diagram (left) and three-dimensional rendering (right)
of an AAA demonstrate a fusiform, or true, aneurysm (arrow). (b) Schematic diagram (left) and three-dimensional ren-
dering (right) of an AAA demonstrate an eccentric aneurysm, or pseudoaneurysm (arrow).

Figure 5. AAA with and without


iliac artery involvement. (a) Sche-
matic diagram (left) and CT angio-
gram (right) demonstrate an AAA
involving the common iliac artery
(arrows). (b) Schematic diagram
(left) and CT angiogram (right)
demonstrate an AAA that does not
involve the common iliac artery.
Blue arrows = normal-sized com-
mon iliac arteries, red arrow = nor-
mal-sized aorta caudal to the AAA.

and high-score groups, choosing the number 14 long, blood loss four times greater, 27% more
to ensure enough patients were in each group. use of contrast material, and substantially lon-
Compared with the low-score group, the high- ger hospital stays and higher costs. In addition,
score group experienced surgery times twice as the average number of endograft implants used
RG • Volume 35 Number 2 Bryce et al 597

Table 1: AAA Anatomy Severity Score Grading Scale


Attribute Absent: Score of 0 Mild: Score of 1 Moderate: Score of 2 Severe: Score of 3
Aortic neck
Length (mm) >25 15–25 10–15 <10
Diameter (mm) <24 24–26 26–28 >28
Angle (degrees) >150 150–135 135–120 <120
Calcification or 0 <25 25–50 >50
thrombus (%)
Aortic aneurysm
Aortic tortuosity index <1.05 1.05–1.15 1.15–1.2 >1.2
Aortic angle (degrees) 160–180 140–159 120–139 <120
Thrombus (%) 0 <25 25–50 >50
Aortic branch vessels No vessels 1 lumbar or infe- 2 vessels with <4- 2 vessels with inferior
rior mesenteric mm diameter mesenteric artery
artery diameter >4 mm
Pelvic perfusion Patent bilateral Single internal Single internal iliac Bilateral internal iliac
internal iliac iliac artery oc- artery occlusion artery occlusion
artery clusion and contralat-
eral internal
iliac artery >50%
stenosis
Iliac artery
Calcification None <25% vessel 25%–50% vessel >50% vessel length
length length
Diameter and occlusive >10 mm, no oc- 8–10 mm, no ste- 7–8 mm, focal <7 mm, stenosis
disease clusive disease nosis <7 mm in stenosis <7 mm in <7 mm in diam-
diameter, or >3 diameter and <3 eter and >3 cm in
cm in length cm in length length, more than
one focal stenosis
<7 mm in diameter
Iliac artery tortuosity <1.25 1.25–1.5 1.5–1.6 >1.6
index
Iliac artery angle 160–180 121–159 90–120 <90
(degrees)
Common iliac artery >30 20–30 10–20 <10
length (mm)
Iliac artery diameter <12.5 mm 12.5–14.5 mm 14.5–17 mm >17 mm

was three in the low-score group and four in the anatomy is the most common reason influenc-
high-score group. Intraoperative adjuncts were ing contraindication to EVAR (17). Aortic neck
required in 54% of patients in the low-score length, aortic neck tortuosity index, aortic neck
group versus 80% in the high-score group; the angle, aortic neck calcification or thrombus, and
most common were distal limb extension and aortic neck diameter are discussed in this sec-
access site adjuncts such as angioplasty and end- tion; the grading system is depicted in Table 1.
arterectomy. Moreover, although both groups
had similar risk factors and comorbidities, hos- Proximal Aortic Neck Length.—Proximal aortic
pital stay lengths did differ, likely because of neck length is measured from the lowest renal
increased surgery time, contrast material use, artery to the top of the aortic aneurysm (Fig 6),
blood loss, and adjunct procedures (16). and its measurement is important in determin-
ing suprarenal or infrarenal fixation. The shorter
Aortic Neck Anatomy the neck, the more complicated the procedure.
Aortic neck morphology greatly influences de- Generally, a 1.5-cm landing zone of normal
vice delivery, deployment, aneurysm exclusion, anatomy is required for infrarenal fixation (12).
and long-term device function, since it is the Landing zone refers to the site at which the pros-
proximal fixation site for the stent-graft and the thesis is placed. If the landing zone is smaller,
most important factor in determining a success- suprarenal fixation, discussed below, may poten-
ful EVAR (4,12,13). Unfavorable aortic neck tially be used.
598 March-April 2015 radiographics.rsna.org

Figure 6. Aortic neck length. Schematic diagram (left) and CT angiogram (right) demonstrate measurement
of the aortic neck proximal to the AAA. Arrow = renal artery.

Figure 7. Aortic neck angle shown on schematic diagram (left) and CT angiogram (right).
The aortic neck angle is the angle in the dashed line denoting the central lumen between the
flow axis of the suprarenal aorta and the infrarenal neck.

Proximal Aortic Neck Angle.—The aortic neck and distal landing zone diameters by 10%–20%;
angle is drawn between the flow axis of the su- therefore, the proximal and distal neck diameter
prarenal aorta and the infrarenal neck (Fig 7) cannot exceed 90% of the available maximal stent-
(4). Angles greater than 150° are most favorable, graft diameter (18). Aortic neck diameter is not
and angles less than 120° are most difficult with always uniform. The shape of the neck may be
regard to delivering and deploying the device to straight, tapered, or reverse tapered. Tapered and
the correct location. Operator experience is im- reverse tapered are defined as having greater than
portant when dealing with angles approaching 3 mm diameter differences proximally and distally
less than 120°. (Fig 9). Reverse tapered—proximal greater than
distal—is associated with increased complication
Proximal Aortic Neck Calcification or Throm- (19). Aburahma et al (19) reported reverse tapered
bus.—Aortic neck calcification or thrombus is to be a strong predictor of early type 1 endoleak.
graded by the percentage of circumferential in- The proximal aortic neck wall may also be bulging
volvement by calcification or thrombus thickness in portions, affecting the seal between the stent-
of at least 2 mm (Fig 8, Table 1). Greater than graft and the aortic wall (20).
50% circumferential involvement is considered
severe; 25%–50% is considered moderate, and Aortic Aneurysm Morphology
less than 25% is considered mild. Aortic aneurysm morphology influences stent-
graft delivery and deployment, risk of distal
Proximal Aortic Neck Diameter.—A diameter embolization of thrombus, long-term device
greater than 28 mm is considered severe according performance, and exclusion or enlargement of
to the scoring system, as larger diameters usually the aneurysm. Aneurysm tortuosity index, angle,
exceed the available stent-graft limit. Stent-grafts thrombus, and branch vessels are described
are typically chosen to overestimate the proximal herein; the grading system is depicted in Table 1.
RG • Volume 35 Number 2 Bryce et al 599

Figure 8. Aortic neck thrombus


and calcification. Top row: Aortic
neck thrombus at least 2 mm thick
is shown on axial contrast mate-
rial–enhanced CT images. Bottom
row: Calcification is shown on axial
unenhanced CT images.

Figure 9. Diagrams show shapes


of the aneurysm neck. The neck
can be straight, tapered, or reverse
tapered; the latter two are defined
as a difference greater than 3 mm
in proximal and distal diameters.

Aortic Aneurysm Tortuosity Index.—The aor- vice. On rare occasions, however, thrombus may
tic tortuosity index is obtained by dividing the break off and cause distal embolus.
distance along the central lumen line (L1 in Fig
10), between the lowest renal artery and the Aneurysm Branch Vessels.—Aneurysm branch
aortic bifurcation, by the straight-line distance vessels, mainly inferior mesenteric and lumbar
from the lowest renal artery to the aortic bifur- arteries, predispose patients to type 2 endoleak,
cation (L2 in Fig 10). A high tortuosity index the most common type of endoleak. The number
(>1.2) indicates that device delivery and deploy- of lumbar arteries and inferior mesenteric arter-
ment will be difficult. ies and their caliber form this portion of the grad-
ing system (Fig 12).
Aortic Aneurysm Angle.—Aortic angle is the A second factor regarding branch vessels that
most acute angle in the line through the central was not included in the grading system has to do
lumen between the lowest renal artery and the with accessory renal arteries, which may be oc-
aortic bifurcation (Fig 11). As with high tortuos- cluded by the stent-graft. If a substantial percent-
ity index, small angles make delivery and deploy- age of a kidney is perfused by an accessory renal
ment of the device difficult. artery, therapeutic attempts at renal artery revas-
cularization can be attempted. In addition, fenes-
Aortic Aneurysm Thrombus.—Aortic aneurysm tration of the stent-graft has been reported to spare
thrombus is classified in increments of 25%, as the accessory artery perfusion (21). Similarly, eval-
described in Table 1. Thrombus is typically soft uation of the superior mesenteric artery is impor-
and does not usually obstruct delivery of the de- tant. If the inferior mesenteric artery is occluded, a
600 March-April 2015 radiographics.rsna.org

Figure 10. Aortic tortuosity index, demonstrated on schematic diagram (left) and CT angiogram (right). The
aortic tortuosity index is obtained by dividing the distance along the central lumen line (L1), between the low-
est renal artery and the aortic bifurcation, by the straight-line distance from the lowest renal artery to the aortic
bifurcation (L2).

Figure 11. Aortic aneurysm angle. Schematic diagram (left) and CT angiogram (right) show
the aortic angle as the most acute angle in the line through the central lumen between the
lowest renal artery and the aortic bifurcation.

diseased superior mesenteric artery can predispose Iliac Artery Anatomy


the patient to mesenteric ischemia. Revasculariza- The morphology of the common femoral and
tion of the superior mesenteric artery, or use of a iliac arteries is important for vascular access and
fenestrated stent-graft, may be warranted. device introduction, as well as adequate fixation
at the distal attachment site and maintenance of
Pelvic Perfusion limb patency. Common iliac artery calcification,
Pelvic perfusion is based largely on the patency diameter, length, and pelvic perfusion grading
of the internal iliac arteries. When the stent-graft systems are depicted in Table 1.
is extended into the external iliac artery because
of a common iliac artery aneurysm or short Iliac Artery Diameter.—Stenotic or occlusive
common iliac artery, the origin of the ipsilateral disease prohibits delivery of the stent-graft.
internal iliac artery is occluded by the stent-graft. A minimal outer diameter of 7 mm is usually
If such a procedure will be performed, it is im- needed for main body device delivery, with a few
portant to note contralateral internal iliac artery exceptions (24). The Endurant II (Medtronic;
patency to prevent pelvic ischemia (Fig 13) as bi- Oak Brook, Ill) and Ovation Prime (TriVascular;
lateral internal iliac artery occlusion significantly Santa Rosa, Calif) devices can potentially be
increases the patient’s risk of pelvic ischemia. Pel- used in a patient with a smaller iliac artery. Cur-
vic ischemia manifests as buttock and thigh clau- rently, the Ovation Prime offers the lowest pro-
dication, impotence, perineal necrosis, and rectal file; in other words, it requires the smallest outer
and colonic necrosis (22). Contralateral internal diameter. Stenotic arteries or occlusive disease
iliac artery occlusion results in buttock claudica- may be addressed with angioplasty and/or stent
tion in as many as 28% of patients and erectile placement. An outer diameter greater than 10
dysfunction in 17% (23). mm is favorable to a certain point, as the com-
RG • Volume 35 Number 2 Bryce et al 601

Figure 12. Aortic aneurysm branches. Schematic diagram (top left),


axial CT image (bottom left), sagittal CT image (bottom center), and
three-dimensional rendering (bottom right) of an AAA show aortic an-
eurysm branches. IMA = inferior mesenteric artery, green arrows = lum-
bar arteries, blue arrows = inferior mesenteric artery, orange arrow =
opacified portion of the aneurysm.

Figure 13. Pelvic perfusion.


(a) Three-dimensional rendering
from CT shows a right common
iliac artery aneurysm (orange ar-
row) with a patent contralateral
internal iliac artery. The pelvis can
be perfused by the contralateral il-
iac artery when the ipsilateral iliac
artery is occluded and the graft
limb is extended into the external
iliac artery. Yellow arrows = patent
internal iliac arteries. (b) Three-
dimensional rendering from CT
shows a left common iliac artery
aneurysm (orange arrow) with an
occluded contralateral internal
iliac artery (yellow arrow). The
pelvis will not be perfused by the
contralateral iliac artery when the
ipsilateral iliac artery is occluded
and the graft limb is extended
into the external iliac artery.

mon iliac artery diameter should typically be 2 Iliac Artery Calcification.—As with iliac luminal
mm smaller than the stent-graft limb diameter diameter, arterial calcification may also influence
(24). A dilated iliac artery affects the distal seal device delivery. In addition, calcified plaque may
zone, preventing successful fixation of the graft embolize. The severity is graded in increments of
limb. Iliac artery aneurysms occur in about 20% 25% (Fig 14). Calcification greater than 50% is
of patients with AAA (25). considered severe.
602 March-April 2015 radiographics.rsna.org

Figure 14. Iliac artery calcification. CT angiograms demonstrate iliac artery calcification, with
severity graded in 25% increments.

Figure 15. Iliac artery tortuosity index demonstrated on schematic diagram (left) and CT angiogram
(right). This index is obtained by dividing the distance along the central lumen line from the aortic bifur-
cation to the common femoral artery (L1) by the straight-line distance from the aortic bifurcation to the
common femoral artery (L2).

Iliac Artery Tortuosity.—The iliac tortuosity Iliac Artery Length.—Adequate length is needed
index is determined by dividing the distance to ensure safe graft limb positioning and seal. If
along the central lumen line from the aortic the common iliac artery is too short, extension of
bifurcation to the common femoral artery (L1 the aortic stent-graft into the external iliac artery,
in Fig 15 ) by the straight-line distance from which complicates the procedure, may be needed
the aortic bifurcation to the common femoral to ensure successful graft limb positioning and an
artery (L2 in Fig 15). An index of less than 1.25 adequate seal (24) (Fig 17). A length greater than
is optimal, and an index of greater than 1.6 is 3 cm is considered ideal.
considered severe.
The Devices
Iliac Artery Angle.—The iliac artery angle is the There are two parts to the EVAR stent-graft
angle line within the central lumen between the device: the delivery system for introducing and
aortic bifurcation and common femoral artery deploying the stent-graft (Fig 18a) and the stent-
(Fig 16). Larger angles are preferable. An angle graft itself. The stent-graft is composed of a self-
smaller than 90° is considered severe. expanding metallic stent framework with a high
RG • Volume 35 Number 2 Bryce et al 603

Figure 16. Iliac artery angle demonstrated on schematic diagram (left) and CT an-
giogram (right). The iliac angle is the angle line within the central lumen between the
aortic bifurcation and common femoral artery.

Figure 17. Iliac artery length. CT


angiogram demonstrates a right
common iliac artery that is 1.1
cm, likely inadequate for a landing
zone.

stances as described below. The AFX is slightly


different than the others, in that the graft material
is outside the self-expanding metallic stent frame-
work. Devices are bifurcated, with the ability for
a limb extension to extend the graft inferiorly and
an aortic cuff to extend the aortic component su-
periorly (Fig 18c).

Proximal Fixation
To ensure adequate proximal fixation, a decision
must be made about suprarenal or infrarenal fixa-
tion. Infrarenal fixation describes placement of
the stent-graft immediately below the most inferi-
orly located renal artery. This is appropriate when
the aortic neck is sufficiently long (Fig 19).
A short aneurysmal neck (Fig 20a) will result
in radial force exerted over a smaller area, re-
sulting in a greater risk of inadequate seal, distal
outward radial force that allows attachment to the stent-graft migration, and type 1 endoleak (4).
artery wall (Fig 18b) and graft fabric that creates In such cases, suprarenal fixation can be used
a new conduit for blood flow and prohibits blood (Fig 20b). Suprarenal fixation describes the
from entering the aneurysm sac (Fig 18b). bare metallic stent component extending above
The following devices are commercially the fabric-covered stent-graft. The junction be-
availablet: Zenith (Cook Medical), Endurant II tween the bare metallic stent and the stent-graft
(Medtronic), AFX (Endologix), Excluder (Gore is placed just below the renal arteries, and the
Medical), and Ovation Prime (TriVascular). In bare metallic stent extends superiorly. This al-
addition to appropriate aortic and iliac diameter lows perfusion to the superior mesenteric artery
compatibility, each device requires adequate ac- and renal arteries, which protrude through the
cess vessel diameter and optimal morphology. The bare metallic stent. Suprarenal fixation endo-
Zenith, Endurant II, AFX, and Ovation Prime can prostheses often have more struts in the supe-
be used for suprarenal fixation, which becomes rior aspect of the stent-graft to help fixate the
an important function to note in certain circum- device. In addition to utilization in AAAs with a
604 March-April 2015 radiographics.rsna.org

Figure 18. EVAR devices. (a) A delivery device, similar to that shown here (AFX Endovascular AAA System; Endologix, Irvine,
Calif), is used to introduce the endoprosthesis. The arrow denotes the proximal tip. (b) Image depicts five stent-grafts, or endo-
prostheses. From left to right, the devices are the Zenith (Cook Medical; Bloomington, Ind), Excluder (Gore Medical; Flagstaff,
Ariz), AFX (Endologix), Ovation Prime (TriVascular), and Endurant II (Medtronic). Orange arrow = bare metal stent of the supra-
renal fixation device, blue arrow = self-expanding metallic stent framework for outward radial force, gray arrow = graft material
that allows a new conduit for blood flow. (c) Limb extension and aortic cuff. Limb extensions and aortic cuffs extend the device
distally and proximally, respectively.

Figure 19. CT angiogram (left) and three-dimensional renderings (right) of an AAA repair demonstrate infrarenal fixation in this
patient with a sufficiently long aneurysmal neck. The stent-graft is positioned just below the renal arteries. Red arrows = renal artery,
black arrow = superior-most aspect of the stent-graft.

short aneurysmal neck, suprarenal fixation may is a theoretic increased risk of mesenteric isch-
also be used with circumferential thrombus or emia and renal dysfunction with this technique
calcification, severe angulation, and tapered or (27). Choke et al (27) reported that one patient
reverse-tapered neck configuration (26). There developed bowel ischemia out of 112 patients
RG • Volume 35 Number 2 Bryce et al 605

Figure 20. Suprarenal fixation in an AAA with a short aortic neck. (a) Three-dimensional rendering
(left) and CT angiogram (right) show an AAA with a 0.8-cm proximal aortic neck. Arrows = renal arteries,
arrowhead = proximal short aortic neck. (b) Three-dimensional renderings demonstrate suprarenal fixa-
tion. The junction between the stent-graft and the bare metal stent (white arrow) is placed just below the
renal arteries. The bare metal stent extends above the renal arteries (red arrows). The superior mesenteric
artery (green arrow) is seen to protrude through the bare metal stent.

who underwent suprarenal fixation. However, in graft placement into the renal arteries along-
a study by Burke et al (28) of 95 patients, none side the main aortic endoprosthesis to maintain
developed bowel ischemia. Moreover, a meta- flow to the covered branch vessels. With this
analysis (29) showed no definite medium-term technique, a renal artery is accessed through a
differences in renal function between patients brachial or axillary artery; a covered stent is de-
with infrarenal versus those with suprarenal de- ployed, with the stent extending into the aorta
vice fixation. in a cranial direction. After the aortic stent-graft
A fenestrated stent-graft is another option in components are deployed, dilation of the renal
patients with short aneurysmal neck anatomy. conduit is performed simultaneously with the
For example, the Zenith Fenestrated device aortic stent-graft by using “kissing balloons” to
(Cook Medical) has fenestrations and scallops preserve renal perfusion and attain an adequate
that accommodate aortic branches and poten- proximal aortic seal (30).
tially can be used for a proximal neck length as
short as 4 mm. The chimney or snorkel technique Distal Fixation
may also be used for juxtarenal aneursyms. The The landing zone for a stent-graft is usually the
chimney or snorkel technique involves parallel common iliac arteries (Fig 21a). However, if
606 March-April 2015 radiographics.rsna.org

Figure 21. Fixation in the common iliac


arteries. (a) Three-dimensional rendering
from CT demonstrates a stent-graft with
fixation in the common iliac arteries (ar-
rows). (b) Three-dimensional rendering
from CT demonstrates a graft limb exten-
sion with fixation in the external iliac ar-
tery (arrow) with occlusion of the ipsilat-
eral internal iliac artery. The contralateral
internal iliac artery is patent.

Figure 22. Accessory renal artery, which complicates AAA repair. (a) CT angiogram demonstrates an accessory
renal artery (arrow) that markedly shortens the proximal aortic neck. (b) Angiogram obtained before emboliza-
tion shows the portion of the kidney perfused by the accessory renal artery.

there is a common iliac artery aneurysm or if phase scan. The field of view should commence
the common iliac artery is too short (less than above the celiac artery, include the aneurysm,
about 1.5 cm), the distal limb is extended past and end at the proximal thigh, where delivery
the common iliac artery (Fig 21b). In such pathways for stent-graft hardware can be evalu-
cases, the internal iliac artery is occluded. As de- ated. Imaging is easiest with a multidetector (16
scribed previously, if there is inadequate perfu- or more detector rows) CT scanner that allows
sion to the pelvis from the contralateral internal thin sections in a reasonable breath-hold time.
iliac artery, the patient is predisposed to pelvic Unenhanced images are used to evaluate arterial
ischemia. wall calcification and to evaluate for possible in-
tramural hematoma in the acute setting (12).
EVAR Technique Magnetic resonance (MR) imaging provides an
option for patients not able to receive iodinated
Preprocedural Imaging Technique contrast material. T1-weighted three-dimensional
CT angiography is the method of choice for pre- angiography provides the most information. In pa-
procedural planning of endovascular repair. The tients with poor renal function, unenhanced MR
imaging protocol should include an unenhanced imaging may be performed by utilizing a steady-
scan followed by a contrast-enhanced arterial state free-precession sequence (12).
RG • Volume 35 Number 2 Bryce et al 607

Figure 23. Iliac artery occlusion, which complicates AAA repair. (a) Three-dimensional rendering from
CT shows a patent internal iliac artery (yellow arrow) that will be occluded by external iliac artery fixation.
Orange arrow = common iliac artery. (b) Three-dimensional rendering from CT in the same patient after
AAA repair with an external iliac limb extension (orange arrow). An embolization coil (yellow arrow) in the
internal iliac artery was placed before AAA repair. Black arrow = patent contralateral internal iliac artery.

Ancillary Procedures and suture-mediated arterial closure devices are


before AAA Stent-Graft Placement used (4). The ipsilateral artery, by convention, is
Before AAA repair, certain interventions may be the artery used to introduce the bifurcated main
warranted. An accessory renal artery (Fig 22) body and attached limb of a modular device. The
that shortens the aortic neck and provides only a contralateral artery is therefore used to introduce
small portion of vascularity to the kidney, a pat- the contralateral iliac limb. The optimal ipsilateral
ent ipsilateral internal iliac artery with planned artery is a larger-caliber artery, without substan-
external iliac artery fixation (Fig 23), or, as more tial stenosis, tortuosity, calcification, or thrombus
recently advocated at some institutions, a patent and with a satisfactory distal landing zone.
inferior mesenteric artery may be embolized to A full digital subtraction aortogram may
try to prevent a type 2 endoleak or retrograde be used to confirm craniocaudal distance and
filling of the aneurysm sac (31,32). This may re-measure lengths; however, this view may be
be done on the day of or days before the AAA omitted with good preoperative CT angiography
repair. Moreover, if there is need to extend the planning. Digital subtraction aortograms are lu-
stent-graft into the external iliac artery because minograms and often not a representation of the
of a common iliac artery aneurysm or a short aneurysm size, as the aneurysm may be partially
common iliac artery, or if an internal iliac artery thrombosed. A measuring or calibrated pigtail
aneurysm necessitates occlusion, internal iliac ar- catheter is first introduced either in the contralat-
tery embolization with coils and/or an Amplatzer eral or in the ipsilateral artery and positioned just
plug (AGA Medical, Plymouth, Minn) may be distal to the subclavian artery in the proximal de-
done weeks before placement of the EVAR to scending thoracic aorta (Fig 24a). The ipsilateral
provide time for development of collaterals that artery is used when it is necessary to confirm the
may mitigate pelvic ischemia (33). length of the ipsilateral stent-graft. A preliminary
digital subtraction arteriogram is acquired to doc-
Procedure ument the location of the renal arteries and ipsi-
EVAR may be performed with general anes- lateral internal iliac artery to determine appropri-
thesia—or possibly even with local or regional ate main body device length (Fig 24b). A sheath
anesthesia (4). A general approach is illustrated is then introduced over a stiff guidewire into the
in Figure 24. The common femoral artery is ac- ipsilateral artery for insertion of the main body of
cessed in a retrograde fashion, traditionally by the endoprosthesis. A “bareback” fixation proce-
surgical exposure via “cut-down” skin incisions dure may also be performed without the sheath,
or, using a more recent technique, by percutane- such as with the Endurant device (Medtronic)
ous arterial puncture, where new smaller sheaths (4). A magnified or pseudomagnified angled or
608 March-April 2015 radiographics.rsna.org

Figure 24. Arteriograms depict the EVAR procedure. (a) A marking pigtail catheter is placed high enough to ensure opacification of
renal arteries in the arteriogram. In this case, the catheter was placed initially in the ipsilateral side. (b) Initial arteriogram is acquired
to locate the renal arteries and internal iliac arteries, in particular the ipsilateral artery. (c) Arteriogram obtained with undeployed
Excluder (Gore Medical) stent-graft just below renal arteries for infrarenal fixation. (d) Stent-graft is deployed just below the renal
arteries. (e) Contralateral sheath injected with contrast material to opacify the ipsilateral internal iliac artery. A marking pigtail catheter
is used to note the length between the gate and the internal iliac artery for contralateral limb placement. (f) Stiff wire is seen here
through the gate, after the gate was selected with a guidewire and angled catheter. (g) Arteriogram depicts a contralateral limb
stent-graft deployed and in a good location. (h) A balloon is used to dilate the superior aortic attachment. (i) Arteriogram after AAA
stent-graft placement shows patent renal arteries and internal and external iliac arteries and no endoleaks.

oblique view centered at the renal arteries im- anatomy with the goal of straightening the cranial-
mediately before main body device deployment caudal neck angle and optimizing visualization
is performed. The angle is determined by the of the renal artery orifices. With the help of the
RG • Volume 35 Number 2 Bryce et al 609

magnification or pseudomagnification view at the There are variations to the described pro-
level of the renal arteries, the main body delivery cedure for most available endoprostheses. The
device is introduced over a stiff guidewire and po- Endologix device, however, has a deployment
sitioned either for suprarenal or infrarenal fixation method different from that described earlier. The
(Fig 24c), with the fabric-covered portion just endoprosthesis rests on the native aortic bifurca-
distal to the lowest renal artery and the main body tion and the device is built toward the infrarenal
carefully deployed to expose the contralateral gate or suprarenal fixation point. This endoprosthesis
(Fig 24d). The stiff guidewire helps in straighten- is designed to preserve the anatomy at the aortic
ing the aortic neck, aneurysm, or iliac artery in bifurcation in a process called anatomic fixation.
the setting of severe tortuosity index or angle. Ballooning of the overlap and attachment sites is
By using a sheath placed in the contralateral not required because the graft, located outside
femoral artery in a retrograde fashion, a guide- the metallic stent framework, quickly conforms to
wire and catheter are used to cannulate the gate, the vessel wall.
the opening to the shorter contralateral limb, In addition to the endovascular procedure,
which may be tedious and time consuming. A surgical ancillary procedures may be performed,
pigtail catheter is usually then placed from the including a cross-femoral bypass conduit to pro-
ipsilateral side through the gate and either spun vide perfusion of the contralateral lower extrem-
within the main body or hooked over the flow ity in a patient with an aorto-uni-iliac stent-graft,
divider to confirm that the gate was successfully an internal iliac artery bypass in a patient at risk
cannulated (Fig 24e). An angiogram may be for pelvic ischemia, endarterectomy in a patient
obtained to determine the length of the contra- with severe atherosclerosis, and patch angioplasty
lateral limb from the gate to the planned distal at a narrow arterial access site (4).
attachment site before deployment of the graft. After the procedure, patients are usually hos-
The contralateral limb graft is then deployed pitalized for 3–5 days, most often in the intensive
over a stiff guidewire (Fig 24f). When the graft care setting (34). A portion of this stay typically is
is deployed through the gate, there is a short in a critical care setting.
overlap between the main body and the contra-
lateral limb, depending on the device—usually Postprocedural Medical Therapy
about 3 cm (Fig 24g). Optimal distal fixation is Postoperative care includes medical management
1 cm proximal to the internal iliac artery (4). If and imaging. Antiplatelet therapy and statins are
unfavorable anatomy precludes this, such as a usually routinely employed after AAA repair to
common iliac or external iliac artery aneurysm, prevent graft-limb thrombosis and peripheral ar-
an iliac extension limb may be used in an overlap terial disease. In patients with existing peripheral
fashion on both the ipsilateral and contralateral arterial disease, aspirin, clopidogrel, and statins
sides. One “balloons” the points of overlap and are usually prescribed (4).
attachment sites (Fig 24h) using a compliant low-
pressure balloon either after deployment of each Postprocedural Imaging Surveillance
component or at the conclusion of deployment of Postprocedural surveillance is performed to detect
all components, depending on the device used. and characterize endoleak, to assess any change
Intraprocedural angiography should be per- in the caliber of the residual AAA sac; to note me-
formed to confirm the location, seal, and patency chanical changes of the device such as migration,
of all graft components, to exclude endoleak, and kinking, or fracture; and to monitor the long-term
to assess the patency of renal arteries, mesenteric durability of the endoprosthesis (4).
arteries, and internal and external iliac arteries CT is most often employed. A typical routine
(Fig 24i). Endoleak due to inadequate proximal for postprocedural surveillance is CT angiogra-
and distal fixation of the stent-graft (type 1) or phy at 1 month, 6 months, and then yearly after
to device failure (type 3) should be corrected EVAR (35). The Society of Interventional Radiol-
immediately by overlapping the stent-graft with ogy, Society for Vascular Surgery, European Soci-
another endoprosthesis piece. An aortic exten- ety for Vascular Surgery, and Cardiovascular and
sion cuff may be used with modular bifurcated Interventional Radiological Society of Europe
graft devices if the proximal fixation is subopti- currently uniformly advocate lifelong imaging
mal. Moreover, narrowing or kinking of the graft surveillance (36). Surveillance with unenhanced
limbs, if present, should also be corrected im- CT has been proposed after the initial post-
mediately with angioplasty or stent placement. EVAR contrast-enhanced study (37). If the inter-
Last, if there is malposition of the stent resulting val volumetric change is 2% or less, surveillance
in compromise of the renal artery or internal iliac with unenhanced CT volumetric analysis can
arteries, this may be corrected by placement of be continued. However, if there is a volumetric
an intravascular stent. increase that exceeds 2%, contrast-enhanced CT
610 March-April 2015 radiographics.rsna.org

should be performed immediately to evaluate for


an endoleak (37). In patients with renal failure,
unenhanced CT alone has been used.
The radiologist interpreting the postoperative
CT scan should analyze the stent-graft compo-
nents with multiplanar imaging to assess for sub-
tle migration. Linked side-by-side unenhanced,
arterial phase, and delayed contrast-enhanced
images should be carefully studied for the pres-
ence of subtle endoleak and to exclude calcifi-
cation within the sac mimicking an endoleak.
Measurement of sac volume is the optimal way
to monitor aneurysm sac size, instead of maxi-
mal sac diameter on a single axial image. It can
be difficult to distinguish type 2 from type 1 or
type 3 endoleak on CT images, and any increase
in sac size with a demonstrated endoleak should
prompt arteriographic imaging with an eye to-
Figure 25. CT angiogram demonstrates lack
ward concurrent treatment.
of opacification of the thrombosed left limb
Contrast-enhanced MR imaging can be per- (arrow).
formed with nitinol-based stents (35). Elgiloy
stents can obscure the lumen, and stainless-steel
stents can cause artifacts (35). Under optimal subsequent changes in aneurysm morphology.
conditions, MR angiography is at least as sensi- Suboptimal anatomy or device selection predis-
tive as CT (38,39). poses patients to experience stent-graft migra-
tion. When a stent-graft migrates, endovascular or
Complications of EVAR open surgical revision is usually required.
Complications shared by both open repair and
EVAR include graft infection, pseudoaneurysm, Endoleaks
graft occlusion, and pelvic ischemia. Complica- Endoleaks, the different types of which are de-
tions specific to or more commonly seen with scribed individually later, are the most common
EVAR include limb thrombosis, endoleak, graft complication after EVAR (4). Researchers at
migration, enlargement of the aneurysm sac, and the Lifeline Foundation Registry for endografts
rupture (14). collected data from 1757 patients in the United
States and recorded a rate of 17% for endoleaks
Limb Thrombosis (43). There are five types of endoleaks: Type 1
Limb thrombosis may occur in as many as 5% of and type 3 endoleaks should be identified and
patients (Fig 25) (40). Limb occlusion in the first fixed during the procedure. Type 2 endoleaks
2 months is usually due to kinking in the hard- occur most commonly and are not immediately
ware of the unsupported stent-graft limb or ex- detrimental.
tension of the small-diameter stent-graft into the Type 1 endoleak is a result of inadequate ap-
external iliac artery. Late occlusion may be due position between the stent-graft and native artery
to graft migration and dislocation of the stent- at either the proximal or distal attachment site.
graft components, which causes major turbulence Therefore, the aneurysm sac is exposed to aortic
of hemodynamics and eventual thrombosis. This pressure and carries a high risk of rupture. This
can be addressed with thrombectomy, re-lining of endoleak is subdivided into type 1A, correspond-
the stent-graft with another stent-graft, anti­co- ing to the proximal portion of the stent-graft (Fig
agulant therapy, or a surgical bypass graft (41). 27a, 27d), and type 1B, corresponding to the dis-
tal portion of the stent-graft (Fig 27b, 27c).
Stent-Graft Migration Type 2 endoleak is the most common type,
Researchers at the Cleveland Clinic (Cleveland, occurring in about 20%–30% of patients and
Ohio) noted a 3.6% rate of device migration at persisting in 10%–15% of patients after 6 months
1 year (Fig 26) in 2003 (42). With more experi- (44). These endoleaks occur when there is ret-
ence, planning, and device improvement, the rate rograde flow of blood into the aneurysm sac
of this complication has improved. Stent-graft through branch vessels such as lumbar arteries
migration takes place when there is inadequate (Fig 28a, 28c) or a patent inferior mesenteric
apposition of the stent-graft onto the arterial artery (Fig 28a, 28b, 28d). These close spontane-
wall, occurring either at initial placement or with ously in about half of patients. Arteries contribut-
RG • Volume 35 Number 2 Bryce et al 611

Figure 26. Coronal (left) and axial (right) unenhanced CT images depict an endoprosthesis (arrows) dislodged
and floating within the aneurysm sac.

Figure 27. Type 1 endoleak. (a) Schematic diagram depicts type 1A and type 1B endoleaks. (b) Intraoperative
arteriogram obtained after stent-graft placement shows a type 1 endoleak emitting from the distal portion of
the graft. Arrow = blood opacifying the AAA sac. (c) Arteriogram demonstrates resolution of the type 1 endoleak
after an overlapping limb extension was placed on the right. (d) Coronal (left) and axial (right) CT angiograms
demonstrate opacified blood filling the aneurysm sac (black arrows) via the superior attachment site of the en-
doprosthesis. White arrows = top of stent-graft.

ing to a type 2 endoleak are often embolized with decrease as shown on follow-up images (43). For
coils or a liquid embolic agent (eg, ethylene–vinyl example, as demonstrated in Figure 28d, a patent
alcohol copolymer [Onyx; Covidien, Plymouth, inferior mesenteric artery supplying the aneu-
Minn]) if they persist beyond 6 months, espe- rysm sac can be accessed through the superior
cially if the sac diameter increases or fails to mesenteric artery and marginal artery. If there is
612 March-April 2015 radiographics.rsna.org

Figure 28. Type 2 endoleak. (a) Schematic diagram depicts two varieties of type 2 endoleak, one with reversal of flow through a
lumbar artery and another through a patent inferior mesenteric artery (IMA). (b) CT angiogram demonstrates a type 2 endoleak (ar-
rowhead) closely related to a patent inferior mesenteric artery. (c) CT angiogram shows a type 2 endoleak (arrowhead) from lumbar
arteries. (d) Aortograms show a patent inferior mesenteric artery (black arrow) supplying the aneurysm sac, which was embolized
with coils (blue arrow).

Figure 29. Type 3 endoleak. (a) Schematic diagram depicts a type 3 endoleak. (b) CT
angiograms show an abnormal collection and stranding surrounding the aneurysm sac,
consistent with rupture. Extravasation of contrast material (arrows) from a limb of the
endograft is seen, which is consistent with a type 3 endoleak and which resulted in sac
rupture. (c) Aortogram obtained with limb cannulation shows extravasation of contrast
material when the culprit limb is cannulated.
RG • Volume 35 Number 2 Bryce et al 613

Figure 30. Type 4 endoleak. (a) Sche-


matic diagram depicts a type 4 endoleak.
(b) Aortogram demonstrates slight opaci-
fication of the aneurysm sac (arrow) from
a type 4 endoleak.

Table 2: Predictors of Aneurysm Sac Growth after EVAR

Predictor Value
Patient age (y) >80
Proximal neck diameter (mm) 28–32 or >32
Proximal neck angle (degrees) <120
Iliac artery Only one > 20 mm
Follow-up Endoleak
Source.—Reference 44.
Note.—Table demonstrates statistically significant predictors of aneu-
rysm sac growth after EVAR.

difficulty cannulating the artery, a liquid embolic smaller than 120°, only one common iliac artery
agent may be injected directly into the aneurysm with a diameter greater than 20 mm, and endo­
sac under CT or fluoroscopic guidance. leaks present at follow-up (Table 2) (45).
Type 3 endoleak occurs through the body of the Sac enlargement leads to sac rupture (Fig 29b).
stent-graft because of a tear in the graft or inad- The EUROSTAR registry data demonstrated an
equate apposition or separation of the components aneurysm rupture rate of 0.4% at 1 year, 2.5% at
of the stent-graft (Fig 29). These endoleaks simi- 2 years, and 3.3% at 4 years (46). May et al (47)
larly expose the aneurysm sac to arterial pressure reported a rupture rate of 2.3% by 17 months.
and must be addressed, usually by re-lining the
stent-graft with a new stent-graft component. Radiation Safety
Type 4 endoleak is caused by too many pores One final drawback to the EVAR procedure is
in the graft. These endoleaks occur intraprocedur- radiation exposure. Radiation exposure during
ally and are transient, usually resolving after with- the procedure is influenced by patient size and
drawal of anticoagulation therapy (Fig 30). With technique, such as fluoroscopy time, distance
newer devices, this is no longer a prominent issue. of the x-ray tube to the skin surface, x-ray unit
Type 5 describes an endoleak with no demon- used, size of the radiation field, normal- versus
strated cause and is also known as endotension. It high-dose continuous dose rate, use of pulse fluo-
is a diagnosis of exclusion. roscopy, and beam attenuation between the tube
and skin surface (48). Badger and colleagues (48)
Sac Enlargement and Rupture saw a weak correlation between aneurysm size
Schanzer et al (44) found certain factors to be and radiation dose as time was increased to can-
predictive of sac enlargement. These factors nulate the gate in larger aneurysms. Weerakkody
include patient age older than 80 years, proximal et al (49) demonstrated that radiation exposure
neck diameter of 28–32 mm, proximal neck di- exceeded 2 Gy in 29% of EVAR patients, 2 Gy
ameter greater than 32 mm, proximal neck angle being the threshold for deterministic skin effects
614 March-April 2015 radiographics.rsna.org

(50). Perhaps more important, however, in addi- the Society of Interventional Radiology and endorsed by
the Cardiovascular and Interventional Radiological Society
tion to the dose acquired during the procedure of Europe and the Canadian Interventional Radiology As-
itself, patients undergo lifelong yearly follow-up sociation. J Vasc Interv Radiol 2010;21(11):1632–1655.
CT examinations, which increase the burden of 4. Schermerhorn ML, O’Malley AJ, Jhaveri A, Cotterill P,
Pomposelli F, Landon BE. Endovascular vs. open repair of
radiation exposure and have important stochas- abdominal aortic aneurysms in the Medicare population. N
tic implications. Kalef-Ezra et al (47) calculated Engl J Med 2008;358(5):464–474.
that within the 1st year alone, a patient receives 5. United Kingdom EVAR Trial Investigators, Greenhalgh RM,
Brown LC, et al. Endovascular versus open repair of abdominal
an effective dose of about 62 mSv, which is 30 aortic aneurysm. N Engl J Med 2010;362(20):1863–1871.
times higher than the dose received from annual 6. Patel VI, Lancaster RT, Mukhopadhyay S, et al. Impact of
background radiation (48). By matching the age chronic kidney disease on outcomes after abdominal aortic
aneurysm repair. J Vasc Surg 2012;56(5):1206–1213.
distribution data of the study by Kalef-Ezra et al 7. Park B, Mavanur A, Drezner AD. Chronic obstructive pul-
with the excess lifetime mortality data from the monary disease is not an independent marker for adverse
National Academy of Sciences, and thereby as- outcomes in endograft repair of abdominal aortic aneurysms.
Ann Vasc Surg 2008;22(3):341–345.
suming a risk factor of 4% per sievert, the excess 8. Feringa HH, Karagiannis S, Vidakovic R, et al. Comparison
mortality due to radiation-induced carcinogenesis of the incidences of cardiac arrhythmias, myocardial ischemia,
from the procedures carried out in the 1st year and cardiac events in patients treated with endovascular versus
open surgical repair of abdominal aortic aneurysms. Am J
was estimated to be one in about 400 (48). After Cardiol 2007;100(9):1479–1484.
10 years, that number increases to one in about 9. Di Centa I, Coggia M, Cochennec F, Alfonsi P, Javerliat
155 (48). However, aneurysms tend to occur I, Goëau-Brissonnière O. Laparoscopic abdominal aortic
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in older patients, with a 10-year survival rate of 1135–1139.
about 44% (51). Radiation exposure is some- 10. Eisenack M, Umscheid T, Tessarek J, Torsello GF, Torsello
thing to keep in mind when dealing with younger GB. Percutaneous endovascular aortic aneurysm repair: a
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glasses; proper angulation of the tube such that 12. Chaikof EL, Fillinger MF, Matsumura JS, et al. Identifying
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13. Rutherford RB. Open versus endovascular stent graft repair
ing the radiation field, also decreases exposure to for abdominal aortic aneurysms: an historical view. Semin
the interventionalist and staff. Lipsitz et al (51) Vasc Surg 2012;25(1):39–48.
reported an annual effective eye dose to an inter- 14. Wyss TR, Brown LC, Powell JT, Greenhalgh RM. Rate and
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ventionalist of 2–7 mSv and effective hand dose abdominal aortic aneurysm repair: data from the EVAR
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Conclusion 2006;111(4):597–606.
EVAR is a procedure that has revolutionized 17. Sternbergh WC 3rd, Money SR, Greenberg RK, Chuter TA;
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18. Stanley BM, Semmens JB, Mai Q, et al. Evaluation of patient
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19. Aburahma AF, Campbell JE, Mousa AY, et al. Clinical
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20. Tsai S, Conrad MF, Patel VI, et al. Durability of open re-
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TM
This journal-based SA-CME activity has been approved for AMA PRA Category 1 Credit . See www.rsna.org/education/search/RG.

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