UNIT 4: ORGANIC REACTIONS AND REAGENTS (18 Hours)

Mannich. Simon-Smith, Heck, reactions.Michacl. Prevost, and Woodwardhydroxylation of alkencs,

Shapiro reaction, Sharpless asymmetric epoxidation, ring formation by Dieckmann,(Thorpè, and
Acyloin condensation. Robinson ring annulations, reduction, and öxidation in synthesis - catalytic
hydrogcnation. AIkali metal rcduction. Birch reduction. Wolff-Kishner reduction, Huang-Milon
nodilication. Clemmenson reduction. LAH, DIBAL, sodium borohydride as reductance. Oppenauer
oxidation. HIO. OsO04, and mCPBA and their applications..Synthetic applications of the following
reagents - Gillman's reagenn, LDA, , 3 dithianes, DQ,(DDC) SeO:, Bakers yeast, NBS,
Vilkinsons's catalyst. Asymmetric reduetions using BINAL-I. Asym1metrie hydroboration using
IPC2BHand IPCBH2. Reduction wih CBH reagent.