Title: The Challenges of Crafting a Gout Research Paper

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These are monoarticular involvement of a foot or ankle joint (especially the first metatarsophalangeal
joint); previous episodes of similar acute arthritis; rapid onset of severe. The gold standard for
diagnosing gout is the identification of MSU crystals in synovial fluid by polarization light
microscopy. Chengdu University of Traditional Chinese Medicine 66. Next to gout, the patient was
diagnosed with Polycythe- mia Vera and he suffered from polyglobulia, thrombocy- tosis and
microcytosis. There is also a renewed interest in important associations between gout and other
comorbidities like hypertension and cardiovascular disease. This will enable us to more accurately
determine the consequence of tophi depositions on joint deformity and functional impair- ments and
to monitor the effect of urate-lowering drugs on tophi formation. Urate transporter 1(URAT-1) is the
key transporter controlling the transport of urate ions from lumen to proximal tubular cells and has
been established to play a critical role in maintenance of urate homeostasis. Help Center Here you'll
find an answer to your question. RISK FACTORS Sex Men have a higher level of serum urate
rendering them significantly more vulnerable to gout with higher probability of development of gout
in men below the age of 30 compared to women of comparable age. Clinical Trial Overview of
Takeda Global Research and Development Center, Inc 49. Non-steroidal anti-inflammatory agents
(NSAIDs) are also used for the treatment of acute pain symptoms. Though highly effective is the
treatment initiated within 24 hrs of pain attack, the NSAIDs have been found to produce
complications in elderly patients with cardiovascular problems and renal malfunction. It is a common
inflammatory arthritis that has increased in prevalence in recent decades. Clinical Trial Overview of
The University of Mississippi Medical Center 56. Using a formal voting process, a panel of 78
international rheumatologists selected 10 key clinical questions pertinent to the diagnosis and
management of gout. Clinical Trial Overview of Mutual Pharmaceutical Company, Inc. 34. Gouty
Arthritis (Gout) Therapeutics Clinical Trials Market, Global, Clinical Trials by St. Clinical Trial
Overview of Dartmouth-Hitchcock Medical Center 69. Comorbidities, including the metabolic
syndrome and impaired renal function are common in gout patients. All these are common to the
metabolic reaction in mammalians. This pathway is responsible for neutrophilic synovitis through
expression of interleukin-8 (IL-8) in the monocytic cells that further leads to neutrophil accumulation
in synovium. GOUT MANAGEMENT A three phase therapeutic regime is followed for the
treatment of gout. Radio- graphic examination ( Figure 1 ) showed sharply margi- nated juxta-
articular erosions and marked soft tissue swelling. Statistics Make data-driven decisions to drive
reader engagement, subscriptions, and campaigns. Clinical Trial Overview of The University of
South Florida 61. Clinical Trial Overview of SK Chemicals Co., Ltd. 46. Comorbidities as
hypertension, chronic kidney disease, cardiovascular diseases, the metabolic syndrome, diabetes,
obesity, hyperlipidemia, and early menopause are associated with a higher prevalence of gout. Note:
Certain sections in the report may be removed or altered based on the availability and relevance of
data for the indicated. We evaluated potential risk factors for incident gout in a nested case-control
study with 50,000 controls frequency-matched by age, sex and calendar time. Maintenance of good
hydration needs to be stressed to those at risk for nephrolithiasis.
RISK FACTORS Sex Men have a higher level of serum urate rendering them significantly more
vulnerable to gout with higher probability of development of gout in men below the age of 30
compared to women of comparable age. The data reveal a precipitating number of gout cases from
the developed countries, while the developing countries on the other hand are faced with an even
higher threat. Contrary to this macrophages with urate crystals failed to perform either of these
actions. A search for crystals in synovial fluid or tophus aspirates is recommended in every person
with suspected gout, because demonstration of monosodium urate (MSU) crystals allows a definite
diagnosis of gout. Clinical Trial Overview of Chengdu University of Traditional Chinese Medicine
66. Upload Read for free FAQ and support Language (EN) Sign in Skip carousel Carousel Previous
Carousel Next What is Scribd. Clinical Trial Overview of University of Massachusetts 71.
Corticosteroids: intra-articular, intravenous, intramuscular or oral corticosteroids are effective in acute
gout. Gout normally results from the interaction of genetic, constitutional and environmental risk
factors. Drug treat- ment aimed at lowering uric acid levels will subsequently lead to tophi resolution
and regain of full range of motion. A major determinant is the degree of elevation of uric acid levels
above the saturation point for urate crystal formation, principally caused by inefficient renal urate
excretion. Primary gout runs in families and follows multifactorial inheritance. These cookies will be
stored in your browser only with your consent. This review aims to provide guidance for gout
management in clinical practice, which includes the diagnosis, treatment of acute episodes, but also
long-term therapy to reduce serum urate, as well as lifestyle changes and prevention of recurrent
episodes. Clinical Trial Overview of SK Chemicals Co., Ltd. 46. Chengdu University of Traditional
Chinese Medicine 66. Such conditions are favored in presence of ethanol which on one hand
increases ATP degradation, simultaneously reducing renal excretion due to dehydration and
metabolic acidosis. Further presence of needle shaped crystals of MSU within the tophi or synovium
lead to gout diagnosis. GOUT MANAGEMENT A three phase therapeutic regime is followed for
the treatment of gout. The first page of the PDF of this article appears above. Full description Save
Save Gout For Later 0% 0% found this document useful, Mark this document as useful 0% 0%
found this document not useful, Mark this document as not useful Embed Share Print Download
now Jump to Page You are on page 1 of 6 Search inside document. Let us write or edit the research
paper on your topic. Terfenadine is a toxic parent drug, with a beneficial active metabolite. This
report provides elemental information and data relating to the clinical trials on Gouty Arthritis
(Gout). A new diagnostic method, dual energy computed tomography, was effective in some selected
cases of gout, as it may reveal uric acid crystals with specific densities in the damaged joints and
periarticular soft tissues. Video Say more by seamlessly including video within your publication.
Chronic tophaceous gout on the other hand often results as a consequence of years of acute gout and
is characterized by skin exhibiting symptoms of nodular tophi, chronic ulcers and panniculitis.
Clinical Trial Overview of Intas Pharmaceuticals Ltd. 51. Well-designed, long-term, controlled
clinical trials evaluating the comparative efficacy and tolerability of treatments for gout are needed.
Maintenance of good hydration needs to be stressed to those at risk for nephrolithiasis.
Competing in the European Molecular Diagnostics Market: France, Germany, Ital. Digital Sales Sell
your publications commission-free as single issues or ongoing subscriptions. Upload Read for free
FAQ and support Language (EN) Sign in Skip carousel Carousel Previous Carousel Next What is
Scribd. Well-designed, long-term, controlled clinical trials evaluating the comparative efficacy and
tolerability of treatments for gout are needed. GIFs Highlight your latest work via email or social
media with custom GIFs. This accounts for the positive correlation observed between serum urate
levels and risk of development of gout (Choi et al., 2005). The silencing of uricase enzymes (present
in non-primates and lower primates); in humans as a part of the evolution process leads to gout
conditions; a disease exclusively occurring in man. Adobe InDesign Design pixel-perfect content like
flyers, magazines and more with Adobe InDesign. Many drugs influence serum uric acid levels
through an effect on renal urate transport. Clinical Trial Overview of Dartmouth-Hitchcock Medical
Center 69. The review of systems was negative for headache, fever, chills, rash, earache, sore throat,
cough, rhinorrhea, vision changes, weight loss, or change in appetite or disposition. Obesity has been
found to be associated with enhance urate synthesis and lower excretion of urate from the kidneys;
thereby leading to raised serum urate levels (Weaver, 2008). Acute attack untreated attacks usually
last two to 21 days depending on cases. This prompted a systematic review and update of the 2006
recommendations. This pain and inflammation are caused by inflammatory response. Obesity and
insulin resistance therefore are risk factors for gout due to involvement of fructose in urate synthesis
(Choi et al., 2005). Figure 2: Urate production pathway: gout pathogenesis (Chou et al., 2005) Figure
3: Urate transport mechanism in human proximal tubule (Chou et al., 2005) Renal Urate Transport
The urate in the kidney proceeds through glomerular filtration, reabsorption of filtered urate, urate
secretion, and finally post secretory reabsorption in renal proximal tubule. URAT 1 is essential for the
activity of both uricosuric and antiuricosuric agents. Top Five Countries Contributing to Clinical
Trials in Central and South America 15. Video Say more by seamlessly including video within your
publication. Recent studies have provided information on dietary risk factors for gout: higher intakes
of red meat, fructose and beer are independently associated with increased risk, whereas higher
intakes of coffee, low-fat dairy products and vitamin C are associated with lower risk. A systematic
review of the literature concerning all aspects of gout diagnosis was performed. The joint should be
rested as much as possible in a position of comfort. Report this Document Download now Save Save
Case Study in Gout For Later 0% (1) 0% found this document useful (1 vote) 1K views 17 pages
Anatomy and Physiology of the Skeletal System and an Overview of the Causes, Risk Factors, and
Symptoms of Gout Uploaded by Paulette Olisco AI-enhanced title and description Gout is a type of
arthritis caused by uric acid crystals building up in the joints, which causes sudden and severe pain,
swelling, and inflammation. Clinical Trial Overview of The University of Nottingham 58. A new
diagnostic method, dual energy computed tomography, was effective in some selected cases of gout,
as it may reveal uric acid crystals with specific densities in the damaged joints and periarticular soft
tissues. The first page of the PDF of this article appears above. Treatment involves lifestyle changes,
medications to lower uric acid levels, and medications to relieve pain and prevent flares. Clinical
Trial Overview of BioCryst Pharmaceuticals, Inc. 38. The University of Texas Southwestern Medical
Center at Dallas 67. Results: In 2012, in the population aged 20 years and above, the prevalence of
gout was 1.8 % (95 % confidence interval (CI) 1.77 to 1.82) and the incidence was 190 cases (95 %
CI 180 to 200) per 100,000 person-years. Cation levels along with several other factors such as
changes in characteristics of extracellular matrix of the joint leading to rise in levels of
nonaggregated proteoglycans, chondroitin sulfate, collagen fibrils etc may also contribute to
crystallization of urates since these molecules act as nucleating agents for urates.