Bin

din
g
prof
ile
Par
oxe
 tine

Receptor Ki (nM)

SERT 0.07 – 0.2

NET 40 – 85

DAT 490

D2 7,700

5-HT1A 21,200
 5-HT2A 6,300

5-HT2C 9,000

α1 1,000 – 2,700

α2 3,900

M1 72

13,700 –
H1
23,700

Pharmacokinetics[edit]
Paroxetine is well-absorbed following oral administration.[83] It has an absolute bioavailability of about
50%, with evidence of a saturable first pass effect.[93] When taken orally, it achieves maximum
concentration in about 6–10 hours[83] and reaches steady-state in 7–14 days.[93] Paroxetine exhibits
significant interindividual variations in volume of distribution and clearance. [93] Less than 2% of an
oral dose is excreted in urine unchanged.[93]
Paroxetine is a mechanism-based inhibitor of CYP2D6.[86][94]